Nr3c1 (nuclear receptor subfamily 3, group C, member 1) - Rat Genome Database

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Gene: Nr3c1 (nuclear receptor subfamily 3, group C, member 1) Mus musculus
Symbol: Nr3c1
Name: nuclear receptor subfamily 3, group C, member 1
RGD ID: 10691
Description: Exhibits several functions, including glucocorticoid receptor activity; identical protein binding activity; and protein kinase binding activity. Involved in several processes, including gland development; glucocorticoid receptor signaling pathway; and regulation of cellular biosynthetic process. Localizes to cytosol; membrane; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skin. Used to study primary hyperaldosteronism. Human ortholog(s) of this gene implicated in several diseases, including anorexia nervosa; lung disease (multiple); major depressive disorder; obesity; and renal cell carcinoma. Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1); PARTICIPATES IN cortisol signaling pathway; forkhead class A signaling pathway; prednisolone pharmacodynamics pathway; INTERACTS WITH (3,4-dihydroxyphenyl)acetic acid; (S)-amphetamine; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: G; glucocorticoid receptor; glucocorticoid receptor 1; glucocorticoid receptor subtype P; GR; Grl; Grl-1; Grl1; nuclear receptor subfamily 3 group C member 1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391839,543,598 - 39,652,485 (-)NCBIGRCm39mm39
GRCm39 Ensembl1839,543,598 - 39,652,474 (-)Ensembl
GRCm381839,410,545 - 39,519,421 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1839,410,545 - 39,519,421 (-)EnsemblGRCm38mm10GRCm38
MGSCv371839,570,199 - 39,646,899 (-)NCBIGRCm37mm9NCBIm37
MGSCv361839,537,961 - 39,615,820 (-)NCBImm8
Celera1840,761,405 - 40,838,026 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1821.09NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
46, XX Disorders of Sex Development  (ISO)
anorexia nervosa  (ISO)
asthma  (ISO)
atrial fibrillation  (ISO)
bipolar disorder  (ISO)
brain ischemia  (ISO)
Burns  (ISO)
cataract  (ISO)
chronic obstructive pulmonary disease  (ISO)
Cocaine-Related Disorders  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Cushing Syndrome  (IMP,ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Edema  (ISO)
end stage renal disease  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (IMP)
Experimental Diabetes Mellitus  (ISO)
Fetal Growth Retardation  (ISO)
Glucocorticoid Receptor Deficiency  (ISO)
glucose metabolism disease  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hypertension  (IMP,ISO)
hypokalemia  (ISO)
interstitial lung disease  (ISO)
lipoid nephrosis  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (IEP,ISO)
major depressive disorder  (ISO)
Malocclusion  (ISO)
mental depression  (ISO)
mood disorder  (ISO)
muscular atrophy  (ISO)
nephrotic syndrome  (ISO)
nephrotic syndrome type 2  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
obstructive lung disease  (ISO)
obstructive sleep apnea  (ISO)
ocular hypertension  (ISO)
Perennial Allergic Rhinitis  (ISO)
polycystic ovary syndrome  (ISO)
post-traumatic stress disorder  (ISO)
primary biliary cholangitis  (ISO)
primary hyperaldosteronism  (IEA)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psychotic disorder  (ISO)
pulmonary sarcoidosis  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
Sepsis  (IEP,ISO)
sinusitis  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
Transplant Rejection  (ISO)
type 2 diabetes mellitus  (ISO)
uveitis  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(3,4-dihydroxyphenyl)acetic acid  (EXP)
(S)-amphetamine  (EXP)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,3,4,7,8-Hexachlorodibenzofuran  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-dithiothreitol  (ISO)
1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
11-deoxycorticosterone  (ISO)
11-deoxycortisol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',4,4'-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-aminophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-Dimethylbenzaldehyde  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-methylcholanthrene  (ISO)
3-phenoxybenzoic acid  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (EXP)
4'-hydroxydiclofenac  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acrolein  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
agomelatine  (EXP)
albuterol  (ISO)
aldehydo-D-glucose  (EXP)
aldosterone  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
