Ttc21a (tetratricopeptide repeat domain 21A) - Rat Genome Database
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Gene: Ttc21a (tetratricopeptide repeat domain 21A) Mus musculus
Analyze
Symbol: Ttc21a
Name: tetratricopeptide repeat domain 21A
RGD ID: 1551133
MGI Page MGI
Description: Involved in flagellated sperm motility and spermatid development. Predicted to localize to intraciliary transport particle A. Is expressed in 4th ventricle; choroid plexus; lateral ventricle choroid plexus; and olfactory epithelium. Human ortholog(s) of this gene implicated in spermatogenic failure 37. Orthologous to human TTC21A (tetratricopeptide repeat domain 21A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4921538N17Rik; AA387572; tetratricopeptide repeat protein 21A; tetratricopeptide repeat-containing hedgehog modulator 2; Thm2; TPR repeat protein 21A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,766,656 - 119,798,496 (+)NCBIGRCm39mm39
GRCm389119,937,589 - 119,969,430 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,937,606 - 119,967,793 (+)EnsemblGRCm38mm10GRCm38
MGSCv379119,846,724 - 119,876,911 (+)NCBIGRCm37mm9NCBIm37
MGSCv369119,786,304 - 119,816,491 (+)NCBImm8
Celera9120,404,834 - 120,435,102 (+)NCBICelera
Cytogenetic Map9F4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:16141072   PMID:16141073   PMID:17971504   PMID:18327258   PMID:18799693   PMID:21267068   PMID:21677750  
PMID:21873635   PMID:30929735  


Genomics

Comparative Map Data
Ttc21a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,766,656 - 119,798,496 (+)NCBIGRCm39mm39
GRCm389119,937,589 - 119,969,430 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,937,606 - 119,967,793 (+)EnsemblGRCm38mm10GRCm38
MGSCv379119,846,724 - 119,876,911 (+)NCBIGRCm37mm9NCBIm37
MGSCv369119,786,304 - 119,816,491 (+)NCBImm8
Celera9120,404,834 - 120,435,102 (+)NCBICelera
Cytogenetic Map9F4NCBI
TTC21A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl339,107,704 - 39,138,903 (+)EnsemblGRCh38hg38GRCh38
GRCh38339,107,680 - 39,139,009 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37339,149,152 - 39,180,394 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36339,124,156 - 39,155,398 (+)NCBINCBI36hg18NCBI36
Build 34339,124,198 - 39,155,394NCBI
Celera339,089,656 - 39,120,906 (+)NCBI
Cytogenetic Map3p22.2NCBI
HuRef339,191,073 - 39,222,318 (+)NCBIHuRef
CHM1_1339,100,229 - 39,131,478 (+)NCBICHM1_1
Ttc21a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08128,622,414 - 128,657,199 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,622,428 - 128,657,955 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,824,105 - 127,858,427 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,895,329 - 124,929,673 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18124,916,314 - 124,949,410 (+)NCBI
Celera8118,813,990 - 118,848,613 (+)NCBICelera
Cytogenetic Map8q32NCBI
Ttc21a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542724,833,071 - 24,862,473 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542724,833,021 - 24,862,199 (-)NCBIChiLan1.0ChiLan1.0
TTC21A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1339,284,159 - 39,315,583 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl339,284,480 - 39,315,375 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0339,003,730 - 39,035,183 (+)NCBIMhudiblu_PPA_v0panPan3
TTC21A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl238,781,582 - 8,811,031 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1238,776,252 - 8,812,480 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ttc21a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647328,362,238 - 28,395,134 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTC21A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1323,797,100 - 23,830,332 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,797,518 - 23,830,334 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21326,057,100 - 26,090,203 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TTC21A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl15277,078 - 308,194 (-)Ensembl
ChlSab1.115276,965 - 308,194 (-)NCBI
Ttc21a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247311,844,044 - 1,873,398 (-)NCBI

Position Markers
UniSTS:236282  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389119,961,921 - 119,962,264UniSTSGRCm38
MGSCv379119,871,039 - 119,871,382UniSTSGRCm37
Celera9120,429,228 - 120,429,571UniSTS
Cytogenetic Map9F4UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:729
Count of miRNA genes:438
Interacting mature miRNAs:518
Transcripts:ENSMUST00000035100, ENSMUST00000159128, ENSMUST00000160790, ENSMUST00000161967
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000035100   ⟹   ENSMUSP00000035100
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,937,606 - 119,967,793 (+)Ensembl
RefSeq Acc Id: ENSMUST00000159128
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,937,635 - 119,967,053 (+)Ensembl
RefSeq Acc Id: ENSMUST00000160790
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,937,636 - 119,962,676 (+)Ensembl
RefSeq Acc Id: ENSMUST00000161967
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,961,618 - 119,966,169 (+)Ensembl
RefSeq Acc Id: NM_028735   ⟹   NP_083011
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,766,672 - 119,796,859 (+)NCBI
GRCm389119,937,606 - 119,967,793 (+)NCBI
MGSCv379119,846,724 - 119,876,911 (+)RGD
Celera9120,404,834 - 120,435,102 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006512321   ⟹   XP_006512384
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,766,656 - 119,798,496 (+)NCBI
GRCm389119,937,589 - 119,969,430 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036155346   ⟹   XP_036011239
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,766,656 - 119,795,433 (+)NCBI
RefSeq Acc Id: XM_036155347   ⟹   XP_036011240
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,771,638 - 119,798,496 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_083011   ⟸   NM_028735
- UniProtKB: Q8C0S4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006512384   ⟸   XM_006512321
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000035100   ⟸   ENSMUST00000035100
RefSeq Acc Id: XP_036011239   ⟸   XM_036155346
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036011240   ⟸   XM_036155347
- Peptide Label: isoform X3

Promoters
RGD ID:6845288
Promoter ID:MM_KWN:59151
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_028735,   NM_028976,   UC009SBR.1,   UC009SBS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369119,846,374 - 119,846,874 (+)MPROMDB
RGD ID:6849276
Promoter ID:MM_XEF:7707
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:NM_001091636
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369119,859,701 - 119,860,201 (+)MPROMDB
RGD ID:8671208
Promoter ID:EPDNEW_M13635
Type:initiation region
Name:Ttc21a_1
Description:Mus musculus tetratricopeptide repeat domain 21A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389119,937,643 - 119,937,703EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921302 AgrOrtholog
Ensembl Genes ENSMUSG00000032514 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000035100 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000035100 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot
InterPro TPR-contain_dom UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
  TPR_repeat UniProtKB/Swiss-Prot
  TTC21A/TTC21B UniProtKB/Swiss-Prot
KEGG Report mmu:74052 UniProtKB/Swiss-Prot
MGD MGI:1921302 ENTREZGENE
NCBI Gene 74052 ENTREZGENE
PANTHER PTHR14699 UniProtKB/Swiss-Prot
Pfam TPR_7 UniProtKB/Swiss-Prot
  TPR_8 UniProtKB/Swiss-Prot
PhenoGen Ttc21a PhenoGen
PROSITE TPR UniProtKB/Swiss-Prot
  TPR_REGION UniProtKB/Swiss-Prot
SMART TPR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot
UniGene Mm.189573 ENTREZGENE
UniProt Q8C0S4 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q0HA37 UniProtKB/Swiss-Prot
  Q3V0A2 UniProtKB/Swiss-Prot
  Q9D5Q9 UniProtKB/Swiss-Prot