Vamp2 (vesicle-associated membrane protein 2)

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Gene: Vamp2 (vesicle-associated membrane protein 2) Mus musculus

Analyze

Symbol:

Vamp2

Name:

vesicle-associated membrane protein 2

RGD ID:

735449

MGI Page

MGI

Description:

Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human VAMP2 (vesicle associated membrane protein 2); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; vasopressin signaling pathway; vasopressin signaling pathway via receptor type 2; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

sy; Syb; Syb-; Syb-2; Syb2; sybII; synaptobrevin II; synaptobrevin-2; VAMP-2; vesicle-associated membrane 2

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	VAMP2 (vesicle associated membrane protein 2)	HGNC	Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Vamp2 (vesicle-associated membrane protein 2)	HGNC	NCBI, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Vamp2 (vesicle associated membrane protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	VAMP2 (vesicle associated membrane protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	VAMP2 (vesicle associated membrane protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Vamp2 (vesicle associated membrane protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	VAMP2 (vesicle associated membrane protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	VAMP2 (vesicle associated membrane protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Vamp2 (vesicle associated membrane protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	VAMP1 (vesicle associated membrane protein 1)	HGNC	OrthoDB
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Vamp2 (vesicle-associated membrane protein 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Homo sapiens (human):	VAMP2 (vesicle associated membrane protein 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Danio rerio (zebrafish):	vamp2 (vesicle-associated membrane protein 2)	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Caenorhabditis elegans (roundworm):	snb-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|Roundup\|TreeFam)
Saccharomyces cerevisiae (baker's yeast):	SNC1	Alliance	DIOPT (InParanoid\|OMA\|OrthoInspector\|PANTHER\|Roundup)
Saccharomyces cerevisiae (baker's yeast):	SNC2	Alliance	DIOPT (InParanoid\|OMA\|OrthoInspector\|PANTHER\|Roundup)
Drosophila melanogaster (fruit fly):	Syb	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Drosophila melanogaster (fruit fly):	nSyb	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)

Latest Assembly:

GRCm38 - Mouse Genome Assembly GRCm38

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	68,979,354 - 68,983,207 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	11	68,979,316 - 68,983,210 (+)	Ensembl
GRCm38	11	69,088,528 - 69,092,381 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	69,088,490 - 69,092,384 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	68,902,030 - 68,905,883 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	11	68,904,723 - 68,908,576 (+)	NCBI			mm8
Celera	11	76,032,081 - 76,035,943 (+)	NCBI		Celera
Cytogenetic Map	11	B3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Diamond-Blackfan anemia (ISO)

dyskeratosis congenita (ISO)

genetic disease (ISO)

Li-Fraumeni syndrome (ISO)

NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA AND AUTISTIC FEATURES WITH OR WITHOUT HYPERKINETIC MOVEMENTS (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane (ISO)

1,2-dimethylhydrazine (EXP)

17alpha-ethynylestradiol (EXP)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (EXP)

3H-1,2-dithiole-3-thione (ISO)

4,4'-diaminodiphenylmethane (EXP)

ammonium chloride (ISO)

benzo[a]pyrene (EXP,ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

buta-1,3-diene (EXP)

C60 fullerene (ISO)

capsaicin (ISO)

carbon nanotube (EXP)

cisplatin (ISO)

clozapine (ISO)

cobalt dichloride (ISO)

D-gluconic acid (ISO)

decabromodiphenyl ether (ISO)

deoxycholic acid (ISO)

dexamethasone (ISO)

diazinon (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

doxorubicin (ISO)

endosulfan (ISO)

ethanol (EXP,ISO)

gamma-tocopherol (EXP)

haloperidol (ISO)

hydrazines (EXP)

hypochlorous acid (EXP)

lead diacetate (ISO)

lead(0) (ISO)

lead(2+) (ISO)

leflunomide (ISO)

methylparaben (ISO)

nicotinamide (ISO)

paracetamol (EXP)

paraquat (ISO)

PCB138 (ISO)

pirinixic acid (EXP,ISO)

pravastatin (EXP)

propiconazole (EXP)

resveratrol (ISO)

streptozocin (ISO)

tamoxifen (EXP)

tetrachloromethane (EXP)

tetraphene (EXP)

thioacetamide (ISO)

tocopherol (EXP)

trimethylamine N-oxide (ISO)

urethane (ISO)

vinclozolin (ISO)

vincristine (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium-ion regulated exocytosis (IDA,IMP)

cellular response to insulin stimulus (IDA)

eosinophil degranulation (ISO)

exocytic insertion of neurotransmitter receptor to postsynaptic membrane (IMP,ISO)

