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Gene: Mst1r (macrophage stimulating 1 receptor (c-met-related tyrosine kinase)) Mus musculus
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Symbol: Mst1r
Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Description: This gene encodes a precursor protein that is proteolytically cleaved to yield an alpha chain and a beta chain which form a membrane-spanning heterodimer. The encoded protein belongs to a family of cell-surface receptor tyrosine kinases involved in signaling from the cell surface to the intracellular environment. The binding of the encoded protein to its ligand, macrophage-stimulating protein, mediates several biological activities including wound healing, tumor immunity, macrophage activation and hematopoiesis as well as cell growth, motility, survival and adhesion. The protein encoded by this gene also functions in early development and the macrophage-mediated inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: c-met-related tyrosine kinase; CD136; CDw136; friend virus susceptibility 2; Fv-2; Fv2; macrophage-stimulating protein receptor; macrophage-stimulating protein receptor precursor (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase); MSP receptor; p185-Ron; PTK8; receptor protein tyrosine kinase, c-met-related; Ron; stem cell-derived tyrosine kinase; STK
Orthologs:
Homo sapiens (human) : MST1R (macrophage stimulating 1 receptor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mst1r (macrophage stimulating 1 receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mst1r (macrophage stimulating 1 receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : MST1R (macrophage stimulating 1 receptor)
Canis lupus familiaris (dog) : MST1R (macrophage stimulating 1 receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mst1r (macrophage stimulating 1 receptor)
Sus scrofa (pig) : MST1R (macrophage stimulating 1 receptor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm389107,906,858 - 107,920,383 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv379107,809,220 - 107,822,714 (+)NCBIGRCm37mm9NCBIm37
MGSCv369107,764,990 - 107,778,484 (+)NCBImm8
Celera9107,515,111 - 107,528,610 (+)NCBICelera
Cytogenetic Map9 F1NCBI
cM Map959.07NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Mst1r
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315100
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.