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Gene: KMT2A (lysine methyltransferase 2A) Homo sapiens
Symbol: KMT2A
Name: lysine methyltransferase 2A
Description: Exhibits several functions, including DNA binding activity; histone methyltransferase activity (H3-K4 specific); and lysine-acetylated histone binding activity. Involved in several processes, including histone modification; positive regulation of cellular response to drug; and regulation of nucleobase-containing compound metabolic process. Localizes to the MLL1 complex and cytosol. Implicated in B- and T-cell mixed leukemia; acute myeloid leukemia; cervical cancer; and non-Hodgkin lymphoma. Biomarker of prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALL-1; CDK6/MLL fusion protein; CXXC-type zinc finger protein 7; CXXC7; FLJ11783; histone-lysine N-methyltransferase 2A; histone-lysine N-methyltransferase MLL; HRX; HTRX1; hypothetical protein FLJ11783; lysine (K)-specific methyltransferase 2A; lysine N-methyltransferase 2A; mixed lineage leukemia 1; MLL; MLL-AF4 der(11) fusion protein; MLL-AF9; MLL/GAS7; MLL/GAS7 fusion protein; MLL/GMPS fusion protein; MLL1; MLL1A; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia protein 1; TET1-MLL; trithorax-like protein; TRX1; WDSTS; zinc finger protein HRX
Mus musculus (house mouse) : Kmt2a (lysine (K)-specific methyltransferase 2A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kmt2a (lysine methyltransferase 2A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kmt2a (lysine methyltransferase 2A)
Pan paniscus (bonobo/pygmy chimpanzee) : KMT2A (lysine methyltransferase 2A)
Canis lupus familiaris (dog) : KMT2A (lysine methyltransferase 2A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kmt2a (lysine methyltransferase 2A)
Sus scrofa (pig) : KMT2A (lysine methyltransferase 2A)
Chlorocebus sabaeus (African green monkey) : KMT2A (lysine methyltransferase 2A)
Heterocephalus glaber (naked mole-rat) : Kmt2a (lysine methyltransferase 2A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl11118,436,490 - 118,526,832 (+)EnsemblGRCh38hg38GRCh38
GRCh3811118,436,492 - 118,526,832 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711118,307,205 - 118,397,539 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611117,812,415 - 117,901,146 (+)NCBINCBI36hg18NCBI36
Build 3411117,812,414 - 117,901,146NCBI
Celera11115,467,997 - 115,556,730 (+)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11114,244,065 - 114,334,229 (+)NCBIHuRef
CHM1_111118,193,852 - 118,284,190 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants