Emilin1 (elastin microfibril interfacer 1) - Rat Genome Database

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Gene: Emilin1 (elastin microfibril interfacer 1) Mus musculus
Analyze
Symbol: Emilin1
Name: elastin microfibril interfacer 1
RGD ID: 1322549
MGI Page MGI
Description: Exhibits extracellular matrix constituent conferring elasticity and identical protein binding activity. Involved in several processes, including negative regulation of signal transduction; regulation of extracellular matrix organization; and regulation of gene expression. Localizes to extracellular matrix. Is expressed in several structures, including early conceptus; embryo mesenchyme; genitourinary system; heart and pericardium; and musculoskeletal system. Orthologous to human EMILIN1 (elastin microfibril interfacer 1); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 5830419M17Rik; AW229038; BB105748; elastin microfibril interface located protein 1; elastin microfibril interface-located protein 1; EMIL; EMILIN-1; gp11; gp115
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,070,729 - 31,078,623 (+)NCBIGRCm39mm39
GRCm39 Ensembl531,070,746 - 31,078,621 (+)Ensembl
GRCm38530,913,387 - 30,921,279 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,913,402 - 30,921,277 (+)EnsemblGRCm38mm10GRCm38
MGSCv37531,216,159 - 31,223,648 (+)NCBIGRCm37mm9NCBIm37
MGSCv36531,190,367 - 31,197,856 (+)NCBImm8
Celera528,393,566 - 28,401,069 (+)NCBICelera
Cytogenetic Map5B1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12221002   PMID:12475644   PMID:12477932   PMID:14701737   PMID:14996434   PMID:15489334   PMID:15705587   PMID:16141072  
PMID:16141073   PMID:18287559   PMID:18411305   PMID:18554416   PMID:18757743   PMID:18799693   PMID:19334288   PMID:20368287   PMID:21267068   PMID:21386911   PMID:21677750   PMID:21873635  
PMID:21949412   PMID:22159717   PMID:22248097   PMID:22814752   PMID:22827975   PMID:23658023   PMID:24006456   PMID:24019067   PMID:25056700   PMID:25445627   PMID:25658937   PMID:28071719  
PMID:28526753   PMID:28717224   PMID:29329412   PMID:30354220   PMID:30408617   PMID:31477791   PMID:31479698   PMID:31624071   PMID:32948785   PMID:33153107  


Genomics

Comparative Map Data
Emilin1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,070,729 - 31,078,623 (+)NCBIGRCm39mm39
GRCm39 Ensembl531,070,746 - 31,078,621 (+)Ensembl
GRCm38530,913,387 - 30,921,279 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,913,402 - 30,921,277 (+)EnsemblGRCm38mm10GRCm38
MGSCv37531,216,159 - 31,223,648 (+)NCBIGRCm37mm9NCBIm37
MGSCv36531,190,367 - 31,197,856 (+)NCBImm8
Celera528,393,566 - 28,401,069 (+)NCBICelera
Cytogenetic Map5B1NCBI
EMILIN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl227,078,615 - 27,086,403 (+)EnsemblGRCh38hg38GRCh38
GRCh38227,078,615 - 27,086,403 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37227,301,483 - 27,309,271 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,155,438 - 27,162,767 (+)NCBINCBI36hg18NCBI36
Build 34227,213,584 - 27,220,914NCBI
Celera227,147,777 - 27,155,615 (+)NCBI
Cytogenetic Map2p23.3NCBI
HuRef227,043,585 - 27,051,425 (+)NCBIHuRef
CHM1_1227,231,349 - 27,239,185 (+)NCBICHM1_1
Emilin1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2625,455,974 - 25,463,736 (-)NCBI
Rnor_6.0 Ensembl626,821,255 - 26,828,972 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0626,821,249 - 26,829,013 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0636,636,864 - 36,644,629 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,438,941 - 25,446,658 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1625,442,200 - 25,449,588 (-)NCBI
Celera624,946,624 - 24,954,341 (-)NCBICelera
Cytogenetic Map6q14NCBI
Emilin1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554699,049,662 - 9,057,684 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554699,049,666 - 9,057,692 (+)NCBIChiLan1.0ChiLan1.0
EMILIN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A27,166,747 - 27,174,525 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A27,166,747 - 27,174,525 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A27,077,551 - 27,085,437 (+)NCBIMhudiblu_PPA_v0panPan3
EMILIN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11721,071,502 - 21,078,888 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1721,071,580 - 21,078,889 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1720,963,506 - 20,971,268 (+)NCBI
ROS_Cfam_1.01721,391,307 - 21,399,069 (+)NCBI
UMICH_Zoey_3.11721,078,565 - 21,086,326 (+)NCBI
UNSW_CanFamBas_1.01721,089,650 - 21,097,411 (+)NCBI
UU_Cfam_GSD_1.01721,136,118 - 21,143,825 (+)NCBI
Emilin1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629265,376,334 - 65,384,198 (+)NCBI
SpeTri2.0NW_0049364935,455,369 - 5,463,205 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EMILIN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3112,031,919 - 112,046,437 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13112,031,910 - 112,039,928 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23119,030,516 - 119,038,504 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EMILIN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,531,973 - 80,539,820 (-)NCBI
Vero_WHO_p1.0NW_02366604531,599,958 - 31,607,798 (+)NCBI
Emilin1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247389,180,944 - 9,189,025 (+)NCBI

