Lss (lanosterol synthase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Lss (lanosterol synthase) Mus musculus
Analyze
Symbol: Lss
Name: lanosterol synthase
RGD ID: 733768
MGI Page MGI
Description: Predicted to enable lanosterol synthase activity. Predicted to be involved in cholesterol biosynthetic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in lipid droplet. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study cataract. Human ortholog(s) of this gene implicated in alopecia-mental retardation syndrome 4; cataract; cataract 44; and hypotrichosis 14. Orthologous to human LSS (lanosterol synthase).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 2,3-epoxysqualene--lanosterol cyclase; 2810025N20Rik; BC029082; D10Ertd116; D10Ertd116e; MGC27893; O; Osc; oxidosqualene--lanosterol cyclase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391076,367,303 - 76,392,973 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1076,367,422 - 76,392,972 (+)EnsemblGRCm39 Ensembl
GRCm381076,531,565 - 76,557,139 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1076,531,588 - 76,557,138 (+)EnsemblGRCm38mm10GRCm38
MGSCv371075,994,372 - 76,016,679 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361075,975,343 - 75,997,650 (+)NCBIMGSCv36mm8
Celera1077,576,142 - 77,598,449 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+/-)-Aegeline  (EXP)
(RS)-coclaurine  (EXP)
(RS)-norcoclaurine  (EXP)
(S)-coclaurine  (EXP)
1,2-dimethylhydrazine  (EXP)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
AB-Fubinaca  (ISO)
acetamide  (ISO)
Acetyl tributyl citrate  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldrin  (EXP)
amiodarone  (EXP,ISO)
amitriptyline  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antimony(0)  (ISO)
arachidonic acid  (ISO)
Archazolid B  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
azoxystrobin  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
buta-1,3-diene  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcitriol  (ISO)
cannabidiol  (EXP,ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpromazine  (ISO)
chromium(6+)  (EXP,ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
clarithromycin  (ISO)
clavulanic acid  (ISO)
clofibric acid  (ISO)
clomipramine  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
DDE  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
Di-n-octyl phthalate  (EXP)
diazinon  (ISO)
dibenzo[a,l]pyrene  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (EXP)
diethyl phthalate  (EXP)
Diisodecyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethylarsinic acid  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
doxepin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (EXP,ISO)
erythromycin A  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
Febrifugine  (ISO)
fenofibrate  (EXP)
fenthion  (EXP)
fipronil  (ISO)
flecainide  (ISO)
fluoranthene  (EXP)
fluoxetine  (ISO)
flusilazole  (EXP)
flutamide  (ISO)
folpet  (EXP)
formaldehyde  (ISO)
Ganoderic acid A  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hexaconazole  (EXP)
hydroquinone  (ISO)
imipramine  (ISO)
indometacin  (EXP)
isoflavones  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
lead(0)  (ISO)
loperamide  (EXP)
loratadine  (ISO)
luteolin  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP)
methyltestosterone  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
obeticholic acid  (ISO)
ouabain  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pentamidine  (ISO)
perfluorobutyric acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perhexiline  (ISO)
phenobarbital  (EXP,ISO)
phenylpropanolamine  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rotenone  (EXP,ISO)
sertraline  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sotalol  (ISO)
succimer  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioridazine  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
triacsin C  (ISO)
triadimefon  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)
vitamin K  (ISO)
vorinostat  (ISO)
Yessotoxin  (ISO)
yohimbine  (EXP)
zaragozic acid A  (EXP,ISO)
zimeldine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, etal., Nature 2002 Dec 5;420(6915):586-90.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
4. Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice. Marmugi A, etal., Toxicology. 2014 Nov 5;325:133-43. doi: 10.1016/j.tox.2014.08.006. Epub 2014 Aug 26.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. Purification of 2,3-oxidosqualene cyclase from rat liver. Moore WR and Schatzman GL, J Biol Chem. 1992 Nov 5;267(31):22003-6.
8. Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat. Mori M, etal., J Clin Invest. 2006 Feb;116(2):395-404. Epub 2006 Jan 26.
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. Human chromosome 21 gene expression atlas in the mouse. Reymond A, etal., Nature 2002 Dec 5;420(6915):582-6.
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
16. Lanosterol reverses protein aggregation in cataracts. Zhao L, etal., Nature. 2015 Jul 30;523(7562):607-11. doi: 10.1038/nature14650. Epub 2015 Jul 22.
