Map3k1 (mitogen-activated protein kinase kinase kinase 1) - Rat Genome Database

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Gene: Map3k1 (mitogen-activated protein kinase kinase kinase 1) Mus musculus
Analyze
Symbol: Map3k1
Name: mitogen-activated protein kinase kinase kinase 1
RGD ID: 733802
MGI Page MGI
Description: Exhibits JUN kinase kinase kinase activity and cytoskeletal protein binding activity. Involved in several processes, including activation of JUN kinase activity; eyelid development in camera-type eye; and positive regulation of actin filament polymerization. Localizes to filamentous actin. Predicted to colocalize with cytoskeleton. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in 46,XY sex reversal 6 and breast cancer. Orthologous to human MAP3K1 (mitogen-activated protein kinase kinase kinase 1); PARTICIPATES IN adenosine signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; ceramide signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MAPK/ERK kinase kinase 1; MAPKKK1; MEK kinase 1; Mekk; MEKK 1; MEKK1; mitogen activated protein kinase kinase kinase 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913111,882,962 - 111,954,803 (-)NCBIGRCm39mm39
GRCm39 Ensembl13111,882,962 - 111,945,527 (-)Ensembl
GRCm3813111,746,428 - 111,818,269 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13111,746,428 - 111,808,993 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713112,536,641 - 112,599,191 (-)NCBIGRCm37mm9NCBIm37
MGSCv3613112,867,468 - 112,929,861 (-)NCBImm8
Celera13116,043,507 - 116,076,666 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1363.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2,4-trimethylbenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,5-hexanedione  (ISO)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetazolamide  (EXP)
alachlor  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (EXP)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
carboplatin  (ISO)
cefaloridine  (ISO)
cisplatin  (EXP,ISO)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
dacarbazine  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
endosulfan  (ISO)
enniatin  (ISO)
flutamide  (ISO)
formaldehyde  (ISO)
furan  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (EXP)
haloperidol  (ISO)
heptachlor  (ISO)
hexachlorobenzene  (ISO)
hyaluronic acid  (EXP)
iohexol  (ISO)
iopamidol  (ISO)
lipopolysaccharide  (EXP)
LY294002  (EXP)
microcystin-LR  (EXP)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel sulfate  (EXP,ISO)
o-anisidine  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
PCB138  (EXP)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
sulindac sulfide  (ISO)
tamoxifen  (EXP)
Tanshinone I  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
tipifarnib  (ISO)
topotecan  (ISO)
tungsten  (EXP)
undecane  (ISO)
urethane  (EXP,ISO)
valproic acid  (ISO)
vincristine  (ISO)
vitamin E  (EXP)
zinc atom  (ISO)
zinc dichloride  (EXP)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cornea morphology  (IAGP)
abnormal corneal stroma morphology  (IAGP)
abnormal eye morphology  (IAGP)
abnormal eye physiology  (IAGP)
abnormal eyelid development  (IAGP)
abnormal eyelid fusion  (IAGP)
abnormal eyelid margin morphology  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal iris morphology  (IAGP)
abnormal keratinocyte morphology  (IAGP)
abnormal Muller cell morphology  (IAGP)
abnormal pinna reflex  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retinal development  (IAGP)
abnormal retinal layer morphology  (IAGP)
abnormal retinal outer nuclear layer morphology  (IAGP)
abnormal retinal pigment epithelium morphology  (IAGP)
abnormal tumor morphology  (IAGP)
abnormal vascular smooth muscle physiology  (IAGP)
abnormal vascular wound healing  (IAGP)
cochlear outer hair cell degeneration  (IAGP)
congestive heart failure  (IAGP)
corneal opacity  (IAGP)
decreased circulating fructosamine level  (IEA)
decreased cochlear inner hair cell number  (IAGP)
decreased fasting circulating glucose level  (IEA)
decreased metastatic potential  (IAGP)
decreased ventricle muscle contractility  (IAGP)
early eyelid opening  (IAGP)
exophthalmos  (IAGP)
eyelids open at birth  (IAGP)
heart inflammation  (IAGP)
impaired fibroblast cell migration  (IAGP)
increased bone mineral content  (IEA)
