Gene: Cdc42 (cell division cycle 42) Mus musculus
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Symbol:
Cdc42
Name:
cell division cycle 42
Description:
Exhibits several functions, including GTP-dependent protein binding activity; GTPase activity; and Rho GDP-dissociation inhibitor binding activity. Involved in several processes, including neuron differentiation; positive regulation of filopodium assembly; and positive regulation of phosphorylation. Localizes to several cellular components, including the leading edge membrane; phagocytic vesicle; and storage vacuole. Used to study microvillus inclusion disease. Human ortholog(s) of this gene implicated in fibrosarcoma. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and hemolymphoid system gland. Orthologous to human CDC42 (cell division cycle 42); PARTICIPATES IN adenosine signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; E-cadherin signaling pathway; INTERACTS WITH (S)-nicotine; 1,4-dichlorobenzene; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
AI747189; AU018915; cell division control protein 42 homolog; cell division cycle 42 homolog; G25K GTP-binding protein
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CDC42 (cell division cycle 42) HGNC
EggNOG, Ensembl, HGNC, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Cdc42 (cell division cycle 42) HGNC
Treefam, EggNOG, NCBI, OMA, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Cdc42 (cell division cycle 42) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CDC42 (cell division cycle 42) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CDC42 (cell division cycle 42) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Cdc42 (cell division cycle 42) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CDC42 (cell division cycle 42) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
CDC42 (cell division cycle 42) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Cdc42 (cell division cycle 42) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Cdc42 (cell division cycle 42)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
CDC42 (cell division cycle 42)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
cdc42l2 (cell division cycle 42 like 2)
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
cdc42 (cell division cycle 42)
Alliance
DIOPT (Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, Roundup, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
CDC42
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
Cdc42
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
cdc-42
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Related Pseudogenes:
Gm12492
Gm18964
Gm7407
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 Ensembl 4 137,319,696 - 137,357,720 (-) Ensembl GRCm38 mm10 GRCm38 GRCm38 4 137,319,696 - 137,357,759 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 4 136,875,611 - 136,913,652 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 4 136,591,779 - 136,608,205 (-) NCBI mm8 Celera 4 135,540,002 - 135,577,876 (-) NCBI Celera Cytogenetic Map 4 D3 NCBI cM Map 4 69.83 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
genetic disease ISO RGD:730976 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10898977 more ... genetic disease ISO RGD:730976 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10898977 more ... Multiple Abnormalities ISO RGD:730976 8554872 ClinVar Annotator: match by term: Multiple congenital anomalies ClinVar PMID:10898977 more ... Multiple Abnormalities ISO RGD:730976 8554872 ClinVar Annotator: match by term: Multiple congenital anomalies ClinVar PMID:10898977 more ... Noonan Like Syndrome ISO RGD:730976 8554872 ClinVar Annotator: match by term: Noonan-Like Syndrome Disorder ClinVar PMID:25741868 , PMID:29394990 Takenouchi-Kosaki Syndrome ISO RGD:730976 8554872 ClinVar Annotator: match by term: Takenouchi-Kosaki syndrome ClinVar PMID:25741868 Takenouchi-Kosaki Syndrome ISO RGD:730976 8554872 ClinVar Annotator: match by term: Takenouchi-Kosaki syndrome ClinVar PMID:10898977 more ... Takenouchi-Kosaki Syndrome ISO RGD:730976 8554872 ClinVar Annotator: match by term: Takenouchi-Kosaki syndrome ClinVar PMID:29394990 Takenouchi-Kosaki Syndrome ISO RGD:730976 8554872 ClinVar Annotator: match by term: Takenouchi-Kosaki syndrome ClinVar PMID:25741868 , PMID:29394990 Takenouchi-Kosaki Syndrome ISO RGD:730976 8554872 ClinVar Annotator: match by term: Takenouchi-Kosaki syndrome ClinVar PMID:25741868 more ...
