Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Hepatomegaly | | ISO | COPS3 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:28108177 | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Hepatomegaly | | ISO | COPS3 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:28108177 | |
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# | Reference Title | Reference Citation |
1. | Mouse brain organization revealed through direct genome-scale TF expression analysis. | Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7. |
2. | MGDs mouse GO annotations | MGD data from the GO Consortium |
3. | MGD IEA | MGD IEA |
4. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
5. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
6. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
7. | The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. | Wei N, etal., Curr Biol 1998 Jul 30-Aug 13;8(16):919-22. |
8. | COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast. | Yan J, etal., Mol Cell Biol 2003 Oct;23(19):6798-808. |
PMID:10349636 | PMID:10782111 | PMID:10922068 | PMID:11042159 | PMID:11076861 | PMID:11114242 | PMID:11217851 | PMID:11337588 | PMID:11704659 | PMID:12477932 | PMID:12520002 | PMID:14610273 |
PMID:15489334 | PMID:16141072 | PMID:16141073 | PMID:17273973 | PMID:17967808 | PMID:18287559 | PMID:21124890 | PMID:21267068 | PMID:21677750 | PMID:21873635 | PMID:21991377 | PMID:22988430 |
PMID:24457600 | PMID:24604556 | PMID:24973710 | PMID:25737280 | PMID:26365490 | PMID:27113764 | PMID:27325702 | PMID:28623958 | PMID:30631038 | PMID:32325033 | PMID:32554809 | PMID:33911083 |
PMID:34264319 | PMID:35491006 | PMID:36451342 |
Cops3 (Mus musculus - house mouse) |
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COPS3 (Homo sapiens - human) |
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Cops3 (Rattus norvegicus - Norway rat) |
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Cops3 (Chinchilla lanigera - long-tailed chinchilla) |
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COPS3 (Pan paniscus - bonobo/pygmy chimpanzee) |
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COPS3 (Canis lupus familiaris - dog) |
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Cops3 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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COPS3 (Sus scrofa - pig) |
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COPS3 (Chlorocebus sabaeus - green monkey) |
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Cops3 (Heterocephalus glaber - naked mole-rat) |
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Variants in Cops3
719 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
RH124371 |
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RH137040 |
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RefSeq Transcripts | NM_001417566 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
NM_011991 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
NR_184531 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
NR_184532 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
NR_184533 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
NR_184534 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
NR_184535 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_030246025 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_036156712 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_003949446 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_004936968 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AC068808 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AF071313 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AK048906 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AK142318 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AK169747 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC068179 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSMUST00000019517 ⟹ ENSMUSP00000019517 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSMUST00000124101 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSMUST00000126489 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSMUST00000130027 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSMUST00000133652 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSMUST00000136901 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSMUST00000141415 ⟹ ENSMUSP00000120305 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSMUST00000156837 ⟹ ENSMUSP00000117288 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | NM_001417566 ⟹ NP_001404495 | ||||||||
RefSeq Status: | VALIDATED | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_011991 ⟹ NP_036121 | ||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | NR_184531 | ||||||||
RefSeq Status: | VALIDATED | ||||||||
Type: | NON-CODING | ||||||||
Position: |
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RefSeq Acc Id: | NR_184532 | ||||||||
RefSeq Status: | VALIDATED | ||||||||
Type: | NON-CODING | ||||||||
Position: |
