Hc (hemolytic complement) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Hc (hemolytic complement) Mus musculus
Analyze
Symbol: Hc
Name: hemolytic complement
RGD ID: 10261
MGI Page MGI
Description: Predicted to enable endopeptidase inhibitor activity. Involved in positive regulation of angiogenesis. Acts upstream of or within several processes, including glomerulus development; inflammatory response to wounding; and neutrophil homeostasis. Predicted to be located in extracellular space. Predicted to be part of membrane attack complex. Is expressed in several structures, including central nervous system; future brain; genitourinary system; hemolymphoid system; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including complement component 5 deficiency; liver cirrhosis; neutropenia; paroxysmal nocturnal hemoglobinuria; and pneumonia. Orthologous to human C5 (complement C5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C5; C5a; complement C5; He; hepatic fibrogenesis 2; Hfib; Hfib2
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39234,873,341 - 34,958,518 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl234,873,343 - 34,951,450 (-)EnsemblGRCm39 Ensembl
GRCm38234,983,329 - 35,068,506 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl234,983,331 - 35,061,438 (-)EnsemblGRCm38mm10GRCm38
MGSCv37234,838,851 - 34,916,961 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36234,805,340 - 34,883,405 (-)NCBIMGSCv36mm8
Celera234,677,654 - 34,755,968 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map223.22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (ISO)
2-palmitoylglycerol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
Actein  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
chondroitin sulfate  (ISO)
chrysene  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
cytochalasin B  (ISO)
D-glucose  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dichloroacetic acid  (EXP)
dicrotophos  (ISO)
dioxygen  (EXP)
dithionite(2-)  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
ethylene glycol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenthion  (EXP)
flutamide  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (ISO)
genistein  (EXP)
glafenine  (ISO)
glucose  (EXP)
glutathione  (ISO)
heparin  (ISO)
herbicide  (EXP)
indometacin  (ISO)
inulin  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
leukotriene B4  (ISO)
levofloxacin  (ISO)
manganese(II) chloride  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
N,N-dimethylsphingosine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (ISO)
nickel atom  (EXP,ISO)
nickel sulfate  (EXP)
O-methyleugenol  (ISO)
olanzapine  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parthenolide  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
picoxystrobin  (ISO)
pifithrin-?  (ISO)
pirinixic acid  (EXP)
poly(styrene)  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
senecionine  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (EXP)
sunitinib  (ISO)
superoxide  (ISO)
T-2 toxin  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thapsigargin  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
tolcapone  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Contribution of anaphylatoxin C5a to late airway responses after repeated exposure of antigen to allergic rats. Abe M, etal., J Immunol. 2001 Oct 15;167(8):4651-60.
2. Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. Arumugam TV, etal., J Hepatol. 2004 Jun;40(6):934-41.
3. Complement factor C5a exerts an anti-inflammatory effect in acute pancreatitis and associated lung injury. Bhatia M, etal., Am J Physiol Gastrointest Liver Physiol. 2001 May;280(5):G974-8.
4. Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H. Bora NS, etal., J Immunol. 2006 Aug 1;177(3):1872-8.
5. Correlation of plasma complement split product levels with allergic respiratory disease activity and relation to allergen immunotherapy. Bowser C, etal., Ann Allergy Asthma Immunol. 2010 Jan;104(1):42-9.
6. Increased activation of the alternative complement pathway in sickle cell disease. Chudwin DS, etal., Clin Immunol Immunopathol. 1985 Oct;37(1):93-7.
7. Complement activation in patients with COVID-19: A novel therapeutic target. Cugno M, etal., J Allergy Clin Immunol. 2020 May 14. pii: S0091-6749(20)30650-3. doi: 10.1016/j.jaci.2020.05.006.
8. Role of IgG and complement component C5 in the initial course of experimental cryptococcosis. Dromer F, etal., Clin Exp Immunol. 1989 Dec;78(3):412-7.
9. Complement activation in cystic fibrosis respiratory fluids: in vivo and in vitro generation of C5a and chemotactic activity. Fick RB Jr, etal., Pediatr Res. 1986 Dec;20(12):1258-68.
10. The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis. Flierl MA, etal., PLoS One. 2008 Jul 2;3(7):e2560.
11. Induction of acute pulmonary inflammation. A differential effect of C5 and the 200,000 molecular weight form of trypsin-activated C5 (C5'). Fowler SR, etal., Am Rev Respir Dis. 1987 Sep;136(3):691-7.
12. Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma. Hasegawa K, etal., Hum Genet. 2004 Sep;115(4):295-301.
13. Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Hillebrandt S, etal., Nat Genet. 2005 Aug;37(8):835-43. Epub 2005 Jul 3.
14. Characterization and expression of the complementary DNA encoding rat histidine decarboxylase. Joseph DR, etal., Proc Natl Acad Sci U S A 1990 Jan;87(2):733-7.
15. Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. Karp CL, etal., Nat Immunol. 2000 Sep;1(3):221-6.
16. Renal C3 complement component: feed forward to diabetic kidney disease. Kelly KJ, etal., Am J Nephrol. 2015;41(1):48-56. doi: 10.1159/000371426. Epub 2015 Jan 30.
17. The role of C5a in the development of thrombotic glomerulonephritis in rats. Kondo C, etal., Clin Exp Immunol. 2001 May;124(2):323-9.
18. Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. Lajoie S, etal., Nat Immunol. 2010 Oct;11(10):928-35. Epub 2010 Aug 29.
19. Accentuated formation of the terminal C5b-9 complement complex in patient plasma precedes development of the adult respiratory distress syndrome. Langlois PF and Gawryl MS, Am Rev Respir Dis. 1988 Aug;138(2):368-75.
20. Complement factor C5a in acute exacerbation of Chronic Obstructive Pulmonary Disease. Marc MM, etal., Scand J Immunol. 2010 May;71(5):386-91.
21. C5 modulates airway hyperreactivity and pulmonary eosinophilia during enhanced respiratory syncytial virus disease by decreasing C3a receptor expression. Melendi GA, etal., J Virol. 2007 Jan;81(2):991-9. Epub 2006 Nov 1.
22. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
23. MGDs mouse GO annotations MGD data from the GO Consortium
24. MGD IEA MGD IEA
25. A recombinant vaccine effectively induces c5a-specific neutralizing antibodies and prevents arthritis. Nandakumar KS, etal., PLoS One. 2010 Oct 20;5(10):e13511.
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. Chemotactic mediator requirements in lung injury following skin burns in rats. Piccolo MT, etal., Exp Mol Pathol. 1999 Aug;66(3):220-6.
28. Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia. Pierangeli SS, etal., Arthritis Rheum. 2005 Jul;52(7):2120-4.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. Mouse MP Annotation Import Pipeline RGD automated import pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. FcgammaRIII is protective against Pseudomonas aeruginosa pneumonia. Rhein LM, etal., Am J Respir Cell Mol Biol. 2008 Apr;38(4):401-6. Epub 2007 Nov 1.
34. Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis. Riedemann NC, etal., FASEB J. 2004 Feb;18(2):370-2. Epub 2003 Dec 19.
35. Activation of the complement system in the adult respiratory distress syndrome. Robbins RA, etal., Am Rev Respir Dis. 1987 Mar;135(3):651-8.
36. Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumonia. Rubins JB, etal., J Clin Invest. 1995 Jan;95(1):142-50.
37. Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat. Short A, etal., Br J Pharmacol. 1999 Feb;126(3):551-4.
38. Response-selective C5a agonists: differential effects on neutropenia and hypotension in the rat. Short AJ, etal., Br J Pharmacol. 1999 Oct;128(3):511-4.
39. Protective effect of C5 shRNA on myocardial ischemia-reperfusion injury in rats. Tang K, etal., Can J Physiol Pharmacol. 2012 Oct;90(10):1394-402. doi: 10.1139/y2012-114. Epub 2012 Oct 15.
40. Mediators of lung injury in mice following systemic activation of complement. Tvedten HW, etal., Am J Pathol. 1985 Apr;119(1):92-100.
41. Myocardial infarction and apoptosis after myocardial ischemia and reperfusion: role of the terminal complement components and inhibition by anti-C5 therapy. Vakeva AP, etal., Circulation. 1998 Jun 9;97(22):2259-67.
42. Circulating immune complexes and complement levels in hemophilic children. Verroust F, etal., J Clin Lab Immunol. 1981 Sep;6(2):127-30.
43. Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat. Woodruff TM, etal., Arthritis Rheum. 2002 Sep;46(9):2476-85.
44. Systemic complement depletion diminishes perihematomal brain edema in rats. Xi G, etal., Stroke. 2001 Jan;32(1):162-7.