Imported Annotations - CTD
Adrenal Gland Neoplasms ISO RGD:730976 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24747643 Animal Mammary Neoplasms ISO RGD:730976 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16316942 carcinoma ISO RGD:730976 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16316942 human immunodeficiency virus infectious disease ISO RGD:730976 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15308739 Mammary Neoplasms, Experimental ISO RGD:730976 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16316942 Necrosis ISO RGD:730976 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19430526 Imported Annotations - MGI
microvillus inclusion disease IEA 13592920 OMIM:251850 MouseDO Imported Annotations - OMIM
Takenouchi-Kosaki Syndrome ISO RGD:730976 7240710 OMIM
(+)-catechin multiple interactions ISO RGD:730976 6480464 [Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of CDC42 mRNA CTD PMID:24763279 (-)-epigallocatechin 3-gallate decreases expression ISO RGD:730976 6480464 epigallocatechin gallate results in decreased expression of CDC42 protein CTD PMID:31195006 (S)-nicotine multiple interactions EXP 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 1,4-dichlorobenzene increases expression EXP 6480464 4-dichlorobenzene results in increased expression of CDC42 mRNA CTD PMID:26975756 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expression EXP 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions EXP 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDC42 mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of CDC42 mRNA CTD PMID:17555576 , PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDC42 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of CDC42 mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression ISO RGD:71043 6480464 2, 4-dinitrotoluene affects the expression of CDC42 mRNA CTD PMID:21346803 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CDC42 mRNA CTD PMID:16054899 4-hydroxyphenyl retinamide increases expression EXP 6480464 Fenretinide results in increased expression of CDC42 mRNA CTD PMID:28973697 acetylsalicylic acid decreases expression ISO RGD:730976 6480464 Aspirin results in decreased expression of CDC42 mRNA CTD PMID:14976132 acrylamide decreases expression ISO RGD:71043 6480464 Acrylamide results in decreased expression of CDC42 mRNA CTD PMID:28959563 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of CDC42 mRNA CTD PMID:19770486 aflatoxin B1 increases methylation ISO RGD:730976 6480464 Aflatoxin B1 results in increased methylation of CDC42 gene, Aflatoxin B1 results in increased methylation of CDC42 promoter CTD PMID:27153756 , PMID:30157460 aldehydo-D-glucose increases expression EXP 6480464 Glucose results in increased expression of CDC42 mRNA, Glucose results in increased expression of CDC42 protein CTD PMID:24659233 aldehydo-D-glucose multiple interactions EXP 6480464 resveratrol inhibits the reaction [Glucose results in increased expression of CDC42 mRNA], resveratrol inhibits the reaction [Glucose results in increased expression of CDC42 protein] CTD PMID:24659233 all-trans-retinoic acid decreases expression ISO RGD:730976 6480464 Tretinoin results in decreased expression of CDC42 mRNA CTD PMID:23724009 ammonium chloride affects expression ISO RGD:71043 6480464 Ammonium Chloride affects the expression of CDC42 mRNA CTD PMID:16483693 antirheumatic drug decreases expression ISO RGD:730976 6480464 Antirheumatic Agents results in decreased expression of CDC42 mRNA CTD PMID:24449571 Aroclor 1254 decreases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of CDC42 mRNA, Chlorodiphenyl (54% Chlorine) results in decreased expression of CDC42 protein CTD PMID:23650126 arsane affects expression ISO RGD:730976 6480464 Arsenic affects the expression of CDC42 mRNA CTD PMID:18414638 arsane affects methylation ISO RGD:730976 6480464 Arsenic affects the methylation of CDC42 gene CTD PMID:25304211 arsenic atom affects expression ISO RGD:730976 6480464 Arsenic affects the expression of CDC42 mRNA CTD PMID:18414638 arsenic atom affects methylation ISO RGD:730976 6480464 Arsenic affects the methylation of CDC42 gene CTD PMID:25304211 arsenous acid increases expression ISO RGD:730976 6480464 Arsenic Trioxide results in increased expression of CDC42 mRNA CTD PMID:20458559 