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Gene: Flt4 (FMS-like tyrosine kinase 4) Mus musculus
Symbol: Flt4
Name: FMS-like tyrosine kinase 4
Description: Exhibits vascular endothelial growth factor-activated receptor activity. Involved in several processes, including lung alveolus development; regulation of blood vessel remodeling; and vasculature development. Predicted to localize to integral component of plasma membrane; nucleoplasm; and receptor complex. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and extraembryonic component. Used to study hereditary lymphedema. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Orthologous to human FLT4 (fms related receptor tyrosine kinase 4); PARTICIPATES IN axitinib pharmacodynamics pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI323512; Chy; chylous ascites; Flt-4; receptor protein tyrosine kinase; tyrosine-protein kinase receptor FLT4; vascular endothelial growth factor receptor 3; vascular endothelial growth factor receptor-3; VEGFR-3; VEGFR3
Homo sapiens (human) : FLT4 (fms related receptor tyrosine kinase 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Flt4 (Fms related receptor tyrosine kinase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Flt4 (fms related receptor tyrosine kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : FLT4 (fms related receptor tyrosine kinase 4)
Canis lupus familiaris (dog) : FLT4 (fms related receptor tyrosine kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Flt4 (fms related receptor tyrosine kinase 4)
Sus scrofa (pig) : FLT4 (fms related receptor tyrosine kinase 4)
Chlorocebus sabaeus (African green monkey) : FLT4 (fms related receptor tyrosine kinase 4)
Heterocephalus glaber (naked mole-rat) : Flt4 (fms related receptor tyrosine kinase 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1149,609,263 - 49,652,739 (+)EnsemblGRCm38mm10GRCm38
GRCm381149,609,679 - 49,652,739 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371149,423,181 - 49,466,241 (+)NCBIGRCm37mm9NCBIm37
MGSCv361149,453,150 - 49,495,652 (+)NCBImm8
Celera1154,171,357 - 54,214,402 (+)NCBICelera
Cytogenetic Map11B1.2NCBI
cM Map1129.69NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Flt4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733489
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.