Additional References at PubMed
PMID:492335   PMID:1311971   PMID:1315305   PMID:1347918   PMID:1362103   PMID:1433507   PMID:1673105   PMID:1679748   PMID:1682866   PMID:1683831   PMID:1686571   PMID:1711041  
PMID:1887331   PMID:1901427   PMID:1916246   PMID:1970329   PMID:1970331   PMID:1985210   PMID:2002550   PMID:2165966   PMID:2303408   PMID:2436653   PMID:2878046   PMID:2880797  
PMID:2926135   PMID:3086235   PMID:3143893   PMID:3156187   PMID:3186715   PMID:3356901   PMID:3572304   PMID:4042679   PMID:4959665   PMID:5003195   PMID:6350178   PMID:6699408  
PMID:6766905   PMID:6952244   PMID:6961423   PMID:7216421   PMID:7743560   PMID:7774911   PMID:7964486   PMID:8015436   PMID:8056315   PMID:8075499   PMID:8088777   PMID:8138038  
PMID:8172644   PMID:8482578   PMID:8486356   PMID:8577718   PMID:8597642   PMID:8623347   PMID:8642293   PMID:8648091   PMID:8649451   PMID:8747923   PMID:8747926   PMID:8795714  
PMID:8799160   PMID:8799161   PMID:8812433   PMID:8833100   PMID:8848495   PMID:8900278   PMID:8903730   PMID:8919358   PMID:8980020   PMID:8992985   PMID:9047380   PMID:9209504  
PMID:9367154   PMID:9485083   PMID:9780168   PMID:9804569   PMID:9824491   PMID:10051620   PMID:10349636   PMID:10449528   PMID:10485651   PMID:10565608   PMID:10601189   PMID:10754334  
PMID:10811844   PMID:10878380   PMID:10964517   PMID:11017920   PMID:11034373   PMID:11042159   PMID:11076861   PMID:11160308   PMID:11217851   PMID:11247825   PMID:11309154   PMID:11433381  
PMID:11485323   PMID:11489951   PMID:11745379   PMID:11836529   PMID:11867678   PMID:12466851   PMID:12477932   PMID:12488432   PMID:12543861   PMID:12618914   PMID:12707300   PMID:12975457  
PMID:13954190   PMID:14247728   PMID:14500254   PMID:14660741   PMID:15033785   PMID:15100315   PMID:15192652   PMID:15379984   PMID:15385488   PMID:15466618   PMID:15529344   PMID:15917267  
PMID:16034133   PMID:16101818   PMID:16141072   PMID:16141073   PMID:16142393   PMID:16154690   PMID:16177324   PMID:16261419   PMID:16272350   PMID:16301658   PMID:16428769   PMID:16452172  
PMID:16517720   PMID:16547268   PMID:16611225   PMID:16715088   PMID:16769899   PMID:16778128   PMID:16836650   PMID:16861630   PMID:16923853   PMID:16944957   PMID:16953841   PMID:16982908  
PMID:17044927   PMID:17082620   PMID:17105819   PMID:17200182   PMID:17322907   PMID:17330941   PMID:17360740   PMID:17383432   PMID:17536017   PMID:17675563   PMID:17687047   PMID:17715065  
PMID:17956862   PMID:17967861   PMID:18063050   PMID:18084313   PMID:18328742   PMID:18378907   PMID:18411281   PMID:18426986   PMID:18454156   PMID:18490515   PMID:18490769   PMID:18524936  
PMID:18524992   PMID:18567839   PMID:18587006   PMID:18692252   PMID:18947875   PMID:19073822   PMID:19119706   PMID:19136662   PMID:19144695   PMID:19169648   PMID:19428302   PMID:19620403  
PMID:19657368   PMID:19706712   PMID:19795417   PMID:19800413   PMID:19805369   PMID:19843088   PMID:19864026   PMID:20002447   PMID:20033053   PMID:20140904   PMID:20357827   PMID:20375626  
PMID:20431069   PMID:20457757   PMID:20591742   PMID:20625009   PMID:20709903   PMID:20930931   PMID:21102504   PMID:21148255   PMID:21267068   PMID:21478262   PMID:21490292   PMID:21677750  
PMID:21704012   PMID:21736743   PMID:21769103   PMID:21801872   PMID:21859896   PMID:21926466   PMID:21929539   PMID:22057273   PMID:22057346   PMID:22058413   PMID:22147692   PMID:22199395  
PMID:22206032   PMID:22277671   PMID:22491257   PMID:22585573   PMID:22688254   PMID:22797180   PMID:22914051   PMID:22952717   PMID:23015755   PMID:23033813   PMID:23074214   PMID:23093649  
PMID:23189195   PMID:23263555   PMID:23420882   PMID:23530212   PMID:23620511   PMID:23625922   PMID:23806181   PMID:23911420   PMID:23936099   PMID:24184716   PMID:24194600   PMID:24260573  
PMID:24386419   PMID:24474777   PMID:24604562   PMID:24607390   PMID:24631530   PMID:24667943   PMID:24682410   PMID:24723363   PMID:24790148   PMID:24842924   PMID:24913232   PMID:24973440  
PMID:25032853   PMID:25039245   PMID:25124749   PMID:25172497   PMID:25391964   PMID:25573852   PMID:25725105   PMID:25739439   PMID:25765875   PMID:25851247   PMID:25933409   PMID:25999468  
PMID:26001927   PMID:26082779   PMID:26402732   PMID:26831747   PMID:27029558   PMID:27105526   PMID:27109176   PMID:27189410   PMID:27235854   PMID:27437704   PMID:27477770   PMID:27480531  
PMID:28028363   PMID:28139294   PMID:28205538   PMID:28223279   PMID:28301559   PMID:28390927   PMID:28490576   PMID:28539427   PMID:28572445   PMID:28806402   PMID:28918528   PMID:29123203  