increased bone mineral density  (IEA)
increased cardiomyocyte apoptosis  (IAGP)
increased cochlear outer hair cell number  (IAGP)
increased corneal stroma thickness  (IAGP)
increased lean body mass  (IEA)
increased mammary gland tumor incidence  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased response of heart to induced stress  (IAGP)
increased retinal apoptosis  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
microphthalmia  (IAGP)
organ of Corti degeneration  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
retinal degeneration  (IAGP)
retinal gliosis  (IAGP)
retinal neovascularization  (IAGP)
retinal photoreceptor degeneration  (IAGP)
thin retinal outer nuclear layer  (IAGP)
References

Additional References at PubMed
PMID:4035594   PMID:4724491   PMID:4865553   PMID:5630254   PMID:6740513   PMID:6883178   PMID:7618106   PMID:8385802   PMID:8597633   PMID:8621675   PMID:9065412   PMID:9078260  
PMID:9135144   PMID:9427625   PMID:9924790   PMID:10349636   PMID:10465784   PMID:10523642   PMID:10575011   PMID:10805784   PMID:10852963   PMID:11042159   PMID:11076861   PMID:11217851  
PMID:11278353   PMID:11756439   PMID:11782455   PMID:11891332   PMID:12048245   PMID:12049732   PMID:12122119   PMID:12458213   PMID:12466851   PMID:12493778   PMID:12520002   PMID:12584189  
PMID:12826667   PMID:12839996   PMID:12878610   PMID:12941696   PMID:14500727   PMID:14586403   PMID:14610273   PMID:14627958   PMID:14967141   PMID:15001576   PMID:15358865   PMID:15558021  
PMID:15601830   PMID:15607429   PMID:15795331   PMID:15882989   PMID:15908922   PMID:16081685   PMID:16141072   PMID:16141073   PMID:16491099   PMID:16557301   PMID:16568086   PMID:16760432  
PMID:16761309   PMID:16887003   PMID:17101801   PMID:17110930   PMID:17143273   PMID:17177285   PMID:17409352   PMID:17681137   PMID:18032450   PMID:18187455   PMID:18287093   PMID:18420486  
PMID:18467339   PMID:18635759   PMID:18855897   PMID:18984593   PMID:19710465   PMID:19737936   PMID:20466638   PMID:20923779   PMID:21129722   PMID:21153343   PMID:21162133   PMID:21267068  
PMID:21559298   PMID:21677750   PMID:21862560   PMID:21873635   PMID:21969564   PMID:22582703   PMID:23201579   PMID:23300479   PMID:24003131   PMID:25224220   PMID:25260751   PMID:25377219  
PMID:26109068   PMID:26496772   PMID:26542706   PMID:26774476   PMID:27528401   PMID:29787744   PMID:31992794   PMID:32290105  


Genomics

Comparative Map Data
Map3k1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913111,882,962 - 111,954,803 (-)NCBIGRCm39mm39
GRCm39 Ensembl13111,882,962 - 111,945,527 (-)Ensembl
GRCm3813111,746,428 - 111,818,269 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13111,746,428 - 111,808,993 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713112,536,641 - 112,599,191 (-)NCBIGRCm37mm9NCBIm37
MGSCv3613112,867,468 - 112,929,861 (-)NCBImm8
Celera13116,043,507 - 116,076,666 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1363.36NCBI
MAP3K1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl556,815,549 - 56,896,152 (+)EnsemblGRCh38hg38GRCh38
GRCh38556,815,543 - 56,896,152 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37556,111,376 - 56,191,979 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36556,146,657 - 56,227,736 (+)NCBINCBI36hg18NCBI36
Celera553,065,179 - 53,146,179 (+)NCBI
Cytogenetic Map5q11.2NCBI
HuRef553,082,897 - 53,163,892 (+)NCBIHuRef
CHM1_1556,113,966 - 56,195,023 (+)NCBICHM1_1
Map3k1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2243,348,572 - 43,414,706 (-)NCBI
Rnor_6.0 Ensembl243,329,516 - 43,393,207 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0243,329,516 - 43,393,203 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0262,373,717 - 62,440,715 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4243,062,252 - 43,126,058 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1242,987,560 - 43,051,968 (-)NCBI
Celera239,134,930 - 39,199,049 (-)NCBICelera
Cytogenetic Map2q14NCBI
Map3k1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544611,021,971 - 11,090,136 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544611,022,091 - 11,090,136 (-)NCBIChiLan1.0ChiLan1.0
MAP3K1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1558,745,573 - 58,826,959 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl558,745,579 - 58,826,959 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0557,116,405 - 57,197,017 (-)NCBIMhudiblu_PPA_v0panPan3
