Slc6a3 (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3) - Rat Genome Database

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Gene: Slc6a3 (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3) Mus musculus
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Symbol: Slc6a3
Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
RGD ID: 11315
MGI Page MGI
Description: Exhibits several functions, including dopamine binding activity; dopamine:sodium symporter activity; and protein N-terminus binding activity. Involved in several processes, including dopamine metabolic process; gland development; and hyaloid vascular plexus regression. Localizes to axon and cell surface. Is expressed in genitourinary system; nervous system; spleen; and submandibular gland. Used to study Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and schizophrenia. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH (20S)-ginsenoside Rg3; (S)-amphetamine; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DA; DA transporter; DAT; Dat1; dopamine transporter 1; sodium-dependent dopamine transporter; solute carrier family 6 member 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391373,684,270 - 73,726,791 (+)NCBIGRCm39mm39
GRCm39 Ensembl1373,684,866 - 73,726,791 (+)Ensembl
GRCm381373,536,128 - 73,578,672 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1373,536,747 - 73,578,672 (+)EnsemblGRCm38mm10GRCm38
MGSCv371373,674,195 - 73,716,120 (+)NCBIGRCm37mm9NCBIm37
MGSCv361374,002,749 - 74,044,674 (+)NCBImm8
Celera1375,865,546 - 75,907,463 (+)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(20S)-ginsenoside Rg3  (EXP)
(R)-noradrenaline  (ISO)
(R)-octopamine  (ISO)
(S)-amphetamine  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine  (EXP,ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,5-dimethoxy-4-bromophenethylamine  (ISO)
2-aminopropiophenone  (EXP)
2-phenylethylamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-nitrotoluene  (ISO)
7-NITROINDAZOLE  (EXP)
acrylamide  (ISO)
albiflorin  (ISO)
alcohol  (EXP)
all-trans-retinoic acid  (ISO)
alpha,alpha-trehalose  (EXP)
AM-251  (ISO)
aminorex  (ISO)
ammonium chloride  (ISO)
amphetamine  (EXP,ISO)
Aroclor 1254  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
atrazine  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bupropion  (ISO)
butyric acid  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
chlorpyrifos  (EXP,ISO)
citalopram  (EXP,ISO)
clozapine  (ISO)
cocaine  (EXP,ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyhalothrin  (ISO)
DDD  (EXP)
DDE  (EXP,ISO)
DDT  (EXP)
dextran sulfate  (EXP)
diazinon  (ISO)
dieldrin  (EXP,ISO)
diethyldithiocarbamic acid  (ISO)
diethylstilbestrol  (ISO)
dihydro-beta-erythroidine  (ISO)
dopamine  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
estrone  (EXP)
ethanol  (EXP)
fluoxetine  (EXP,ISO)
ganglioside GM1  (ISO)
geraniol  (EXP)
glyburide  (EXP)
haloperidol  (EXP,ISO)
heptachlor  (EXP,ISO)
herbicide  (ISO)
ibogaine  (ISO)
ibuprofen  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
isoliquiritigenin  (EXP)
ketamine  (ISO)
linalool  (ISO)
lipopolysaccharide  (EXP)
maneb  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
Mazindol  (EXP,ISO)
Mecamylamine  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
mephedrone  (EXP,ISO)
mepyramine  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methcathinone  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (EXP)
methylphenidate  (EXP,ISO)
minocycline  (EXP)
modafinil  (EXP,ISO)
monensin A  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
naltrexone  (EXP,ISO)
nicotine  (EXP,ISO)
nomifensine  (ISO)
Nonylphenol  (ISO)
octopamine  (ISO)
oleic acid  (EXP)
oxidopamine  (ISO)
paraquat  (EXP,ISO)
permethrin  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperazines  (ISO)
piperidines  (ISO)
pirinixic acid  (EXP,ISO)
probenecid  (EXP)
propofol  (EXP)
quinolinic acid  (ISO)
quinpirole  (ISO)
