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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315100
Species: Mus musculus
RGD Object: Gene
Symbol: Mst1r
Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mst1raffects expressionEXP 6480464CTDAcetaminophen affects the expression of MST1R mRNAPMID:17562736
Mst1raffects response to substanceEXP 6480464CTDMST1R protein affects the susceptibility to AcetaminophenPMID:22575169
Mst1rmultiple interactionsEXP 6480464CTD[MST1R protein mutant form co-treated with Acetaminophen] results in increased expression of CX3CL1 mRNA; [MST1R protein mutant form co-treated with Acetaminophen] results in increased expression of CX3CR1 mRNA; [MST1R protein mutant form co-treated with Acetaminophen] results in increased expression of NOS2 protein; MST1R protein affects the reaction [Acetaminophen results in decreased abundance of Glutathione]; MST1R protein affects the reaction [Acetaminophen results in decreased expression of ADGRE1 protein]; MST1R protein affects the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; MST1R protein affects the reaction [Acetaminophen results in increased expression of CCR2 mRNA]; MST1R protein affects the reaction [Acetaminophen results in increased expression of CXCL2 mRNA]; MST1R protein affects the reaction [Acetaminophen results in increased expression of HMOX1 mRNA]; MST1R protein affects the reaction [Acetaminophen results in increased expression of IL10 mRNA]; MST1R protein affects the reaction [Acetaminophen results in increased expression of IL12B mRNA]; MST1R protein affects the reaction [Acetaminophen results in increased expression of IL1B mRNA]; MST1R protein affects the reaction [Acetaminophen results in increased expression of TNF mRNA]; MST1R protein affects the reaction [Acetaminophen results in increased expression of TNFRSF1A protein]PMID:22575169
Mst1rdecreases expressionISOMst1r (Rattus norvegicus)6480464CTDAcetaminophen results in decreased expression of MST1R mRNAPMID:33387578
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