atrazine increases expression ISO RGD:730976 6480464 Atrazine results in increased expression of CDC42 mRNA CTD PMID:22378314 bazedoxifene increases expression ISO RGD:730976 6480464 bazedoxifene results in increased expression of CDC42 mRNA CTD PMID:19914376 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of CDC42 mRNA CTD PMID:20504355 , PMID:22228805 benzo[a]pyrene affects methylation ISO RGD:730976 6480464 Benzo(a)pyrene affects the methylation of CDC42 promoter CTD PMID:30157460 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:730976 6480464 7 more ... CTD PMID:20018196 , PMID:30011042 bortezomib decreases expression ISO RGD:730976 6480464 Bortezomib results in decreased expression of CDC42 mRNA CTD PMID:20977926 cadmium atom increases oxidation EXP 6480464 Cadmium results in increased oxidation of CDC42 protein CTD PMID:24077948 cadmium atom multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of and affects the localization of CDC42 protein CTD PMID:29939372 cadmium dichloride increases expression ISO RGD:71043 6480464 Cadmium Chloride results in increased expression of CDC42 protein CTD PMID:15618353 cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of and affects the localization of CDC42 protein CTD PMID:29939372 calcium atom multiple interactions EXP 6480464 Calcium promotes the reaction [PAFAH1B1 protein binds to IQGAP1 protein binds to CDC42 protein] CTD PMID:16369480 calcium(0) multiple interactions EXP 6480464 Calcium promotes the reaction [PAFAH1B1 protein binds to IQGAP1 protein binds to CDC42 protein] CTD PMID:16369480 carbon nanotube decreases expression ISO RGD:730976 6480464 Nanotubes, Carbon results in decreased expression of CDC42 mRNA CTD PMID:23634900 carboplatin decreases expression ISO RGD:71043 6480464 Carboplatin results in decreased expression of CDC42 mRNA CTD PMID:18172885 casticin decreases expression EXP 6480464 casticin results in decreased expression of CDC42 mRNA CTD PMID:28444820 cefaloridine decreases expression ISO RGD:71043 6480464 Cephaloridine results in decreased expression of CDC42 mRNA CTD PMID:18172885 chrysene decreases expression EXP 6480464 chrysene results in decreased expression of CDC42 mRNA CTD PMID:26377693 cisplatin multiple interactions ISO RGD:730976 6480464 [Cisplatin co-treated with Quercetin] results in increased expression of CDC42 mRNA, [Piroxicam co-treated with Cisplatin] results in increased expression of CDC42 mRNA CTD PMID:21858171 , PMID:27514524 cisplatin increases expression ISO RGD:730976 6480464 Cisplatin results in increased expression of CDC42 mRNA CTD PMID:25450742 cisplatin decreases expression ISO RGD:71043 6480464 Cisplatin results in decreased expression of CDC42 mRNA, Cisplatin results in decreased expression of CDC42 protein CTD PMID:18172885 , PMID:23628706 copper atom multiple interactions EXP 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of CDC42 mRNA more ... CTD PMID:15467011 , PMID:16629173 copper(0) multiple interactions EXP 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of CDC42 mRNA more ... CTD PMID:15467011 , PMID:16629173 CU-O LINKAGE decreases expression ISO RGD:730976 6480464 cupric oxide results in decreased expression of CDC42 protein CTD PMID:25470785 D-glucose increases expression EXP 6480464 Glucose results in increased expression of CDC42 mRNA, Glucose results in increased expression of CDC42 protein CTD PMID:24659233 D-glucose multiple interactions EXP 6480464 resveratrol inhibits the reaction [Glucose results in increased expression of CDC42 mRNA], resveratrol inhibits the reaction [Glucose results in increased expression of CDC42 protein] CTD PMID:24659233 dexamethasone multiple interactions EXP 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CDC42 mRNA CTD PMID:16054899 dexamethasone decreases expression ISO RGD:71043 6480464 Dexamethasone results in decreased expression of CDC42 mRNA CTD PMID:29111458 diarsenic trioxide increases expression ISO RGD:730976 6480464 Arsenic Trioxide results in increased expression of CDC42 mRNA CTD PMID:20458559 disodium selenite increases expression ISO RGD:730976 6480464 Sodium Selenite results in increased expression of CDC42 mRNA CTD PMID:18175754 ethanol decreases expression ISO RGD:71043 6480464 Ethanol results in decreased expression of CDC42 protein CTD PMID:20133374 , PMID:20829428 ethanol affects splicing EXP 6480464 Ethanol affects the splicing of CDC42 mRNA CTD PMID:30319688 ethanol multiple interactions ISO RGD:71043 6480464 Ethanol results in decreased expression of [CDC42 protein binds to Guanosine Triphosphate] CTD PMID:20829428 flusilazole affects expression EXP 6480464 flusilazole affects the expression of CDC42 mRNA CTD PMID:21195148 formaldehyde increases expression ISO RGD:730976 6480464 Formaldehyde results in increased expression of CDC42 mRNA CTD PMID:23649840 fumonisin B1 increases expression EXP 6480464 fumonisin B1 results in increased expression of CDC42 mRNA CTD PMID:16221962 gallic acid decreases expression ISO RGD:730976 6480464 Gallic Acid results in decreased expression of CDC42 protein CTD PMID:23153558 gamma-hexachlorocyclohexane decreases expression ISO RGD:71043 6480464 Hexachlorocyclohexane results in decreased expression of CDC42 mRNA CTD PMID:17785943 gentamycin increases expression ISO RGD:71043 6480464 Gentamicins results in increased expression of CDC42 mRNA CTD PMID:22061828 glucose multiple interactions EXP 6480464 resveratrol inhibits the reaction [Glucose results in increased expression of CDC42 mRNA], resveratrol inhibits the reaction [Glucose results in increased expression of CDC42 protein] CTD PMID:24659233 glucose increases expression EXP 6480464 Glucose results in increased expression of CDC42 mRNA, Glucose results in increased expression of CDC42 protein CTD PMID:24659233 glyphosate decreases expression ISO RGD:71043 6480464 glyphosate results in decreased expression of CDC42 mRNA CTD PMID:26302742 GTP multiple interactions ISO RGD:730976 6480464 Resveratrol promotes the reaction [CDC42 protein binds to Guanosine Triphosphate] more ... CTD PMID:15217905 more ... GTP multiple interactions ISO RGD:71043 6480464 Ethanol results in decreased expression of [CDC42 protein binds to Guanosine Triphosphate] CTD PMID:20829428 GTP multiple interactions EXP 6480464 Risedronic Acid results in increased abundance of [Guanosine Triphosphate binds to CDC42 protein], Zoledronic Acid results in increased abundance of [Guanosine Triphosphate binds to CDC42 protein] CTD PMID:16734383 haloperidol increases expression ISO RGD:71043 6480464 Haloperidol results in increased expression of CDC42 mRNA CTD PMID:15860345 hexaconazole affects expression EXP 6480464 hexaconazole affects the expression of CDC42 mRNA CTD PMID:21195148 hydralazine multiple interactions ISO RGD:730976 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of CDC42 mRNA CTD PMID:17183730 hypochlorous acid increases expression EXP 6480464 Hypochlorous Acid results in increased expression of CDC42 mRNA CTD PMID:19376150 indometacin increases expression ISO RGD:71043 6480464 Indomethacin results in increased expression of CDC42 mRNA CTD PMID:18299717 kainic acid increases expression ISO RGD:71043 6480464 Kainic Acid results in increased expression of CDC42 mRNA CTD PMID:19700661 lead(0) decreases expression ISO RGD:730976 6480464 Lead results in decreased expression of CDC42 mRNA CTD PMID:19921347 lead(0) affects expression ISO RGD:730976 6480464 Lead affects the expression of CDC42 mRNA CTD PMID:28903495 lead(2+) decreases expression ISO RGD:730976 6480464 Lead results in decreased expression of CDC42 mRNA CTD PMID:19921347 lead(2+) affects expression ISO RGD:730976 6480464 Lead affects the expression of CDC42 mRNA CTD PMID:28903495 lovastatin increases expression ISO RGD:730976 6480464 Lovastatin results in increased expression of CDC42 protein CTD PMID:18766339 lovastatin decreases expression EXP 6480464 Lovastatin results in decreased expression of CDC42 mRNA CTD PMID:20493250 mercury dichloride decreases expression ISO RGD:71043 6480464 Mercuric Chloride results in decreased expression of CDC42 protein CTD PMID:22223485 methyl methanesulfonate increases expression ISO RGD:730976 6480464 Methyl Methanesulfonate results in increased expression of CDC42 mRNA CTD PMID:23649840 methylmercury chloride decreases expression ISO RGD:71043 6480464 methylmercuric chloride results in decreased expression of CDC42 protein CTD PMID:22223485 methylseleninic acid decreases expression ISO RGD:730976 6480464 methylselenic acid results in decreased expression of CDC42 mRNA CTD PMID:11830524 microcystin-LR increases expression EXP 6480464 cyanoginosin LR