raloxifene  (ISO)
reboxetine  (EXP)
reserpine  (EXP)
rotenone  (ISO)
rottlerin  (EXP)
SCH 23390  (EXP)
selenium atom  (ISO)
serotonin  (ISO)
simazine  (EXP,ISO)
staurosporine  (ISO)
sulpiride  (EXP,ISO)
tamoxifen  (ISO)
telmisartan  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tryptamine  (ISO)
tyramine  (ISO)
valproic acid  (ISO)
vanoxerine dihydrochloride  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
WIN 55212-2  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
Parkinson's disease pathway  (IEA)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal action potential  (IAGP)
abnormal adenohypophysis morphology  (IAGP)
abnormal associative learning  (IAGP)
abnormal autophagy  (IAGP)
abnormal axon morphology  (IAGP)
abnormal axonal transport  (IAGP)
abnormal behavior  (IAGP)
abnormal behavioral response to addictive substance  (IAGP)
abnormal behavioral response to xenobiotic  (IAGP)
abnormal chemokine secretion  (IAGP)
abnormal CNS synaptic transmission  (IAGP)
abnormal dendrite morphology  (IAGP)
abnormal dopaminergic neuron morphology  (IAGP)
abnormal dorsal striatum morphology  (IAGP)
abnormal excitatory postsynaptic currents  (IAGP)
abnormal gait  (IAGP)
abnormal grooming behavior  (IAGP)
abnormal inhibitory postsynaptic currents  (IAGP)
abnormal innervation  (IAGP)
abnormal limb posture  (IAGP)
abnormal locomotor activation  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal lysosome morphology  (IAGP)
abnormal lysosome physiology  (IAGP)
abnormal maternal nurturing  (IAGP)
abnormal midbrain morphology  (IAGP)
abnormal miniature excitatory postsynaptic currents  (IAGP)
abnormal miniature inhibitory postsynaptic currents  (IAGP)
abnormal mitochondrial morphology  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal mitochondrial shape  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal neurotransmitter uptake  (IAGP)
abnormal noradrenaline level  (IAGP)
abnormal operant conditioning behavior  (IAGP)
abnormal physiological response to xenobiotic  (IAGP)
abnormal pituitary gland physiology  (IAGP)
abnormal pituitary secretion  (IAGP)
abnormal respiratory electron transport chain  (IAGP)
abnormal response to novel object  (IAGP)
abnormal response to novel odor  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal short term object recognition memory  (IAGP)
abnormal single cell response  (IAGP)
abnormal sleep behavior  (IEA)
abnormal spatial learning  (IAGP)
abnormal striatum morphology  (IAGP)
abnormal substantia nigra morphology  (IAGP)
abnormal substantia nigra pars compacta morphology  (IAGP)
abnormal substantia nigra pars reticulata morphology  (IAGP)
abnormal synapse morphology  (IAGP)
abnormal synaptic bouton morphology  (IAGP)
abnormal synaptic dopamine release  (IAGP)
abnormal synaptic vesicle number  (IAGP)
abnormal tooth morphology  (IEA)
absent teeth  (IEA)
adenohypophysis hypoplasia  (IAGP)
behavioral despair  (IAGP)
bradykinesia  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased dopamine level  (IAGP)
decreased dopaminergic neuron number  (IAGP)
decreased exploration in new environment  (IAGP)
decreased fasting circulating glucose level  (IEA)
decreased lactotroph cell number  (IAGP)
decreased length of long bones  (IAGP)
decreased mitochondrial number  (IAGP)
decreased mitochondrial size  (IAGP)
decreased neuron number  (IAGP)
decreased neurotransmitter release  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased somatotroph cell number  (IAGP)
decreased susceptibility to dopaminergic neuron neurotoxicity  (IAGP)
decreased vertical activity  (IAGP)
disproportionate dwarf  (IAGP)
enhanced behavioral response to cocaine  (IAGP)
enhanced behavioral response to nicotine  (IAGP)
enhanced long term potentiation  (IAGP)
hindlimb paralysis  (IAGP)
hunched posture  (IAGP)
hyperactivity  (IAGP)
hypoactivity  (IAGP)
hypopituitarism  (IAGP)
impaired behavioral response to cocaine  (IAGP)
impaired behavioral response to nicotine  (IAGP)