PMID:29277896   PMID:29336888   PMID:29362231   PMID:29383821   PMID:29459677   PMID:29497373   PMID:29520270   PMID:29599777   PMID:29681511   PMID:29716893   PMID:29920276   PMID:29942300  
PMID:30074477   PMID:30390695   PMID:30395590   PMID:30429287   PMID:30429364   PMID:30552328   PMID:30569594   PMID:30714990   PMID:30910380   PMID:31076642   PMID:31084499   PMID:31196979  
PMID:31274379   PMID:31340811   PMID:31484063   PMID:31543464   PMID:31594939   PMID:31624141   PMID:32191644   PMID:32325033   PMID:33495506   PMID:33565394   PMID:33839682   PMID:33852847  
PMID:34001980   PMID:34039739   PMID:34473953   PMID:34543680   PMID:34702956   PMID:35509858   PMID:35649359   PMID:35840625   PMID:35960843   PMID:36002185   PMID:36692963   PMID:36720219  
PMID:36924504   PMID:37055506   PMID:37057874   PMID:37220746   PMID:37541213   PMID:37603848   PMID:37610411   PMID:38071913   PMID:38314895   PMID:38326494   PMID:38355793   PMID:38691454  
PMID:38833371   PMID:38881889  


Genomics

Comparative Map Data
Hc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39234,873,341 - 34,958,518 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl234,873,343 - 34,951,450 (-)EnsemblGRCm39 Ensembl
GRCm38234,983,329 - 35,068,506 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl234,983,331 - 35,061,438 (-)EnsemblGRCm38mm10GRCm38
MGSCv37234,838,851 - 34,916,961 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36234,805,340 - 34,883,405 (-)NCBIMGSCv36mm8
Celera234,677,654 - 34,755,968 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map223.22NCBI
C5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389120,952,335 - 121,074,865 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9120,932,987 - 121,075,195 (-)EnsemblGRCh38hg38GRCh38
GRCh379123,714,613 - 123,837,143 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369122,754,434 - 122,852,375 (-)NCBINCBI36Build 36hg18NCBI36
Build 349120,794,168 - 120,892,108NCBI
Celera994,363,035 - 94,461,011 (-)NCBICelera
Cytogenetic Map9q33.2NCBI
HuRef993,332,095 - 93,430,452 (-)NCBIHuRef
CHM1_19123,861,740 - 123,959,592 (-)NCBICHM1_1
T2T-CHM13v2.09133,148,474 - 133,270,972 (-)NCBIT2T-CHM13v2.0
C5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8338,668,174 - 38,759,468 (-)NCBIGRCr8
mRatBN7.2318,270,696 - 18,361,994 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl318,270,696 - 18,361,994 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx321,338,177 - 21,436,625 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0329,923,207 - 30,021,653 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0328,177,076 - 28,275,525 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0314,049,993 - 14,113,931 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0314,206,466 - 14,229,141 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl314,049,995 - 14,229,080 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0319,525,468 - 19,547,636 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0319,369,981 - 19,432,948 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4314,011,115 - 14,102,744 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1313,962,273 - 13,963,756 (-)NCBI
Celera312,987,748 - 13,080,508 (-)NCBICelera
Cytogenetic Map3p11NCBI
C5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21118,270,718 - 18,393,732 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1918,273,303 - 18,396,082 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0992,069,574 - 92,202,513 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19120,416,256 - 120,548,366 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9120,426,354 - 120,523,856 (-)Ensemblpanpan1.1panPan2
C5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11173,953,727 - 74,029,919 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1173,953,727 - 74,029,851 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1172,364,536 - 72,439,848 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01175,089,862 - 75,165,511 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1175,089,988 - 75,165,437 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11173,598,023 - 73,673,494 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01173,629,460 - 73,704,118 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01174,367,743 - 74,443,207 (-)NCBIUU_Cfam_GSD_1.0
