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Gene: Flt4 (FMS-like tyrosine kinase 4) Mus musculus
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Symbol: Flt4
Name: FMS-like tyrosine kinase 4
Description: Exhibits vascular endothelial growth factor-activated receptor activity. Involved in several processes, including lung alveolus development; regulation of blood vessel remodeling; and vasculature development. Predicted to localize to integral component of plasma membrane; nucleoplasm; and receptor complex. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and extraembryonic component. Used to study hereditary lymphedema. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Orthologous to human FLT4 (fms related receptor tyrosine kinase 4); PARTICIPATES IN axitinib pharmacodynamics pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI323512; Chy; chylous ascites; Flt-4; receptor protein tyrosine kinase; tyrosine-protein kinase receptor FLT4; vascular endothelial growth factor receptor 3; vascular endothelial growth factor receptor-3; VEGFR-3; VEGFR3
Orthologs:
Homo sapiens (human) : FLT4 (fms related receptor tyrosine kinase 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Flt4 (Fms related receptor tyrosine kinase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Flt4 (fms related receptor tyrosine kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : FLT4 (fms related receptor tyrosine kinase 4)
Canis lupus familiaris (dog) : FLT4 (fms related receptor tyrosine kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Flt4 (fms related receptor tyrosine kinase 4)
Sus scrofa (pig) : FLT4 (fms related receptor tyrosine kinase 4)
Chlorocebus sabaeus (African green monkey) : FLT4 (fms related receptor tyrosine kinase 4)
Heterocephalus glaber (naked mole-rat) : Flt4 (fms related receptor tyrosine kinase 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1149,609,263 - 49,652,739 (+)EnsemblGRCm38mm10GRCm38
GRCm381149,609,679 - 49,652,739 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371149,423,181 - 49,466,241 (+)NCBIGRCm37mm9NCBIm37
MGSCv361149,453,150 - 49,495,652 (+)NCBImm8
Celera1154,171,357 - 54,214,402 (+)NCBICelera
Cytogenetic Map11B1.2NCBI
cM Map1129.69NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Flt4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733489
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.