impaired conditioned place preference behavior  (IAGP)
impaired coordination  (IAGP)
impaired olfaction  (IAGP)
increased circulating chloride level  (IEA)
increased circulating phosphate level  (IEA)
increased circulating sodium level  (IEA)
increased dopamine level  (IAGP)
increased exploration in new environment  (IAGP)
increased interleukin-1 beta secretion  (IAGP)
increased microglial cell activation  (IAGP)
increased mitochondrial size  (IAGP)
increased neuron number  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased serotonin level  (IAGP)
increased stereotypic behavior  (IAGP)
increased susceptibility to dopaminergic neuron neurotoxicity  (IAGP)
increased thigmotaxis  (IAGP)
increased vertical activity  (IAGP)
induced hyperactivity  (IAGP)
kyphosis  (IAGP)
lactation failure  (IAGP)
lethality at weaning, complete penetrance  (IAGP)
lethality, incomplete penetrance  (IAGP)
loss of dopaminergic neurons  (IAGP)
microgliosis  (IAGP)
muscle hypertonia  (IAGP)
muscle spasm  (IAGP)
neurodegeneration  (IAGP)
neuron degeneration  (IAGP)
neuron hypertrophy  (IAGP)
neuronal cytoplasmic inclusions  (IAGP)
neuronal intranuclear inclusions  (IAGP)
no abnormal phenotype detected  (IAGP)
pituitary intermediate lobe hypoplasia  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
reduced long term potentiation  (IAGP)
short stride length  (IAGP)
slow postnatal weight gain  (IAGP)
small pituitary gland  (IAGP)
tremors  (IAGP)
weight loss  (IAGP)
References

Additional References at PubMed
PMID:7637582   PMID:8180472   PMID:8628395   PMID:8903735   PMID:8942444   PMID:9037545   PMID:9247269   PMID:9482784   PMID:9520487   PMID:9634552   PMID:9636213   PMID:10072302  
PMID:10195128   PMID:10349636   PMID:10375632   PMID:10404198   PMID:10564358   PMID:10617152   PMID:10637574   PMID:10651856   PMID:10677550   PMID:10792459   PMID:10907725   PMID:10915639  
PMID:10971639   PMID:10998124   PMID:11042159   PMID:11076861   PMID:11150348   PMID:11172062   PMID:11217851   PMID:11312315   PMID:11320258   PMID:11343649   PMID:11404425   PMID:11506886  
PMID:11572967   PMID:11784783   PMID:11803442   PMID:12006604   PMID:12044470   PMID:12099912   PMID:12193195   PMID:12401330   PMID:12466851   PMID:12477932   PMID:12480184   PMID:12586455  
PMID:12617953   PMID:12655306   PMID:12699766   PMID:12764108   PMID:12958210   PMID:14561867   PMID:14593425   PMID:14622207   PMID:14681479   PMID:14684259   PMID:14691264   PMID:14973278  
PMID:14980210   PMID:15136721   PMID:15245485   PMID:15354185   PMID:15447669   PMID:15489334   PMID:15492001   PMID:15542711   PMID:15572278   PMID:15584907   PMID:15710042   PMID:15719221  
PMID:15748955   PMID:15763133   PMID:15856082   PMID:15911120   PMID:16024787   PMID:16050778   PMID:16051150   PMID:16125675   PMID:16141072   PMID:16141073   PMID:16339193   PMID:16364897  
PMID:16423542   PMID:16436185   PMID:16525059   PMID:16602821   PMID:16638624   PMID:16643512   PMID:16675138   PMID:16754872   PMID:16765459   PMID:16848782   PMID:16865686   PMID:16950153  
PMID:16954211   PMID:16968817   PMID:17000016   PMID:17035544   PMID:17046697   PMID:17065224   PMID:17065462   PMID:17151600   PMID:17159989   PMID:17227870   PMID:17250681   PMID:17251429  
PMID:17255472   PMID:17298183   PMID:17433376   PMID:17452640   PMID:17522168   PMID:17584943   PMID:17664021   PMID:17687036   PMID:17761882   PMID:18056810   PMID:18184785   PMID:18197357  
PMID:18347339   PMID:18363853   PMID:18470912   PMID:18495356   PMID:18510945   PMID:18596615   PMID:18617632   PMID:18671743   PMID:18690111   PMID:18701073   PMID:18790059   PMID:18799693  
PMID:18929645   PMID:18953410   PMID:19142237   PMID:19144721   PMID:19176817   PMID:19299613   PMID:19339600   PMID:19357284   PMID:19381303   PMID:19439492   PMID:19482066   PMID:19515692  
PMID:19520064   PMID:19553461   PMID:19576892   PMID:19615345   PMID:19619134   PMID:19666516   PMID:19729052   PMID:19750226   PMID:19750538   PMID:19766189   PMID:19780901   PMID:19842188  
