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Gene: Nr3c1 (nuclear receptor subfamily 3, group C, member 1) Mus musculus
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Symbol: Nr3c1
Name: nuclear receptor subfamily 3, group C, member 1
Description: Exhibits several functions, including glucocorticoid receptor activity; identical protein binding activity; and protein kinase binding activity. Involved in several processes, including gland development; maternal behavior; and regulation of cellular biosynthetic process. Localizes to the cytosol; membrane; and nucleus. Used to study primary hyperaldosteronism. Human ortholog(s) of this gene implicated in several diseases, including anorexia nervosa; lung disease (multiple); major depressive disorder; obesity; and renal cell carcinoma. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; head mesenchyme; and skin. Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1); PARTICIPATES IN cortisol signaling pathway; forkhead class A signaling pathway; prednisolone pharmacodynamics pathway; INTERACTS WITH (3,4-dihydroxyphenyl)acetic acid; (S)-amphetamine; 1,2,3,4,7,8-Hexachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: glucocorticoid receptor; glucocorticoid receptor 1; glucocorticoid receptor subtype P; GR; Grl-1; Grl1; nuclear receptor subfamily 3 group C member 1
Orthologs:
Homo sapiens (human) : NR3C1 (nuclear receptor subfamily 3 group C member 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nr3c1 (nuclear receptor subfamily 3, group C, member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nr3c1 (nuclear receptor subfamily 3 group C member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NR3C1 (nuclear receptor subfamily 3 group C member 1)
Canis lupus familiaris (dog) : NR3C1 (nuclear receptor subfamily 3 group C member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr3c1 (nuclear receptor subfamily 3 group C member 1)
Sus scrofa (pig) : NR3C1 (nuclear receptor subfamily 3 group C member 1)
Chlorocebus sabaeus (green monkey) : NR3C1 (nuclear receptor subfamily 3 group C member 1)
Heterocephalus glaber (naked mole-rat) : Nr3c1 (nuclear receptor subfamily 3 group C member 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1839,410,545 - 39,519,421 (-)Ensembl
GRCm381839,410,545 - 39,519,421 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371839,570,199 - 39,646,899 (-)NCBIGRCm37mm9NCBIm37
MGSCv361839,537,961 - 39,615,820 (-)NCBImm8
Celera1840,761,405 - 40,838,026 (-)NCBICelera
Cytogenetic Map18 B3NCBI
cM Map1821.09NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
 
More on Nr3c1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10691
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-02-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.