Additional References at PubMed
PMID:8889548   PMID:10051316   PMID:10349636   PMID:10613844   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:14681479   PMID:15489334   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:19119143   PMID:19796621   PMID:20096683   PMID:21267068   PMID:21677750   PMID:21873635   PMID:24194600   PMID:25755092   PMID:26108225   PMID:27626380  
PMID:28031458   PMID:29212953   PMID:29748249   PMID:30550785   PMID:32101538   PMID:32266943   PMID:32325033   PMID:34926465   PMID:38355793  


Genomics

Comparative Map Data
Lss
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391076,367,303 - 76,392,973 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1076,367,422 - 76,392,972 (+)EnsemblGRCm39 Ensembl
GRCm381076,531,565 - 76,557,139 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1076,531,588 - 76,557,138 (+)EnsemblGRCm38mm10GRCm38
MGSCv371075,994,372 - 76,016,679 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361075,975,343 - 75,997,650 (+)NCBIMGSCv36mm8
Celera1077,576,142 - 77,598,449 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.1NCBI
LSS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382146,188,446 - 46,228,774 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2146,188,141 - 46,228,824 (-)EnsemblGRCh38hg38GRCh38
GRCh372147,608,360 - 47,648,688 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362146,432,788 - 46,473,119 (-)NCBINCBI36Build 36hg18NCBI36
Build 342146,433,466 - 46,473,119NCBI
Celera2132,720,748 - 32,761,140 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2132,990,213 - 33,031,026 (-)NCBIHuRef
CHM1_12147,167,889 - 47,208,226 (-)NCBICHM1_1
T2T-CHM13v2.02144,570,708 - 44,611,332 (-)NCBIT2T-CHM13v2.0
Lss
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,090,641 - 12,118,230 (-)NCBIGRCr8
mRatBN7.22012,091,138 - 12,118,858 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,092,774 - 12,118,762 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2012,789,080 - 12,815,472 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,150,002 - 12,176,395 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02012,621,780 - 12,648,174 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02012,844,522 - 12,870,474 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2012,842,884 - 12,870,497 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,337,114 - 15,338,473 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02015,000,298 - 15,027,581 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42012,507,575 - 12,534,612 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12012,507,801 - 12,534,839 (-)NCBI
Celera2013,590,952 - 13,616,816 (-)NCBICelera
Cytogenetic Map20p12NCBI
Lss
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540742,633,658 - 42,653,399 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540742,633,658 - 42,653,399 (-)NCBIChiLan1.0ChiLan1.0
LSS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22242,290,120 - 42,328,031 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12137,162,576 - 37,201,020 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02132,535,564 - 32,571,379 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12145,787,252 - 45,822,181 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2145,787,252 - 45,822,181 (-)Ensemblpanpan1.1panPan2
LSS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13139,479,255 - 39,502,439 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3139,480,581 - 39,503,042 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3138,707,040 - 38,730,234 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03139,120,352 - 39,143,563 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3139,120,357 - 39,143,585 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13138,982,033 - 39,005,248 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03138,942,696 - 38,965,462 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03139,460,908 - 39,484,125 (-)NCBIUU_Cfam_GSD_1.0
Lss
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497138,779,602 - 38,807,151 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936778323,014 - 351,102 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936778323,120 - 351,100 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LSS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.213218,517,444 - 218,539,989 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LSS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1289,809,065 - 89,846,295 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl289,811,698 - 89,846,242 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605418,194,151 - 18,231,629 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lss
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474531,306,807 - 31,325,199 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474531,301,648 - 31,325,283 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lss
637 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1787
Count of miRNA genes:788
Interacting mature miRNAs:1021
Transcripts:ENSMUST00000048678, ENSMUST00000159013, ENSMUST00000159172, ENSMUST00000160671, ENSMUST00000162282, ENSMUST00000162475, ENSMUST00000162848, ENSMUST00000163049
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106684818792258673Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75338568109338767Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075338568109338767Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073506901107507047Mouse
4142107Obrq12_mobesity resistance QTL 12 (mouse)Not determined7398721682491121Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075338568109338767Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse

Markers in Region
UniSTS:236391  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381076,555,141 - 76,555,440UniSTSGRCm38
MGSCv371076,017,886 - 76,018,185UniSTSGRCm37
Celera1077,599,656 - 77,599,955UniSTS
Cytogenetic Map10C1UniSTS
cM Map1041.1UniSTS
D10Ertd116e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381076,553,666 - 76,553,888UniSTSGRCm38
MGSCv371076,016,411 - 76,016,633UniSTSGRCm37
Celera1077,598,181 - 77,598,403UniSTS
Cytogenetic Map10C1UniSTS
cM Map1043.0UniSTS
cM Map1041.1UniSTS
Lss  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10C1UniSTS
cM Map1041.1UniSTS
