Gene: Hadhb (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta) Mus musculus
Analyze
Symbol:
Hadhb
Name:
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
Description:
Exhibits acetyl-CoA C-acyltransferase activity and long-chain-3-hydroxyacyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation. Localizes to the mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial metabolism disease and mitochondrial trifunctional protein deficiency. Is expressed in heart; liver; and placenta. Orthologous to human HADHB (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta); PARTICIPATES IN carnitine palmitoyltransferase I deficiency pathway; ethylmalonic encephalopathy pathway; fatty acid beta degradation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
4930479F15Rik; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta aubunit; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit; Mtpb; TP-beta; trifunctional enzyme subunit beta, mitochondrial
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
HADHB (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Hadhb (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Hadhb (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
HADHB (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
HADHB (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Hadhb (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
HADHB (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Hadhb (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
HADHB (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
hadhb (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta)
Alliance
DIOPT (Hieranoid, OrthoFinder, PhylomeDB, ZFIN)
Caenorhabditis elegans (roundworm):
B0303.3
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Drosophila melanogaster (fruit fly):
Thiolase
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, Roundup, TreeFam)
Related Pseudogenes:
Gm13910
Gm9108
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 5 30,155,253 - 30,184,593 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 5 30,481,862 - 30,511,123 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 5 30,486,109 - 30,515,370 (+) NCBI mm8 Celera 5 27,672,791 - 27,702,131 (+) NCBI Celera Cytogenetic Map 5 B1 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
Charcot-Marie-Tooth disease ISO RGD:736480 8554872 ClinVar Annotator: match by term: Charcot-Marie-Tooth disease ClinVar PMID:24314034 Long-Chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency ISO RGD:736480 8554872 ClinVar Annotator: match by term: LCHAD Deficiency ClinVar mitochondrial trifunctional protein deficiency ISO RGD:736480 8554872 ClinVar Annotator: match by term: Mitochondrial trifunctional protein deficiency ClinVar PMID:25741868 , PMID:28492532 mitochondrial trifunctional protein deficiency ISO RGD:736480 8554872 ClinVar Annotator: match by term: Mitochondrial trifunctional protein deficiency ClinVar PMID:12754706 more ... mitochondrial trifunctional protein deficiency ISO RGD:736480 8554872 ClinVar Annotator: match by term: Mitochondrial trifunctional protein deficiency ClinVar PMID:26109258 mitochondrial trifunctional protein deficiency ISO RGD:736480 8554872 ClinVar Annotator: match by term: Trifunctional protein deficiency with myopathy and neuropathy ClinVar PMID:12754706 , PMID:28492532 mitochondrial trifunctional protein deficiency ISO RGD:736480 8554872 ClinVar Annotator: match by term: Mitochondrial trifunctional protein deficiency ClinVar PMID:25741868 mitochondrial trifunctional protein deficiency ISO RGD:736480 8554872 ClinVar Annotator: match by term: Mitochondrial trifunctional protein deficiency ClinVar PMID:23757202 , PMID:24033266 mitochondrial trifunctional protein deficiency ISO RGD:736480 8554872 ClinVar Annotator: match by term: Mitochondrial trifunctional protein deficiency ClinVar mitochondrial trifunctional protein deficiency ISO RGD:736480 8554872 ClinVar Annotator: match by OMIM:609015 ClinVar PMID:19880769 mitochondrial trifunctional protein deficiency ISO RGD:736480 8554872 ClinVar Annotator: match by term: Mitochondrial trifunctional protein deficiency ClinVar PMID:24664533 mitochondrial trifunctional protein deficiency ISO RGD:736480 8554872 ClinVar Annotator: match by OMIM:609015 ClinVar PMID:8163672 , PMID:8651282 mitochondrial trifunctional protein deficiency ISO RGD:736480 8554872 ClinVar Annotator: match by OMIM:609015 ClinVar PMID:19699128 mitochondrial trifunctional protein deficiency ISO RGD:736480 8554872 ClinVar Annotator: match by OMIM:609015 ClinVar PMID:8651282 mitochondrial trifunctional protein deficiency ISO RGD:736480 8554872 ClinVar Annotator: match by OMIM:609015 ClinVar PMID:19699128 , PMID:9259266 mitochondrial trifunctional protein deficiency ISO RGD:736480 8554872 ClinVar Annotator: match by term: Trifunctional protein deficiency with myopathy and neuropathy ClinVar PMID:28492532 mitochondrial trifunctional protein deficiency ISO RGD:736480 8554872 ClinVar Annotator: match by term: Mitochondrial trifunctional protein deficiency ClinVar PMID:17143551 , PMID:25741868 mitochondrial trifunctional protein deficiency ISO RGD:736480 8554872 ClinVar Annotator: match by term: Mitochondrial trifunctional protein deficiency ClinVar PMID:21549624 , PMID:25741868
Imported Annotations - CTD
Breast Neoplasms ISO RGD:736480 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21466612 fatty liver disease ISO RGD:736480 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17116638 heart disease ISO RGD:736480 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17116638 lipid metabolism disorder ISO RGD:736480 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17116638 Imported Annotations - OMIM
mitochondrial trifunctional protein deficiency ISO RGD:736480 7240710 OMIM
(2-trans,6-trans)-farnesol multiple interactions ISO RGD:736480 6480464 [Farnesol analog co-treated with Oleic Acid] results in increased expression of HADHB mRNA CTD PMID:30611723 (2-trans,6-trans)-farnesol increases expression ISO RGD:736480 6480464 Farnesol analog results in increased expression of HADHB mRNA CTD PMID:30611723 1,3-dinitrobenzene increases oxidation ISO RGD:620513 6480464 3-dinitrobenzene results in increased oxidation of HADHB protein CTD PMID:25716674 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of HADHB mRNA CTD PMID:19484750 17beta-estradiol multiple interactions ISO RGD:736480 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of HADHB mRNA CTD PMID:30165855 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of HADHB mRNA CTD PMID:19770486 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of HADHB mRNA CTD PMID:20702594 , PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:620513 6480464 Tetrachlorodibenzodioxin results in decreased expression of HADHB mRNA CTD PMID:21215274 2,3,7,8-Tetrachlorodibenzofuran affects expression EXP 6480464 2 more ... CTD PMID:20702594 2,6-dinitrotoluene affects expression ISO RGD:620513 6480464 2, 6-dinitrotoluene affects the expression of HADHB mRNA CTD PMID:21346803 3,3',4,4'-tetrachlorobiphenyl multiple interactions EXP 6480464 3 more ... CTD PMID:19467301 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of HADHB mRNA, [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of HADHB mRNA CTD PMID:23428407 , PMID:24848799 4,4'-diaminodiphenylmethane increases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in increased expression of HADHB mRNA CTD PMID:18648102 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime multiple interactions ISO RGD:736480 6480464 [6-(4-chlorophenyl)imidazo(2 more ... CTD PMID:30611723 ammonium chloride affects expression ISO RGD:620513 6480464 Ammonium Chloride affects the expression of HADHB mRNA CTD PMID:16483693 Aroclor 1254 decreases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of HADHB mRNA CTD PMID:23650126 benzo[a]pyrene multiple interactions EXP 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of HADHB mRNA] CTD PMID:22228805 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of HADHB mRNA CTD PMID:22228805 bezafibrate increases expression EXP 6480464 Bezafibrate results in increased expression of HADHB mRNA CTD PMID:17118139 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of HADHB mRNA] CTD PMID:19850644 bis(2-ethylhexyl) phthalate increases expression ISO RGD:620513 6480464 Diethylhexyl Phthalate results in increased expression of HADHB mRNA CTD PMID:22672789 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of HADHB