Pfn1 (profilin 1) - Rat Genome Database

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Gene: Pfn1 (profilin 1) Mus musculus
Analyze
Symbol: Pfn1
Name: profilin 1
RGD ID: 733333
MGI Page MGI
Description: Enables small GTPase binding activity. Involved in modification of postsynaptic actin cytoskeleton; modulation of chemical synaptic transmission; and synapse maturation. Acts upstream of or within neural tube closure and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; cochlea; hemolymphoid system; liver; and lung. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 18. Orthologous to human PFN1 (profilin 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: actin binding protein; P; Pfn; profilin I; profilin-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm6235  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,542,670 - 70,547,625 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,542,676 - 70,545,470 (-)EnsemblGRCm39 Ensembl
GRCm381170,651,844 - 70,656,799 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,651,850 - 70,654,644 (-)EnsemblGRCm38mm10GRCm38
MGSCv371170,465,349 - 70,468,152 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,468,044 - 70,470,830 (-)NCBIMGSCv36mm8
Celera1178,202,791 - 78,205,594 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1143.21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
ampicillin  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
beauvericin  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
captan  (EXP)
carbon nanotube  (EXP,ISO)
carmustine  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
clobetasol  (EXP)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
CU-O LINKAGE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
dihydroartemisinin  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enniatin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
flutamide  (ISO)
folic acid  (EXP)
folpet  (EXP)
FR900359  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glafenine  (ISO)
graphite  (ISO)
haloperidol  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
malathion  (ISO)
methimazole  (ISO)
methyl methanesulfonate  (ISO)
metronidazole  (ISO)
microcystin-LR  (EXP)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
neomycin  (ISO)
nicotine  (ISO)
ouabain  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
pirinixic acid  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rotenone  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sulfadimethoxine  (ISO)
T-2 toxin  (ISO)
tanespimycin  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP,ISO)
vinclozolin  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cell morphology  (IAGP)
abnormal cell nucleus morphology  (IAGP)
abnormal chondrocyte differentiation  (IAGP)
abnormal chondrocyte physiology  (IAGP)
abnormal cornea morphology  (IEA)
abnormal long bone epiphyseal plate proliferative zone  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal mitotic cytokinesis  (IAGP)
abnormal skeleton development  (IAGP)
abnormal vascular endothelial cell migration  (IAGP)
abnormal vascular wound healing  (IAGP)
anencephaly  (IAGP)
atherosclerotic lesions  (IAGP)
binucleate  (IAGP)
corneal opacity  (IEA)
decreased angiogenesis  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IEA)
decreased circulating fructosamine level  (IEA)
decreased embryo size  (IAGP)
decreased length of long bones  (IAGP)
decreased survivor rate  (IAGP)
decreased total body fat amount  (IEA)
delayed wound healing  (IAGP)
embryonic lethality before implantation, complete penetrance  (IAGP)
exencephaly  (IAGP)
fused cornea and lens  (IEA)
impaired macrophage chemotaxis  (IAGP)
improved glucose tolerance  (IEA)
incomplete rostral neuropore closure  (IAGP)
increased cell nucleus count  (IAGP)
increased circulating amylase level  (IEA)
increased circulating magnesium level  (IEA)
increased width of hypertrophic chondrocyte zone  (IAGP)
kyphoscoliosis  (IAGP)
lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
short femur  (IAGP)
short humerus  (IAGP)
weakness  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach. Gronborg M, etal., Mol Cell Proteomics. 2006 Jan;5(1):157-71. Epub 2005 Oct 8.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1968707   PMID:2717414   PMID:3356709   PMID:6457647   PMID:7720072   PMID:8449498   PMID:8861907   PMID:8889548   PMID:8975902   PMID:9196007   PMID:9463375   PMID:9507200  
PMID:9653646   PMID:10069337   PMID:10349636   PMID:10445846   PMID:10508862   PMID:11042159   PMID:11076861   PMID:11274401   PMID:11318612   PMID:11322760   PMID:11826110   PMID:12477932  
PMID:12520002   PMID:12967995   PMID:14610273   PMID:14630798   PMID:14767055   PMID:15139017   PMID:15489334   PMID:15615774   PMID:15654839   PMID:16141072   PMID:16141073   PMID:16319076  
PMID:17049405   PMID:17210567   PMID:17615372   PMID:17942408   PMID:18307411   PMID:19262563   PMID:20129697   PMID:21677750   PMID:21873635   PMID:21980262   PMID:22081137   PMID:22253883  
PMID:22693641   PMID:22773831   PMID:22864186   PMID:23000962   PMID:23246311   PMID:23576398   PMID:23845993   PMID:23884883   PMID:24006456   PMID:24200680   PMID:24385538   PMID:24457600  
PMID:24598164   PMID:24598388   PMID:24700464   PMID:24721909   PMID:24747440   PMID:25187265   PMID:25447542   PMID:25495756   PMID:25629407   PMID:26271366   PMID:26951674   PMID:26956799  
PMID:27568566   PMID:27575556   PMID:27899360   PMID:28233307   PMID:28378742   PMID:28638990   PMID:29096761   PMID:29669786   PMID:29739775   PMID:30072444   PMID:30196744   PMID:30550785  
PMID:30595499   PMID:30713523   PMID:30833597   PMID:30973865   PMID:31040226   PMID:31346562   PMID:31611772   PMID:31867667   PMID:31945017   PMID:32291804   PMID:32325033   PMID:32392277  
PMID:32444495   PMID:32554809   PMID:33162813   PMID:33184056   PMID:33599011   PMID:33601422   PMID:34133714   PMID:34478742   PMID:34571959   PMID:35428898   PMID:35628504   PMID:36114006  
PMID:36293380   PMID:36599901   PMID:37451478   PMID:37847555  