results in increased expression of CDC42 mRNA CTD PMID:17654400 N-methyl-4-phenylpyridinium decreases expression ISO RGD:730976 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of CDC42 mRNA CTD PMID:24810058 Niclosamide decreases expression ISO RGD:730976 6480464 Niclosamide results in decreased expression of CDC42 mRNA CTD PMID:29251334 Niclosamide decreases phosphorylation ISO RGD:730976 6480464 Niclosamide results in decreased phosphorylation of CDC42 protein CTD PMID:29251334 nicotine multiple interactions EXP 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 NSC 23766 multiple interactions ISO RGD:730976 6480464 NSC 23766 inhibits the reaction [Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein]] CTD PMID:22166487 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of CDC42 mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:730976 6480464 Acetaminophen results in increased expression of CDC42 mRNA CTD PMID:26690555 pentachlorophenol increases expression EXP 6480464 Pentachlorophenol results in increased expression of CDC42 mRNA CTD PMID:23892564 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of CDC42 mRNA CTD PMID:19363144 piroxicam multiple interactions ISO RGD:730976 6480464 [Piroxicam co-treated with Cisplatin] results in increased expression of CDC42 mRNA CTD PMID:21858171 Propiverine affects binding ISO RGD:71043 6480464 propiverine binds to CDC42 protein CTD PMID:29273565 quercetin multiple interactions ISO RGD:730976 6480464 [Cisplatin co-treated with Quercetin] results in increased expression of CDC42 mRNA CTD PMID:27514524 resveratrol multiple interactions EXP 6480464 [resveratrol co-treated with beta-1 more ... CTD PMID:17690738 , PMID:24659233 resveratrol multiple interactions ISO RGD:730976 6480464 resveratrol promotes the reaction [CDC42 protein binds to Guanosine Triphosphate], resveratrol results in increased activity of and affects the localization of CDC42 protein CTD PMID:15217905 Risedronate sodium multiple interactions EXP 6480464 Risedronic Acid results in increased abundance of [Guanosine Triphosphate binds to CDC42 protein] CTD PMID:16734383 Risedronate sodium multiple interactions ISO RGD:730976 6480464 Risedronic Acid results in increased abundance of [Guanosine Triphosphate binds to CDC42 protein] CTD PMID:16734383 rotenone decreases expression ISO RGD:71043 6480464 Rotenone results in decreased expression of CDC42 protein CTD PMID:22223485 rotenone decreases activity ISO RGD:71043 6480464 Rotenone results in decreased activity of CDC42 protein CTD PMID:18480073 SB 431542 increases expression ISO RGD:730976 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of CDC42 protein CTD PMID:25670856 simvastatin decreases activity EXP 6480464 Simvastatin results in decreased activity of CDC42 protein CTD PMID:17169357 sodium arsenite decreases expression ISO RGD:71043 6480464 sodium arsenite results in decreased expression of CDC42 protein CTD PMID:19072884 sodium dichromate increases expression ISO RGD:71043 6480464 sodium bichromate results in increased expression of CDC42 mRNA CTD PMID:12325037 tamoxifen affects expression EXP 6480464 Tamoxifen affects the expression of CDC42 mRNA CTD PMID:17555576 tert-butyl hydroperoxide increases expression ISO RGD:730976 6480464 tert-Butylhydroperoxide results in increased expression of CDC42 mRNA CTD PMID:15336504 testosterone increases expression EXP 6480464 Testosterone results in increased expression of CDC42 mRNA CTD PMID:19693291 titanium dioxide decreases expression EXP 6480464 titanium dioxide results in decreased expression of CDC42 mRNA CTD PMID:23557971 tremolite asbestos decreases expression ISO RGD:730976 6480464 tremolite results in decreased expression of CDC42 protein CTD PMID:22578742 triadimefon affects expression EXP 6480464 triadimefon affects the expression of CDC42 mRNA CTD PMID:21195148 Triptolide decreases expression ISO RGD:71043 6480464 triptolide results in decreased expression of CDC42 mRNA, triptolide results in decreased expression of CDC42 protein CTD PMID:27554044 valproic acid multiple interactions ISO RGD:730976 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of CDC42 mRNA CTD PMID:17183730 valproic acid decreases expression ISO RGD:730976 6480464 Valproic Acid results in decreased expression of CDC42 mRNA CTD PMID:23179753 