Golgi to plasma membrane protein transport (IMP)

hormone secretion (IDA)

long-term synaptic potentiation (IMP)

membrane fusion (IMP)

mucus secretion (ISO)

natural killer cell degranulation (ISO)

neutrophil degranulation (ISO)

positive regulation of intracellular protein transport (IMP)

protein transport (ISO)

protein-containing complex assembly (ISO)

regulated exocytosis (IDA)

regulation of calcium ion-dependent exocytosis (TAS)

regulation of delayed rectifier potassium channel activity (ISO)

regulation of exocytosis (IDA,ISO)

regulation of histamine secretion by mast cell (ISO)

regulation of synaptic vesicle recycling (ISO)

regulation of vesicle-mediated transport (IMP)

response to glucose (ISO)

SNARE complex assembly (IBA,ISO)

synaptic vesicle docking (IDA,IMP)

synaptic vesicle endocytosis (IMP)

synaptic vesicle exocytosis (IMP,ISO)

vesicle fusion (IBA,ISO)

vesicle-mediated transport (ISO)

Cellular Component

cell junction (IEA)

clathrin-coated vesicle (ISO)

cytoplasm (IDA)

cytoplasmic vesicle (IDA)

cytoplasmic vesicle membrane (IDA,TAS)

integral component of membrane (IEA)

integral component of synaptic vesicle membrane (ISO)

intracellular membrane-bounded organelle (ISO)

intracellular organelle (ISO)

membrane (ISO)

neuron projection (ISO)

neuron projection terminus (ISO)

perinuclear region of cytoplasm (IDA)

plasma membrane (IBA,IDA,ISO)

secretory granule (IDA,ISO)

secretory granule membrane (ISO,TAS)

SNARE complex (IBA,IDA,ISO)

storage vacuole (IDA)

synapse (IDA)

synaptic vesicle (IDA,ISO)

synaptic vesicle membrane (IDA,ISO)

synaptobrevin 2-SNAP-25-syntaxin-1a complex (IDA,ISO)

synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex (ISO)

synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex (ISO)

trans-Golgi network (IDA)

vesicle (IDA,ISO)

voltage-gated potassium channel complex (ISO)

zymogen granule membrane (IDA)

Molecular Function

calcium-dependent protein binding (ISO)

calmodulin binding (IDA)

identical protein binding (ISO)

ion channel binding (ISO)

myosin binding (ISO)

phospholipid binding (IDA)

protein binding (IPI,ISO)

protein C-terminus binding (ISO)

protein-containing complex binding (ISO)

SNAP receptor activity (IBA)

SNARE binding (IDA,ISO)

syntaxin binding (IBA,IPI,ISO)

syntaxin-1 binding (IBA,IDA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

insulin responsive facilitative sugar transporter mediated glucose transport pathway (ISO)

insulin secretion pathway (TAS)

vasopressin signaling pathway (ISO)

vasopressin signaling pathway via receptor type 2 (IEA,ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal adrenal chromaffin cell morphology (IAGP)

abnormal CNS synaptic transmission (IAGP)

abnormal excitatory postsynaptic currents (IAGP)

abnormal excitatory postsynaptic potential (IAGP)

abnormal miniature excitatory postsynaptic currents (IAGP)

abnormal motor capabilities/coordination/movement (IAGP)

abnormal neurotransmitter secretion (IAGP)

abnormal postnatal growth/weight/body size (IAGP)

abnormal sleep pattern (IAGP)

decreased anxiety-related response (IAGP)

decreased body weight (IAGP)

decreased neurotransmitter release (IAGP)

enhanced paired-pulse facilitation (IAGP)

neonatal lethality, complete penetrance (IAGP)

neonatal lethality, incomplete penetrance (IAGP)

no abnormal phenotype detected (IAGP)

postnatal growth retardation (IAGP)

postnatal lethality (IAGP)

postnatal lethality, complete penetrance (IAGP)

prenatal lethality, incomplete penetrance (IAGP)

