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Gene: Dbh (dopamine beta hydroxylase) Mus musculus
Symbol: Dbh
Name: dopamine beta hydroxylase
Description: Predicted to have copper ion binding activity and dopamine beta-monooxygenase activity. Involved in several processes, including behavioral response to ethanol; catecholamine metabolic process; and learning or memory. Localizes to secretory granule lumen and secretory granule membrane. Is expressed in several structures, including adrenal gland; alimentary system; and nervous system. Used to study dopamine beta-hydroxylase deficiency. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dopamine beta-hydroxylase; dopamine beta-monooxygenase
Homo sapiens (human) : DBH (dopamine beta-hydroxylase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dbh (dopamine beta-hydroxylase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dbh (dopamine beta-hydroxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : DBH (dopamine beta-hydroxylase)
Canis lupus familiaris (dog) : DBH (dopamine beta-hydroxylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dbh (dopamine beta-hydroxylase)
Sus scrofa (pig) : DBH (dopamine beta-hydroxylase)
Chlorocebus sabaeus (African green monkey) : DBH (dopamine beta-hydroxylase)
Heterocephalus glaber (naked mole-rat) : Dbh (dopamine beta-hydroxylase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl227,165,233 - 27,183,200 (+)EnsemblGRCm38mm10GRCm38
GRCm38227,165,507 - 27,183,204 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37227,021,027 - 27,038,724 (+)NCBIGRCm37mm9NCBIm37
MGSCv36226,987,242 - 27,004,928 (+)NCBImm8
Celera226,868,411 - 26,886,118 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Dbh
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10460
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.