mRNA CTD PMID:19850644 buspirone increases expression ISO RGD:620513 6480464 Buspirone results in increased expression of HADHB mRNA CTD PMID:24136188 cadmium atom increases oxidation EXP 6480464 Cadmium results in increased oxidation of HADHB protein CTD PMID:24496640 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon analog results in increased expression of HADHB mRNA CTD PMID:25620056 ciprofibrate increases expression ISO RGD:620513 6480464 ciprofibrate results in increased expression of HADHB mRNA CTD PMID:27225895 clofibrate increases expression ISO RGD:620513 6480464 Clofibrate results in increased expression of HADHB mRNA CTD PMID:12851107 , PMID:18670166 clofibrate increases expression EXP 6480464 Clofibrate results in increased expression of HADHB mRNA CTD PMID:23811191 clofibrate decreases expression ISO RGD:620513 6480464 Clofibrate results in decreased expression of HADHB protein CTD PMID:20118634 Clofop multiple interactions ISO RGD:736480 6480464 [fenofibric acid binds to PPARA protein] which results in increased expression of HADHB mRNA CTD PMID:16197558 copper atom decreases expression ISO RGD:620513 6480464 Copper deficiency results in decreased expression of HADHB mRNA CTD PMID:19821111 copper(0) decreases expression ISO RGD:620513 6480464 Copper deficiency results in decreased expression of HADHB mRNA CTD PMID:19821111 copper(2+) decreases expression ISO RGD:620513 6480464 Copper deficiency results in decreased expression of HADHB mRNA CTD PMID:19821111 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of HADHB mRNA CTD PMID:19770486 dehydroepiandrosterone increases expression ISO RGD:620513 6480464 Dehydroepiandrosterone results in increased expression of HADHB mRNA CTD PMID:16940010 dexamethasone multiple interactions EXP 6480464 [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of HADHB mRNA, [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of HADHB mRNA CTD PMID:23428407 , PMID:24848799 dextran sulfate multiple interactions EXP 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of HADHB mRNA CTD PMID:29950665 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of HADHB mRNA CTD PMID:17361019 dichloroacetic acid increases expression EXP 6480464 Dichloroacetic Acid results in increased expression of HADHB mRNA CTD PMID:28962523 dicrotophos decreases expression ISO RGD:736480 6480464 dicrotophos results in decreased expression of HADHB mRNA CTD PMID:28302478 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of HADHB mRNA CTD PMID:26873546 doxorubicin decreases expression ISO RGD:736480 6480464 Doxorubicin results in decreased expression of HADHB mRNA CTD PMID:29803840 endosulfan increases expression ISO RGD:620513 6480464 Endosulfan results in increased expression of HADHB mRNA CTD PMID:29391264 ethanol multiple interactions EXP 6480464 Ethanol affects the expression of and affects the splicing of HADHB mRNA CTD PMID:30319688 ethanol increases expression EXP 6480464 Ethanol results in increased expression of HADHB mRNA CTD PMID:30319688 farnesol multiple interactions ISO RGD:736480 6480464 [Farnesol analog co-treated with Oleic Acid] results in increased expression of HADHB mRNA CTD PMID:30611723 farnesol increases expression ISO RGD:736480 6480464 Farnesol analog results in increased expression of HADHB mRNA CTD PMID:30611723 fenofibrate increases expression EXP 6480464 Fenofibrate results in increased expression of HADHB mRNA CTD PMID:17118139 fenofibrate increases expression ISO RGD:736480 6480464 Fenofibrate results in increased expression of HADHB mRNA CTD PMID:24752549 , PMID:25572481 fenofibrate decreases expression ISO RGD:620513 6480464 Fenofibrate results in decreased expression of HADHB protein CTD PMID:20118634 fenofibrate affects expression ISO RGD:620513 6480464 Fenofibrate affects the expression of HADHB mRNA CTD PMID:20801182 finasteride increases expression ISO RGD:620513 6480464 Finasteride results in increased expression of HADHB mRNA CTD PMID:24136188 flutamide decreases expression EXP 6480464 Flutamide analog results in decreased expression of HADHB mRNA, Flutamide results in decreased expression of HADHB mRNA CTD PMID:17702527 , PMID:19442681 gentamycin decreases expression ISO RGD:620513 6480464 Gentamicins results in