References

References - curated


1.	Boone M and Deen PM, Pflugers Arch. 2008 Sep;456(6):1005-24. Epub 2008 Apr 23.
2.	Larance M, etal., Mol Endocrinol. 2008 Feb;22(2):226-33. Epub 2007 Aug 23.
3.	MGD and Homologene mouse data transfer
4.	MGD data from the GO Consortium
5.	MGD IEA
6.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7.	Pin CL, etal., J Cell Biol 2001 Nov 12;155(4):519-30. Epub 2001 Nov 5.
8.	Pipeline to import KEGG annotations from KEGG into RGD
9.	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10.	RGD automated import pipeline
11.	RGD automated import pipeline for gene-chemical interactions
12.	Serikawa T, etal., Genetics 1992 Jul;131(3):701-21.
13.	Wang Z and Thurmond DC, J Cell Sci. 2009 Apr 1;122(Pt 7):893-903.
14.	Yeung RS, etal., Mamm Genome 1993;4(10):585-8.
15.	Zaid H, etal., Biochem J. 2008 Jul 15;413(2):201-15.

Additional References at PubMed

PMID:1976629	PMID:7553862	PMID:8268655	PMID:8707843	PMID:8738414	PMID:8889548	PMID:9430681	PMID:10349636	PMID:10379359	PMID:10394363	PMID:10657302	PMID:11042159
PMID:11076861	PMID:11217851	PMID:11423996	PMID:11691998	PMID:11739749	PMID:11753414	PMID:12145198	PMID:12192047	PMID:12477932	PMID:12490950	PMID:12590134	PMID:14610273
PMID:14622142	PMID:14681479	PMID:14715936	PMID:14985357	PMID:15071120	PMID:15145078	PMID:15154671	PMID:15217342	PMID:15355848	PMID:15363411	PMID:15475946	PMID:15489334
PMID:15537656	PMID:15920476	PMID:15935055	PMID:16141072	PMID:16141073	PMID:16269331	PMID:16387638	PMID:16506193	PMID:16565726	PMID:16602821	PMID:16621800	PMID:16793874
PMID:17065550	PMID:17114649	PMID:17283335	PMID:17313651	PMID:17543467	PMID:17548353	PMID:18227281	PMID:18227507	PMID:18250339	PMID:18385322	PMID:18505797	PMID:18535671
PMID:18692471	PMID:18703708	PMID:18706977	PMID:18827011	PMID:19097053	PMID:19116659	PMID:19144828	PMID:19188424	PMID:19196426	PMID:19521566	PMID:19703397	PMID:19759285
PMID:19805029	PMID:19812247	PMID:20006577	PMID:20057356	PMID:20114047	PMID:20582536	PMID:20620875	PMID:20685972	PMID:20798282	PMID:20921140	PMID:20937897	PMID:20943658
PMID:21040848	PMID:21151134	PMID:21293061	PMID:21378973	PMID:21562257	PMID:21645620	PMID:21708949	PMID:21775603	PMID:21792921	PMID:21828338	PMID:21844343	PMID:21873635
PMID:21957264	PMID:21994363	PMID:22183055	PMID:22184197	PMID:22187053	PMID:22213797	PMID:22375059	PMID:22406549	PMID:22508512	PMID:22661231	PMID:22946563	PMID:23077667
PMID:23136435	PMID:23141539	PMID:23178715	PMID:23385584	PMID:23395379	PMID:23460677	PMID:23638301	PMID:23791195	PMID:24120845	PMID:24356748	PMID:24469400	PMID:24488208
PMID:24705552	PMID:24744148	PMID:24794856	PMID:24944211	PMID:25071457	PMID:25374362	PMID:25438880	PMID:25501368	PMID:25855187	PMID:25959820	PMID:26153704	PMID:26209658
PMID:26290230	PMID:26387718	PMID:26412491	PMID:26496610	PMID:26572858	PMID:26585489	PMID:26663078	PMID:26854222	PMID:26871701	PMID:27256505	PMID:27292642	PMID:27325702
PMID:27343350	PMID:27358447	PMID:27466336	PMID:27534441	PMID:27713690	PMID:28945220	PMID:29056747	PMID:29288152	PMID:29773651	PMID:30012692	PMID:30144509	PMID:30275816
PMID:30868103	PMID:31160536	PMID:31216055	PMID:31536487	PMID:32098978	PMID:32325033	PMID:32616842