Genomics

Comparative Map Data
Pfn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,542,670 - 70,547,625 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,542,676 - 70,545,470 (-)EnsemblGRCm39 Ensembl
GRCm381170,651,844 - 70,656,799 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,651,850 - 70,654,644 (-)EnsemblGRCm38mm10GRCm38
MGSCv371170,465,349 - 70,468,152 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,468,044 - 70,470,830 (-)NCBIMGSCv36mm8
Celera1178,202,791 - 78,205,594 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1143.21NCBI
PFN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38174,945,652 - 4,948,530 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl174,945,652 - 4,949,061 (-)EnsemblGRCh38hg38GRCh38
GRCh37174,848,947 - 4,851,825 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,789,692 - 4,792,570 (-)NCBINCBI36Build 36hg18NCBI36
Build 34174,789,693 - 4,792,570NCBI
Celera174,863,758 - 4,866,636 (-)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef174,736,535 - 4,739,971 (-)NCBIHuRef
CHM1_1174,858,279 - 4,861,714 (-)NCBICHM1_1
T2T-CHM13v2.0174,836,000 - 4,838,878 (-)NCBIT2T-CHM13v2.0
Pfn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,863,882 - 55,866,587 (-)NCBIGRCr8
mRatBN7.21055,365,263 - 55,367,968 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,365,262 - 55,527,631 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1060,045,873 - 60,048,577 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,534,379 - 59,537,083 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01055,033,485 - 55,036,189 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01057,273,003 - 57,275,708 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,273,005 - 57,275,708 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01057,018,597 - 57,021,302 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,531,661 - 57,534,366 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11057,545,285 - 57,547,989 (-)NCBI
Celera1054,510,819 - 54,513,524 (-)NCBICelera
RH 3.4 Map9783.99RGD
Cytogenetic Map10q24NCBI
Pfn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546710,357,838 - 10,360,651 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546710,357,838 - 10,360,651 (-)NCBIChiLan1.0ChiLan1.0
PFN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21912,555,720 - 12,559,224 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11714,524,079 - 14,526,976 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0174,993,853 - 4,996,811 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1174,981,765 - 4,984,676 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl174,981,765 - 4,985,022 (-)Ensemblpanpan1.1panPan2
PFN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1531,670,483 - 31,671,891 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,670,194 - 31,671,895 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha531,807,352 - 31,810,011 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0531,772,763 - 31,775,424 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl531,772,755 - 31,775,415 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1531,739,303 - 31,741,962 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0531,699,008 - 31,701,668 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0531,875,384 - 31,878,044 (+)NCBIUU_Cfam_GSD_1.0
Pfn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560253,134,909 - 53,137,871 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366772,762,971 - 2,766,149 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366772,762,971 - 2,766,038 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PFN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1251,961,952 - 51,965,464 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11251,962,642 - 51,965,570 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,031,353 - 54,034,283 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PFN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,426,853 - 4,430,259 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl164,426,962 - 4,429,713 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605917,203,582 - 17,206,997 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pfn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247868,803,118 - 8,805,960 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247868,803,247 - 8,805,958 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:537
Count of miRNA genes:326
Interacting mature miRNAs:362
Transcripts:ENSMUST00000018437, ENSMUST00000108549, ENSMUST00000177669, ENSMUST00000178254
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116707819179813912Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
36049778Ars6_mantibody response to SARS-CoV 6, day 15, IgM (mouse)116899082672490826Mouse
36049779Ars7_mantibody response to SARS-CoV 7, day 29, IgG1 (mouse)116899082672490826Mouse
36049784Ars8_mantibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049785Ars9_mantibody response to SARS-CoV 9, day 29, IgM (mouse)116899082672490826Mouse
36049786Ars10_mantibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049787Ars11_mantibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse)116899082672490826Mouse
36049788Ars1_mantibody response to SARS-CoV 1, day 7, IgG1 (mouse)116899082672490826Mouse
36049789Ars2_mantibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049790Ars3_mantibody response to SARS-CoV 3, day 7, IgG2b (mouse)116899082672490826Mouse
36049791Ars4_mantibody response to SARS-CoV 4, day 7, IgG3 (mouse)116899082672490826Mouse
36049792Ars5_mantibody response to SARS-CoV 5, day 7, IgM (mouse)116899082672490826Mouse
35673314Ari2_mantibody response to influenza 2, day 10, IgG3 (mouse)116899082672490826Mouse