amitriptyline  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (ISO)
arsane  (EXP)
arsenic acid  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Aurin  (ISO)
avobenzone  (ISO)
aziridines  (EXP,ISO)
beclomethasone  (ISO)
benzbromarone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzoyl peroxide  (EXP)
betamethasone  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
budesonide  (ISO)
butachlor  (ISO)
butanal  (ISO)
Butylparaben  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (EXP,ISO)
carbon nanotube  (EXP)
celecoxib  (ISO)
chlorpromazine  (EXP)
choline  (EXP)
chromium(6+)  (ISO)
ciclopirox  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (EXP)
cisplatin  (EXP,ISO)
citalopram  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clotrimazole  (ISO)
clozapine  (EXP)
cobalt atom  (ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
compound 48/80  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP,ISO)
corticotropin  (ISO)
cortisol  (EXP,ISO)
cortisone  (ISO)
cortivazol  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cycloheximide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP)
daunorubicin  (ISO)
deflazacort  (ISO)
dehydroepiandrosterone  (ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichloromethane  (EXP)
diclofenac  (ISO)
Dicyclohexyl phthalate  (EXP)
diisopropyl fluorophosphate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endrin  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
ethiofencarb  (ISO)
ethyl myristate  (ISO)
fenchone  (ISO)
fenvalerate  (ISO)
fludrocortisone  (ISO)
flumethasone  (ISO)
fluoranthene  (EXP)
fluoxetine  (EXP,ISO)
flutamide  (ISO)
fluticasone  (ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
formaldehyde  (ISO)
formoterol fumarate  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
Fusarenone X  (EXP)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
ginsenoside Re  (ISO)
glafenine  (ISO)
glucose  (EXP)
hexadecanoic acid  (ISO)
homovanillic acid  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (EXP,ISO)
idazoxan  (ISO)
irinotecan  (ISO)
isoquinolines  (ISO)
ketoconazole  (EXP,ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (ISO)
L-methionine  (EXP)
lamotrigine  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP,ISO)
lithium chloride  (ISO)
lithium hydride  (EXP,ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
methylparaben  (EXP)
methylprednisolone aceponate  (ISO)
methylseleninic acid  (ISO)
methyltestosterone  (ISO)
miconazole  (ISO)
mifepristone  (EXP,ISO)
mirex  (ISO)
mitomycin C  (EXP)
mitoxantrone  (ISO)
molybdate  (ISO)
mometasone furoate  (ISO)
morphine  (ISO)
N,O-dimethyltyramine  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-butylbenzenesulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
okadaic acid  (EXP)
omeprazole  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pararosaniline free base  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
Phenoxybenzamine  (EXP)
phenylbutazone  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (ISO)
phosgene  (EXP)
pirinixic acid  (EXP,ISO)
Polygodial  (ISO)
potassium chloride  (ISO)
potassium chromate  (ISO)
prednisolone  (ISO)
prednisone  (EXP)
prednylidene  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
promegestone  (ISO)
propiconazole  (EXP)
propylparaben  (ISO)
protoporphyrin  (ISO)
puromycin  (EXP)
quercetin  (EXP,ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
reserpine  (ISO)
resmethrin  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (EXP)
rotenone  (ISO)
S-methyl methanethiosulfonate  (ISO)
Salmeterol xinafoate  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
selenium atom  (ISO)
selenous acid  (ISO)
senecionine  (ISO)
silicon dioxide  (EXP)
sirolimus  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
spiperone  (EXP)
spiroxamine  (ISO)
succimer  (EXP)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
tauroursodeoxycholic acid  (ISO)
tenofovir disoproxil fumarate  (ISO)
terbutaline  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetramethrin  (ISO)
tetraphene  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
thyroxine  (ISO)
titanium dioxide  (EXP)
tolcapone  (ISO)
tolterodine tartrate  (ISO)
tolylfluanid  (EXP,ISO)
topotecan  (ISO)
torcetrapib  (ISO)
triamcinolone  (ISO)
triamcinolone acetonide  (EXP,ISO)
tributyl phosphate  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trifluoperazine  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
