KMT2A (lysine methyltransferase 2A) - Rat Genome Database

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Gene: KMT2A (lysine methyltransferase 2A) Pan paniscus
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Symbol: KMT2A
Name: lysine methyltransferase 2A
RGD ID: 11739974
Description: ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); INVOLVED IN cellular response to transforming growth factor beta stimulus (ortholog); membrane depolarization (ortholog); peptidyl-lysine monomethylation (ortholog); PARTICIPATES IN DNA modification pathway; histone modification pathway; ASSOCIATED WITH Acute Erythroleukemia (ortholog); acute lymphoblastic leukemia (ortholog); acute monocytic leukemia (ortholog); FOUND IN cytosol (inferred); histone methyltransferase complex (inferred); MLL1 complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: histone-lysine N-methyltransferase 2A; MLL; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29119,139,884 - 119,230,967 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111120,244,773 - 120,335,992 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011113,273,198 - 113,364,404 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111117,203,337 - 117,294,755 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11117,204,820 - 117,290,100 (+)EnsemblpanPan2panpan1.1
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KMT2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29119,139,884 - 119,230,967 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111120,244,773 - 120,335,992 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011113,273,198 - 113,364,404 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111117,203,337 - 117,294,755 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11117,204,820 - 117,290,100 (+)EnsemblpanPan2panpan1.1
KMT2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811118,436,492 - 118,526,832 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11118,436,456 - 118,526,832 (+)Ensemblhg38GRCh38
GRCh3711118,307,207 - 118,397,547 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611117,812,415 - 117,901,146 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3411117,812,414 - 117,901,146NCBI
Celera11115,467,997 - 115,556,730 (+)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11114,244,065 - 114,334,229 (+)NCBIHuRef
CHM1_111118,193,852 - 118,284,190 (+)NCBICHM1_1
T2T-CHM13v2.011118,455,794 - 118,546,121 (+)NCBIT2T-CHM13v2.0
Kmt2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39944,714,652 - 44,793,492 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl944,714,652 - 44,792,594 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38944,803,355 - 44,881,352 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl944,803,355 - 44,881,296 (-)Ensemblmm10GRCm38
MGSCv37944,611,438 - 44,689,357 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36944,554,350 - 44,632,269 (-)NCBIMGSCv36mm8
Celera942,068,287 - 42,146,334 (-)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map924.84NCBI
Kmt2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8854,013,547 - 54,089,219 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl854,013,547 - 54,089,317 (-)EnsemblGRCr8
mRatBN7.2845,116,763 - 45,193,320 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl845,118,814 - 45,193,181 (-)EnsemblmRatBN7.2
Rnor_6.0849,110,407 - 49,185,872 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl849,114,990 - 49,158,971 (-)Ensemblrn6Rnor6.0
Rnor_5.0847,728,915 - 47,804,551 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4847,759,175 - 47,834,586 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera844,701,780 - 44,782,476 (-)NCBICelera
Cytogenetic Map8q22NCBI
Kmt2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541219,586,141 - 19,665,527 (+)Ensembl
ChiLan1.0NW_00495541219,586,435 - 19,670,149 (+)NCBIChiLan1.0ChiLan1.0
KMT2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1515,212,559 - 15,302,825 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl515,217,348 - 15,270,971 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha515,263,739 - 15,351,690 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0515,154,723 - 15,242,720 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl515,155,965 - 15,242,720 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1515,293,171 - 15,381,085 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0515,196,657 - 15,284,731 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0515,237,660 - 15,325,572 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kmt2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947100,558,662 - 100,644,258 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365423,391,774 - 3,562,147 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365423,480,071 - 3,566,823 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KMT2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl945,743,397 - 45,824,884 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1945,743,566 - 45,828,559 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2950,878,276 - 50,914,778 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KMT2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11109,819,748 - 109,912,763 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1109,853,758 - 109,908,113 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604316,125,381 - 16,218,277 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kmt2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478413,824,541 - 13,908,077 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478413,824,507 - 13,912,672 (+)NCBIHetGla 1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000039745   ⟹   ENSPPAP00000017046
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11117,204,820 - 117,290,100 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000039749   ⟹   ENSPPAP00000017050
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11117,205,036 - 117,290,100 (+)Ensembl
RefSeq Acc Id: XM_055094920   ⟹   XP_054950895
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v29119,139,884 - 119,230,967 (+)NCBI
NHGRI_mPanPan111120,244,774 - 120,335,992 (+)NCBI
RefSeq Acc Id: XM_055094922   ⟹   XP_054950897
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v29119,139,884 - 119,230,967 (+)NCBI
NHGRI_mPanPan111120,244,776 - 120,335,992 (+)NCBI
RefSeq Acc Id: XM_055094923   ⟹   XP_054950898
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v29119,139,884 - 119,230,967 (+)NCBI
NHGRI_mPanPan111120,244,777 - 120,335,992 (+)NCBI
RefSeq Acc Id: XM_055094924   ⟹   XP_054950899
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v29119,139,884 - 119,230,967 (+)NCBI
NHGRI_mPanPan111120,244,778 - 120,335,992 (+)NCBI
RefSeq Acc Id: XM_055094925   ⟹   XP_054950900
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v29119,139,884 - 119,230,967 (+)NCBI
NHGRI_mPanPan111120,244,784 - 120,335,992 (+)NCBI
Ensembl Acc Id: ENSPPAP00000017046   ⟸   ENSPPAT00000039745
Ensembl Acc Id: ENSPPAP00000017050   ⟸   ENSPPAT00000039749
RefSeq Acc Id: XP_054950895   ⟸   XM_055094920
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AMY2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054950897   ⟸   XM_055094922
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AMY2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054950898   ⟸   XM_055094923
- Peptide Label: isoform X3
- UniProtKB: A0A2R9AMY2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054950899   ⟸   XM_055094924
- Peptide Label: isoform X4
- UniProtKB: A0A2R9AMY2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054950900   ⟸   XM_055094925
- Peptide Label: isoform X5
- UniProtKB: A0A2R9AMY2 (UniProtKB/TrEMBL)
Protein Domains
Bromo   CXXC-type   PHD-type   Post-SET   SET


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000031591 Ensembl, UniProtKB/TrEMBL
  ENSPPAG00050026724 ENTREZGENE
Ensembl Transcript ENSPPAT00000039745.1 UniProtKB/TrEMBL
  ENSPPAT00000039749.1 UniProtKB/TrEMBL
  ENSPPAT00050056837 ENTREZGENE
  ENSPPAT00050056878 ENTREZGENE
Gene3D-CATH 1.20.920.10 UniProtKB/TrEMBL
  2.170.270.10 UniProtKB/TrEMBL
  3.30.160.360 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  6.10.250.2390 UniProtKB/TrEMBL
InterPro Bromodomain UniProtKB/TrEMBL
  Bromodomain-like_sf UniProtKB/TrEMBL
  EPHD UniProtKB/TrEMBL
  FYrich_C UniProtKB/TrEMBL
  FYrich_N UniProtKB/TrEMBL
  KMT2A_2B_SET UniProtKB/TrEMBL
  KMT2A_ePHD UniProtKB/TrEMBL
  KMT2A_PHD1 UniProtKB/TrEMBL
  KMT2A_PHD2 UniProtKB/TrEMBL
  KMT2A_PHD3 UniProtKB/TrEMBL
  MeTrfase_trithorax UniProtKB/TrEMBL
  Post-SET_dom UniProtKB/TrEMBL
  SET_dom UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/TrEMBL
  Znf_CXXC UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_PHD UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene KMT2A ENTREZGENE
PANTHER HISTONE-LYSINE-N-METHYLTRANSFERASE 2 KMT2 FAMILY MEMBER UniProtKB/TrEMBL
  PTHR45838:SF2 UniProtKB/TrEMBL
Pfam FYRC UniProtKB/TrEMBL
  FYRN UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
  zf-CXXC UniProtKB/TrEMBL
  zf-HC5HC2H UniProtKB/TrEMBL
  zf-HC5HC2H_2 UniProtKB/TrEMBL
PIRSF Methyltransferase_trithorax UniProtKB/TrEMBL
PROSITE BROMODOMAIN_2 UniProtKB/TrEMBL
  EPHD UniProtKB/TrEMBL
  FYRC UniProtKB/TrEMBL
  FYRN UniProtKB/TrEMBL
  POST_SET UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
  ZF_CXXC UniProtKB/TrEMBL
  ZF_PHD_2 UniProtKB/TrEMBL
SMART BROMO UniProtKB/TrEMBL
  FYRC UniProtKB/TrEMBL
  FYRN UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
  PostSET UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
Superfamily-SCOP SSF47370 UniProtKB/TrEMBL
  SSF57903 UniProtKB/TrEMBL
  SSF82199 UniProtKB/TrEMBL
UniProt A0A2R9AI62_PANPA UniProtKB/TrEMBL
  A0A2R9AMY2 ENTREZGENE, UniProtKB/TrEMBL