Ctrl (chymotrypsin-like) - Rat Genome Database

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Gene: Ctrl (chymotrypsin-like) Mus musculus
Analyze
Symbol: Ctrl
Name: chymotrypsin-like
RGD ID: 733172
MGI Page MGI
Description: Enables peptidase activity. Acts upstream of or within proteolysis. Predicted to be located in extracellular space. Is expressed in brain; embryo; pancreas; and pancreas tip epithelium. Orthologous to human CTRL (chymotrypsin like).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 0910001G08Rik; 1810004D15Rik; AV005227; chym; chymopasin; chymotrypsin A CTRA-1; chymotrypsin-like protease CTRL-1; Ctr; Ctra; Ctra-1; Ctra1; FLJ00366; mFLJ00366
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,658,626 - 106,660,494 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,658,635 - 106,660,494 (-)EnsemblGRCm39 Ensembl
GRCm388105,931,994 - 105,933,862 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,932,003 - 105,933,862 (-)EnsemblGRCm38mm10GRCm38
MGSCv378108,455,894 - 108,457,762 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368108,820,789 - 108,822,991 (-)NCBIMGSCv36mm8
Celera8110,160,042 - 110,161,910 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.06NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IBA,IDA)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1820020   PMID:8889548   PMID:9069116   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11961105   PMID:12477932   PMID:12732630   PMID:15537664   PMID:16141072   PMID:16141073  
PMID:18554416   PMID:19592578   PMID:20152175   PMID:21267068   PMID:21780244   PMID:21873635   PMID:25063451   PMID:32678161  


Genomics

Comparative Map Data
Ctrl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,658,626 - 106,660,494 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,658,635 - 106,660,494 (-)EnsemblGRCm39 Ensembl
GRCm388105,931,994 - 105,933,862 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,932,003 - 105,933,862 (-)EnsemblGRCm38mm10GRCm38
MGSCv378108,455,894 - 108,457,762 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368108,820,789 - 108,822,991 (-)NCBIMGSCv36mm8
Celera8110,160,042 - 110,161,910 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.06NCBI
CTRL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381667,929,574 - 67,931,862 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1667,927,640 - 67,932,365 (-)EnsemblGRCh38hg38GRCh38
GRCh371667,963,477 - 67,965,765 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,520,974 - 66,523,266 (-)NCBINCBI36Build 36hg18NCBI36
Build 341666,520,974 - 66,523,266NCBI
Celera1652,471,930 - 52,474,222 (-)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1653,837,043 - 53,839,348 (-)NCBIHuRef
CHM1_11669,371,652 - 69,373,957 (-)NCBICHM1_1
T2T-CHM13v2.01673,725,348 - 73,727,636 (-)NCBIT2T-CHM13v2.0
Ctrl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,737,078 - 50,740,659 (-)NCBIGRCr8
mRatBN7.21933,827,279 - 33,829,129 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,827,229 - 33,833,626 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1940,642,815 - 40,644,665 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,296,130 - 41,297,980 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,594,680 - 43,596,530 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01937,905,864 - 37,907,714 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,905,864 - 37,907,714 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,772,599 - 48,775,409 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,774,031 - 35,775,881 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11935,778,911 - 35,780,759 (-)NCBI
Celera1933,254,828 - 33,256,678 (-)NCBICelera
Cytogenetic Map19q12NCBI
Ctrl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554848,781,928 - 8,783,929 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554848,781,928 - 8,783,929 (+)NCBIChiLan1.0ChiLan1.0
CTRL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21877,456,564 - 77,460,908 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11683,367,990 - 83,370,113 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01648,270,961 - 48,274,248 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11667,658,148 - 67,661,410 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1667,658,451 - 67,660,582 (-)Ensemblpanpan1.1panPan2
CTRL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1581,565,155 - 81,567,472 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl581,565,418 - 81,567,472 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha581,554,912 - 81,557,457 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0582,000,253 - 82,002,798 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl582,000,740 - 82,003,005 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1581,826,462 - 81,829,007 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0581,508,592 - 81,511,137 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0582,150,811 - 82,153,356 (+)NCBIUU_Cfam_GSD_1.0
Ctrl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934941,299,179 - 41,302,980 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647518,286,133 - 18,288,091 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647518,284,495 - 18,288,938 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTRL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl628,540,808 - 28,542,773 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1628,540,187 - 28,542,820 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CTRL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1559,508,058 - 59,510,392 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl559,508,380 - 59,510,330 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604722,234,344 - 22,235,738 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctrl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474618,447,574 - 18,449,964 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474618,447,042 - 18,449,888 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ctrl
55 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:121
Interacting mature miRNAs:129
Transcripts:ENSMUST00000034368
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873929123107929226Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined876402145110402251Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined876411976110412125Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined876411976110412125Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined879245241113245331Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879808806113809031Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881819296115819296Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)882345783116345783Mouse
1301766Desp1_mdespair 1 (mouse)Not determined885486208119486373Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined886443553120443701Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined886443553120443701Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined886443553120443701Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889726628130027694Mouse
1357494Obsty2_mobesity 2 (mouse)Not determined896245241129745061Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)897626632130127694Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)898390634130127694Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined898563635130127694Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899828531130127694Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899828531130127694Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100965309130127694Mouse
1300560Tgl1_mtriglyceride level 1 (mouse)Not determined8102486208111650036Mouse
1300681Pgia22_mproteoglycan induced arthritis 22 (mouse)Not determined8102486208116025457Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8103443553127781786Mouse
11532691Sluc38_msusceptibility to lung cancer 38 (mouse)8105033977130127694Mouse
11532692Sluc38a_msusceptibility to lung cancer 38a (mouse)8105033977130127694Mouse
14746994Manh65_mmandible shape 65 (mouse)8106489629130127694Mouse

