Pcbp1 (poly(rC) binding protein 1) - Rat Genome Database
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Gene: Pcbp1 (poly(rC) binding protein 1) Mus musculus
Analyze
Symbol: Pcbp1
Name: poly(rC) binding protein 1
RGD ID: 1557062
MGI Page MGI
Description: Is expressed in embryo. Orthologous to human PCBP1 (poly(rC) binding protein 1); PARTICIPATES IN iron homeostasis pathway; iron storage pathway; spliceosome pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: [a]CP; [a]CP-1; alpha-CP1; alphaCP-1; heterogeneous nuclear ribonucleoprotein E1; hnRNP E1; hnRNP-E1; poly(rC)-binding protein 1; WBP1; WBP17
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39686,501,462 - 86,503,171 (-)NCBIGRCm39mm39
GRCm39 Ensembl686,501,474 - 86,503,303 (-)Ensembl
GRCm38686,524,480 - 86,526,189 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl686,524,492 - 86,526,321 (-)EnsemblGRCm38mm10GRCm38
MGSCv37686,474,488 - 86,476,165 (-)NCBIGRCm37mm9NCBIm37
MGSCv36686,490,128 - 86,491,801 (-)NCBImm8
Celera688,462,456 - 88,464,133 (-)NCBICelera
Cytogenetic Map6D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA,ISO)
cytoplasmic ribonucleoprotein granule  (ISO)
cytosol  (ISO)
nuclear speck  (ISO)
nucleoplasm  (IBA,ISO)
nucleus  (IBA,IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10455157   PMID:10744724   PMID:11042159   PMID:11076861   PMID:11591653   PMID:12477932   PMID:14610273   PMID:15102471   PMID:15489334   PMID:15836633  
PMID:16141072   PMID:16141073   PMID:16775011   PMID:16979592   PMID:17383969   PMID:18307411   PMID:18799693   PMID:20154680   PMID:21267068   PMID:21565611   PMID:21873635   PMID:22673621  
PMID:22801551   PMID:23665500   PMID:23937658   PMID:24457600   PMID:24480778   PMID:25737280   PMID:25894693   PMID:26296893   PMID:26336360   PMID:26370502   PMID:26426291   PMID:26527618  
PMID:27113764   PMID:27160897   PMID:28077174   PMID:28375153   PMID:28378742   PMID:28381556   PMID:28671696   PMID:29530978   PMID:29958803   PMID:30068389   PMID:30333137   PMID:30562941  
PMID:30595499   PMID:30713523   PMID:31189591   PMID:32325033   PMID:32581705  


Genomics

Comparative Map Data
Pcbp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39686,501,462 - 86,503,171 (-)NCBIGRCm39mm39
GRCm39 Ensembl686,501,474 - 86,503,303 (-)Ensembl
GRCm38686,524,480 - 86,526,189 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl686,524,492 - 86,526,321 (-)EnsemblGRCm38mm10GRCm38
MGSCv37686,474,488 - 86,476,165 (-)NCBIGRCm37mm9NCBIm37
MGSCv36686,490,128 - 86,491,801 (-)NCBImm8
Celera688,462,456 - 88,464,133 (-)NCBICelera
Cytogenetic Map6D1NCBI
PCBP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl270,087,477 - 70,089,203 (+)EnsemblGRCh38hg38GRCh38
GRCh38270,087,477 - 70,089,203 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37270,314,609 - 70,316,335 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36270,168,203 - 70,169,836 (+)NCBINCBI36hg18NCBI36
Build 34270,226,351 - 70,227,983NCBI
Celera270,165,361 - 70,167,111 (+)NCBI
Cytogenetic Map2p13.3NCBI
HuRef270,051,034 - 70,052,784 (+)NCBIHuRef
CHM1_1270,244,214 - 70,245,976 (+)NCBICHM1_1
Pcbp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24118,972,698 - 118,974,722 (-)NCBI
Rnor_6.0 Ensembl4118,327,533 - 118,328,602 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04118,327,185 - 118,329,223 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04182,898,435 - 182,899,895 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44120,719,092 - 120,732,363 (-)NCBIRGSC3.4rn4RGSC3.4
Celera4107,943,493 - 107,944,933 (-)NCBICelera
Cytogenetic Map4q34NCBI
Pcbp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542415,046,011 - 15,047,081 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542415,045,642 - 15,047,184 (-)NCBIChiLan1.0ChiLan1.0
PCBP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A71,260,610 - 71,262,047 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A71,258,331 - 71,261,658 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A70,144,217 - 70,145,938 (+)NCBIMhudiblu_PPA_v0panPan3
PCBP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11068,686,278 - 68,687,916 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Pcbp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649114,280,616 - 14,282,148 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCBP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl372,378,648 - 72,380,362 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1372,378,643 - 72,380,364 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2375,813,906 - 75,815,624 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PCBP1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11437,013,486 - 37,015,119 (-)NCBI
ChlSab1.1 Ensembl1437,013,880 - 37,014,947 (-)Ensembl
Pcbp1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247623,330,978 - 3,332,582 (-)NCBI