C5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947189,622,879 - 189,804,753 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364879,391,804 - 9,474,159 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364879,391,774 - 9,474,168 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,995,668 - 261,133,483 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,995,662 - 261,088,868 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21293,077,418 - 293,163,277 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q2.13NCBI
C5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11218,525,855 - 18,624,048 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1218,525,880 - 18,623,636 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603524,390,627 - 24,506,352 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Hc
2554 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:754
Count of miRNA genes:430
Interacting mature miRNAs:496
Transcripts:ENSMUST00000028233, ENSMUST00000125549, ENSMUST00000151628, ENSMUST00000156049, ENSMUST00000156412
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
12904005Cfq2_mconditioned fear QTL 2 (mouse)22702264256396228Mouse
14746979Manh51_mmandible shape 51 (mouse)22896112962961129Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
26884438Sklq12_mskull length QTL 12, 16 week (mouse)22459001254890012Mouse
12904008Cfq6_mconditioned fear QTL 6 (mouse)23120303544508204Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
4142130Pgis2_mproteoglycan induced spondylitis 2 (mouse)Not determined22530805156971811Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
14746997Mancz2_mmandible centroid size 2 (mouse)22896112962961129Mouse
12792980Fbmd1_mfemoral bone mineral density 1, females only (mouse)22503449245034492Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
1300795Stia2_mserum transfer induced arthritis 2 (mouse)Not determined23487334334951450Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
13464253Ifvrq1_minfluenza virus resistance QTL 1 (mouse)23303449252034492Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22760206084013384Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
10402413Rmp5_mresistance to mousepox 5 (mouse)Not determined23487334334951450Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse

Markers in Region
Hc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38235,043,047 - 35,043,256UniSTSGRCm38
MGSCv37234,898,567 - 34,898,776UniSTSGRCm37
Celera234,737,624 - 34,737,833UniSTS
Cytogenetic Map2cen-C1UniSTS
cM Map223.5UniSTS
Hc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2cen-C1UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000028233   ⟹   ENSMUSP00000028233
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl234,873,343 - 34,951,450 (-)Ensembl
GRCm38.p6 Ensembl234,983,331 - 35,061,438 (-)Ensembl
Ensembl Acc Id: ENSMUST00000125549
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl234,881,302 - 34,890,863 (-)Ensembl
GRCm38.p6 Ensembl234,991,290 - 35,000,851 (-)Ensembl
Ensembl Acc Id: ENSMUST00000151628
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl234,884,976 - 34,896,339 (-)Ensembl
GRCm38.p6 Ensembl234,994,964 - 35,006,327 (-)Ensembl
Ensembl Acc Id: ENSMUST00000156049
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl234,881,208 - 34,883,348 (-)Ensembl
GRCm38.p6 Ensembl234,991,196 - 34,993,336 (-)Ensembl
Ensembl Acc Id: ENSMUST00000156412   ⟹   ENSMUSP00000144345
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl234,873,715 - 34,909,657 (-)Ensembl
GRCm38.p6 Ensembl234,983,703 - 35,019,645 (-)Ensembl
RefSeq Acc Id: NM_010406   ⟹   NP_034536
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39234,873,341 - 34,951,424 (-)NCBI
GRCm38234,983,329 - 35,061,412 (-)NCBI
MGSCv37234,838,851 - 34,916,961 (-)RGD
Celera234,677,654 - 34,755,968 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017315669   ⟹   XP_017171158
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39234,873,341 - 34,958,518 (-)NCBI
GRCm38234,983,329 - 35,068,506 (-)NCBI
Sequence:
RefSeq Acc Id: NP_034536   ⟸   NM_010406
- Peptide Label: preproprotein
- UniProtKB: P06684 (UniProtKB/Swiss-Prot),   A2AS36 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017171158   ⟸   XM_017315669
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000028233   ⟸   ENSMUST00000028233
Ensembl Acc Id: ENSMUSP00000144345   ⟸   ENSMUST00000156412
Protein Domains
Anaphylatoxin-like   Ig-like   NTR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06684-F1-model_v2 AlphaFold P06684 1-1680 view protein structure

Promoters
RGD ID:6831573
Promoter ID:MM_KWN:28860
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000029215
