Ttc21a (tetratricopeptide repeat domain 21A) - Rat Genome Database
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Gene: Ttc21a (tetratricopeptide repeat domain 21A) Mus musculus
Analyze
Symbol: Ttc21a
Name: tetratricopeptide repeat domain 21A
RGD ID: 1551133
MGI Page MGI
Description: Involved in flagellated sperm motility and spermatid development. Predicted to localize to intraciliary transport particle A. Is expressed in 4th ventricle; choroid plexus; lateral ventricle choroid plexus; and olfactory epithelium. Human ortholog(s) of this gene implicated in spermatogenic failure 37. Orthologous to human TTC21A (tetratricopeptide repeat domain 21A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4921538N17Rik; AA387572; tetratricopeptide repeat protein 21A; tetratricopeptide repeat-containing hedgehog modulator 2; Thm2; TPR repeat protein 21A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,766,656 - 119,798,496 (+)NCBIGRCm39mm39
GRCm389119,937,589 - 119,969,430 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,937,606 - 119,967,793 (+)EnsemblGRCm38mm10GRCm38
MGSCv379119,846,724 - 119,876,911 (+)NCBIGRCm37mm9NCBIm37
MGSCv369119,786,304 - 119,816,491 (+)NCBImm8
Celera9120,404,834 - 120,435,102 (+)NCBICelera
Cytogenetic Map9F4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:16141072   PMID:16141073   PMID:17971504   PMID:18327258   PMID:18799693   PMID:21267068   PMID:21677750  
PMID:21873635   PMID:30929735  


Genomics

Comparative Map Data
Ttc21a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,766,656 - 119,798,496 (+)NCBIGRCm39mm39
GRCm389119,937,589 - 119,969,430 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,937,606 - 119,967,793 (+)EnsemblGRCm38mm10GRCm38
MGSCv379119,846,724 - 119,876,911 (+)NCBIGRCm37mm9NCBIm37
MGSCv369119,786,304 - 119,816,491 (+)NCBImm8
Celera9120,404,834 - 120,435,102 (+)NCBICelera
Cytogenetic Map9F4NCBI
TTC21A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl339,107,704 - 39,138,903 (+)EnsemblGRCh38hg38GRCh38
GRCh38339,107,680 - 39,139,009 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37339,149,152 - 39,180,394 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36339,124,156 - 39,155,398 (+)NCBINCBI36hg18NCBI36
Build 34339,124,198 - 39,155,394NCBI
Celera339,089,656 - 39,120,906 (+)NCBI
Cytogenetic Map3p22.2NCBI
HuRef339,191,073 - 39,222,318 (+)NCBIHuRef
CHM1_1339,100,229 - 39,131,478 (+)NCBICHM1_1
Ttc21a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08128,622,414 - 128,657,199 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,622,428 - 128,657,955 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,824,105 - 127,858,427 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,895,329 - 124,929,673 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18124,916,314 - 124,949,410 (+)NCBI
Celera8118,813,990 - 118,848,613 (+)NCBICelera
Cytogenetic Map8q32NCBI
Ttc21a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542724,833,071 - 24,862,473 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542724,833,021 - 24,862,199 (-)NCBIChiLan1.0ChiLan1.0
TTC21A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1339,284,159 - 39,315,583 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl339,284,480 - 39,315,375 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0339,003,730 - 39,035,183 (+)NCBIMhudiblu_PPA_v0panPan3
TTC21A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl238,781,582 - 8,811,031 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1238,776,252 - 8,812,480 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ttc21a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647328,362,238 - 28,395,134 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTC21A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1323,797,100 - 23,830,332 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,797,518 - 23,830,334 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21326,057,100 - 26,090,203 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TTC21A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl15277,078 - 308,194 (-)Ensembl
ChlSab1.115276,965 - 308,194 (-)NCBI
Ttc21a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247311,844,044 - 1,873,398 (-)NCBI

Position Markers
UniSTS:236282  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389119,961,921 - 119,962,264UniSTSGRCm38
MGSCv379119,871,039 - 119,871,382UniSTSGRCm37
Celera9120,429,228 - 120,429,571UniSTS
Cytogenetic Map9F4UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:729
Count of miRNA genes:438
Interacting mature miRNAs:518
Transcripts:ENSMUST00000035100, ENSMUST00000159128, ENSMUST00000160790, ENSMUST00000161967
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000035100   ⟹   ENSMUSP00000035100
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,937,606 - 119,967,793 (+)Ensembl
RefSeq Acc Id: ENSMUST00000159128
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,937,635 - 119,967,053 (+)Ensembl
RefSeq Acc Id: ENSMUST00000160790
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,937,636 - 119,962,676 (+)Ensembl
RefSeq Acc Id: ENSMUST00000161967
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,961,618 - 119,966,169 (+)Ensembl
RefSeq Acc Id: NM_028735   ⟹   NP_083011
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,766,672 - 119,796,859 (+)NCBI
GRCm389119,937,606 - 119,967,793 (+)NCBI
MGSCv379119,846,724 - 119,876,911 (+)RGD
Celera9120,404,834 - 120,435,102 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006512321   ⟹   XP_006512384
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,766,656 - 119,798,496 (+)NCBI
GRCm389119,937,589 - 119,969,430 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036155346   ⟹   XP_036011239
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,766,656 - 119,795,433 (+)NCBI
RefSeq Acc Id: XM_036155347   ⟹   XP_036011240
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,771,638 - 119,798,496 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_083011   ⟸   NM_028735
- UniProtKB: Q8C0S4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006512384   ⟸   XM_006512321
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000035100   ⟸   ENSMUST00000035100
RefSeq Acc Id: XP_036011239   ⟸   XM_036155346
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036011240   ⟸   XM_036155347
- Peptide Label: isoform X3

Promoters
RGD ID:6845288
Promoter ID:MM_KWN:59151
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_028735,   NM_028976,   UC009SBR.1,   UC009SBS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369119,846,374 - 119,846,874 (+)MPROMDB
RGD ID:6849276
Promoter ID:MM_XEF:7707
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:NM_001091636
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369119,859,701 - 119,860,201 (+)MPROMDB
RGD ID:8671208
Promoter ID:EPDNEW_M13635
Type:initiation region
Name:Ttc21a_1
Description:Mus musculus tetratricopeptide repeat domain 21A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389119,937,643 - 119,937,703EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921302 AgrOrtholog
Ensembl Genes ENSMUSG00000032514 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000035100 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000035100 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot
InterPro TPR-contain_dom UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
  TPR_repeat UniProtKB/Swiss-Prot
  TTC21A/TTC21B UniProtKB/Swiss-Prot
KEGG Report mmu:74052 UniProtKB/Swiss-Prot
MGD MGI:1921302 ENTREZGENE
NCBI Gene 74052 ENTREZGENE
PANTHER PTHR14699 UniProtKB/Swiss-Prot
Pfam TPR_7 UniProtKB/Swiss-Prot
  TPR_8 UniProtKB/Swiss-Prot
PhenoGen Ttc21a PhenoGen
PROSITE TPR UniProtKB/Swiss-Prot
  TPR_REGION UniProtKB/Swiss-Prot
SMART TPR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot
UniGene Mm.189573 ENTREZGENE
UniProt Q8C0S4 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q0HA37 UniProtKB/Swiss-Prot
  Q3V0A2 UniProtKB/Swiss-Prot
  Q9D5Q9 UniProtKB/Swiss-Prot