Vamp2 (vesicle-associated membrane protein 2) - Rat Genome Database
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Gene: Vamp2 (vesicle-associated membrane protein 2) Mus musculus
Analyze
Symbol: Vamp2
Name: vesicle-associated membrane protein 2
RGD ID: 735449
MGI Page MGI
Description: Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human VAMP2 (vesicle associated membrane protein 2); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; vasopressin signaling pathway; vasopressin signaling pathway via receptor type 2; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: sy; Syb; Syb-; Syb-2; Syb2; sybII; synaptobrevin II; synaptobrevin-2; VAMP-2; vesicle-associated membrane 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391168,979,354 - 68,983,207 (+)NCBIGRCm39mm39
GRCm39 Ensembl1168,979,316 - 68,983,210 (+)Ensembl
GRCm381169,088,528 - 69,092,381 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,088,490 - 69,092,384 (+)EnsemblGRCm38mm10GRCm38
MGSCv371168,902,030 - 68,905,883 (+)NCBIGRCm37mm9NCBIm37
MGSCv361168,904,723 - 68,908,576 (+)NCBImm8
Celera1176,032,081 - 76,035,943 (+)NCBICelera
Cytogenetic Map11B3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:1976629   PMID:7553862   PMID:8268655   PMID:8707843   PMID:8738414   PMID:8889548   PMID:9430681   PMID:10349636   PMID:10379359   PMID:10394363   PMID:10657302   PMID:11042159  
PMID:11076861   PMID:11217851   PMID:11423996   PMID:11691998   PMID:11739749   PMID:11753414   PMID:12145198   PMID:12192047   PMID:12477932   PMID:12490950   PMID:12590134   PMID:14610273  
PMID:14622142   PMID:14681479   PMID:14715936   PMID:14985357   PMID:15071120   PMID:15145078   PMID:15154671   PMID:15217342   PMID:15355848   PMID:15363411   PMID:15475946   PMID:15489334  
PMID:15537656   PMID:15920476   PMID:15935055   PMID:16141072   PMID:16141073   PMID:16269331   PMID:16387638   PMID:16506193   PMID:16565726   PMID:16602821   PMID:16621800   PMID:16793874  
PMID:17065550   PMID:17114649   PMID:17283335   PMID:17313651   PMID:17543467   PMID:17548353   PMID:18227281   PMID:18227507   PMID:18250339   PMID:18385322   PMID:18505797   PMID:18535671  
PMID:18692471   PMID:18703708   PMID:18706977   PMID:18827011   PMID:19097053   PMID:19116659   PMID:19144828   PMID:19188424   PMID:19196426   PMID:19521566   PMID:19703397   PMID:19759285  
PMID:19805029   PMID:19812247   PMID:20006577   PMID:20057356   PMID:20114047   PMID:20582536   PMID:20620875   PMID:20685972   PMID:20798282   PMID:20921140   PMID:20937897   PMID:20943658  
PMID:21040848   PMID:21151134   PMID:21293061   PMID:21378973   PMID:21562257   PMID:21645620   PMID:21708949   PMID:21775603   PMID:21792921   PMID:21828338   PMID:21844343   PMID:21873635  
PMID:21957264   PMID:21994363   PMID:22183055   PMID:22184197   PMID:22187053   PMID:22213797   PMID:22375059   PMID:22406549   PMID:22508512   PMID:22661231   PMID:22946563   PMID:23077667  
PMID:23136435   PMID:23141539   PMID:23178715   PMID:23385584   PMID:23395379   PMID:23460677   PMID:23638301   PMID:23791195   PMID:24120845   PMID:24356748   PMID:24469400   PMID:24488208  
PMID:24705552   PMID:24744148   PMID:24794856   PMID:24944211   PMID:25071457   PMID:25374362   PMID:25438880   PMID:25501368   PMID:25855187   PMID:25959820   PMID:26153704   PMID:26209658  
PMID:26290230   PMID:26387718   PMID:26412491   PMID:26496610   PMID:26572858   PMID:26585489   PMID:26663078   PMID:26854222   PMID:26871701   PMID:27256505   PMID:27292642   PMID:27325702  
PMID:27343350   PMID:27358447   PMID:27466336   PMID:27534441   PMID:27713690   PMID:28945220   PMID:29056747   PMID:29288152   PMID:29773651   PMID:30012692   PMID:30144509   PMID:30275816  
PMID:30868103   PMID:31160536   PMID:31216055   PMID:31536487   PMID:32098978   PMID:32325033   PMID:32616842  