PMID:19906957   PMID:19932884   PMID:20002202   PMID:20016108   PMID:20018672   PMID:20023653   PMID:20062537   PMID:20093142   PMID:20167208   PMID:20223200   PMID:20382201   PMID:20386724  
PMID:20451634   PMID:20457670   PMID:20551317   PMID:20558209   PMID:20610757   PMID:20616081   PMID:20634895   PMID:20720111   PMID:20738906   PMID:20858707   PMID:20976142   PMID:20980993  
PMID:21057506   PMID:21060884   PMID:21092858   PMID:21144620   PMID:21148012   PMID:21209835   PMID:21233488   PMID:21267068   PMID:21270893   PMID:21296093   PMID:21368124   PMID:21399631  
PMID:21421642   PMID:21432587   PMID:21439946   PMID:21499253   PMID:21525407   PMID:21677750   PMID:21743470   PMID:21768369   PMID:21795541   PMID:21813695   PMID:21873635   PMID:21880899  
PMID:21880920   PMID:21900559   PMID:21983691   PMID:21990355   PMID:22034972   PMID:22034973   PMID:22069189   PMID:22090423   PMID:22114279   PMID:22118191   PMID:22131425   PMID:22143804  
PMID:22163275   PMID:22196339   PMID:22238104   PMID:22251459   PMID:22258508   PMID:22267337   PMID:22278924   PMID:22330100   PMID:22393477   PMID:22434189   PMID:22483304   PMID:22537018  
PMID:22542182   PMID:22564125   PMID:22572477   PMID:22712725   PMID:22748019   PMID:22778257   PMID:22781838   PMID:22809709   PMID:22841315   PMID:22859504   PMID:22875923   PMID:22914740  
PMID:22961549   PMID:23034651   PMID:23042896   PMID:23083326   PMID:23100428   PMID:23152632   PMID:23197738   PMID:23217170   PMID:23240026   PMID:23264561   PMID:23305992   PMID:23458603  
PMID:23481388   PMID:23534961   PMID:23558143   PMID:23637192   PMID:23681253   PMID:23817546   PMID:23817550   PMID:23863478   PMID:23884410   PMID:23921954   PMID:23933217   PMID:23959937  
PMID:23977020   PMID:23978383   PMID:24098148   PMID:24133278   PMID:24150248   PMID:24155314   PMID:24194600   PMID:24332984   PMID:24348261   PMID:24486705   PMID:24497577   PMID:24550305  
PMID:24673634   PMID:24742619   PMID:24776686   PMID:24790206   PMID:24799694   PMID:24802380   PMID:24811384   PMID:24843012   PMID:24886986   PMID:24952961   PMID:24979798   PMID:25005251  
PMID:25063810   PMID:25068655   PMID:25071457   PMID:25091505   PMID:25171792   PMID:25258080   PMID:25331903   PMID:25339743   PMID:25447236   PMID:25505322   PMID:25609609   PMID:25611513  
PMID:25611514   PMID:25714923   PMID:25752644   PMID:25762688   PMID:25782435   PMID:25817859   PMID:25915474   PMID:25918399   PMID:25936602   PMID:25948263   PMID:26056851   PMID:26080439  
PMID:26086365   PMID:26139373   PMID:26164566   PMID:26182419   PMID:26203861   PMID:26207352   PMID:26232228   PMID:26278050   PMID:26287463   PMID:26321632   PMID:26335381   PMID:26341832  
PMID:26359992   PMID:26364547   PMID:26365765   PMID:26377476   PMID:26402461   PMID:26407721   PMID:26430123   PMID:26464985   PMID:26551563   PMID:26565913   PMID:26681446   PMID:26699459  
PMID:26871628   PMID:26879466   PMID:26904943   PMID:26912775   PMID:26929359   PMID:26961958   PMID:27003179   PMID:27036891   PMID:27038906   PMID:27053209   PMID:27079169   PMID:27124299  
PMID:27124386   PMID:27163179   PMID:27181061   PMID:27246266   PMID:27273769   PMID:27292633   PMID:27317935   PMID:27346361   PMID:27407143   PMID:27408780   PMID:27467571   PMID:27468917  
PMID:27568516   PMID:27581458   PMID:27618675   PMID:27618677   PMID:27626380   PMID:27647894   PMID:27659966   PMID:27681312   PMID:27703142   PMID:27716510   PMID:27760002   PMID:27886263  
PMID:27889578   PMID:27930324   PMID:27966077   PMID:27974817   PMID:27976722   PMID:28009292   PMID:28038352   PMID:28054919   PMID:28103482   PMID:28132830   PMID:28174244   PMID:28192395  
PMID:28194005   PMID:28228269   PMID:28244870   PMID:28283558   PMID:28285820   PMID:28297663   PMID:28297715   PMID:28334611   PMID:28375739   PMID:28376279   PMID:28394253   PMID:28454982  