undecan-2-one  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (ISO)
verapamil  (EXP)
vinclozolin  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (IMP)
aging  (ISO)
androgen metabolic process  (ISO)
brain development  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to magnesium ion  (ISO)
cellular response to steroid hormone stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
chromatin organization  (IEA)
chromatin remodeling  (ISO)
chromatin-mediated maintenance of transcription  (ISO)
circadian rhythm  (ISO)
female pregnancy  (ISO)
glucocorticoid mediated signaling pathway  (IEA)
glucocorticoid metabolic process  (IMP)
glucocorticoid receptor signaling pathway  (IDA,IMP)
intracellular steroid hormone receptor signaling pathway  (IBA)
lung development  (ISO)
mammary gland duct morphogenesis  (IMP)
maternal behavior  (IGI)
muscle atrophy  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of glucocorticoid mediated signaling pathway  (IDA)
negative regulation of synaptic plasticity  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
negative regulation of vascular permeability  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of glucocorticoid receptor signaling pathway  (ISO)
positive regulation of glutamate secretion  (ISO)
positive regulation of neuron apoptotic process  (IGI)
positive regulation of pri-miRNA transcription by RNA polymerase II  (IDA,ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of cell population proliferation  (ISO)
regulation of glucocorticoid biosynthetic process  (IMP)
regulation of gluconeogenesis  (IMP)
regulation of glucose metabolic process  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription, DNA-templated  (IDA,ISO)
response to activity  (ISO)
response to arsenic-containing substance  (ISO)
response to calcium ion  (ISO)
response to corticosterone  (ISO)
response to dexamethasone  (ISO)
response to electrical stimulus  (ISO)
response to inactivity  (ISO)
response to insulin  (ISO)
response to mercury ion  (ISO)
response to radiation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adipose tissue distribution  (IAGP)
abnormal adrenal chromaffin cell morphology  (IAGP)
abnormal adrenal cortex morphology  (IAGP)
abnormal adrenal gland morphology  (IAGP)
abnormal adrenal gland zona fasciculata morphology  (IAGP)
abnormal adrenal gland zona glomerulosa morphology  (IAGP)
abnormal adrenal gland zona reticularis morphology  (IAGP)
abnormal alveolocapillary membrane morphology  (IAGP)
abnormal atrial thrombosis  (IAGP)
abnormal behavioral response to addictive substance  (IAGP)
abnormal blood-brain barrier function  (IAGP)
abnormal bone mineral density  (IAGP)
abnormal bone ossification  (IAGP)
abnormal branching involved in terminal bronchiole morphogenesis  (IAGP)
abnormal calcium ion homeostasis  (IAGP)
abnormal cecum morphology  (IAGP)
abnormal circulating corticosterone level  (IAGP)
abnormal fear/anxiety-related behavior  (IAGP)
abnormal heart echocardiography feature  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal hypothalamus physiology  (IAGP)
abnormal interferon level  (IAGP)
abnormal interleukin level  (IAGP)
abnormal interleukin-6 secretion  (IAGP)
abnormal liver physiology  (IAGP)
abnormal lung development  (IAGP)
abnormal lung morphology  (IAGP)
abnormal mammary gland alveolus morphology  (IAGP)
abnormal mammary gland growth during pregnancy  (IAGP)
abnormal monocyte cell number  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal osteoblast differentiation  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal physiological response to xenobiotic  (IAGP)
abnormal pulmonary alveolus epithelial cell morphology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal respiratory system development  (IAGP)
abnormal response to CNS ischemic injury  (IAGP)
abnormal surfactant secretion  (IAGP)
abnormal thoracic cavity morphology  (IAGP)
abnormal thymocyte apoptosis  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
absent adrenal medulla  (IAGP)
absent adrenergic chromaffin cells  (IAGP)
absent circulating adrenaline  (IAGP)
absent long term depression  (IAGP)
atelectasis  (IAGP)
behavioral despair  (IAGP)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
cecum inflammation  (IAGP)
congestive heart failure  (IAGP)
cyanosis  (IAGP)
decreased adrenaline level  (IAGP)
decreased anxiety-related response  (IAGP)
decreased B cell number  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased CD4-positive, alpha beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased circulating adrenocorticotropin level  (IAGP)
