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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bromocriptine
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Accession:CHEBI:3181 term browser browse the term
Definition:An indole alkaloid that has formula C32H40BrN5O5.
Synonyms:exact_synonym: (5'alpha)-2-bromo-12'-hydroxy-5'-(2-methylpropyl)-2'-(propan-2-yl)-3',6',18-trioxoergotaman
 related_synonym: (5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-3',6',18-trioxoergotaman;   (5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione;   (5'alpha)-2-bromo-12'-hydroxy-5'-isobutyl-2'-isopropyl-3',6',18-trioxoergotaman;   2-bromo-alpha-ergocryptine;   2-bromo-alpha-ergokryptin;   2-bromo-alpha-ergokryptine;   Formula=C32H40BrN5O5;   InChI=1S/C32H40BrN5O5/c1-16(2)12-24-29(40)37-11-7-10-25(37)32(42)38(24)30(41)31(43-32,17(3)4)35-28(39)18-13-20-19-8-6-9-22-26(19)21(27(33)34-22)14-23(20)36(5)15-18/h6,8-9,13,16-18,23-25,34,42H,7,10-12,14-15H2,1-5H3,(H,35,39)/t18-,23-,24+,25+,31-,32+/m1/s1;   InChIKey=OZVBMTJYIDMWIL-AYFBDAFISA-N;   SMILES=[H][C@@]12Cc3c(Br)[nH]c4cccc(C1=C[C@H](CN2C)C(=O)N[C@@]1(O[C@]2(O)N([C@@H](CC(C)C)C(=O)N5CCC[C@@]25[H])C1=O)C(C)C)c34;   bromocriptinum;   bromocryptine;   bromoergocriptine
 xref: Beilstein:741357;   CAS:25614-03-3;   DrugBank:DB01200;   Drug_Central:403;   KEGG:C06856;   KEGG:D03165;   LINCS:LSM-6550
 xref_mesh: MESH:D001971
 xref: Patent:DE1926045;   Patent:US3752814;   Wikipedia:Bromocriptine



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bromocriptine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions
EXP Bromocriptine results in increased expression of ABCB1 protein
Clozapine inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]; Spiperone inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]
CTD PMID:9111066 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases activity
increases expression
multiple interactions
EXP Bromocriptine results in increased activity of ABCB1B promoter
Bromocriptine results in increased expression of ABCB1B mRNA
Clozapine inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; eticlopride inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Pertussis Toxin inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Spiperone inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]
CTD PMID:9111066 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression
multiple interactions
EXP Bromocriptine results in increased expression of AKR1C3 mRNA
methyl cellosolve inhibits the reaction [Bromocriptine results in increased expression of AKR1C3 mRNA]
CTD PMID:21427058 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Bromocriptine results in increased expression of ATF3 mRNA; Bromocriptine results in increased expression of ATF3 protein CTD PMID:21867702 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP Bromocriptine results in increased expression of BAX protein
[Bromocriptine co-treated with Octreotide] results in increased expression of BAX protein
CTD PMID:15046398 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases secretion ISO Bromocriptine results in decreased secretion of BDNF protein CTD PMID:12770616 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [Bromocriptine co-treated with Estradiol] results in decreased expression of CTNNB1 protein CTD PMID:11786374 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions
decreases expression
EXP Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of CYP11A1 mRNA]
Bromocriptine results in decreased expression of CYP11A1 protein
CTD PMID:12742521 PMID:21427058 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Bromocriptine results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Bromocriptine results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects binding
affects metabolic processing
multiple interactions
ISO Bromocriptine binds to CYP3A4 protein
CYP3A4 protein affects the metabolism of Bromocriptine
Bromocriptine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]
CTD PMID:15286053 PMID:17198380 PMID:19299527 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dbh dopamine beta-hydroxylase decreases activity ISO Bromocriptine results in decreased activity of DBH protein CTD PMID:501350 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Drd2 dopamine receptor D2 affects expression
affects response to substance
multiple interactions
decreases expression
increases expression
increases response to substance
ISO
EXP
Bromocriptine affects the expression of DRD2 mRNA
DRD2 protein affects the susceptibility to Bromocriptine
Bromocriptine binds to and results in increased activity of DRD2 mRNA; Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]
Bromocriptine results in decreased expression of DRD2 mRNA
[Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA
Bromocriptine results in increased expression of DRD2 mRNA
DRD2 polymorphism results in increased susceptibility to Bromocriptine
CTD PMID:1534540 PMID:8103596 PMID:15781964 PMID:16901644 PMID:20063113 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 multiple interactions
decreases expression
EXP [1-Methyl-4-phenylpyridinium co-treated with Bromocriptine] results in decreased expression of DRD3 mRNA
Bromocriptine results in decreased expression of DRD3 mRNA
CTD PMID:17000468 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [Bromocriptine co-treated with Estradiol] results in increased expression of ESR1 protein CTD PMID:11786374 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression ISO Bromocriptine results in increased expression of FSHB protein CTD PMID:86031 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Gdnf glial cell derived neurotrophic factor decreases expression
decreases secretion
ISO Bromocriptine results in decreased expression of GDNF mRNA
Bromocriptine results in decreased secretion of GDNF protein
CTD PMID:12770616 NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Gh1 growth hormone 1 increases expression
decreases expression
ISO Bromocriptine results in increased expression of GH1 protein
Bromocriptine results in decreased expression of GH1 protein
CTD PMID:772175 PMID:3226523 PMID:3745407 PMID:7293648 PMID:19420816 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Bromocriptine results in increased expression of HMOX1 mRNA; Bromocriptine results in increased expression of HMOX1 protein CTD PMID:21867702 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions ISO [Bromocriptine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Bromocriptine binds to and results in decreased activity of HTR7 protein CTD PMID:18996971 PMID:19509219 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
JBrowse link
