Cbr4 (carbonyl reductase 4) - Rat Genome Database
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Gene: Cbr4 (carbonyl reductase 4) Mus musculus
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Symbol: Cbr4
Name: carbonyl reductase 4
RGD ID: 1621320
MGI Page MGI
Description: Predicted to have several functions, including 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity; NADPH binding activity; and oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor. Predicted to be involved in several processes, including fatty acid biosynthetic process; glycoside metabolic process; and protein tetramerization. Localizes to mitochondrion. Orthologous to human CBR4 (carbonyl reductase 4); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; carbon nanotube.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3-ketoacyl-[acyl-carrier-protein] reductase beta subunit; 3-oxoacyl-[acyl-carrier-protein] reductase; A730083J17Rik; BC009118; carbonyl reductase family member 4; KAR beta subunit; MGC6971; quinone reductase CBR4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39861,940,768 - 61,956,534 (+)NCBIGRCm39mm39
GRCm38861,487,734 - 61,503,500 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl861,487,734 - 61,506,694 (+)EnsemblGRCm38mm10GRCm38
MGSCv37863,966,531 - 63,982,297 (+)NCBIGRCm37mm9NCBIm37
MGSCv36860,656,117 - 60,671,212 (+)NCBImm8
MGSCv36864,379,926 - 64,395,624 (+)NCBImm8
Celera864,050,917 - 64,066,676 (+)NCBICelera
Cytogenetic Map8B3.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:16141072   PMID:16141073   PMID:18614015   PMID:21677750  
PMID:21873635   PMID:27113764   PMID:29669786   PMID:32581705  


Genomics

Comparative Map Data
Cbr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39861,940,768 - 61,956,534 (+)NCBIGRCm39mm39
GRCm38861,487,734 - 61,503,500 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl861,487,734 - 61,506,694 (+)EnsemblGRCm38mm10GRCm38
MGSCv37863,966,531 - 63,982,297 (+)NCBIGRCm37mm9NCBIm37
MGSCv36860,656,117 - 60,671,212 (+)NCBImm8
MGSCv36864,379,926 - 64,395,624 (+)NCBImm8
Celera864,050,917 - 64,066,676 (+)NCBICelera
Cytogenetic Map8B3.1NCBI
CBR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4168,863,770 - 169,010,275 (-)EnsemblGRCh38hg38GRCh38
GRCh384168,894,484 - 169,010,284 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374169,815,774 - 169,931,468 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364170,145,316 - 170,167,997 (-)NCBINCBI36hg18NCBI36
Celera4167,240,084 - 167,262,804 (-)NCBI
Cytogenetic Map4q32.3NCBI
HuRef4165,662,191 - 165,684,917 (-)NCBIHuRef
CHM1_14169,885,180 - 169,907,907 (-)NCBICHM1_1
Cbr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01631,944,328 - 31,972,553 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1631,956,753 - 31,972,507 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01631,794,520 - 31,810,263 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41631,943,125 - 31,957,556 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11631,943,200 - 31,957,630 (-)NCBI
Celera1628,625,441 - 28,641,135 (-)NCBICelera
Cytogenetic Map16p12NCBI
Cbr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540337,206,634 - 37,226,407 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540337,201,474 - 37,226,414 (+)NCBIChiLan1.0ChiLan1.0
CBR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14173,182,755 - 173,309,905 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4173,282,162 - 173,309,905 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04161,103,477 - 161,235,840 (-)NCBIMhudiblu_PPA_v0panPan3
CBR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2519,597,518 - 19,618,180 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12519,475,562 - 19,618,144 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cbr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365161,184,859 - 1,205,668 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CBR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1420,621,981 - 20,682,232 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11420,621,960 - 20,642,351 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21421,908,782 - 21,929,179 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CBR4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17115,223,813 - 115,246,925 (-)NCBI
ChlSab1.1 Ensembl7115,223,386 - 115,246,818 (-)Ensembl
Cbr4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624769564,148 - 603,402 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83383736267837502Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:471
Count of miRNA genes:296
Interacting mature miRNAs:326
Transcripts:ENSMUST00000034058, ENSMUST00000126575, ENSMUST00000130495, ENSMUST00000150932, ENSMUST00000155442, ENSMUST00000156535
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034058   ⟹   ENSMUSP00000034058
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl861,487,734 - 61,506,694 (+)Ensembl
RefSeq Acc Id: ENSMUST00000126575   ⟹   ENSMUSP00000117069
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl861,487,735 - 61,491,587 (+)Ensembl
RefSeq Acc Id: ENSMUST00000130495
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl861,487,769 - 61,503,329 (+)Ensembl
RefSeq Acc Id: ENSMUST00000150932
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl861,494,829 - 61,503,389 (+)Ensembl
RefSeq Acc Id: ENSMUST00000155442
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl861,491,410 - 61,503,329 (+)Ensembl
RefSeq Acc Id: ENSMUST00000156535
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl861,487,755 - 61,491,905 (+)Ensembl
RefSeq Acc Id: NM_145595   ⟹   NP_663570
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,940,768 - 61,956,534 (+)NCBI
GRCm38861,487,734 - 61,503,500 (+)ENTREZGENE
MGSCv37863,966,531 - 63,982,297 (+)RGD
Celera864,050,917 - 64,066,676 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_663570   ⟸   NM_145595
- UniProtKB: Q91VT4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034058   ⟸   ENSMUST00000034058
RefSeq Acc Id: ENSMUSP00000117069   ⟸   ENSMUST00000126575

Promoters
RGD ID:8667151
Promoter ID:EPDNEW_M11606
Type:multiple initiation site
Name:Cbr4_1
Description:Mus musculus carbonyl reductase 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38861,487,734 - 61,487,794EPDNEW
RGD ID:6842892
Promoter ID:MM_KWN:54503
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_145595,   OTTMUST00000077816,   OTTMUST00000077817,   OTTMUST00000077818,   UC009LUA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36863,966,424 - 63,966,924 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2384567 AgrOrtholog
Ensembl Genes ENSMUSG00000031641 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034058 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000117069 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034058 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000126575 UniProtKB/TrEMBL
InterPro NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot
  SDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:234309 UniProtKB/Swiss-Prot
MGD MGI:2384567 ENTREZGENE
NCBI Gene 234309 ENTREZGENE
Pfam adh_short UniProtKB/TrEMBL
PhenoGen Cbr4 PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/Swiss-Prot
PROSITE ADH_SHORT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.29059 ENTREZGENE
UniProt CBR4_MOUSE UniProtKB/Swiss-Prot
  D3Z6C4_MOUSE UniProtKB/TrEMBL
  Q91VT4 ENTREZGENE
UniProt Secondary Q3UBY4 UniProtKB/Swiss-Prot
  Q8BXV1 UniProtKB/Swiss-Prot