decreased circulating corticosterone level  (IAGP)
decreased circulating noradrenaline level  (IAGP)
decreased circulating testosterone level  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased erythroid progenitor cell number  (IAGP)
decreased macrophage cell number  (IAGP)
decreased noradrenaline level  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to neuronal excitotoxicity  (IAGP)
decreased T cell apoptosis  (IAGP)
decreased thymocyte apoptosis  (IAGP)
decreased type I pneumocyte number  (IAGP)
dilated heart left ventricle  (IAGP)
enlarged adrenal glands  (IAGP)
enlarged adrenocortical cell nuclei  (IAGP)
enlarged adrenocortical cells  (IAGP)
enlarged heart  (IAGP)
enlarged myocardial fiber  (IAGP)
heart inflammation  (IAGP)
hypersecretion of corticotropin-releasing hormone  (IAGP)
hypoactivity  (IAGP)
impaired lung alveolus development  (IAGP)
increased adrenocorticotropin level  (IAGP)
increased body length  (IAGP)
increased circulating adrenocorticotropin level  (IAGP)
increased circulating aldosterone level  (IAGP)
increased circulating angiotensinogen level  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating glucocorticoid level  (IAGP)
increased heart weight  (IAGP)
increased interleukin-1 beta secretion  (IAGP)
increased left ventricle weight  (IAGP)
increased liver triglyceride level  (IAGP)
increased lung weight  (IAGP)
increased mean systemic arterial blood pressure  (IAGP)
increased renin activity  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased type II pneumocyte number  (IAGP)
lethality, complete penetrance  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
osteoporosis  (IAGP)
pathological neovascularization  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
poor circulation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
pulmonary hyperplasia  (IAGP)
respiratory distress  (IAGP)
respiratory failure  (IAGP)
small adrenal glands  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
thick ventricular wall  (IAGP)
thin adrenal cortex  (IAGP)
thymus hypoplasia  (IAGP)

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Additional References at PubMed
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Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391839,543,598 - 39,652,485 (-)NCBIGRCm39mm39
GRCm39 Ensembl1839,543,598 - 39,652,474 (-)Ensembl
GRCm381839,410,545 - 39,519,421 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1839,410,545 - 39,519,421 (-)EnsemblGRCm38mm10GRCm38
MGSCv371839,570,199 - 39,646,899 (-)NCBIGRCm37mm9NCBIm37
MGSCv361839,537,961 - 39,615,820 (-)NCBImm8
Celera1840,761,405 - 40,838,026 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1821.09NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl5143,277,931 - 143,435,512 (-)EnsemblGRCh38hg38GRCh38
GRCh385143,277,931 - 143,435,512 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375142,657,496 - 142,815,077 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365142,637,689 - 142,795,270 (-)NCBINCBI36hg18NCBI36
Build 345142,639,324 - 142,763,087NCBI
Celera5138,738,770 - 138,896,297 (-)NCBI
Cytogenetic Map5q31.3NCBI
HuRef5137,804,733 - 137,962,312 (-)NCBIHuRef
CHM1_15142,091,205 - 142,248,804 (-)NCBICHM1_1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21831,271,681 - 31,393,320 (-)NCBI
Rnor_6.0 Ensembl1831,728,373 - 31,749,647 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01831,728,373 - 32,704,022 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01831,408,742 - 31,442,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01832,347,227 - 32,348,480 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41832,371,496 - 32,459,145 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11832,406,765 - 32,494,411 (-)NCBI
Celera1830,905,394 - 30,993,522 (-)NCBICelera
RH 3.4 Map18442.9RGD
Cytogenetic Map18p11NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541510,494,640 - 10,586,221 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541510,494,704 - 10,585,778 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.15144,741,452 - 144,865,341 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5144,741,452 - 144,865,269 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05138,634,278 - 139,089,171 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1238,124,568 - 38,242,510 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl238,123,190 - 38,240,755 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha235,173,176 - 35,283,390 (-)NCBI