MAP3K1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1243,918,210 - 43,996,817 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl243,917,604 - 43,995,209 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha240,979,535 - 41,058,128 (+)NCBI
ROS_Cfam_1.0244,400,091 - 44,478,773 (+)NCBI
UMICH_Zoey_3.1241,477,057 - 41,555,639 (+)NCBI
UNSW_CanFamBas_1.0242,280,433 - 42,359,075 (+)NCBI
UU_Cfam_GSD_1.0243,100,342 - 43,179,022 (+)NCBI
Map3k1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213202,144,631 - 202,220,196 (-)NCBI
SpeTri2.0NW_00493648011,082,811 - 11,156,691 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1635,871,799 - 35,946,987 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11635,872,301 - 35,947,097 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21638,138,087 - 38,212,844 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1453,040,731 - 53,120,784 (+)NCBI
ChlSab1.1 Ensembl453,084,023 - 53,120,772 (+)Ensembl
Map3k1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247592,360,655 - 2,429,189 (-)NCBI

Position Markers
G67066  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813111,802,313 - 111,802,777UniSTSGRCm38
MGSCv3713112,592,521 - 112,592,985UniSTSGRCm37
Celera13116,102,771 - 116,103,235UniSTS
Cytogenetic Map13D2.2UniSTS
RH74713  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13D2.2UniSTS
cM Map1361.0UniSTS
ECD10515  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813111,746,568 - 111,747,151UniSTSGRCm38
MGSCv3713112,536,776 - 112,537,359UniSTSGRCm37
Celera13116,043,642 - 116,044,225UniSTS
Cytogenetic Map13D2.2UniSTS
REN28005  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813111,808,749 - 111,808,988UniSTSGRCm38
MGSCv3713112,598,957 - 112,599,196UniSTSGRCm37
Cytogenetic Map13D2.2UniSTS
Map3k1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13D2.2UniSTS
cM Map1361.0UniSTS
Map3k1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813111,746,676 - 111,746,860UniSTSGRCm38
MGSCv3713112,536,884 - 112,537,068UniSTSGRCm37
Celera13116,043,750 - 116,043,934UniSTS
Cytogenetic Map13D2.2UniSTS
cM Map1361.0UniSTS
Map3k1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813111,750,455 - 111,750,554UniSTSGRCm38
MGSCv3713112,540,663 - 112,540,762UniSTSGRCm37
Celera13116,047,500 - 116,047,599UniSTS
Cytogenetic Map13D2.2UniSTS
cM Map1361.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20293442112761890Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55572541112294569Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55572541112294569Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55572541112294569Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55572541112294569Mouse
4141266Mol3_mmodifier of LPS-response 3 (mouse)Not determined75984481112294569Mouse
12880414V125Dq10_mvitamin D active form serum level QTL 10 (mouse)1377900000111900000Mouse
10045623Heal18_mwound healing regeneration 18 (mouse)Not determined1379102537113102654Mouse
1558741Ses10_msalmonella enteritidis susceptibility 10 (mouse)Not determined1382603460116603598Mouse
4142465Pbwg17_mpostnatal body weight growth 17 (mouse)Not determined1383739552117739748Mouse
14700691Cisaq1_mcoxsackieviral infection serum ALT QTL 1 (mouse)1386000000120000000Mouse
4140995Fbtq6_mfemoral bone trait QTL 6 (mouse)Not determined1386205109120205250Mouse
4141728Egaq4_mearly growth adjusted QTL 4 (mouse)Not determined87753866112294569Mouse
1300939Hrtfm6_mheart failure modifier 6 (mouse)Not determined1391247158120421639Mouse
1300876Tanidd2_mtally ho associated non-insulin dependednt diabetes mellitus 2 (mouse)Not determined1391828769120421639Mouse
1301142Heal2_mwound healing/regeneration 2 (mouse)Not determined1393738733120421639Mouse
4142338Skmw18_mskeletal muscle weight 18 (mouse)Not determined1394391865120421639Mouse
1558763Gct9_mgranulosa cell tumorigenesis 9 (mouse)Not determined1394900290120421639Mouse
1357468Rplag_mreduced platelet aggregation (mouse)Not determined1395365596120421639Mouse
14746974Manh75_mmandible shape 75 (mouse)1399250111120421639Mouse
12879496Fexq2_mfear expression QTL 2 (mouse)13100604983120421639Mouse
13824989Pbsq1_mpercent broken sperm QTL 1 (mouse)13102000000112000000Mouse