PMID:28461218   PMID:28462393   PMID:28466093   PMID:28535798   PMID:28595911   PMID:28669546   PMID:28714952   PMID:28781050   PMID:28821671   PMID:28855580   PMID:28894175   PMID:28905875  
PMID:28923595   PMID:28938472   PMID:28941296   PMID:28963257   PMID:28964912   PMID:29030221   PMID:29030431   PMID:29038581   PMID:29167404   PMID:29177188   PMID:29180115   PMID:29241537  
PMID:29251597   PMID:29256865   PMID:29304042   PMID:29321139   PMID:29337309   PMID:29355693   PMID:29398114   PMID:29420469   PMID:29527566   PMID:29615705   PMID:29621487   PMID:29656872  
PMID:29656874   PMID:29676260   PMID:29676731   PMID:29739866   PMID:29754751   PMID:29760401   PMID:29791835   PMID:29802391   PMID:29949769   PMID:29958943   PMID:30007419   PMID:30043140  
PMID:30057204   PMID:30093665   PMID:30100256   PMID:30146163   PMID:30177795   PMID:30210305   PMID:30228121   PMID:30245012   PMID:30292429   PMID:30295607   PMID:30297767   PMID:30318411  
PMID:30323275   PMID:30344040   PMID:30367968   PMID:30373717   PMID:30440089   PMID:30442663   PMID:30503173   PMID:30522820   PMID:30539268   PMID:30540946   PMID:30556810   PMID:30568192  
PMID:30578419   PMID:30590105   PMID:30605672   PMID:30623173   PMID:30635563   PMID:30664247   PMID:30689541   PMID:30718509   PMID:30726725   PMID:30736837   PMID:30804529   PMID:30837265  
PMID:30920369   PMID:30933310   PMID:30936473   PMID:30970251   PMID:31003725   PMID:31091455   PMID:31094705   PMID:31097625   PMID:31109961   PMID:31144295   PMID:31175277   PMID:31189104  
PMID:31202540   PMID:31204082   PMID:31209151   PMID:31226324   PMID:31277924   PMID:31324539   PMID:31348890   PMID:31365862   PMID:31449520   PMID:31481399   PMID:31486769   PMID:31505196  
PMID:31537790   PMID:31548368   PMID:31596232   PMID:31604921   PMID:31610370   PMID:31619451   PMID:31644913   PMID:31648898   PMID:31665630   PMID:31704785   PMID:31750563   PMID:31826983  
PMID:31835787   PMID:31872525   PMID:31890743   PMID:31923430   PMID:31953402   PMID:31954621   PMID:31974110   PMID:32005751   PMID:32005765   PMID:32027824   PMID:32027825   PMID:32048995  
PMID:32075716   PMID:32075770   PMID:32132171   PMID:32142670   PMID:32191871   PMID:32192190   PMID:32214250   PMID:32244769   PMID:32259476   PMID:32294466   PMID:32317389   PMID:32415886  
PMID:32490813   PMID:32499648   PMID:32561725   PMID:32564285   PMID:32576620   PMID:32576854   PMID:32579581   PMID:32579938   PMID:32581380   PMID:32581704   PMID:32588892   PMID:32640184  
PMID:32651365   PMID:32747789   PMID:32847967   PMID:32901079   PMID:32923630   PMID:32928885   PMID:32961129   PMID:32989293   PMID:33046554   PMID:33153031   PMID:33234607   PMID:33340529  
PMID:33345774   PMID:33483429   PMID:33526942  


Genomics

Comparative Map Data
Slc6a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391373,684,270 - 73,726,791 (+)NCBIGRCm39mm39
GRCm39 Ensembl1373,684,866 - 73,726,791 (+)Ensembl
GRCm381373,536,128 - 73,578,672 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1373,536,747 - 73,578,672 (+)EnsemblGRCm38mm10GRCm38
MGSCv371373,674,195 - 73,716,120 (+)NCBIGRCm37mm9NCBIm37
MGSCv361374,002,749 - 74,044,674 (+)NCBImm8
Celera1375,865,546 - 75,907,463 (+)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.1NCBI
SLC6A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl51,392,794 - 1,445,440 (-)EnsemblGRCh38hg38GRCh38
GRCh3851,392,794 - 1,445,440 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3751,392,909 - 1,445,555 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3651,445,909 - 1,498,538 (-)NCBINCBI36hg18NCBI36
Build 3451,445,908 - 1,498,543NCBI
Celera51,429,610 - 1,484,220 (-)NCBI
Cytogenetic Map5p15.33NCBI
HuRef51,373,680 - 1,426,892 (-)NCBIHuRef
CHM1_151,392,820 - 1,445,528 (-)NCBICHM1_1
Slc6a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2129,709,443 - 29,750,413 (-)NCBI