ROS_Cfam_1.0238,573,084 - 38,692,463 (-)NCBI
UMICH_Zoey_3.1235,654,977 - 35,765,222 (-)NCBI
UNSW_CanFamBas_1.0236,468,553 - 36,579,023 (-)NCBI
UU_Cfam_GSD_1.0237,270,194 - 37,380,458 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213149,386,116 - 149,482,864 (+)NCBI
SpeTri2.0NW_00493650410,960,069 - 11,056,834 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl2144,822,937 - 144,956,095 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12144,822,937 - 144,956,451 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22151,051,816 - 151,185,046 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12345,904,926 - 46,031,804 (-)NCBI
ChlSab1.1 Ensembl2345,904,873 - 46,031,125 (-)Ensembl
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046247742,496,276 - 2,603,894 (-)NCBI

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381839,414,301 - 39,414,401UniSTSGRCm38
MGSCv371839,573,955 - 39,574,055UniSTSGRCm37
Celera1840,765,161 - 40,765,261UniSTS
Cytogenetic Map18B3UniSTS
cM Map1820.0UniSTS
Whitehead_YAC18 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381839,486,861 - 39,487,074UniSTSGRCm38
MGSCv371839,646,515 - 39,646,728UniSTSGRCm37
Celera1840,837,669 - 40,837,855UniSTS
Cytogenetic Map18B3UniSTS
cM Map1820.0UniSTS
Whitehead Genetic1814.2UniSTS
Whitehead_YAC18 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371839,646,560 - 39,646,767UniSTSGRCm37
MGSCv371839,646,000 - 39,646,463UniSTSGRCm37
Celera1840,837,714 - 40,837,894UniSTS
Celera1840,837,154 - 40,837,617UniSTS
Cytogenetic Map18B3UniSTS
cM Map1820.0UniSTS
cM Map1820.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381839,486,346 - 39,486,809UniSTSGRCm38
MGSCv371839,646,000 - 39,646,463UniSTSGRCm37
Celera1840,837,154 - 40,837,617UniSTS
Cytogenetic Map18B3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18B3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381839,486,906 - 39,487,113UniSTSGRCm38
MGSCv371839,646,560 - 39,646,767UniSTSGRCm37
Celera1840,837,714 - 40,837,894UniSTS
Cytogenetic Map18B3UniSTS
cM Map1820.0UniSTS

QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060800000Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961139571Mouse
1558873Hrtfm7_mheart failure modifier 7 (mouse)Not determined18795390741954049Mouse
13504732Cath6_mcarotid atherosclerosis 6 (mouse)181350407347504073Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181389696666965891Mouse
1300994Pvcan3_mprotection against vaginal candidiasis 3 (mouse)Not determined181606658750066723Mouse
1301307Phospq1_mphospholipid QTL 1 (mouse)Not determined181800665152006806Mouse
1558743Kcal1_mkilocalorie 1 (mouse)Not determined181888582152885939Mouse
1300638Im7_mimmunoregulatory 7 (mouse)Not determined181888582152885939Mouse
11532709Sluc41_msusceptibility to lung cancer 41 (mouse)182082063757457636Mouse
13463476Hctq8_mhematocrit QTL 8 (mouse)182108452755084674Mouse
1301570Sluc14_msusceptibility to lung cancer 14 (mouse)Not determined182248686156487074Mouse
1300877Adip8_madiposity 8 (mouse)Not determined182248686156487074Mouse
11532710Sluc41a_msusceptibility to lung cancer 41a (mouse)182248686156487074Mouse
11532715Sluc41b_msusceptibility to lung cancer 41b (mouse)182248686156487074Mouse
11532716Sluc41c_msusceptibility to lung cancer 41c (mouse)182248686156487074Mouse
4142031Moen1_mmodifier of engrailed QTL 1 (mouse)Not determined182398250757982677Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182476282478296340Mouse
12904950Smmq3_msoleus muscle mass QTL 3 (mouse)182592381059923810Mouse
25823167Hrsq5_mhost response to SARS QTL 5, D3% weight (mouse)182710806258694005Mouse
25823171Hrsq10_mhost response to SARS QTL 10, D4% weight (mouse)182710806258694005Mouse
25823174Hrsq11_mhost response to SARS QTL 11, log titer (mouse)182710806258694005Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182797631361976451Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2799753761997672Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182953484763534993Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183010000064100000Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183185541365855562Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183295797666958154Mouse
1301771Pcyts6_mplasmacytoma susceptibility 6 (mouse)Not determined183552556069525779Mouse
11041903Lmr27_mleishmaniasis resistance 27 (mouse)183605451444976451Mouse
4142366Chlq10_mcirculating hormone level QTL 10 (mouse)Not determined183615795070158108Mouse