decreased expression of HADHB mRNA CTD PMID:22061828 GW 7647 increases expression ISO RGD:736480 6480464 GW 7647 results in increased expression of HADHB mRNA CTD PMID:30611723 GW 7647 multiple interactions ISO RGD:736480 6480464 [GW 7647 co-treated with Oleic Acid] results in increased expression of HADHB mRNA more ... CTD PMID:30611723 lead(0) decreases expression ISO RGD:736480 6480464 Lead results in decreased expression of HADHB mRNA CTD PMID:19921347 lead(2+) decreases expression ISO RGD:736480 6480464 Lead results in decreased expression of HADHB mRNA CTD PMID:19921347 leflunomide increases expression ISO RGD:620513 6480464 leflunomide results in increased expression of HADHB mRNA CTD PMID:24136188 methotrexate increases expression ISO RGD:736480 6480464 Methotrexate results in increased expression of HADHB mRNA CTD PMID:17400583 microcystin-LR decreases expression EXP 6480464 cyanoginosin LR results in decreased expression of HADHB protein CTD PMID:26984711 N-ethyl-N-nitrosourea increases mutagenesis EXP 6480464 Ethylnitrosourea results in increased mutagenesis of HADHB exon CTD PMID:17116638 nefazodone increases expression ISO RGD:620513 6480464 nefazodone results in increased expression of HADHB mRNA CTD PMID:24136188 nimesulide increases expression ISO RGD:620513 6480464 nimesulide results in increased expression of HADHB mRNA CTD PMID:24136188 ochratoxin A decreases expression ISO RGD:736480 6480464 ochratoxin A results in decreased expression of HADHB protein CTD PMID:26861962 oleic acid multiple interactions ISO RGD:736480 6480464 [6-(4-chlorophenyl)imidazo(2 more ... CTD PMID:30611723 oleic acid increases expression ISO RGD:736480 6480464 Oleic Acid results in increased expression of HADHB mRNA CTD PMID:30611723 paracetamol decreases expression ISO RGD:736480 6480464 Acetaminophen results in decreased expression of HADHB mRNA CTD PMID:22230336 perfluorobutanesulfonic acid increases expression ISO RGD:620513 6480464 perfluorobutanesulfonic acid results in increased expression of HADHB mRNA CTD PMID:22071372 perfluorobutyric acid decreases expression ISO RGD:620513 6480464 perfluorobutyric acid results in decreased expression of HADHB mRNA CTD PMID:22071372 perfluorododecanoic acid increases expression ISO RGD:620513 6480464 perfluorododecanoic acid results in increased expression of HADHB mRNA CTD PMID:22071372 perfluorohexanesulfonic acid increases expression ISO RGD:620513 6480464 perfluorohexanesulfonic acid results in increased expression of HADHB mRNA CTD PMID:22071372 perfluorohexanoic acid increases expression ISO RGD:620513 6480464 perfluorohexanoic acid results in increased expression of HADHB mRNA CTD PMID:22071372 perfluorononanoic acid increases expression ISO RGD:620513 6480464 perfluorononanoic acid results in increased expression of HADHB mRNA CTD PMID:22071372 perfluorooctane-1-sulfonic acid increases expression ISO RGD:620513 6480464 perfluorooctane sulfonic acid results in increased expression of HADHB mRNA CTD PMID:18692542 , PMID:19162173 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:620513 6480464 perfluorooctane sulfonic acid results in decreased expression of HADHB mRNA CTD PMID:22071372 perfluorooctane-1-sulfonic acid increases expression EXP 6480464 perfluorooctane sulfonic acid results in increased expression of HADHB mRNA CTD PMID:19429403 , PMID:20936131 perfluorooctane-1-sulfonic acid multiple interactions EXP 6480464 PPARA protein promotes the reaction [perfluorooctane sulfonic acid results in increased expression of HADHB mRNA] CTD PMID:20936131 perfluorooctanoic acid multiple interactions EXP 6480464 PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of HADHB mRNA] CTD PMID:18467677 , PMID:20936131 perfluorooctanoic acid increases expression ISO RGD:620513 6480464 perfluorooctanoic acid results in increased expression of HADHB mRNA CTD PMID:16221955 more ... perfluorooctanoic acid increases expression EXP 6480464 perfluorooctanoic acid results in increased expression of HADHB mRNA CTD PMID:17681415 more ... perfluoroundecanoic acid increases expression ISO RGD:620513 6480464 perfluoroundecanoic acid results in increased expression of HADHB mRNA CTD PMID:22071372 phenobarbital decreases expression ISO RGD:620513 6480464 Phenobarbital