Position Markers
AW229038  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38530,921,080 - 30,921,203UniSTSGRCm38
MGSCv37531,223,453 - 31,223,576UniSTSGRCm37
Celera528,400,874 - 28,400,997UniSTS
Cytogenetic Map5B1UniSTS
cM Map518.1UniSTS
Whitehead/MRC_RH5386.0UniSTS
Emilin1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38530,915,643 - 30,916,962UniSTSGRCm38
MGSCv37531,218,016 - 31,219,335UniSTSGRCm37
Celera528,395,425 - 28,396,756UniSTS
Cytogenetic Map5B1UniSTS
cM Map5 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401122Pgia41_mproteoglycan induced arthritis 41 (mouse)Not determined561814634618282Mouse
15039371Nmrs21_mNAFLD-associated magnetic resonance shift 21 (mouse)5329982537299825Mouse
1301806Actd2_mactivity-distance traveled 2 (mouse)Not determined5517952239179654Mouse
4141207Imrfq1_mimmune response to Factor IX QTL 1 (mouse)Not determined5791911941919241Mouse
7394748Mom5_mmodifier of Min 5 (mouse)Not determined5879767233318293Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5884069387693978Mouse
1357478Kdnw1_mkidney weight 1 (mouse)Not determined5886594940372526Mouse
14696730Kidlq1_mkidney weight, left QTL 1 (mouse)51340580847405808Mouse
1301685Estq2_mestradiol regulated response QTL 2 (mouse)Not determined51547674049476846Mouse
1300719Iba5_minduction of brown adipocytes 5 (mouse)Not determined52052964954529790Mouse
1301776Skts3_mskin tumor susceptibility 3 (mouse)Not determined52150995255510060Mouse
11537368Hmtb10_mhemostasis and thrombosis 10 (mouse)52189582554342976Mouse
11537367Hmtb11_mhemostasis and thrombosis 11 (mouse)52189582564649236Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526236236138457140Mouse
1300701Cd8ts1_mCD8 T cell subset 1 (mouse)Not determined52705800661058109Mouse
1301555Alcp10_malcohol preference locus 10 (mouse)Not determined53086693364867138Mouse
1301403Alcp9_malcohol preference locus 9 (mouse)Not determined53086693364867138Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:745
Count of miRNA genes:429
Interacting mature miRNAs:497
Transcripts:ENSMUST00000031055, ENSMUST00000166839, ENSMUST00000171922, ENSMUST00000172453
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000031055   ⟹   ENSMUSP00000031055
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl530,913,402 - 30,921,277 (+)Ensembl
RefSeq Acc Id: ENSMUST00000201169
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl530,913,739 - 30,920,865 (+)Ensembl
RefSeq Acc Id: ENSMUST00000202368
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl530,919,921 - 30,921,049 (+)Ensembl
RefSeq Acc Id: NM_133918   ⟹   NP_598679
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39531,071,130 - 31,078,619 (+)NCBI
GRCm38530,913,786 - 30,921,275 (+)NCBI
MGSCv37531,216,159 - 31,223,648 (+)RGD
Celera528,393,566 - 28,401,069 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006503649   ⟹   XP_006503712
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39531,070,729 - 31,078,623 (+)NCBI
GRCm38530,913,387 - 30,921,279 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_598679   ⟸   NM_133918
- Peptide Label: precursor
- UniProtKB: Q99K41 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006503712   ⟸   XM_006503649
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000031055   ⟸   ENSMUST00000031055
Protein Domains
C1q   Collagen-like   EMI

Promoters
RGD ID:6886312
Promoter ID:EPDNEW_M6607
Type:initiation region
Name:Emilin1_1
Description:Mus musculus elastin microfibril interfacer 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38530,913,757 - 30,913,817EPDNEW
RGD ID:6837414
Promoter ID:MM_KWN:41786
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000031055,   UC008WWL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36531,215,111 - 31,216,012 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1926189 AgrOrtholog
Ensembl Genes ENSMUSG00000029163 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000031055 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000031055 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C1q_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Collagen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EMI_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:100952 UniProtKB/Swiss-Prot
MGD MGI:1926189 ENTREZGENE
NCBI Gene 100952 ENTREZGENE
Pfam C1q UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Collagen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EMI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Emilin1 PhenoGen
PROSITE C1Q UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EMI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART C1Q UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49842 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt EMIL1_MOUSE UniProtKB/Swiss-Prot
  Q3U254_MOUSE UniProtKB/TrEMBL
  Q3USG5_MOUSE UniProtKB/TrEMBL
  Q3UUU0_MOUSE UniProtKB/TrEMBL
  Q99K41 ENTREZGENE