Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of CTRB1 mRNA | CTD | PMID:22206623 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of CTRB1 mRNA and Tetrachlorodibenzodioxin affects the expression of CTRL mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | CTRL (Homo sapiens) | 6480464 | [Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in decreased expression of CTRL mRNA | CTD | PMID:29704546 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of CTRB1 mRNA | CTD | PMID:25975270 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CTRB1 mRNA | CTD | PMID:33387578 | 2,4,6-trinitrobenzenesulfonic acid | decreases expression | EXP | | 6480464 | Trinitrobenzenesulfonic Acid results in decreased expression of CTRB1 mRNA | CTD | PMID:17982090 | acrylamide | affects expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | Acrylamide affects the expression of CTRB1 mRNA | CTD | PMID:28959563 | all-trans-retinoic acid | multiple interactions | EXP | | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of CTRB1 mRNA | CTD | PMID:36189433 | ammonium chloride | affects expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of CTRB1 mRNA and Ammonium Chloride affects the expression of CTRL mRNA | CTD | PMID:16483693 | atrazine | decreases expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | Atrazine results in decreased expression of CTRB1 mRNA | CTD | PMID:36841081 | benzo[a]pyrene | increases methylation | ISO | CTRL (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of CTRL 5' UTR | CTD | PMID:27901495 | bisphenol A | multiple interactions | ISO | Ctrl (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Genistein] results in increased methylation of CTRB1 gene | CTD | PMID:28505145 | bisphenol A | decreases methylation | ISO | CTRL (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of CTRL gene | CTD | PMID:31601247 | bisphenol A | increases expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of CTRL mRNA | CTD | PMID:34947998 | bisphenol A | decreases expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of CTRB1 mRNA and bisphenol A results in decreased expression of CTRL mRNA | CTD | PMID:25181051 more ... | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25620056 | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25620056 | carnosic acid | decreases expression | EXP | | 6480464 | salvin results in decreased expression of CTRB1 protein | CTD | PMID:35926579 | chlorohydrocarbon | multiple interactions | ISO | Ctrl (Rattus norvegicus) | 6480464 | [Hydrocarbons more ... | CTD | PMID:30744511 | chloroquine | decreases expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | Chloroquine results in decreased expression of CTRB1 mRNA | CTD | PMID:19393257 | chlorpyrifos | increases expression | EXP | | 6480464 | Chlorpyrifos results in increased expression of CTRL mRNA | CTD | PMID:37019170 | ciguatoxin CTX1B | affects expression | EXP | | 6480464 | Ciguatoxins affects the expression of CTRL mRNA | CTD | PMID:18353800 | clozapine | increases expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | Clozapine results in increased expression of CTRL mRNA | CTD | PMID:16715494 | cocaine | affects expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | Cocaine affects the expression of CTRL mRNA | CTD | PMID:20187946 | cocaine | increases expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | Cocaine results in increased expression of CTRL mRNA | CTD | PMID:27899881 | copper atom | multiple interactions | ISO | CTRL (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of CTRL mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | CTRL (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of CTRL mRNA | CTD | PMID:20971185 | Cuprizon | increases expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | Cuprizone results in increased expression of CTRB1 mRNA | CTD | PMID:27523638 | dexamethasone | increases expression | EXP | | 6480464 | Dexamethasone results in increased expression of CTRB1 mRNA | CTD | PMID:22733784 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of CTRB1 mRNA | CTD | PMID:25629700 | folic acid | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of CTRB1 mRNA | CTD | PMID:22206623 | genistein | multiple interactions | ISO | Ctrl (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Genistein] results in increased methylation of CTRB1 gene | CTD | PMID:28505145 | gentamycin | increases expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of CTRB1 mRNA | CTD | PMID:33387578 | haloperidol | increases expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | Haloperidol results in increased expression of CTRL mRNA | CTD | PMID:16715494 | lead diacetate | increases expression | EXP | | 6480464 | lead acetate results in increased expression of CTRB1 mRNA and lead acetate results in increased expression of CTRL mRNA | CTD | PMID:20542052 and PMID:22609695 | methamphetamine | increases expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | Methamphetamine results in increased expression of CTRL mRNA | CTD | PMID:19564919 | methotrexate | decreases expression | ISO | CTRL (Homo sapiens) | 6480464 | Methotrexate