results in decreased expression of HADHB mRNA CTD PMID:19162173 phlorizin increases expression EXP 6480464 Phlorhizin results in increased expression of HADHB mRNA CTD PMID:22538082 picrotoxin decreases expression ISO RGD:620513 6480464 Picrotoxin results in decreased expression of HADHB mRNA CTD PMID:15170462 pirinixic acid multiple interactions EXP 6480464 PPARA protein promotes the reaction [pirinixic acid results in increased expression of HADHB mRNA] CTD PMID:17950772 , PMID:18467677 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of HADHB mRNA CTD PMID:15375163 more ... pirinixic acid increases expression ISO RGD:620513 6480464 pirinixic acid results in increased expression of HADHB mRNA CTD PMID:16940010 more ... pravastatin decreases expression EXP 6480464 Pravastatin results in decreased expression of HADHB mRNA CTD PMID:27225895 pravastatin decreases expression ISO RGD:620513 6480464 Pravastatin results in decreased expression of HADHB mRNA CTD PMID:27225895 propiconazole decreases expression EXP 6480464 propiconazole results in decreased expression of HADHB mRNA CTD PMID:21278054 resveratrol increases expression EXP 6480464 resveratrol results in increased expression of HADHB protein CTD PMID:25505154 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of HADHB mRNA CTD PMID:17702527 SB 431542 increases expression ISO RGD:736480 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of HADHB protein CTD PMID:25670856 sodium arsenite increases expression ISO RGD:620513 6480464 sodium arsenite results in increased expression of HADHB protein CTD PMID:29459688 Soman decreases expression ISO RGD:620513 6480464 Soman results in decreased expression of HADHB mRNA CTD PMID:19281266 sulforaphane increases expression EXP 6480464 sulforafan results in increased expression of HADHB mRNA CTD PMID:30529165 sulindac decreases expression ISO RGD:620513 6480464 Sulindac results in decreased expression of HADHB mRNA CTD PMID:24136188 tacrolimus hydrate decreases expression EXP 6480464 Tacrolimus results in decreased expression of HADHB mRNA CTD PMID:25270620 Tesaglitazar increases expression ISO RGD:620513 6480464 tesaglitazar results in increased expression of HADHB mRNA CTD PMID:21515302 tetrachloromethane affects expression ISO RGD:620513 6480464 Carbon Tetrachloride affects the expression of HADHB mRNA CTD PMID:15963342 , PMID:16239168 titanium dioxide decreases expression EXP 6480464 titanium dioxide results in decreased expression of HADHB mRNA CTD PMID:23557971 titanium dioxide multiple interactions EXP 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of HADHB mRNA CTD PMID:29950665 titanium dioxide decreases expression ISO RGD:736480 6480464 titanium dioxide results in decreased expression of HADHB protein CTD PMID:30910687 tributylstannane increases expression EXP 6480464 tributyltin results in increased expression of HADHB mRNA CTD PMID:23428407 , PMID:24848799 trichloroethene increases expression ISO RGD:620513 6480464 Trichloroethylene results in increased expression of HADHB mRNA CTD PMID:27618143 trichloroethene decreases methylation ISO RGD:620513 6480464 Trichloroethylene results in decreased methylation of HADHB promoter CTD PMID:27618143 troglitazone increases expression ISO RGD:620513 6480464 troglitazone results in increased expression of HADHB mRNA CTD PMID:21515302 valproic acid decreases methylation ISO RGD:736480 6480464 Valproic Acid results in decreased methylation of HADHB gene CTD PMID:29154799 valproic acid increases expression ISO RGD:736480 6480464 Valproic Acid results in increased expression of HADHB mRNA CTD PMID:29501571 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of HADHB mRNA CTD PMID:21427059 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of HADHB mRNA CTD PMID:17292431 vinclozolin decreases expression ISO RGD:620513 6480464 vinclozolin results in decreased expression of HADHB mRNA CTD PMID:23555832 zaragozic acid A affects expression EXP 6480464 squalestatin 1 affects the expression of HADHB mRNA CTD PMID:27225895 zaragozic acid A affects expression ISO RGD:620513 6480464 squalestatin 1 affects the expression of HADHB mRNA CTD PMID:27225895