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36234,856,561 - 34,857,061 (-)MPROMDB
RGD ID:6831570
Promoter ID:MM_KWN:28861
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000029213
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36234,862,311 - 34,862,811 (-)MPROMDB
RGD ID:6831574
Promoter ID:MM_KWN:28862
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000029216
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36234,875,111 - 34,875,611 (-)MPROMDB
RGD ID:6831569
Promoter ID:MM_KWN:28863
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000029212
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36234,916,561 - 34,917,061 (-)MPROMDB
RGD ID:6877110
Promoter ID:EPDNEW_M2006
Type:initiation region
Name:Hc_1
Description:Mus musculus hemolytic complement , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38235,061,412 - 35,061,472EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96031 AgrOrtholog
Ensembl Genes ENSMUSG00000026874 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000028233 ENTREZGENE
  ENSMUST00000028233.7 UniProtKB/Swiss-Prot
  ENSMUST00000156412.3 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.20 UniProtKB/Swiss-Prot
  2.20.130.20 UniProtKB/Swiss-Prot
  2.40.50.120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.1540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1930 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1940 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.20.50.160 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anaphylotoxins (complement system) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A-macroglobulin_rcpt-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A-macroglobulin_rcpt-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M/Complement_sys UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_N_BRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha-macroglobulin_TED UniProtKB/Swiss-Prot
  Anaphylatoxin/fibulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anaphylatoxin_comp_syst UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anaphylatoxn UniProtKB/TrEMBL
  C3/4/5_MG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C5_CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  Immune_Resp_Modulators UniProtKB/TrEMBL
  Macroglobln_a2 UniProtKB/Swiss-Prot
  MG2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Netrin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Netrin_module_non-TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Terpenoid_cyclase/PrenylTrfase UniProtKB/Swiss-Prot
  TIMP-like_OB-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15139 UniProtKB/Swiss-Prot
MGD MGI:96031 ENTREZGENE
NCBI Gene 15139 ENTREZGENE
PANTHER IG GAMMA-2A CHAIN C REGION SECRETED FORM-RELATED UniProtKB/TrEMBL
  IMMUNOGLOBULIN HEAVY CONSTANT GAMMA 1-RELATED UniProtKB/TrEMBL
  MACROGLOBULIN / COMPLEMENT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11412:SF83 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAPASIN UniProtKB/TrEMBL
Pfam A2M UniProtKB/Swiss-Prot
  A2M_BRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANATO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C1-set UniProtKB/TrEMBL
  C5_CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TED_complement UniProtKB/Swiss-Prot
  V-set UniProtKB/TrEMBL
PhenoGen Hc PhenoGen
PRINTS ANAPHYLATOXN UniProtKB/TrEMBL
PROSITE ANAPHYLATOXIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANAPHYLATOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
  IG_MHC UniProtKB/TrEMBL
  NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART A2M UniProtKB/Swiss-Prot
  A2M_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANATO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C345C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGc1 UniProtKB/TrEMBL
  IGv UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF47686 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48239 UniProtKB/Swiss-Prot
  SSF48726 UniProtKB/TrEMBL
  SSF49410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50242 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0B6VMB2_MOUSE UniProtKB/TrEMBL
  A0A0C6E3V3_MOUSE UniProtKB/TrEMBL
  A0A0E4B366_MOUSE UniProtKB/TrEMBL
  A0A0F7QZE4_MOUSE UniProtKB/TrEMBL
  A0A0F7R1P3_MOUSE UniProtKB/TrEMBL
  A0A0J9YUU3_MOUSE UniProtKB/TrEMBL
  A2AS36 ENTREZGENE
  CO5_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8BNV3_MOUSE UniProtKB/TrEMBL
  Q99KX9_MOUSE UniProtKB/TrEMBL
UniProt Secondary A2AS36 UniProtKB/Swiss-Prot