results in decreased expression of CTRL mRNA | CTD | PMID:24449571 | methoxychlor | affects methylation | ISO | Ctrl (Rattus norvegicus) | 6480464 | Methoxychlor affects the methylation of CTRB1 gene | CTD | PMID:35440735 | methylmercury chloride | multiple interactions | ISO | Ctrl (Rattus norvegicus) | 6480464 | [Hydrocarbons more ... | CTD | PMID:30744511 | mono(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of CTRB1 mRNA | CTD | PMID:36189433 | monosodium L-glutamate | increases expression | EXP | | 6480464 | Sodium Glutamate results in increased expression of CTRB1 mRNA | CTD | PMID:22078008 | N-acetyl-L-cysteine | multiple interactions | ISO | CTRL (Homo sapiens) | 6480464 | Acetylcysteine inhibits the reaction [plumbagin results in decreased activity of CTRL protein] | CTD | PMID:31276663 | N-ethyl-N-nitrosourea | increases mutagenesis | EXP | | 6480464 | Ethylnitrosourea results in increased mutagenesis of CTRB1 intron | CTD | PMID:27776689 | N-nitrosodiethylamine | increases expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | Diethylnitrosamine results in increased expression of CTRB1 mRNA | CTD | PMID:20360939 | nickel atom | increases expression | ISO | CTRL (Homo sapiens) | 6480464 | Nickel results in increased expression of CTRL mRNA | CTD | PMID:24768652 and PMID:25583101 | ozone | multiple interactions | ISO | CTRL (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of CTRL mRNA | CTD | PMID:35430440 | paracetamol | increases expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of CTRB1 mRNA | CTD | PMID:33387578 | phenobarbital | affects expression | EXP | | 6480464 | Phenobarbital affects the expression of CTRL mRNA | CTD | PMID:23091169 | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of CTRB1 mRNA | CTD | PMID:23091169 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of CTRB1 mRNA and pirinixic acid results in increased expression of CTRL mRNA | CTD | PMID:17426115 | plumbagin | decreases activity | ISO | CTRL (Homo sapiens) | 6480464 | plumbagin results in decreased activity of CTRL protein | CTD | PMID:31276663 | plumbagin | multiple interactions | ISO | CTRL (Homo sapiens) | 6480464 | Acetylcysteine inhibits the reaction [plumbagin results in decreased activity of CTRL protein] | CTD | PMID:31276663 | quercetin | increases expression | ISO | CTRL (Homo sapiens) | 6480464 | Quercetin results in increased expression of CTRL mRNA | CTD | PMID:21632981 | SCH-351591 | increases expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | SCH 351591 results in increased expression of CTRL mRNA | CTD | PMID:20585143 | senecionine | decreases expression | EXP | | 6480464 | senecionine results in decreased expression of CTRB1 protein | CTD | PMID:35357534 | silicon dioxide | increases expression | ISO | CTRL (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of CTRL mRNA | CTD | PMID:25895662 | sodium dichromate | decreases expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | sodium bichromate results in decreased expression of CTRB1 mRNA and sodium bichromate results in decreased expression of CTRL mRNA | CTD | PMID:22561333 | Soman | increases expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | Soman results in increased expression of CTRB1 mRNA | CTD | PMID:19281266 | sunitinib | increases expression | ISO | CTRL (Homo sapiens) | 6480464 | Sunitinib results in increased expression of CTRL mRNA | CTD | PMID:31533062 | T-2 toxin | affects expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | T-2 Toxin affects the expression of CTRB1 protein | CTD | PMID:26141394 | tamoxifen | decreases expression | ISO | CTRL (Homo sapiens) | 6480464 | Tamoxifen results in decreased expression of CTRL mRNA | CTD | PMID:15590111 | Tesaglitazar | increases expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | tesaglitazar results in increased expression of CTRL mRNA | CTD | PMID:21515302 | theophylline | increases expression | ISO | CTRL (Homo sapiens) | 6480464 | Theophylline results in increased expression of CTRL mRNA | CTD | PMID:18951874 | thioacetamide | increases expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of CTRB1 mRNA | CTD | PMID:34492290 | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of CTRB1 mRNA and titanium dioxide results in increased expression of CTRL mRNA | CTD | PMID:23409001 | trichloroethene | increases expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased expression of CTRB1 mRNA | CTD | PMID:33387578 | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of CTRL mRNA | CTD | PMID:33045310 | troglitazone | increases expression | ISO | Ctrl (Rattus norvegicus) | 6480464 | troglitazone results in increased expression of CTRL mRNA | CTD | PMID:21515302 | uranium atom | affects expression | ISO | CTRL (Homo sapiens) | 6480464 | Uranium affects the expression of CTRL mRNA | CTD | PMID:15672453 | urethane | decreases expression | ISO | CTRL (Homo sapiens) | 6480464 | Urethane results in decreased expression of CTRL mRNA | CTD | PMID:28818685 | valproic acid | increases methylation | ISO | CTRL (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of CTRL gene | CTD | PMID:29154799 | |