Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Msh2 (mutS homolog 2) Mus musculus
Analyze
Symbol: Msh2
Name: mutS homolog 2
Description: Exhibits ATPase activity and DNA binding activity. Contributes to guanine/thymine mispair binding activity. Involved in several processes, including DNA metabolic process; negative regulation of cell cycle; and regulation of DNA recombination. Localizes to the MutSalpha complex. Used to study Lynch syndrome. Human ortholog(s) of this gene implicated in Lynch syndrome (multiple); breast cancer; colorectal cancer; and urinary bladder cancer. Is expressed in several structures, including genitourinary system; heart; liver; lung; and tail dorsal root ganglion. Orthologous to human MSH2 (mutS homolog 2); PARTICIPATES IN altered mismatch repair pathway; colorectal cancer pathway; mismatch repair pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI788990; DNA mismatch repair protein Msh2; mutS protein homolog 2
Orthologs:
Homo sapiens (human) : MSH2 (mutS homolog 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Msh2 (mutS homolog 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Msh2 (mutS homolog 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MSH2 (mutS homolog 2)
Canis lupus familiaris (dog) : MSH2 (mutS homolog 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Msh2 (mutS homolog 2)
Sus scrofa (pig) : MSH2 (mutS homolog 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381787,672,532 - 87,723,713 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371788,071,897 - 88,123,053 (+)NCBIGRCm37mm9NCBIm37
MGSCv361787,580,883 - 87,632,039 (+)NCBImm8
Celera1792,079,522 - 92,130,140 (+)NCBICelera
Cytogenetic Map17 E4NCBI
cM Map1757.87NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model