warfarin decreases expression EXP 6480464 Warfarin results in decreased expression of CDC42 mRNA CTD PMID:20493250 zinc oxide multiple interactions ISO RGD:730976 6480464 [RAC1 protein binds to CDC42 protein] affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein] more ... CTD PMID:22166487 zoledronic acid multiple interactions EXP 6480464 zoledronic acid results in increased abundance of [Guanosine Triphosphate binds to CDC42 protein] CTD PMID:16734383 zoledronic acid multiple interactions ISO RGD:730976 6480464 zoledronic acid results in increased expression of [CDC42 protein binds to Guanosine Triphosphate], zoledronic acid results in increased expression of and affects the localization of CDC42 protein CTD PMID:28871336
Biological Process actin cytoskeleton organization IBA PANTHER:PTN001530052 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 actin filament branching ISO RGD:71043 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 actin filament organization ISO RGD:71043 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 actin filament organization IBA PANTHER:PTN001530052 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 adherens junction organization IMP MGI:MGI:3619134 2290270 (MGI:MGI:3664674, PMID:16892058) MGI MGI:MGI:3664674 , PMID:16892058 cardiac conduction system development IGI MGI:MGI:97350 2290270 (MGI:MGI:5052204, PMID:21690310) MGI MGI:MGI:5052204 , PMID:21690310 Cdc42 protein signal transduction ISO RGD:71043 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 Cdc42 protein signal transduction IBA PANTHER:PTN000632904 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 cell differentiation IEA UniProtKB-KW:KW-0221 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 cell migration IBA PANTHER:PTN000632904 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 cell projection assembly IBA PANTHER:PTN000632904 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 cell-cell adhesion TAS 2290270 (MGI:MGI:3687818, PMID:10954424) UniProtKB MGI:MGI:3687818 , PMID:10954424 cellular protein localization IMP 2290270 (MGI:MGI:3689461, PMID:16621792) MGI MGI:MGI:3689461 , PMID:16621792 cellular response to interferon-gamma IDA 2290270 (MGI:MGI:3828867, PMID:19144319) MGI MGI:MGI:3828867 , PMID:19144319 cortical cytoskeleton organization IBA PANTHER:PTN001530052 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 dendritic cell migration IGI MGI:MGI:1921396 2290270 (MGI:MGI:5427550, PMID:22461490) MGI MGI:MGI:5427550 , PMID:22461490 dendritic spine morphogenesis IMP 2290270 (MGI:MGI:5825418, PMID:25851601) UniProtKB MGI:MGI:5825418 , PMID:25851601 endocytosis IMP 2290270 (MGI:MGI:5607692, PMID:24792215) MGI MGI:MGI:5607692 , PMID:24792215 endocytosis IBA PANTHER:PTN000632904 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 endosomal transport TAS 2290270 (MGI:MGI:3687818, PMID:10954424) UniProtKB MGI:MGI:3687818 , PMID:10954424 establishment of Golgi localization ISO RGD:71043 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 establishment or maintenance of apical/basal cell polarity IMP MGI:MGI:3619134 2290270 (MGI:MGI:3664674, PMID:16892058) MGI MGI:MGI:3664674 , PMID:16892058 establishment or maintenance of cell polarity TAS 2290270 (MGI:MGI:3687818, PMID:10954424) UniProtKB MGI:MGI:3687818 , PMID:10954424 establishment or maintenance of cell polarity IBA PANTHER:PTN001530052 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 filopodium assembly IDA 2290270 (MGI:MGI:2447568, PMID:10699171) MGI MGI:MGI:2447568 , PMID:10699171 Golgi organization ISO RGD:71043 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 heart contraction IGI MGI:MGI:97350 2290270 (MGI:MGI:5052204, PMID:21690310) MGI MGI:MGI:5052204 , PMID:21690310 modification of synaptic structure ISO RGD:71043 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 modification of synaptic structure IBA PANTHER:PTN000633069 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 nervous system development IEA UniProtKB-KW:KW-0524 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 neuron fate determination IMP MGI:MGI:3619134 2290270 (MGI:MGI:3664674, PMID:16892058) MGI MGI:MGI:3664674 , PMID:16892058 nuclear migration IMP 2290270 (MGI:MGI:3580741, PMID:15882626) MGI MGI:MGI:3580741 , PMID:15882626 nuclear migration IMP MGI:MGI:3619134 2290270 (MGI:MGI:3664674, PMID:16892058) MGI MGI:MGI:3664674 , PMID:16892058 nucleus localization IMP MGI:MGI:3619134 2290270 (MGI:MGI:3664674, PMID:16892058) MGI MGI:MGI:3664674 , PMID:16892058 organelle transport along microtubule ISO RGD:71043 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of catalytic activity ISO RGD:71043 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of DNA replication ISO RGD:71043 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of epithelial cell proliferation involved in lung morphogenesis IMP 2290270 (MGI:MGI:5467649, PMID:23219958) CACAO MGI:MGI:5467649 , PMID:23219958 positive regulation of filopodium assembly IMP 2290270 (MGI:MGI:5825422, PMID:22494997) UniProtKB MGI:MGI:5825422 , PMID:22494997 positive regulation of intracellular protein transport ISO RGD:71043 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of JNK cascade ISO RGD:71043 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of MAPK cascade IDA 2290270 (MGI:MGI:3850924, PMID:19244314) MGI MGI:MGI:3850924 , PMID:19244314 positive regulation of neuron apoptotic process ISO RGD:71043 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of phosphatidylinositol 3-kinase activity IMP 2290270 (MGI:MGI:3587490, PMID:15728722) MGI MGI:MGI:3587490 , PMID:15728722 positive regulation of pinocytosis IMP 2290270 (MGI:MGI:5607692, PMID:24792215) UniProt MGI:MGI:5607692 , PMID:24792215 positive regulation of synapse structural plasticity ISO RGD:71043 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 regulation of actin cytoskeleton organization IBA PANTHER:PTN001530052 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 regulation of cell shape IBA PANTHER:PTN001530052 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 regulation of mitotic nuclear division IMP MGI:MGI:3619134 2290270 (MGI:MGI:3664674, PMID:16892058) MGI MGI:MGI:3664674 , PMID:16892058 regulation of modification of postsynaptic structure ISO RGD:71043 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 regulation of protein binding IDA 2290270 (MGI:MGI:3850924, PMID:19244314) MGI MGI:MGI:3850924 , PMID:19244314 Rho protein signal transduction TAS 2290270 (MGI:MGI:1929482, PMID:10490598) MGI MGI:MGI:1929482 , PMID:10490598 Rho protein signal transduction IBA PANTHER:PTN000632671 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 small GTPase mediated signal transduction IEA InterPro:IPR003578 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 sprouting angiogenesis ISO RGD:71043 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 Cellular Component apical part of cell IDA 2290270 (MGI:MGI:3664674, PMID:16892058) MGI MGI:MGI:3664674 , PMID:16892058 cell cortex IBA PANTHER:PTN001530052 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 cell periphery IDA 2290270 (MGI:MGI:4367296, PMID:19796622) MGI MGI:MGI:4367296 , PMID:19796622 cell projection IDA 2290270 (MGI:MGI:3587490, PMID:15728722) MGI MGI:MGI:3587490 , PMID:15728722 cell projection IBA PANTHER:PTN001530052 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 cell-cell junction IDA 2290270 (MGI:MGI:5544872, PMID:23793062) MGI MGI:MGI:5544872 , PMID:23793062 cytoplasm IDA 2290270 (MGI:MGI:3574751 more ... MGI MGI:MGI:3574751 more ... cytoplasm IBA PANTHER:PTN001530052 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 cytoplasmic vesicle IBA PANTHER:PTN001530052 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 cytoskeleton IBA PANTHER:PTN001530052 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 cytosol IDA 2290270 (MGI:MGI:5314863, PMID:21828338) MGI MGI:MGI:5314863 , PMID:21828338 dendritic spine IBA PANTHER:PTN000633069 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 Golgi membrane ISO RGD:71043 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 intracellular IEA InterPro:IPR003578 2290270 UniProt GO_REF:0000002, MGI:MGI:2152098 intracellular membrane-bounded organelle IBA PANTHER:PTN001530052 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 leading edge membrane IDA 2290270 (MGI:MGI:5427550, PMID:22461490) MGI MGI:MGI:5427550 , PMID:22461490 membrane IEA UniProtKB-KW:KW-0472 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 myelin sheath HDA 2290270 (MGI:MGI:3834050, PMID:17634366) UniProt MGI:MGI:3834050 , PMID:17634366 neuron projection IBA PANTHER:PTN000633069 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 