15039381Ltgq8_mliver triglyceride QTL 8 (mouse)183807349772073497Mouse
15039383Mvlq5_mmicrovesicular liver lesion QTL 5 (mouse)183807349772073497Mouse
15039384Liviq1_mliver inflammation QTL 1 (mouse)183807349772073497Mouse
15039386Mvlq4_mmacrovesicular liver lesion QTL 4 (mouse)183807349772073497Mouse
12050070Nabq2_mnasal bone morphology QTL 2 (mouse)183897060572970721Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183948686184620653Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID

Predicted Target Of
Summary Value
Count of predictions:3814
Count of miRNA genes:787
Interacting mature miRNAs:1069
Transcripts:ENSMUST00000025300, ENSMUST00000097592, ENSMUST00000115567, ENSMUST00000115571, ENSMUST00000124115, ENSMUST00000131885, ENSMUST00000150483, ENSMUST00000152853
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Nucleotide Sequences
RefSeq Transcripts NM_001361209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001361210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001361211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001361212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030250338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030250339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036160990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA124418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC007995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC124417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC129912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC129913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ176909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY232938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN720992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ504162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU118151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU118152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM236293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG946717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X66367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z97061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000025300   ⟹   ENSMUSP00000025300
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1839,411,987 - 39,489,846 (-)Ensembl
RefSeq Acc Id: ENSMUST00000097592   ⟹   ENSMUSP00000095199
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1839,414,482 - 39,487,232 (-)Ensembl
RefSeq Acc Id: ENSMUST00000115567   ⟹   ENSMUSP00000111229
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1839,410,545 - 39,490,674 (-)Ensembl
RefSeq Acc Id: ENSMUST00000115571   ⟹   ENSMUSP00000111233
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1839,410,547 - 39,487,245 (-)Ensembl
RefSeq Acc Id: ENSMUST00000124115   ⟹   ENSMUSP00000119630
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1839,486,844 - 39,491,301 (-)Ensembl
RefSeq Acc Id: ENSMUST00000131885   ⟹   ENSMUSP00000121144
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1839,487,086 - 39,489,283 (-)Ensembl
RefSeq Acc Id: ENSMUST00000150483   ⟹   ENSMUSP00000119432
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1839,487,160 - 39,491,299 (-)Ensembl
RefSeq Acc Id: ENSMUST00000152853   ⟹   ENSMUSP00000120082
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1839,424,436 - 39,489,888 (-)Ensembl
RefSeq Acc Id: ENSMUST00000237944   ⟹   ENSMUSP00000157832
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1839,487,128 - 39,519,421 (-)Ensembl
RefSeq Acc Id: NM_001361209   ⟹   NP_001348138
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391839,543,598 - 39,623,723 (-)NCBI
GRCm381839,410,545 - 39,490,670 (-)NCBI
RefSeq Acc Id: NM_001361210   ⟹   NP_001348139
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391839,543,598 - 39,623,966 (-)NCBI
GRCm381839,410,545 - 39,490,913 (-)NCBI
RefSeq Acc Id: NM_001361211   ⟹   NP_001348140
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391839,543,598 - 39,622,829 (-)NCBI
GRCm381839,410,545 - 39,489,776 (-)NCBI
RefSeq Acc Id: NM_001361212   ⟹   NP_001348141
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391839,543,598 - 39,652,474 (-)NCBI
GRCm381839,410,545 - 39,519,421 (-)NCBI
RefSeq Acc Id: NM_008173   ⟹   NP_032199
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391839,543,598 - 39,622,332 (-)NCBI
GRCm381839,410,545 - 39,489,279 (-)NCBI
MGSCv371839,570,199 - 39,646,899 (-)RGD
Celera1840,761,405 - 40,838,026 (-)RGD