Genomics

Comparative Map Data

Vamp2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	68,979,354 - 68,983,207 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	11	68,979,316 - 68,983,210 (+)	Ensembl
GRCm38	11	69,088,528 - 69,092,381 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	69,088,490 - 69,092,384 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	68,902,030 - 68,905,883 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	11	68,904,723 - 68,908,576 (+)	NCBI			mm8
Celera	11	76,032,081 - 76,035,943 (+)	NCBI		Celera
Cytogenetic Map	11	B3	NCBI

VAMP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	17	8,159,149 - 8,163,546 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	17	8,159,147 - 8,162,948 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	17	8,062,465 - 8,066,266 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	8,003,189 - 8,007,017 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	17	8,003,188 - 8,007,017	NCBI
Celera	17	8,089,806 - 8,093,640 (-)	NCBI
Cytogenetic Map	17	p13.1	NCBI
HuRef	17	7,957,475 - 7,960,724 (-)	NCBI		HuRef
CHM1_1	17	8,071,269 - 8,075,097 (-)	NCBI		CHM1_1

Vamp2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	53,793,581 - 53,797,815 (+)	NCBI
Rnor_6.0 Ensembl	10	55,675,575 - 55,679,450 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	10	55,675,171 - 55,679,405 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	10	55,418,231 - 55,422,465 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	55,848,264 - 55,852,132 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	10	55,861,886 - 55,865,753 (+)	NCBI
Celera	10	52,959,486 - 52,963,354 (+)	NCBI		Celera
Cytogenetic Map	10	q24	NCBI

Vamp2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955467	8,793,296 - 8,796,771 (+)	NCBI	ChiLan1.0	ChiLan1.0

VAMP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	17	48,228,253 - 48,231,948 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	17	43,495,464 - 43,499,348 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

VAMP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	32,975,372 - 32,977,967 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Vamp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936595	1,385,692 - 1,389,484 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

VAMP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	12	53,378,407 - 53,382,243 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	55,853,614 - 55,857,435 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

VAMP2
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	7,539,098 - 7,542,466 (-)	NCBI

Vamp2
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624786	10,723,791 - 10,727,654 (-)	NCBI

Position Markers

Vamp2

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	11	B3	UniSTS
cM Map	11		UniSTS

