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Gene: Dbh (dopamine beta hydroxylase) Mus musculus
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Symbol: Dbh
Name: dopamine beta hydroxylase
Description: Predicted to have copper ion binding activity and dopamine beta-monooxygenase activity. Involved in several processes, including behavioral response to ethanol; catecholamine metabolic process; and learning or memory. Localizes to secretory granule lumen and secretory granule membrane. Is expressed in several structures, including adrenal gland; alimentary system; and nervous system. Used to study dopamine beta-hydroxylase deficiency. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dopamine beta-hydroxylase; dopamine beta-monooxygenase
Orthologs:
Homo sapiens (human) : DBH (dopamine beta-hydroxylase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dbh (dopamine beta-hydroxylase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dbh (dopamine beta-hydroxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : DBH (dopamine beta-hydroxylase)
Canis lupus familiaris (dog) : DBH (dopamine beta-hydroxylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dbh (dopamine beta-hydroxylase)
Sus scrofa (pig) : DBH (dopamine beta-hydroxylase)
Chlorocebus sabaeus (African green monkey) : DBH (dopamine beta-hydroxylase)
Heterocephalus glaber (naked mole-rat) : Dbh (dopamine beta-hydroxylase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl227,165,233 - 27,183,200 (+)EnsemblGRCm38mm10GRCm38
GRCm38227,165,507 - 27,183,204 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37227,021,027 - 27,038,724 (+)NCBIGRCm37mm9NCBIm37
MGSCv36226,987,242 - 27,004,928 (+)NCBImm8
Celera226,868,411 - 26,886,118 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Dbh
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10460
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.