G Ins2 insulin 2 decreases expression ISO Bromocriptine results in decreased expression of INS protein CTD PMID:16803851 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression ISO Bromocriptine results in increased expression of LHB protein CTD PMID:86031 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Bromocriptine promotes the reaction [Estrogens results in increased phosphorylation of and affects the localization of MAPK1 protein] CTD PMID:19595700 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Bromocriptine promotes the reaction [Estrogens results in increased phosphorylation of and affects the localization of MAPK3 protein] CTD PMID:19595700 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases localization ISO Bromocriptine results in increased localization of NFE2L2 protein CTD PMID:21867702 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ngf nerve growth factor increases secretion ISO Bromocriptine results in increased secretion of NGF protein CTD PMID:12770616 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of NOS2 protein] CTD PMID:21867702 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions EXP Bromocriptine affects the reaction [methyl cellosolve results in increased expression of NR5A2 mRNA] CTD PMID:21427058 NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of PCNA protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PCNA protein] CTD PMID:15677882 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pomc proopiomelanocortin decreases expression
increases expression
multiple interactions
EXP
ISO
Bromocriptine results in decreased expression of POMC protein alternative form
Bromocriptine results in increased expression of POMC mRNA; Bromocriptine results in increased expression of POMC protein modified form
Bromocriptine inhibits the reaction [POMC protein results in decreased secretion of Corticosterone]
CTD PMID:1325994 PMID:6274577 PMID:12742521 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Prkcd protein kinase C, delta multiple interactions
affects localization
EXP Bromocriptine promotes the reaction [Estrogens results in increased expression of and results in increased cleavage of PRKCD protein]
Bromocriptine affects the localization of PRKCD protein
CTD PMID:19595700 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prl prolactin multiple interactions
decreases secretion
decreases expression
ISO
EXP
Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]; Bromocriptine inhibits the reaction [Nalorphine results in increased expression of PRL protein]; Bromocriptine inhibits the reaction [VIP protein results in increased expression of PRL protein]
Bromocriptine results in decreased secretion of PRL protein
Bromocriptine results in decreased expression of PRL protein
Bromocriptine inhibits the reaction [Amisulpride results in increased secretion of PRL protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PRL mRNA]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PRL protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]; Bromocriptine inhibits the reaction [Estradiol results in increased expression of PRL protein]; Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of PRL protein]; Estradiol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Ethanol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Haloperidol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Sulpiride inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]
CTD PMID:86031 PMID:86795 PMID:90217 PMID:1407345 PMID:1874184 More... NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions EXP Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of SCARB1 mRNA] CTD PMID:21427058 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Bromocriptine inhibits the reaction [[SOD1 protein mutant form co-treated with Lipopolysaccharides] results in increased secretion of TNF protein]; Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of NOS2 protein]; Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of TNF protein] CTD PMID:21867702 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression EXP Bromocriptine results in decreased expression of STAR protein CTD PMID:12742521 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stat5a signal transducer and activator of transcription 5A affects localization ISO Bromocriptine affects the localization of STAT5A protein CTD PMID:17884938 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions EXP Bromocriptine inhibits the reaction [Estradiol results in increased expression of TGFA mRNA] CTD PMID:1534540 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of TGFB1 protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in decreased expression of TGFB1 protein] CTD PMID:15677882 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Bromocriptine inhibits the reaction [[SOD1 protein mutant form co-treated with Lipopolysaccharides] results in increased secretion of TNF protein]; Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of TNF protein]
Bromocriptine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD PMID:11752888 PMID:21867702 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP [Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of VEGFA protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in decreased expression of VEGFA protein] CTD PMID:15677882 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vip vasoactive intestinal peptide multiple interactions ISO
EXP
Bromocriptine inhibits the reaction [VIP protein results in increased expression of PRL protein]
[Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of VIP protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of VIP mRNA]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of VIP protein]
CTD PMID:6441721 PMID:15677882 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216
JBrowse link

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  CHEBI ontology 20056
    role 20008
      biological role 20007
        pharmacological role 19087
          antagonist 16715
            hormone antagonist 12751
              bromocriptine 41
                bromocriptine methanesulfonate 0
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    subatomic particle 20054
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                atom 20054
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19752
                        hydrogen molecular entity 19745
                          hydrides 19114
                            organic hydride 18653
                              organic fundamental parent 18653
                                natural product fundamental parent 14668
                                  alkaloid fundamental parent 2591
                                    indole alkaloid fundamental parent 1430
                                      ergotaman 43
                                        bromocriptine 41
                                          bromocriptine methanesulfonate 0
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