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RefSeq Acc Id: | NR_184533 | ||||||||
RefSeq Status: | VALIDATED | ||||||||
Type: | NON-CODING | ||||||||
Position: |
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RefSeq Acc Id: | NR_184534 | ||||||||
RefSeq Status: | VALIDATED | ||||||||
Type: | NON-CODING | ||||||||
Position: |
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RefSeq Acc Id: | NR_184535 | ||||||||
RefSeq Status: | VALIDATED | ||||||||
Type: | NON-CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_030246025 ⟹ XP_030101885 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_036156712 ⟹ XP_036012605 | ||||||||
Type: | CODING | ||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XR_003949446 | ||||||||||||
Type: | NON-CODING | ||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XR_004936968 | ||||||||
Type: | NON-CODING | ||||||||
Position: |
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Sequence: |
Protein RefSeqs | NP_001404495 | (Get FASTA) | NCBI Sequence Viewer |
NP_036121 | (Get FASTA) | NCBI Sequence Viewer | |
XP_030101885 | (Get FASTA) | NCBI Sequence Viewer | |
XP_036012605 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAC33900 | (Get FASTA) | NCBI Sequence Viewer |
AAH68179 | (Get FASTA) | NCBI Sequence Viewer | |
BAC33487 | (Get FASTA) | NCBI Sequence Viewer | |
BAE25027 | (Get FASTA) | NCBI Sequence Viewer | |
BAE41343 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSMUSP00000019517 | ||
ENSMUSP00000019517.4 | |||
ENSMUSP00000117288.2 | |||
ENSMUSP00000120305.2 | |||
GenBank Protein | O88543 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_036121 ⟸ NM_011991 |
- Peptide Label: | isoform 1 |
- UniProtKB: | O88543 (UniProtKB/Swiss-Prot), Q3UQL2 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_030101885 ⟸ XM_030246025 |
- Peptide Label: | isoform X1 |
RefSeq Acc Id: | ENSMUSP00000117288 ⟸ ENSMUST00000156837 |
RefSeq Acc Id: | ENSMUSP00000019517 ⟸ ENSMUST00000019517 |
RefSeq Acc Id: | ENSMUSP00000120305 ⟸ ENSMUST00000141415 |
RefSeq Acc Id: | XP_036012605 ⟸ XM_036156712 |
- Peptide Label: | isoform X1 |
RefSeq Acc Id: | NP_001404495 ⟸ NM_001417566 |
- Peptide Label: | isoform 2 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-O88543-F1-model_v2 | AlphaFold | O88543 | 1-423 | view protein structure |
RGD ID: | 6820655 | ||||||||
Promoter ID: | MM_KWN:7667 | ||||||||
Type: | Non-CpG | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | MPROMDB | ||||||||
Tissues & Cell Lines: | Liver | ||||||||
Transcripts: | OTTMUST00000018395 | ||||||||
Position: |
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RGD ID: | 6820652 | ||||||||
Promoter ID: | MM_KWN:7671 | ||||||||
Type: | CpG-Island | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | MPROMDB | ||||||||
Tissues & Cell Lines: | 3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, Brain, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen | ||||||||
Transcripts: | OTTMUST00000018389, OTTMUST00000018390, OTTMUST00000018391, OTTMUST00000018393, OTTMUST00000018394 | ||||||||
Position: |
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RGD ID: | 8674844 | ||||||||
Promoter ID: | EPDNEW_M15453 | ||||||||
Type: | initiation region | ||||||||
Name: | Cops3_1 | ||||||||
Description: | Mus musculus COP9 signalosome subunit 3 , mRNA. | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | MGI:1349409 | AgrOrtholog |
Ensembl Genes | ENSMUSG00000019373 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Ensembl Transcript | ENSMUST00000019517 | ENTREZGENE |
ENSMUST00000019517.10 | UniProtKB/Swiss-Prot | |
ENSMUST00000141415.2 | UniProtKB/TrEMBL | |
ENSMUST00000156837.2 | UniProtKB/TrEMBL | |
Gene3D-CATH | 1.10.10.10 | UniProtKB/TrEMBL |
1.25.40.570 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
InterPro | CSN3_C | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PCI_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
WH-like_DNA-bd_sf | UniProtKB/TrEMBL | |
WH_DNA-bd_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | mmu:26572 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
MGD | MGI:1349409 | ENTREZGENE |
NCBI Gene | 26572 | ENTREZGENE |
PANTHER | 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PTHR10758:SF1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | CSN3-like_C | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PCI | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Cops3 | PhenoGen |
PROSITE | PCI | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
SMART | PINT | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Superfamily-SCOP | SSF46785 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
UniProt | CSN3_MOUSE | UniProtKB/Swiss-Prot |
D3Z036_MOUSE | UniProtKB/TrEMBL | |
F6YCA7_MOUSE | UniProtKB/TrEMBL | |
O88543 | ENTREZGENE | |
Q3TEA5_MOUSE | UniProtKB/TrEMBL | |
Q3UQL2 | ENTREZGENE, UniProtKB/TrEMBL |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2015-12-22 | Cops3 | COP9 signalosome subunit 3 | COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana) | Symbol and/or name change | 5135510 | APPROVED |