Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (R,R)-tramadol | multiple interactions | ISO | RGD:1603576 | 6480464 | Tramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | (S)-nicotine | multiple interactions | ISO | RGD:1603576 | 6480464 | Nicotine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | 17beta-estradiol | multiple interactions | ISO | RGD:1603576 | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of SLC47A2 mRNA, Estradiol promotes the reaction [ESR2 protein affects the expression of SLC47A2 mRNA] | CTD | PMID:20404318, PMID:30165855 | 17beta-estradiol | increases expression | ISO | RGD:1603576 | 6480464 | Estradiol results in increased expression of SLC47A2 mRNA | CTD | PMID:23019147 | 2,3',4,4',5-Pentachlorobiphenyl | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1603576 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SLC47A2 mRNA | CTD | PMID:20106945 | 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile | multiple interactions | ISO | RGD:1603576 | 6480464 | Verapamil inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium], Verapamil inhibits the reaction [SLC47A2 protein results in increased uptake of Tetraethylammonium] | CTD | PMID:22419765, PMID:27989701 | 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile | decreases activity | ISO | RGD:1603576 | 6480464 | Verapamil results in decreased activity of SLC47A2 protein | CTD | PMID:28629854, PMID:31364238 | 2-Ethyl-1,3-hexanediol | multiple interactions | ISO | RGD:1603576 | 6480464 | ethohexadiol affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | 3-[[oxo(pyridin-4-yl)methyl]hydrazo]-N-(phenylmethyl)propanamide | multiple interactions | ISO | RGD:1603576 | 6480464 | Nialamide inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | 3-Amino-1-methyl-5H-pyrido[4,3-b]indole | decreases activity | ISO | RGD:1603576 | 6480464 | 3-amino-1-methyl-5H-pyrido4, 3-bindole results in decreased activity of SLC47A2 protein | CTD | PMID:30189235 | agmatine | multiple interactions | ISO | RGD:1603576 | 6480464 | Agmatine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | amantadine | multiple interactions | ISO | RGD:1603576 | 6480464 | Amantadine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | amiloride | multiple interactions | ISO | RGD:1603576 | 6480464 | Amiloride inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | amitriptyline | multiple interactions | ISO | RGD:1603576 | 6480464 | Amitriptyline inhibits the reaction [SLC47A2 protein results in increased import of Tetraethylammonium] | CTD | PMID:28629854 | atropine | multiple interactions | ISO | RGD:1603576 | 6480464 | Atropine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzoapyrene results in decreased expression of SLC47A2 mRNA | CTD | PMID:23735875 | benzo[a]pyrene | affects methylation | ISO | RGD:1603576 | 6480464 | Benzoapyrene affects the methylation of SLC47A2 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | RGD:1603576 | 6480464 | Benzoapyrene results in increased expression of SLC47A2 mRNA | CTD | PMID:20106945 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | RGD:1603576 | 6480464 | Diethylhexyl Phthalate results in decreased expression of SLC47A2 mRNA | CTD | PMID:31163220 | bisphenol A | decreases expression | ISO | RGD:1562382 | 6480464 | bisphenol A results in decreased expression of SLC47A2 mRNA | CTD | PMID:25181051 | cadmium atom | increases uptake | ISO | RGD:1603576 | 6480464 | SLC47A2 protein results in increased uptake of Cadmium | CTD | PMID:27871888 | cadmium atom | increases response to substance | ISO | RGD:1603576 | 6480464 | SLC47A2 protein results in increased susceptibility to Cadmium | CTD | PMID:27871888 | cadmium atom | multiple interactions | ISO | RGD:1603576 | 6480464 | Cadmium inhibits the reaction [SLC47A2 protein results in increased uptake of Metformin], Cimetidine inhibits the reaction [SLC47A2 protein results in increased uptake of Cadmium] | CTD | PMID:27871888 | caffeine | multiple interactions | ISO | RGD:1603576 | 6480464 | Caffeine affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | chloramphenicol | multiple interactions | ISO | RGD:1603576 | 6480464 | Chloramphenicol affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | cimetidine | multiple interactions | ISO | RGD:1603576 | 6480464 | Cimetidine inhibits the reaction [SLC47A2 protein results in increased uptake of 4-4-dimethylaminostyryl-1-methylpyridinium], Cimetidine inhibits the reaction [SLC47A2 protein results in increased uptake of Cadmium] | CTD | PMID:21599003, PMID:27871888 | cinchonidine | multiple interactions | ISO | RGD:1603576 | 6480464 | cinchonidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | cinchonine | multiple interactions | ISO | RGD:1603576 | 6480464 | cinchonine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | clonidine | multiple interactions | ISO | RGD:1603576 | 6480464 | Clonidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | clonidine (amino form) | multiple interactions | ISO | RGD:1603576 | 6480464 | Clonidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | clonidine (imino form) | multiple interactions | ISO | RGD:1603576 | 6480464 | Clonidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | clothianidin | decreases activity | ISO | RGD:1603576 | 6480464 | clothianidin results in decreased activity of SLC47A2 protein | CTD | PMID:31364238 | creatinine | multiple interactions | ISO | RGD:1603576 | 6480464 | Creatinine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | cyclosporin A | decreases expression | ISO | RGD:1603576 | 6480464 | Cyclosporine results in decreased expression of SLC47A2 mRNA | CTD | PMID:20106945 | dextran sulfate | multiple interactions | EXP | | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of SLC47A2 mRNA | CTD | PMID:29950665 | famotidine | multiple interactions | ISO | RGD:1603576 | 6480464 | Famotidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | genistein | increases expression | ISO | RGD:1603576 | 6480464 | Genistein results in increased expression of SLC47A2 mRNA | CTD | PMID:23019147 | Guanfacine | multiple interactions | ISO | RGD:1603576 | 6480464 | Guanfacine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | guanidine | multiple interactions | ISO | RGD:1603576 | 6480464 | Guanidine affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | histamine | multiple interactions | ISO | RGD:1603576 | 6480464 | Histamine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | imiquimod | multiple interactions | ISO | RGD:1603576 | 6480464 | imiquimod inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | ketoconazole | multiple interactions | ISO | RGD:1603576 | 6480464 | Ketoconazole inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | lead(0) | affects expression | ISO | RGD:1603576 | 6480464 | Lead affects the expression of SLC47A2 mRNA | CTD | PMID:28903495 | lead(2+) | affects expression | ISO | RGD:1603576 | 6480464 | Lead affects the expression of SLC47A2 mRNA | CTD | PMID:28903495 | mercury dichloride | increases expression | EXP | | 6480464 | Mercuric Chloride results in increased expression of SLC47A2 mRNA | CTD | PMID:27720909 | metformin | increases uptake | ISO | RGD:1603576 | 6480464 | SLC47A2 protein results in increased uptake of Metformin | CTD | PMID:22419765 more ... | metformin | multiple interactions | ISO | RGD:1603576 | 6480464 | Cadmium inhibits the reaction [SLC47A2 protein results in increased uptake of Metformin] more ... | CTD | PMID:22419765 more ... | methylmercury chloride | increases expression | EXP | | 6480464 | methylmercuric chloride results in increased expression of SLC47A2 mRNA | CTD | PMID:27720909 | midodrine | multiple interactions | ISO | RGD:1603576 | 6480464 | Midodrine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | N-methyl-4-phenylpyridinium | increases uptake | ISO | RGD:1603576 | 6480464 | SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium | CTD | PMID:22419765 | N-methyl-4-phenylpyridinium | multiple interactions | ISO | RGD:1603576 | 6480464 | 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] more ... | CTD | PMID:22419765 | N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine | multiple interactions | ISO | RGD:1603576 | 6480464 | Ranitidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | naloxone | multiple interactions | ISO | RGD:1603576 | 6480464 | Naloxone inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | nickel atom | increases expression | ISO | RGD:1603576 | 6480464 | Nickel results in increased expression of SLC47A2 mRNA | CTD | PMID:24768652, PMID:25583101 | nicotine | multiple interactions | ISO | RGD:1603576 | 6480464 | Nicotine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | NMN zwitterion | multiple interactions | ISO | RGD:1603576 | 6480464 | Nicotinamide Mononucleotide inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | Ondansetron | multiple interactions | ISO | RGD:1603576 | 6480464 | Ondansetron inhibits the reaction [SLC47A2 protein results in increased uptake of 4-4-dimethylaminostyryl-1-methylpyridinium], Ondansetron inhibits the reaction [SLC47A2 protein results in increased uptake of Metformin] | CTD | PMID:21599003, PMID:24001450 | paracetamol | decreases expression | ISO | RGD:1603576 | 6480464 | Acetaminophen results in decreased expression of SLC47A2 mRNA | CTD | PMID:29067470 | paraquat | multiple interactions | ISO | RGD:1603576 | 6480464 | Paraquat inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | phenformin | multiple interactions | ISO | RGD:1603576 | 6480464 | Phenformin inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | phentolamine | multiple interactions | ISO | RGD:1603576 | 6480464 | Phentolamine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | procainamide | multiple interactions | ISO | RGD:1603576 | 6480464 | Procainamide analog inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium], Procainamide inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | proguanil | multiple interactions | ISO | RGD:1603576 | 6480464 | Proguanil inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | propranolol | multiple interactions | ISO | RGD:1603576 | 6480464 | Propranolol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | pyrimethamine | multiple interactions | ISO | RGD:1603576 | 6480464 | Pyrimethamine analog inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] more ... | CTD | PMID:22419765, PMID:32305507 | pyrimethamine | decreases activity | ISO | RGD:1603576 | 6480464 | Pyrimethamine results in decreased activity of SLC47A2 protein | CTD | PMID:32305507 | quinidine | multiple interactions | ISO | RGD:1603576 | 6480464 | Quinidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | quinine | multiple interactions | ISO | RGD:1603576 | 6480464 | Quinine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | ranitidine | multiple interactions | ISO | RGD:1603576 | 6480464 | Ranitidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | scopolamine | multiple interactions | ISO | RGD:1603576 | 6480464 | Scopolamine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | serotonin | multiple interactions | ISO | RGD:1603576 | 6480464 | Serotonin inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | silicon dioxide | decreases expression | ISO | RGD:1603576 | 6480464 | Silicon Dioxide analog results in decreased expression of SLC47A2 mRNA | CTD | PMID:25895662 | sulfadimethoxine | multiple interactions | ISO | RGD:1603576 | 6480464 | Sulfadimethoxine affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | sulfamerazine | multiple interactions | ISO | RGD:1603576 | 6480464 | Sulfamerazine affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | tacrine | multiple interactions | ISO | RGD:1603576 | 6480464 | Tacrine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | tetraethylammonium | multiple interactions | ISO | RGD:1603576 | 6480464 | Amitriptyline inhibits the reaction [SLC47A2 protein results in increased import of Tetraethylammonium] more ... | CTD | PMID:22419765 more ... | tetraethylammonium | increases import | ISO | RGD:1603576 | 6480464 | SLC47A2 protein results in increased import of Tetraethylammonium | CTD | PMID:28629854 | tetraethylammonium | increases uptake | ISO | RGD:1603576 | 6480464 | SLC47A2 protein results in increased uptake of Tetraethylammonium | CTD | PMID:27989701, PMID:32305507 | ticlopidine | multiple interactions | ISO | RGD:1603576 | 6480464 | Ticlopidine affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | titanium dioxide | multiple interactions | EXP | | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of SLC47A2 mRNA | CTD | PMID:29950665 | tramadol | multiple interactions | ISO | RGD:1603576 | 6480464 | Tramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | trichlormethiazide | multiple interactions | ISO | RGD:1603576 | 6480464 | Trichlormethiazide affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | trimethoprim | multiple interactions | ISO | RGD:1603576 | 6480464 | Trimethoprim inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate | multiple interactions | ISO | RGD:1603576 | 6480464 | Atropine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | tyramine | multiple interactions | ISO | RGD:1603576 | 6480464 | Tyramine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] | CTD | PMID:22419765 | valproic acid | increases methylation | ISO | RGD:1603576 | 6480464 | Valproic Acid results in increased methylation of SLC47A2 gene | CTD | PMID:29154799 | verapamil | decreases activity | ISO | RGD:1603576 | 6480464 | Verapamil results in decreased activity of SLC47A2 protein | CTD | PMID:28629854, PMID:31364238 | verapamil | multiple interactions | ISO | RGD:1603576 | 6480464 | Verapamil inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium], Verapamil inhibits the reaction [SLC47A2 protein results in increased uptake of Tetraethylammonium] | CTD | PMID:22419765, PMID:27989701 | zafirlukast | multiple interactions | ISO | RGD:1603576 | 6480464 | zafirlukast inhibits the reaction [SLC47A2 protein results in increased uptake of 4-4-dimethylaminostyryl-1-methylpyridinium] | CTD | PMID:21599003 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
References - curated
| 1. | Gong L, etal., Pharmacogenet Genomics. 2012 Nov;22(11):820-7. doi: 10.1097/FPC.0b013e3283559b22. |
| 2. | RGD automated import pipeline |
| 3. | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:10349636 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:12466851 | PMID:12477932 | PMID:14681479 | PMID:16141072 | PMID:16141073 | PMID:17715386 | PMID:18573474 | PMID:20016398 |
| PMID:21267068 | PMID:21677750 | PMID:21873635 | PMID:24194600 | PMID:27626380 |
Genomics