QTLs in Region (GRCm38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
26884453	Sklq16_m	skull length QTL 16, 16 week (mouse)					11	3300000	72800000	Mouse
13208559	Wght10_m	weight 10 (mouse)					11	4000000	89000000	Mouse
13208558	Lgth12_m	body length 12 (mouse)					11	4000000	95000000	Mouse
1300905	Scc6_m	colon tumor susceptibility 6 (mouse)			Not determined		11	6930277	89128908	Mouse
1559002	Lmrq4_m	Leishmania major resistance QTL 4 (mouse)			Not determined		11	12318637	69794121	Mouse
1357859	Lvrq7_m	liver weight QTL 7 (mouse)			Not determined		11	12318637	118131898	Mouse
39128214	Lwq20_m	liver weight QTL 20 (mouse)					11	12318637	118131898	Mouse
4141894	Nidd6k_m	Nidd6 on KK-A (mouse)			Not determined			19174204	97007000	Mouse
10412246	Dfs2_m	dental fluorosis suseptibility 2 (mouse)			Not determined		11	21857364	95990405	Mouse
1357782	Char8_m	P. chabaudi malaria resistance QTL 8 (mouse)			Not determined		11	35687789	69794161	Mouse
13208569	Bmiq10_m	body mass index QTL 10 (mouse)					11	36000000	85000000	Mouse
1301328	Mol4_m	modifier of LPS-response 4 (mouse)			Not determined		11	36391750	83590530	Mouse
1301788	Lbw8_m	lupus NZB x NZW 8 (mouse)			Not determined		11	36612460	70618665	Mouse
1301896	Tria1_m	T-cell receptor induced activation 1 (mouse)			Not determined		11	36722738	70723028	Mouse
4141853	Skmw17_m	skeletal muscle weight 17 (mouse)			Not determined		11	37190115	71190238	Mouse
10766457	Nwa3_m	New Zealand White autoimmunity 3 (mouse)					11	38125289	72125383	Mouse
11532698	Sluc36a_m	susceptibility to lung cancer 36a (mouse)					11	42365791	76365904	Mouse
11532699	Sluc36b_m	susceptibility to lung cancer 36b (mouse)					11	42365791	76365904	Mouse
4142300	Ctrq3_m	C. trachomatis resistance QTL 3 (mouse)			Not determined		11	44739211	76963931	Mouse
4141367	Inf1_m	acute ozone induced inflammation (mouse)			Not determined			44739211	113167183	Mouse
4141000	Nidd3_m	non-insulin-dependent diabetes mellitus 3 (mouse)			Not determined			45151201	79151308	Mouse
1302021	Nidd1n_m	non-insulin-dependent diabetes mellitus 1 in NSY (mouse)			Not determined		11	45275046	80087498	Mouse
1357878	Mastr_m	modifier of astrocytoma (mouse)			Not determined		11	45817754	89927907	Mouse
1300765	Bbaa4_m	B.burgdorferi-associated arthritis 4 (mouse)			Not determined		11	46294341	80294436	Mouse
1301988	Bmd11_m	bone mineral density 11 (mouse)			Not determined		11	46428581	80428696	Mouse
1301830	Ssta4_m	susceptibility to Salmonella typhimurium antigens 4 (mouse)			Not determined		11	50187365	84187585	Mouse
13524840	Ppiq9a_m	prepulse inhibition QTL 9a (mouse)					11	52603559	86603559	Mouse
1300774	Pgia7_m	proteoglycan induced arthritis 7 (mouse)			Not determined		11	53499762	87499911	Mouse
4141830	Pregq1_m	pregnancy QTL 1 (mouse)			Not determined		11	54235926	83842826	Mouse
4141875	Etax9_m	ethanol induced ataxia 9 (mouse)			Not determined			55394159	72319101	Mouse
4142121	Tmc1m2_m	Tmc1 modifier 2 (mouse)			Not determined		11	56973201	114267131	Mouse
1300664	Etohcta9_m	ethanol conditioned taste aversion 9 (mouse)			Not determined		11	57863834	91863932	Mouse
10053682	Eae45_m	experimental allergic encephalomyelitis susceptibility 45 (mouse)			Not determined		11	58599729	74863932	Mouse
1300924	Ity2_m	immunity to S. typhimurium 2 (mouse)			Not determined		1	58617204	87804412	Mouse
4141982	Skts-fp2_m	skin tumor susceptibility in FVB and PWK 2 (mouse)			Not determined			58828440	85175703	Mouse
11532697	Sluc36_m	susceptibility to lung cancer 36 (mouse)					11	59365791	69591873	Mouse
1301987	Pid3_m	prior incubation determinant 3 (mouse)			Not determined		11	61795994	88808902	Mouse
1301319	Dautb4_m	dopamine uptake transporter binding 4 (mouse)			Not determined		11	62265179	96265327	Mouse
27226730	Tibmd1_m	tibia midshaft diameter 1, 5 week (mouse)					11	62700000	109500000	Mouse
1301999	Lmr15_m	leishmaniasis resistance 15 (mouse)			Not determined		11	63428581	81939647	Mouse
10044004	Stzid3_m	streptozotocin induced diabetes susceptibility 3 (mouse)			Not determined		11	63428581	94173092	Mouse
11039501	Ltpr6a_m	Leishmania tropica response 6a (mouse)					11	64939510	98939647	Mouse
11039502	Ltpr6b_m	Leishmania tropica response 6b (mouse)					11	64939510	98939647	Mouse
11039515	Ltpr6_m	Leishmania tropica response 6 (mouse)					11	64939510	98939647	Mouse
1301546	Pcir2_m	periosteal circumference 2 (mouse)			Not determined		11	66842594	100842826	Mouse
1357766	Si5lq6_m	serum IGFBP-5 level QTL 6 (mouse)			Not determined		11	66842594	100842826	Mouse
4141012	Femwf6_m	femur work to failure 6 (mouse)			Not determined			66842594	100842826	Mouse
1301833	Tbbmd5_m	total body bone mineral density 5 (mouse)			Not determined		11	66842594	100842826	Mouse
1300784	Prdt3_m	prion disease incubation time 3 (mouse)			Not determined		11	66842594	100842826	Mouse
1300628	Lgth6_m	body length 6 (mouse)			Not determined		11	66842594	100842826	Mouse
4142316	Ity2b_m	immunity to S. typhimurium 2b (mouse)			Not determined		11	67187365	79923086	Mouse
27226783	Tibl5_m	tibia length 5, 5 week (mouse)					11	68300000	102000000	Mouse

