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Gene: Kmt2a (lysine methyltransferase 2A) Rattus norvegicus
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Symbol: Kmt2a
Name: lysine methyltransferase 2A
Description: Predicted to have several functions, including DNA binding activity; histone methyltransferase activity (H3-K4 specific); and lysine-acetylated histone binding activity. Involved in membrane depolarization and response to potassium ion. Predicted to localize to the MLL1 complex and cytosol. Human ortholog(s) of this gene implicated in B- and T-cell mixed leukemia; acute myeloid leukemia; cervical cancer; and non-Hodgkin lymphoma. Orthologous to human KMT2A (lysine methyltransferase 2A); PARTICIPATES IN DNA modification pathway; histone modification pathway; INTERACTS WITH (RS)-amphetamine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: MODEL
Also known as: histone-lysine N-methyltransferase 2A; histone-lysine N-methyltransferase MLL; lysine (K)-specific methyltransferase 2A; Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or trithorax Drosophila gene); Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene); Mll; Mll1; Mll_mapped; myeloid/lymphoid or mixed-lineage leukemia; myeloid/lymphoid or mixed-lineage leukemia (mapped); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia 1
Orthologs:
Homo sapiens (human) : KMT2A (lysine methyltransferase 2A)  HGNC  Alliance
Mus musculus (house mouse) : Kmt2a (lysine (K)-specific methyltransferase 2A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kmt2a (lysine methyltransferase 2A)
Pan paniscus (bonobo/pygmy chimpanzee) : KMT2A (lysine methyltransferase 2A)
Canis lupus familiaris (dog) : KMT2A (lysine methyltransferase 2A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kmt2a (lysine methyltransferase 2A)
Sus scrofa (pig) : KMT2A (lysine methyltransferase 2A)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0849,110,407 - 49,185,872 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0847,728,915 - 47,804,551 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4847,759,175 - 47,834,586 (-)NCBIRGSC3.4rn4RGSC3.4
Celera844,701,780 - 44,782,476 (-)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Kmt2a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1586165
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.