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Gene: Cdc42 (cell division cycle 42) Mus musculus
Symbol: Cdc42
Name: cell division cycle 42
Description: Exhibits several functions, including GTP-dependent protein binding activity; GTPase activity; and Rho GDP-dissociation inhibitor binding activity. Involved in several processes, including neuron differentiation; positive regulation of filopodium assembly; and positive regulation of phosphorylation. Localizes to several cellular components, including the leading edge membrane; phagocytic vesicle; and storage vacuole. Used to study microvillus inclusion disease. Human ortholog(s) of this gene implicated in fibrosarcoma. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and hemolymphoid system gland. Orthologous to human CDC42 (cell division cycle 42); PARTICIPATES IN adenosine signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; E-cadherin signaling pathway; INTERACTS WITH (S)-nicotine; 1,4-dichlorobenzene; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI747189; AU018915; cell division control protein 42 homolog; cell division cycle 42 homolog; G25K GTP-binding protein
Homo sapiens (human) : CDC42 (cell division cycle 42)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cdc42 (cell division cycle 42)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdc42 (cell division cycle 42)
Pan paniscus (bonobo/pygmy chimpanzee) : CDC42 (cell division cycle 42)
Canis lupus familiaris (dog) : CDC42 (cell division cycle 42)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdc42 (cell division cycle 42)
Sus scrofa (pig) : CDC42 (cell division cycle 42)
Chlorocebus sabaeus (African green monkey) : CDC42 (cell division cycle 42)
Heterocephalus glaber (naked mole-rat) : Cdc42 (cell division cycle 42)
more info ...
Related Pseudogenes: Gm12492   Gm18964   Gm7407  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl4137,319,696 - 137,357,720 (-)EnsemblGRCm38mm10GRCm38
GRCm384137,319,696 - 137,357,759 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374136,875,611 - 136,913,652 (-)NCBIGRCm37mm9NCBIm37
MGSCv364136,591,779 - 136,608,205 (-)NCBImm8
Celera4135,540,002 - 135,577,876 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map469.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Cell Lines
Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Cdc42
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730977
Created: 2003-12-10
Species: Mus musculus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.