4142400Tgq24_mtriglyceride QTL 24 (mouse)Not determined102466094120421639Mouse
4141826Tbqt5_mtibia bone quality traits 5 (mouse)Not determined13103205109116906680Mouse
4142334Svtms_msurvival time modifier of Sod2 (mouse)Not determined13107477080119339836Mouse
4141704Hipq1_mhyperinsulin production QTL 1 (mouse)Not determined110272953119339836Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1169
Count of miRNA genes:619
Interacting mature miRNAs:777
Transcripts:ENSMUST00000109267, ENSMUST00000130594, ENSMUST00000133364, ENSMUST00000145055, ENSMUST00000175936
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000109267   ⟹   ENSMUSP00000104890
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl13111,746,428 - 111,808,993 (-)Ensembl
RefSeq Acc Id: ENSMUST00000130594
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl13111,753,568 - 111,754,704 (-)Ensembl
RefSeq Acc Id: ENSMUST00000133364
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl13111,767,609 - 111,768,553 (-)Ensembl
RefSeq Acc Id: ENSMUST00000145055   ⟹   ENSMUSP00000117863
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl13111,767,984 - 111,808,315 (-)Ensembl
RefSeq Acc Id: ENSMUST00000175936
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl13111,748,793 - 111,751,373 (-)Ensembl
RefSeq Acc Id: NM_011945   ⟹   NP_036075
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3913111,882,962 - 111,945,527 (-)NCBI
GRCm3813111,746,428 - 111,808,993 (-)NCBI
MGSCv3713112,536,641 - 112,599,191 (-)RGD
Celera13116,043,507 - 116,076,666 (-)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017315516   ⟹   XP_017171005
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3913111,883,124 - 111,954,803 (-)NCBI
GRCm3813111,746,590 - 111,818,269 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036158051   ⟹   XP_036013944
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3913111,883,124 - 111,945,025 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_036075   ⟸   NM_011945
- UniProtKB: F8VQ72 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017171005   ⟸   XM_017315516
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000117863   ⟸   ENSMUST00000145055
RefSeq Acc Id: ENSMUSP00000104890   ⟸   ENSMUST00000109267
RefSeq Acc Id: XP_036013944   ⟸   XM_036158051
- Peptide Label: isoform X1
Protein Domains
Protein kinase   RING-type   SWIM-type

Promoters
RGD ID:8681300
Promoter ID:EPDNEW_M18680
Type:multiple initiation site
Name:Map3k1_1
Description:Mus musculus mitogen-activated protein kinase kinase kinase 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3813111,808,994 - 111,809,054EPDNEW
RGD ID:6824131
Promoter ID:MM_KWN:15258
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Kidney,   Liver,   Lung,   Spleen
Transcripts:OTTMUST00000047962
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3613112,544,771 - 112,545,777 (-)MPROMDB
RGD ID:6824128
Promoter ID:MM_KWN:15259
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000047961
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3613112,558,411 - 112,558,911 (-)MPROMDB
RGD ID:6824143
Promoter ID:MM_KWN:15260
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000022274,   OTTMUST00000047959,   OTTMUST00000047960,   OTTMUST00000047967
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3613112,597,461 - 112,599,587 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1346872 AgrOrtholog
Ensembl Genes ENSMUSG00000021754 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000104890 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000117863 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000109267 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000145055 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_SWIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:26401 UniProtKB/TrEMBL
MGD MGI:1346872 ENTREZGENE
NCBI Gene 26401 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SWIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MAP3K1 RGD
PhenoGen Map3k1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_SWIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YVX9_MOUSE UniProtKB/TrEMBL
  F8VQ72 ENTREZGENE, UniProtKB/TrEMBL
  M3K1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q60831 UniProtKB/Swiss-Prot
  Q9R0U3 UniProtKB/Swiss-Prot
  Q9R256 UniProtKB/Swiss-Prot