Rnor_6.0 Ensembl132,321,580 - 32,363,983 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0132,323,011 - 32,363,983 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0133,745,060 - 33,788,878 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4130,516,568 - 30,557,540 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1130,518,078 - 30,558,861 (-)NCBI
Celera128,357,426 - 28,397,883 (-)NCBICelera
Cytogenetic Map1p11NCBI
Slc6a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955504721,429 - 747,630 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955504721,470 - 747,553 (-)NCBIChiLan1.0ChiLan1.0
SLC6A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.151,437,567 - 1,488,829 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl51,437,567 - 1,488,829 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v051,687,079 - 1,739,729 (-)NCBIMhudiblu_PPA_v0panPan3
SLC6A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13411,209,118 - 11,245,456 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3411,210,939 - 11,246,742 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3415,719,083 - 15,755,282 (+)NCBI
ROS_Cfam_1.03411,109,747 - 11,147,167 (+)NCBI
UMICH_Zoey_3.13411,160,852 - 11,196,981 (+)NCBI
UNSW_CanFamBas_1.03411,139,913 - 11,176,047 (+)NCBI
UU_Cfam_GSD_1.03411,350,821 - 11,387,021 (+)NCBI
Slc6a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213244,198,128 - 244,239,922 (+)NCBI
SpeTri2.0NW_004936815359,775 - 400,690 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC6A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1679,186,108 - 79,220,297 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11679,186,114 - 79,220,302 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21685,853,611 - 85,887,787 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC6A3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.141,209,013 - 1,258,797 (-)NCBI
ChlSab1.1 Ensembl41,209,019 - 1,258,866 (-)Ensembl
Vero_WHO_p1.0NW_02366605435,775,947 - 35,824,591 (-)NCBI
Slc6a3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624751694,165 - 720,287 (-)NCBI

Position Markers
Slc6a3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13C1UniSTS
cM Map1341.0UniSTS
PMC304098P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381373,562,305 - 73,562,405UniSTSGRCm38
MGSCv371373,699,753 - 73,699,853UniSTSGRCm37
Celera1375,891,096 - 75,891,196UniSTS
Cytogenetic Map13C1UniSTS
cM Map1341.0UniSTS
D1Wox51  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381373,577,720 - 73,577,826UniSTSGRCm38
MGSCv371373,715,168 - 73,715,274UniSTSGRCm37
Celera1375,906,511 - 75,906,617UniSTS
Cytogenetic Map13C1UniSTS
cM Map1341.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13390000075900000Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20293442112761890Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133587692596102654Mouse
15039353Nmrs35_mNAFLD-associated magnetic resonance shift 35 (mouse)134044044074440440Mouse
1300668Pas10_mpulmonary adenoma susceptibility 10 (mouse)Not determined134134122875341344Mouse
4142331Bxs6_mBXSB/MpJ autoimmune nephritis 6 (mouse)Not determined4505696683596627Mouse
10412109Bxs7_mBXSB/MpJ autoimmune nephritis 7 (mouse)Not determined134505696683596627Mouse
4142372Moo2_mmodifier of Odc2 (mouse)Not determinedX5017034784170495Mouse
1300916Mobe2_mmodifier of obesity 2 (mouse)Not determined135017034784170495Mouse
1301666Eae13_msusceptibility to experimental allergic encephalomyelitis 13 (mouse)Not determined135017034784170495Mouse
1300573Elsgp2_melevated serum gp70 2 (mouse)Not determined135046870984468908Mouse
14746975Manh74_mmandible shape 74 (mouse)135232915086329150Mouse
1302073Pgct1_mprimordial germ cell tumor locus 1 (mouse)Not determined135367266487672778Mouse
1357563Bmch6_mbone mechanical trait 6 (mouse)Not determined135523686189237021Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55572541112294569Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55572541112294569Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55572541112294569Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55572541112294569Mouse