Lss  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10C1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001428574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_146006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_190410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_190411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004936110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC007937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC158618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK012813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK014742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK031271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK044016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY474863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ128932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GN121505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB965962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB966165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HD023372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HD023575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000048678   ⟹   ENSMUSP00000046856
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1076,367,441 - 76,391,313 (+)Ensembl
GRCm38.p6 Ensembl1076,531,607 - 76,555,479 (+)Ensembl
Ensembl Acc Id: ENSMUST00000159013
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1076,367,422 - 76,371,402 (+)Ensembl
GRCm38.p6 Ensembl1076,531,588 - 76,535,568 (+)Ensembl
Ensembl Acc Id: ENSMUST00000159172
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1076,367,516 - 76,371,557 (+)Ensembl
GRCm38.p6 Ensembl1076,531,682 - 76,535,723 (+)Ensembl
Ensembl Acc Id: ENSMUST00000160671
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1076,367,446 - 76,392,972 (+)Ensembl
GRCm38.p6 Ensembl1076,531,612 - 76,557,138 (+)Ensembl
Ensembl Acc Id: ENSMUST00000162282
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1076,388,105 - 76,389,067 (+)Ensembl
GRCm38.p6 Ensembl1076,552,271 - 76,553,233 (+)Ensembl
Ensembl Acc Id: ENSMUST00000162475
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1076,367,441 - 76,384,702 (+)Ensembl
GRCm38.p6 Ensembl1076,531,607 - 76,548,868 (+)Ensembl
Ensembl Acc Id: ENSMUST00000162848
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1076,387,044 - 76,392,452 (+)Ensembl
GRCm38.p6 Ensembl1076,551,210 - 76,556,618 (+)Ensembl
Ensembl Acc Id: ENSMUST00000163049   ⟹   ENSMUSP00000125575
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1076,377,716 - 76,378,580 (+)Ensembl
GRCm38.p6 Ensembl1076,541,882 - 76,542,746 (+)Ensembl
RefSeq Acc Id: NM_146006   ⟹   NP_666118
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391076,367,439 - 76,392,973 (+)NCBI
GRCm381076,531,605 - 76,557,139 (+)NCBI
MGSCv371075,994,372 - 76,016,679 (+)RGD
Celera1077,576,142 - 77,598,449 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006513284   ⟹   XP_006513347
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391076,367,399 - 76,383,224 (+)NCBI
GRCm381076,531,565 - 76,547,393 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030244922   ⟹   XP_030100782
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391076,367,443 - 76,392,973 (+)NCBI
GRCm381076,531,625 - 76,557,139 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036155651   ⟹   XP_036011544
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391076,367,337 - 76,392,973 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036155652   ⟹   XP_036011545
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391076,367,409 - 76,392,973 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004936110
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391076,367,303 - 76,392,973 (+)NCBI
Sequence:
RefSeq Acc Id: NP_666118   ⟸   NM_146006
- UniProtKB: Q8BVJ4 (UniProtKB/Swiss-Prot),   Q8K307 (UniProtKB/Swiss-Prot),   Q8BLN5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006513347   ⟸   XM_006513284
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_030100782   ⟸   XM_030244922
- Peptide Label: isoform X3
Ensembl Acc Id: ENSMUSP00000125575   ⟸   ENSMUST00000163049
Ensembl Acc Id: ENSMUSP00000046856   ⟸   ENSMUST00000048678
RefSeq Acc Id: XP_036011544   ⟸   XM_036155651
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036011545   ⟸   XM_036155652
- Peptide Label: isoform X3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BLN5-F1-model_v2 AlphaFold Q8BLN5 1-733 view protein structure

Promoters
RGD ID:6819546
Promoter ID:MM_KWN:4639
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000069008,   OTTMUST00000069009,   OTTMUST00000069010,   OTTMUST00000069012,   OTTMUST00000069013
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361075,993,906 - 75,994,492 (+)MPROMDB
RGD ID:6819547
Promoter ID:MM_KWN:4640
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000069014
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361076,004,596 - 76,005,096 (+)MPROMDB
RGD ID:6819544
Promoter ID:MM_KWN:4641
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000069011
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361076,013,546 - 76,014,897 (+)MPROMDB
RGD ID:8672380
Promoter ID:EPDNEW_M14221
Type:initiation region
Name:Lss_1
Description:Mus musculus lanosterol synthase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381076,531,652 - 76,531,712EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1336155 AgrOrtholog
Ensembl Genes ENSMUSG00000033105 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000048678 ENTREZGENE
  ENSMUST00000048678.7 UniProtKB/Swiss-Prot
  ENSMUST00000160671 ENTREZGENE
  ENSMUST00000163049.2 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.20 UniProtKB/Swiss-Prot
  6.20.120.20 UniProtKB/Swiss-Prot
InterPro SQ_cyclase_C UniProtKB/Swiss-Prot
  SQ_cyclase_N UniProtKB/Swiss-Prot
  Squalene_cyclase UniProtKB/Swiss-Prot
  Terpene_synthase_CS UniProtKB/Swiss-Prot
  Terpenoid_cyclase/PrenylTrfase UniProtKB/Swiss-Prot
KEGG Report mmu:16987 UniProtKB/Swiss-Prot
MGD MGI:1336155 ENTREZGENE
NCBI Gene 16987 ENTREZGENE
PANTHER LANOSTEROL SYNTHASE UniProtKB/Swiss-Prot
  PTHR11764 UniProtKB/Swiss-Prot
Pfam SQHop_cyclase_C UniProtKB/Swiss-Prot
  SQHop_cyclase_N UniProtKB/Swiss-Prot
PhenoGen Lss PhenoGen
PROSITE TERPENE_SYNTHASES UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48239 UniProtKB/Swiss-Prot
UniProt ERG7_MOUSE UniProtKB/Swiss-Prot
  F7BJL0_MOUSE UniProtKB/TrEMBL
  Q8BLN5 ENTREZGENE
  Q8BVJ4 ENTREZGENE
  Q8K307 ENTREZGENE
  Q8VCN8_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q8BVJ4 UniProtKB/Swiss-Prot
  Q8K307 UniProtKB/Swiss-Prot