Markers in Region
AV005227  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388105,932,129 - 105,932,343UniSTSGRCm38
MGSCv378108,456,029 - 108,456,243UniSTSGRCm37
Celera8110,160,177 - 110,160,391UniSTS
Cytogenetic Map8D3UniSTS
cM Map853.0UniSTS
Whitehead/MRC_RH81234.06UniSTS
Ctrl  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388105,932,585 - 105,932,658UniSTSGRCm38
MGSCv378108,456,485 - 108,456,558UniSTSGRCm37
Celera8110,160,633 - 110,160,706UniSTS
Cytogenetic Map8D3UniSTS
cM Map853.06UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000034368   ⟹   ENSMUSP00000034368
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8106,658,635 - 106,660,494 (-)Ensembl
GRCm38.p6 Ensembl8105,932,003 - 105,933,862 (-)Ensembl
RefSeq Acc Id: ENSMUST00000212561
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8106,659,206 - 106,660,087 (-)Ensembl
GRCm38.p6 Ensembl8105,932,574 - 105,933,455 (-)Ensembl
RefSeq Acc Id: NM_023182   ⟹   NP_075671
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398106,658,626 - 106,660,494 (-)NCBI
GRCm388105,931,994 - 105,933,862 (-)ENTREZGENE
MGSCv378108,455,894 - 108,457,762 (-)RGD
Celera8110,160,042 - 110,161,910 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_075671   ⟸   NM_023182
- Peptide Label: precursor
- UniProtKB: Q9ER05 (UniProtKB/TrEMBL),   Q9D7P8 (UniProtKB/TrEMBL),   Q9D960 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034368   ⟸   ENSMUST00000034368
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ER05-F1-model_v2 AlphaFold Q9ER05 1-264 view protein structure

Promoters
RGD ID:8668139
Promoter ID:EPDNEW_M12101
Type:multiple initiation site
Name:Ctrl_1
Description:Mus musculus chymotrypsin-like , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm388105,933,847 - 105,933,907EPDNEW
RGD ID:6842991
Promoter ID:MM_KWN:55582
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver
Transcripts:NM_023182,   OTTMUST00000076849
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368108,456,856 - 108,458,142 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88558 AgrOrtholog
Ensembl Genes ENSMUSG00000031896 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034368 ENTREZGENE
  ENSMUST00000034368.8 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Pept_cys/ser_Trypsin-like UniProtKB/TrEMBL
  Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report mmu:109660 UniProtKB/TrEMBL
MGD MGI:88558 ENTREZGENE
NCBI Gene 109660 ENTREZGENE
PANTHER CHYMOTRYPSIN-LIKE PROTEASE CTRL-1 UniProtKB/TrEMBL
  CHYMOTRYPSIN-RELATED UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Ctrl PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
UniProt Q9D7P8 ENTREZGENE, UniProtKB/TrEMBL
  Q9D960 ENTREZGENE, UniProtKB/TrEMBL
  Q9DC82_MOUSE UniProtKB/TrEMBL
  Q9ER05 ENTREZGENE, UniProtKB/TrEMBL