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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cabergoline
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Accession:CHEBI:3286 term browser browse the term
Definition:An N-acylurea that is (8R)-ergoline-8-carboxamide in which the hydrogen attached to the piperidine nitrogen (position 6) is substituted by an allyl group and the hydrogens attached to the carboxamide nitrogen are substituted by a 3-(dimethylamino)propyl group and an N-ethylcarbamoyl group. A dopamine D2 receptor agonist, cabergoline is used in the management of Parkinson's disease and of disorders associated with hyperprolactinaemia.
Synonyms:exact_synonym: (8beta)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-6-(prop-2-en-1-yl)ergoline-8-carboxamide
 related_synonym: (8R)-6-allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide;   (8beta)-N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide;   1-((6-allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea;   1-[(6-allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea;   1-ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea;   Formula=C26H37N5O2;   InChI=1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1;   InChIKey=KORNTPPJEAJQIU-KJXAQDMKSA-N;   SMILES=[H][C@@]12Cc3c[nH]c4cccc(c34)[C@@]1([H])C[C@H](CN2CC=C)C(=O)N(CCCN(C)C)C(=O)NCC;   cabergolina;   cabergolinum
 xref: Beilstein:6020775;   CAS:81409-90-7;   DrugBank:DB00248;   Drug_Central:460;   HMDB:HMDB0014393;   KEGG:C08187;   KEGG:D00987;   LINCS:LSM-3939
 xref_mesh: MESH:C047047
 xref: PMID:22075008;   PMID:22336848;   PMID:22740242;   PMID:23110560;   PMID:23743769;   Patent:BE888243;   Patent:US4526892;   VSDB:1830;   Wikipedia:Cabergoline


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cabergoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain derived neurotrophic factor increases expression ISO Cabergoline results in increased expression of BDNF protein CTD PMID:35104500 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression ISO Cabergoline results in increased expression of CREB1 protein modified form CTD PMID:35104500 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO Cabergoline binds to and results in increased activity of DRD2 protein CTD PMID:35104500 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Gdnf glial cell line derived neurotrophic factor increases expression
increases secretion		 EXP cabergoline results in increased expression of GDNF mRNA
cabergoline results in increased secretion of GDNF protein		 CTD PMID:12770616 NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056 		JBrowse link
G Ngf nerve growth factor increases expression
increases secretion		 EXP cabergoline results in increased expression of NGF mRNA
cabergoline results in increased secretion of NGF protein		 CTD PMID:12770616 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Prl prolactin decreases expression
decreases secretion
multiple interactions		 ISO cabergoline results in decreased expression of PRL protein
cabergoline results in decreased secretion of PRL protein
Haloperidol inhibits the reaction [cabergoline results in decreased secretion of PRL protein]; Sulpiride inhibits the reaction [cabergoline results in decreased secretion of PRL protein]		 CTD PMID:2570719 PMID:3745407 PMID:7670571 PMID:15377706 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 22192
    role 22177
      application 21760
        pharmaceutical 21174
          drug 21174
            antineoplastic agent 18894
              cabergoline 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 22192
    subatomic particle 22184
      composite particle 22184
        hadron 22184
          baryon 22184
            nucleon 22184
              atomic nucleus 22184
                atom 22184
                  main group element atom 22118
                    p-block element atom 22118
                      carbon group element atom 21918
                        carbon atom 21844
                          organic molecular entity 21844
                            heteroorganic entity 21497
                              organochalcogen compound 20983
                                organooxygen compound 20824
                                  carbon oxoacid 19607
                                    carboxylic acid 19603
                                      carboacyl group 18296
                                        univalent carboacyl group 18296
                                          carbamoyl group 18109
                                            carboxamide 18109
                                              monocarboxylic acid amide 15836
                                                urea 5745
                                                  ureas 5743
                                                    N-acylurea 72
                                                      cabergoline 6
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