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ279848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK131636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL596117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV448567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX527156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR933736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY467596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000018437   ⟹   ENSMUSP00000018437
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,542,676 - 70,545,470 (-)Ensembl
GRCm38.p6 Ensembl1170,651,850 - 70,654,644 (-)Ensembl
RefSeq Acc Id: ENSMUST00000108549   ⟹   ENSMUSP00000104189
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,543,448 - 70,545,424 (-)Ensembl
GRCm38.p6 Ensembl1170,652,622 - 70,654,598 (-)Ensembl
RefSeq Acc Id: ENSMUST00000177669
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,543,438 - 70,545,434 (-)Ensembl
GRCm38.p6 Ensembl1170,652,612 - 70,654,608 (-)Ensembl
RefSeq Acc Id: ENSMUST00000178254   ⟹   ENSMUSP00000136219
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,542,765 - 70,545,447 (-)Ensembl
GRCm38.p6 Ensembl1170,651,939 - 70,654,621 (-)Ensembl
RefSeq Acc Id: NM_011072   ⟹   NP_035202
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,542,673 - 70,545,476 (-)NCBI
GRCm381170,651,847 - 70,654,650 (-)ENTREZGENE
MGSCv371170,465,349 - 70,468,152 (-)RGD
Celera1178,202,791 - 78,205,594 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030245658   ⟹   XP_030101518
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,542,670 - 70,547,625 (-)NCBI
GRCm381170,651,844 - 70,656,799 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036156422   ⟹   XP_036012315
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,542,670 - 70,547,316 (-)NCBI
Sequence:
RefSeq Acc Id: NP_035202   ⟸   NM_011072
- UniProtKB: P10924 (UniProtKB/Swiss-Prot),   P62962 (UniProtKB/Swiss-Prot),   Q3U7V7 (UniProtKB/TrEMBL),   Q5SX50 (UniProtKB/TrEMBL),   Q8CEH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030101518   ⟸   XM_030245658
- Peptide Label: isoform X1
- UniProtKB: P62962 (UniProtKB/Swiss-Prot),   P10924 (UniProtKB/Swiss-Prot),   Q5SX50 (UniProtKB/TrEMBL),   Q3U7V7 (UniProtKB/TrEMBL),   Q8CEH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000136219   ⟸   ENSMUST00000178254
RefSeq Acc Id: ENSMUSP00000104189   ⟸   ENSMUST00000108549
RefSeq Acc Id: ENSMUSP00000018437   ⟸   ENSMUST00000018437
RefSeq Acc Id: XP_036012315   ⟸   XM_036156422
- Peptide Label: isoform X1
- UniProtKB: P62962 (UniProtKB/Swiss-Prot),   P10924 (UniProtKB/Swiss-Prot),   Q5SX50 (UniProtKB/TrEMBL),   Q3U7V7 (UniProtKB/TrEMBL),   Q8CEH8 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62962-F1-model_v2 AlphaFold P62962 1-140 view protein structure

Promoters
RGD ID:6848591
Promoter ID:MM_TRO:1586
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:MTR012833.11.1483.3
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361170,466,081 - 70,467,412 (-)MPROMDB
RGD ID:6848592
Promoter ID:MM_TRO:1587
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   Kidney,   MEF_B4
Transcripts:MTR012833.11.1483.2
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361170,467,089 - 70,467,589 (-)MPROMDB
RGD ID:6821535
Promoter ID:MM_KWN:8242
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000108549,   NM_011072
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361170,467,856 - 70,468,602 (-)MPROMDB
RGD ID:8675354
Promoter ID:EPDNEW_M15707
Type:initiation region
Name:Pfn1_1
Description:Mus musculus profilin 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381170,654,635 - 70,654,695EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97549 AgrOrtholog
Ensembl Genes ENSMUSG00000018293 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000018437 ENTREZGENE
  ENSMUST00000018437.3 UniProtKB/Swiss-Prot
  ENSMUST00000108549.2 UniProtKB/TrEMBL
  ENSMUST00000178254.2 UniProtKB/TrEMBL
Gene3D-CATH Dynein light chain 2a, cytoplasmic UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PFN UniProtKB/Swiss-Prot
  PFN UniProtKB/Swiss-Prot
  PFN UniProtKB/TrEMBL
  PFN UniProtKB/TrEMBL
  PFN_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Profilin1/2/3_vertebrate UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Profilin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18643 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97549 ENTREZGENE
NCBI Gene 18643 ENTREZGENE
PANTHER PROFILIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13936:SF14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Profilin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pfn1 PhenoGen
PRINTS PROFILINMAML UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROFILIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PROF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55770 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt J3QMC2_MOUSE UniProtKB/TrEMBL
  P10924 ENTREZGENE
  P62962 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3U7V7 ENTREZGENE, UniProtKB/TrEMBL
  Q5SX49_MOUSE UniProtKB/TrEMBL
  Q5SX50 ENTREZGENE, UniProtKB/TrEMBL
  Q8CEH8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P10924 UniProtKB/Swiss-Prot