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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11152
Species: Mus musculus
RGD Object: Gene
Symbol: Prl
Name: prolactin
Acc ID: CHEBI:3286
Term: cabergoline
Definition: An N-acylurea that is (8R)-ergoline-8-carboxamide in which the hydrogen attached to the piperidine nitrogen (position 6) is substituted by an allyl group and the hydrogens attached to the carboxamide nitrogen are substituted by a 3-(dimethylamino)propyl group and an N-ethylcarbamoyl group. A dopamine D2 receptor agonist, cabergoline is used in the management of Parkinson's disease and of disorders associated with hyperprolactinaemia.
Chemical ID: MESH:C047047
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prldecreases expressionISOPRL (Homo sapiens)6480464CTDcabergoline results in decreased expression of PRL proteinPMID:15377706 PMID:3745407
Prldecreases secretionISOPrl (Rattus norvegicus)6480464CTDcabergoline results in decreased secretion of PRL proteinPMID:7670571
Prldecreases secretionISOPRL (Homo sapiens)6480464CTDcabergoline results in decreased secretion of PRL proteinPMID:2570719
Prlmultiple interactionsISOPrl (Rattus norvegicus)6480464CTDHaloperidol inhibits the reaction [cabergoline results in decreased secretion of PRL protein]; Sulpiride inhibits the reaction [cabergoline results in decreased secretion of PRL protein]PMID:7670571
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