Biological Process fatty acid beta-oxidation TAS 2290270 (MGI:MGI:2135592, PMID:11390422) MGI MGI:MGI:2135592 , PMID:11390422 fatty acid beta-oxidation IBA EcoGene:EG14128 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 fatty acid beta-oxidation ISO RGD:620513 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 fatty acid metabolic process IEA UniProtKB-KW:KW-0276 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 lipid metabolic process IEA UniProtKB-KW:KW-0443 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 Cellular Component endoplasmic reticulum ISO UniProtKB:P55084 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 membrane IEA UniProtKB-KW:KW-0472 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 mitochondrial fatty acid beta-oxidation multienzyme complex IC GO:0003988, GO:0016509 2290270 (MGI:MGI:3697529, PMID:17116638) MGI MGI:MGI:3697529 , PMID:17116638 mitochondrial fatty acid beta-oxidation multienzyme complex ISO RGD:620513 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 mitochondrial inner membrane ISO UniProtKB:P55084 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 mitochondrial inner membrane HDA 2290270 (MGI:MGI:3590069, PMID:12865426) MGI MGI:MGI:3590069 , PMID:12865426 mitochondrial nucleoid ISO UniProtKB:P55084 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 mitochondrial outer membrane ISO UniProtKB:P55084 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 mitochondrion TAS 2290270 (MGI:MGI:2135592, PMID:11390422) MGI MGI:MGI:2135592 , PMID:11390422 mitochondrion IBA MGI:MGI:2136381 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 mitochondrion HDA 2290270 (MGI:MGI:2682130 more ... MGI MGI:MGI:2682130 more ... mitochondrion ISO UniProtKB:P55084 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 mitochondrion ISO RGD:620513 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 mitochondrion IMP MGI:MGI:3698125 2290270 (MGI:MGI:3697529, PMID:17116638) MGI MGI:MGI:3697529 , PMID:17116638 Molecular Function 3-hydroxyacyl-CoA dehydrogenase activity ISO RGD:620513 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 acetyl-CoA C-acyltransferase activity IDA 2290270 (MGI:MGI:3606365, PMID:15240869) MGI MGI:MGI:3606365 , PMID:15240869 acetyl-CoA C-acyltransferase activity IBA EcoGene:EG13097 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 acetyl-CoA C-acyltransferase activity ISO RGD:620513 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 acetyl-CoA C-acyltransferase activity IMP MGI:MGI:3698125 2290270 (MGI:MGI:3697529, PMID:17116638) MGI MGI:MGI:3697529 , PMID:17116638 acetyl-CoA C-myristoyltransferase activity IEA EC:2.3.1.155 2290270 UniProt GO_REF:0000003, MGI:MGI:2152096 catalytic activity IEA InterPro:IPR016039 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 enoyl-CoA hydratase activity ISO RGD:620513 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 enoyl-CoA hydratase activity IBA PANTHER:PTN001052874 , RGD:620513 2290270 (PMID:21873635) GO_Central PMID:21873635 fatty-acyl-CoA binding ISO RGD:620513 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 long-chain-3-hydroxyacyl-CoA dehydrogenase activity IMP MGI:MGI:3698125 2290270 (MGI:MGI:3697529, PMID:17116638) MGI MGI:MGI:3697529 , PMID:17116638 long-chain-3-hydroxyacyl-CoA dehydrogenase activity IBA MGI:MGI:2136381 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 long-chain-3-hydroxyacyl-CoA dehydrogenase activity ISO RGD:620513 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 long-chain-enoyl-CoA hydratase activity ISO RGD:620513 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 long-chain-enoyl-CoA hydratase activity IBA PANTHER:PTN001052874 , RGD:620513 2290270 (PMID:21873635) GO_Central PMID:21873635 NAD binding ISO RGD:620513 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 protein-containing complex binding ISO RGD:620513 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 transferase activity IEA UniProtKB-KW:KW-0808 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 transferase activity, transferring acyl groups IEA UniProtKB-KW:KW-0012 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 transferase activity, transferring acyl groups other than amino-acyl groups IEA InterPro:IPR002155 more ... 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098
Gene-Chemical Interaction Annotations