Position Markers
PCBP1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38687,512,845 - 87,512,966UniSTSGRCm38
GRCm38686,524,562 - 86,524,684UniSTSGRCm38
MGSCv37687,462,839 - 87,462,960UniSTSGRCm37
MGSCv37686,474,556 - 86,474,678UniSTSGRCm37
Celera688,462,524 - 88,462,646UniSTS
Celera689,448,029 - 89,448,150UniSTS
Cytogenetic Map6D1UniSTS
A006T05  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38687,513,135 - 87,513,294UniSTSGRCm38
GRCm38686,525,032 - 86,525,191UniSTSGRCm38
MGSCv37687,463,129 - 87,463,288UniSTSGRCm37
MGSCv37686,475,026 - 86,475,185UniSTSGRCm37
Celera688,462,994 - 88,463,153UniSTS
Celera689,448,319 - 89,448,478UniSTS
Cytogenetic Map6D1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:80
Interacting mature miRNAs:89
Transcripts:ENSMUST00000053015
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000053015   ⟹   ENSMUSP00000054863
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl686,524,492 - 86,526,321 (-)Ensembl
RefSeq Acc Id: NM_011865   ⟹   NP_035995
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39686,501,462 - 86,503,171 (-)NCBI
GRCm38686,524,480 - 86,526,189 (-)NCBI
MGSCv37686,474,488 - 86,476,165 (-)RGD
Celera688,462,456 - 88,464,133 (-)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035995   ⟸   NM_011865
- UniProtKB: P60335 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000054863   ⟸   ENSMUST00000053015
Protein Domains
KH

Promoters
RGD ID:6839726
Promoter ID:MM_KWN:46741
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_011865
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36686,474,521 - 86,476,227 (-)MPROMDB
RGD ID:6890290
Promoter ID:EPDNEW_M8596
Type:initiation region
Name:Pcbp1_2
Description:Mus musculus poly binding protein 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8597  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38686,525,936 - 86,525,996EPDNEW
RGD ID:6890292
Promoter ID:EPDNEW_M8597
Type:initiation region
Name:Pcbp1_1
Description:Mus musculus poly binding protein 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8596  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38686,526,178 - 86,526,238EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1345635 AgrOrtholog
Ensembl Genes ENSMUSG00000051695 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000054863 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000053015 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1370.10 UniProtKB/Swiss-Prot
InterPro KH_dom UniProtKB/Swiss-Prot
  KH_dom_type_1 UniProtKB/Swiss-Prot
  KH_dom_type_1_sf UniProtKB/Swiss-Prot
KEGG Report mmu:23983 UniProtKB/Swiss-Prot
MGD MGI:1345635 ENTREZGENE
NCBI Gene 23983 ENTREZGENE
Pfam KH_1 UniProtKB/Swiss-Prot
PhenoGen Pcbp1 PhenoGen
PROSITE KH_TYPE_1 UniProtKB/Swiss-Prot
SMART SM00322 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54791 UniProtKB/Swiss-Prot
UniProt P60335 ENTREZGENE, UniProtKB/Swiss-Prot