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1660
Count of miRNA genes:	662
Interacting mature miRNAs:	828
Transcripts:	ENSMUST00000021273, ENSMUST00000117780, ENSMUST00000146847, ENSMUST00000149559, ENSMUST00000149780
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_009497	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF007168	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK090178	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL645527	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC039745	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC055105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466601	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U60150	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000021273 ⟹ ENSMUSP00000021273

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	11	69,088,490 - 69,092,384 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000117780 ⟹ ENSMUSP00000112611

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	11	69,088,510 - 69,090,690 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000146847

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	11	69,089,606 - 69,090,176 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000149559

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	11	69,088,543 - 69,090,050 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000149780

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	11	69,088,522 - 69,089,675 (+)	Ensembl

RefSeq Acc Id:

NM_009497 ⟹ NP_033523

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	11	68,979,354 - 68,983,207 (+)	NCBI
GRCm38	11	69,088,528 - 69,092,381 (+)	ENTREZGENE
MGSCv37	11	68,902,030 - 68,905,883 (+)	RGD
Celera	11	76,032,081 - 76,035,943 (+)	RGD
cM Map	11		ENTREZGENE

Sequence:

show sequence

AGTCCCGGGTAGCCAGCGCCAGTCGGAGCCAGCGCGAGCCGCCGCCGCCGCCGTCGCCGTCACT
GCCTCTGCCAAGTCCACTGCCCGCTACCCCCGCCATGTCGGCTACCGCTGCCACCGTCCCGCCT
GCCGCCCCGGCCGGCGAGGGTGGCCCCCCTGCACCTCCTCCAAACCTTACTAGTAACAGGAGAC
TGCAGCAGACCCAGGCCCAGGTGGATGAGGTGGTGGACATCATGAGGGTGAATGTGGACAAGGT
CCTGGAGCGGGACCAGAAGTTGTCGGAGCTGGATGACCGTGCAGATGCCCTCCAGGCAGGGGCC
TCCCAGTTTGAAACAAGTGCAGCCAAGCTCAAGCGCAAATACTGGTGGAAAAACCTCAAGATGA
TGATCATCTTGGGAGTGATCTGCGCCATCATCCTCATCATCATCATCGTTTACTTCAGCACTTA
AATCCCTGAGGAGTCTGCCCTGCCTAAGAAGGGCCTCTCCCCCACCCCCAGCCGTTCCTCCACC
TCTCAGCCATATCTTTCAGCCCCCTCCCTTGGATCCGTGTGTGTGTGTGTGTCCGTGTGTGTGC
CCCCTGTAAATAGCCAGCTGTTATTTATACATATATAATATTATATATATTTGGTCTGTTTGTA
GTTTTATTACTAGAAGATTTTTTCCGGTTGTCCTTAACACCCCTTCCTGAGGTTCCCATCACCT
CTCTCTCACCCTCTGTCCCTTTTCCTCTTTCCTGATCAGCCCCAAGTCCCTTCATTTGCATCTG
CTATGCAATAGCCCCTCTCCTCCTTCCCTTGGATTTAACCGATCTTTCCCTTATCTTCCCTGTA
CAATCCCAGGCCCTCCCAAAACAAAAGCAAACCCCACAGAAACAAACAGAACACCCCACCTGTC
TAGGCTTCCCTAGGCTGCATCTTTGTATCCCTTGGGAGGCTCTGAGACTGGTTCCACTTGGTCC
TAAGAATCCCAAGATTTTCTGGGAGCTTCCAACATGTTGATTAGCATATCATTTGCATACGCTG
TCTGTTTCATTTTGTTTTGTTTGTTAGTTTTTTGTTTCCTTTCTGATCCATCACTCTTCACTCT
TCTGTGTTTTTTCTTTCTTTCTTTTCGGAAGAGTCAGTCTCCATTGGTCCTCTTACCACACTTT
TATTAGCACGACATTATCTGCAGGTGGTGGGGAGTCTGGACTTTTGGGGAACCAGGCTGCTCTG
GACCCCAAGGTTTCCTCCTCCCAACCCCTCTAGTCTAGTTTGCTTCCCTTACCCCGTTTCCCAC
ACCTCTTGTACCCTCCTCTCCCTCCCCCAGCTGGTGTGTAAGTGTCTTGGAGTTCAGTGTGTTA
TGATGGACCAATAATTCTGCCACTCGGGGTCTCTCCCTACATTCCTGCTCCCCAGTTTTCATGT
GGGGCACTCAACTGACATTCCCAGGGGGTCTCGCTCCCTCCCATCTGCCTGATCTGCTGCCTCC
TCCCATCAGGAGAACTGGGGGCCGACCACAATCTGGTTCTTTGAGGAGGGGTGGCTCCAGTGTG
TGGGGGTCATCACTGCCTTGGGGAGGAGTGGGACAAAACAGAATCCCCCTAATTCCTGCCTGAA
GTCTCTGGCCTCATCCTTGCTAGAGGTTCGACTGAAAACTTTCCTCCCCAGTCTGGGGGGGGGG
TATTACCCCCATCACTGCCCAGCTCCTCTGACTGCCCCCCTGTATTCAGGGTGGGGGTACTAGT
CACTGCCAATATGTGTTGGGACTTGCTGGAGGATGGGGATCCTCGTCCTTCTCCAGGGCTGTTG
AGCCCAGAGAGAGAGAGTGTGAGAGAGAAAGCAAGCTATTTCCTTGTTGAGTACAATGATAGAG
GAAGGATCTAATCTTTTTAAATGGCACAGTTTTAGGGATCTGAGGGTACAGCCCCTTAACCTGC
CTTGGGGGGGGTTGTTCCCCAAACTCTTGCCCCCCACACACCAGGTTTTCTGTGTGGAGGGGAA
CCAAGGAGATCTAAACTGTGGTGTGAAAGGGTAGGAGAGATGCTGGGGGTGGGGGTGCTTGTGT
TTTAGACCCCCAATATTATCCCAGTGTCCCCTGCCTTCCTTCTTCCCCTGCCCCATGCCCCCAA
TTCTGTGGCGCATCCAGATTGTGAAAATGTACAATAAACGTGTAATGAGTAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_033523	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB03463	(Get FASTA)	NCBI Sequence Viewer
	AAB62931	(Get FASTA)	NCBI Sequence Viewer
	AAH39745	(Get FASTA)	NCBI Sequence Viewer
	AAH55105	(Get FASTA)	NCBI Sequence Viewer
	BAC41125	(Get FASTA)	NCBI Sequence Viewer
	EDL10477	(Get FASTA)	NCBI Sequence Viewer
	P63044	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_033523 ⟸ NM_009497
- UniProtKB:	P63044 (UniProtKB/Swiss-Prot), Q8CHR4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSATAATVPPAAPAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVLERDQKLSELD DRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVICAIILIIIIVYFST hide sequence

RefSeq Acc Id:

ENSMUSP00000021273 ⟸ ENSMUST00000021273

RefSeq Acc Id:

ENSMUSP00000112611 ⟸ ENSMUST00000117780

Protein Domains

v-SNARE coiled-coil homology

Promoters

RGD ID:

6822434

Promoter ID:

MM_KWN:8030

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B6, Spleen

Transcripts:

ENSMUST00000117780, OTTMUST00000013340, OTTMUST00000013342, OTTMUST00000013343, OTTMUST00000013344

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	11	68,902,056 - 68,903,347 (+)	MPROMDB

RGD ID:

8675144

Promoter ID:

EPDNEW_M15603

Type:

initiation region

Name:

Vamp2_1

Description:

Mus musculus vesicle-associated membrane protein 2 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	11	69,088,528 - 69,088,588	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1313277	AgrOrtholog
Ensembl Genes	ENSMUSG00000020894	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000021273	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUSP00000112611	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000021273	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUST00000117780	UniProtKB/TrEMBL
InterPro	Synaptobrevin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Synaptobrevin/VAMP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	V_SNARE_CC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VAMP2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:22318	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:1313277	ENTREZGENE
NCBI Gene	22318	ENTREZGENE
PANTHER	PTHR45701	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR45701:SF5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Synaptobrevin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Vamp2	PhenoGen
PIRSF	Synaptobrevin_euk	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	SYNAPTOBREVN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	SYNAPTOBREVIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	V_SNARE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	B0QZN5_MOUSE	UniProtKB/TrEMBL
	O35619_MOUSE	UniProtKB/TrEMBL
	P63044	ENTREZGENE
	Q8CHR4	ENTREZGENE, UniProtKB/TrEMBL
	VAMP2_MOUSE	UniProtKB/Swiss-Prot
UniProt Secondary	Q64357	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)