1558850Sgp3_mserum gp70 production 3 (mouse)Not determined135632264376823195Mouse
10402414Sgp5_mserum gp70 production 5 (mouse)Not determined1356322643105285678Mouse
1357553Cia28_mcollagen induced arthritis 28 (mouse)Not determined135648143696102654Mouse
10412163Wra1_mwheel running activity 1 (mouse)Not determined135898448192984619Mouse
1300941Skl6_mskeletal size (tail length) 6 (mouse)Not determined136410270298102826Mouse
1301949Skull20_mskull morphology 20 (mouse)Not determined136410270298102826Mouse
1301445Listr2_mlisteriosis resistance 2 (mouse)Not determined1366596482100596627Mouse
1301593Heal8_mwound healing/regeneration 8 (mouse)Not determined1367905880101906000Mouse
14696726Kidrq3_mkidney weight, right QTL 3 (mouse)1368068947102068947Mouse
14747007Mancz11_mmandible centroid size 11 (mouse)1369963165103963165Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:510
Count of miRNA genes:337
Interacting mature miRNAs:402
Transcripts:ENSMUST00000022100
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000022100   ⟹   ENSMUSP00000022100
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1373,536,747 - 73,578,672 (+)Ensembl
RefSeq Acc Id: NM_010020   ⟹   NP_034150
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391373,684,866 - 73,726,791 (+)NCBI
GRCm381373,536,747 - 73,578,672 (+)NCBI
MGSCv371373,674,195 - 73,716,120 (+)RGD
Celera1375,865,546 - 75,907,463 (+)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006517083   ⟹   XP_006517146
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391373,684,270 - 73,726,791 (+)NCBI
GRCm381373,536,147 - 73,578,672 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006517084   ⟹   XP_006517147
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391373,684,863 - 73,718,071 (+)NCBI
GRCm381373,536,128 - 73,569,952 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017315377   ⟹   XP_017170866
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391373,684,848 - 73,719,519 (+)NCBI
GRCm381373,536,132 - 73,571,402 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034150   ⟸   NM_010020
- UniProtKB: Q61327 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006517147   ⟸   XM_006517084
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006517146   ⟸   XM_006517083
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017170866   ⟸   XM_017315377
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000022100   ⟸   ENSMUST00000022100

Promoters
RGD ID:8680870
Promoter ID:EPDNEW_M18430
Type:multiple initiation site
Name:Slc6a3_1
Description:Mus musculus solute carrier family 6 (neurotransmitter transporter,dopamine), member 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381373,536,803 - 73,536,863EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:94862 AgrOrtholog
Ensembl Genes ENSMUSG00000021609 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000022100 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000022100 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Na/ntran_symport UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na/ntran_symport_dopamine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SNS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13162 UniProtKB/Swiss-Prot
MGD MGI:94862 ENTREZGENE
NCBI Gene 13162 ENTREZGENE
PANTHER PTHR11616 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SLC6A3 RGD
PhenoGen Slc6a3 PhenoGen
PRINTS DOPTRANSPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NANEUSMPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NA_NEUROTRAN_SYMP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF161070 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q3UVW5_MOUSE UniProtKB/TrEMBL
  Q61327 ENTREZGENE
  Q8C009_MOUSE UniProtKB/TrEMBL
  Q9JJ41_MOUSE UniProtKB/TrEMBL
  Q9R0X6_MOUSE UniProtKB/TrEMBL
  SC6A3_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q60719 UniProtKB/Swiss-Prot
  Q9R1I2 UniProtKB/Swiss-Prot