phagocytic vesicle IDA 2290270 (MGI:MGI:3828867, PMID:19144319) MGI MGI:MGI:3828867 , PMID:19144319 plasma membrane IDA 2290270 (MGI:MGI:5314863 more ... MGI MGI:MGI:5314863 more ... plasma membrane IBA PANTHER:PTN001530052 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 plasma membrane TAS 2290270 Reactome Reactome:R-MMU-3928643 more ... plasma membrane ISO RGD:71043 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 Schaffer collateral - CA1 synapse ISO RGD:71043 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 secretory granule ISO RGD:71043 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 storage vacuole IDA 2290270 (MGI:MGI:5314863, PMID:21828338) MGI MGI:MGI:5314863 , PMID:21828338 Molecular Function GTP binding ISO UniProtKB:P60953 2290270 (MGI:MGI:5506989, PMID:23620790) MGI MGI:MGI:5506989 , PMID:23620790 GTP binding IBA PANTHER:PTN000632671 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 GTP binding ISO RGD:71043 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 GTP-dependent protein binding IPI UniProtKB:Q9Z101 2290270 (MGI:MGI:3687818, PMID:10954424) UniProtKB MGI:MGI:3687818 , PMID:10954424 GTPase activity TAS 2290270 (MGI:MGI:1929482, PMID:10490598) MGI MGI:MGI:1929482 , PMID:10490598 GTPase activity IBA PANTHER:PTN000632671 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 GTPase activity ISO UniProtKB:P60953 2290270 (MGI:MGI:5903668, PMID:27917469) MGI MGI:MGI:5903668 , PMID:27917469 GTPase activity IGI MGI:MGI:1347084 2290270 (MGI:MGI:3828237, PMID:18838382) MGI MGI:MGI:3828237 , PMID:18838382 GTPase activity IDA 2290270 (MGI:MGI:2447568 more ... MGI MGI:MGI:2447568 more ... GTPase activity ISA RefSeq:NP_001782 2290270 (MGI:MGI:2662668, PMID:12637522) MGI MGI:MGI:2662668 , PMID:12637522 hydrolase activity IEA UniProtKB-KW:KW-0378 2290270 UniProt GO_REF:0000004, MGI:MGI:1354194 mitogen-activated protein kinase kinase kinase binding ISO RGD:71043 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 nucleotide binding IEA UniProtKB-KW:KW-0547 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 protein binding IPI RefSeq:573460 2290270 (MGI:MGI:52805, PMID:8464478) MGI MGI:MGI:52805 , PMID:8464478 protein binding IPI UniProtKB:P49817 more ... 2290270 (MGI:MGI:5314863, PMID:21828338) MGI MGI:MGI:5314863 , PMID:21828338 protein binding IPI UniProtKB:P63044 2290270 (MGI:MGI:4441124, PMID:15537656) IntAct MGI:MGI:4441124 , PMID:15537656 protein binding IPI UniProtKB:Q13153 2290270 (MGI:MGI:3828223 more ... IntAct MGI:MGI:3828223 more ... protein binding IPI UniProtKB:Q02248 2290270 (MGI:MGI:3687818, PMID:10954424) UniProtKB MGI:MGI:3687818 , PMID:10954424 protein binding IPI UniProtKB:Q9NPB6 2290270 (MGI:MGI:3687818, PMID:10954424) UniProtKB MGI:MGI:3687818 , PMID:10954424 protein binding IPI UniprotKB:O54967 2290270 (MGI:MGI:3828237, PMID:18838382) MGI MGI:MGI:3828237 , PMID:18838382 protein binding IPI UniProtKB:O88643 2290270 (MGI:MGI:3583726 more ... MGI MGI:MGI:3583726 more ... protein binding IPI UniProtKB:O54967 2290270 (MGI:MGI:3590361, PMID:16052498) MGI MGI:MGI:3590361 , PMID:16052498 protein binding IPI UniProtKB:B9EKT6 , UniProtKB:Q9JKF1 2290270 (MGI:MGI:3835718, PMID:18604197) MGI MGI:MGI:3835718 , PMID:18604197 protein binding IPI UniProtKB:Q640L3 2290270 (MGI:MGI:3698674, PMID:17000758) MGI MGI:MGI:3698674 , PMID:17000758 protein binding IPI UniProtKB:Q5KTP7 more ... 2290270 (MGI:MGI:3529612, PMID:15710388) MGI MGI:MGI:3529612 , PMID:15710388 protein binding IPI UniProtKB:Q80YF9 2290270 (MGI:MGI:2663651, PMID:12773384) MGI MGI:MGI:2663651 , PMID:12773384 protein binding IPI UniProtKB:Q9QZT9 2290270 (MGI:MGI:1929482, PMID:10490598) MGI MGI:MGI:1929482 , PMID:10490598 protein binding IPI UniProtKB:Q9Z0X0 2290270 (MGI:MGI:1929302, PMID:11035016) MGI MGI:MGI:1929302 , PMID:11035016 protein kinase binding IPI UniProtKB:Q5S006 2290270 (MGI:MGI:5318010, PMID:21048939) BHF-UCL MGI:MGI:5318010 , PMID:21048939 protein kinase binding IBA PANTHER:PTN001530052 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 Rho GDP-dissociation inhibitor binding NOT IDA 2290270 (MGI:MGI:5525991, PMID:23358418) MGI MGI:MGI:5525991 , PMID:23358418 Rho GDP-dissociation inhibitor binding IDA 2290270 (MGI:MGI:5525991, PMID:23358418) MGI MGI:MGI:5525991 , PMID:23358418
Gene-Chemical Interaction Annotations