Genomics

Comparative Map Data
Vamp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391168,979,354 - 68,983,207 (+)NCBIGRCm39mm39
GRCm39 Ensembl1168,979,316 - 68,983,210 (+)Ensembl
GRCm381169,088,528 - 69,092,381 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,088,490 - 69,092,384 (+)EnsemblGRCm38mm10GRCm38
MGSCv371168,902,030 - 68,905,883 (+)NCBIGRCm37mm9NCBIm37
MGSCv361168,904,723 - 68,908,576 (+)NCBImm8
Celera1176,032,081 - 76,035,943 (+)NCBICelera
Cytogenetic Map11B3NCBI
VAMP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl178,159,149 - 8,163,546 (-)EnsemblGRCh38hg38GRCh38
GRCh38178,159,147 - 8,162,948 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37178,062,465 - 8,066,266 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36178,003,189 - 8,007,017 (-)NCBINCBI36hg18NCBI36
Build 34178,003,188 - 8,007,017NCBI
Celera178,089,806 - 8,093,640 (-)NCBI
Cytogenetic Map17p13.1NCBI
HuRef177,957,475 - 7,960,724 (-)NCBIHuRef
CHM1_1178,071,269 - 8,075,097 (-)NCBICHM1_1
Vamp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21053,793,581 - 53,797,815 (+)NCBI
Rnor_6.0 Ensembl1055,675,575 - 55,679,450 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01055,675,171 - 55,679,405 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01055,418,231 - 55,422,465 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41055,848,264 - 55,852,132 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11055,861,886 - 55,865,753 (+)NCBI
Celera1052,959,486 - 52,963,354 (+)NCBICelera
Cytogenetic Map10q24NCBI
Vamp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554678,793,296 - 8,796,771 (+)NCBIChiLan1.0ChiLan1.0
VAMP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11748,228,253 - 48,231,948 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01743,495,464 - 43,499,348 (+)NCBIMhudiblu_PPA_v0panPan3
VAMP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,975,372 - 32,977,967 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Vamp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365951,385,692 - 1,389,484 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VAMP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11253,378,407 - 53,382,243 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,853,614 - 55,857,435 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VAMP2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,539,098 - 7,542,466 (-)NCBI
Vamp2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478610,723,791 - 10,727,654 (-)NCBI

Position Markers
Vamp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B3UniSTS
cM Map11 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11330000072800000Mouse
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111231863769794121Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113568778969794161Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113661246070618665Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113672273870723028Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113719011571190238Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113812528972125383Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114236579176365904Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114236579176365904Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114473921176963931Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4141000Nidd3_mnon-insulin-dependent diabetes mellitus 3 (mouse)Not determined4515120179151308Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114527504680087498Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5539415972319101Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115859972974863932Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15861720487804412Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5882844085175703Mouse
11532697Sluc36_msusceptibility to lung cancer 36 (mouse)115936579169591873Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116179599488808902Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116226517996265327Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116342858181939647Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116342858194173092Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116493951098939647Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116493951098939647Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116493951098939647Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166842594100842826Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166842594100842826Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66842594100842826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166842594100842826Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166842594100842826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166842594100842826Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116718736579923086Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168300000102000000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1660
Count of miRNA genes:662
Interacting mature miRNAs:828
Transcripts:ENSMUST00000021273, ENSMUST00000117780, ENSMUST00000146847, ENSMUST00000149559, ENSMUST00000149780
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000021273   ⟹   ENSMUSP00000021273
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1169,088,490 - 69,092,384 (+)Ensembl
RefSeq Acc Id: ENSMUST00000117780   ⟹   ENSMUSP00000112611
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1169,088,510 - 69,090,690 (+)Ensembl
RefSeq Acc Id: ENSMUST00000146847
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1169,089,606 - 69,090,176 (+)Ensembl
RefSeq Acc Id: ENSMUST00000149559
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1169,088,543 - 69,090,050 (+)Ensembl
RefSeq Acc Id: ENSMUST00000149780
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1169,088,522 - 69,089,675 (+)Ensembl
RefSeq Acc Id: NM_009497   ⟹   NP_033523
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391168,979,354 - 68,983,207 (+)NCBI
GRCm381169,088,528 - 69,092,381 (+)ENTREZGENE
MGSCv371168,902,030 - 68,905,883 (+)RGD
Celera1176,032,081 - 76,035,943 (+)RGD
cM Map11 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033523   ⟸   NM_009497
- UniProtKB: P63044 (UniProtKB/Swiss-Prot),   Q8CHR4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000021273   ⟸   ENSMUST00000021273
RefSeq Acc Id: ENSMUSP00000112611   ⟸   ENSMUST00000117780
Promoters
RGD ID:6822434
Promoter ID:MM_KWN:8030
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B6,   Spleen
Transcripts:ENSMUST00000117780,   OTTMUST00000013340,   OTTMUST00000013342,   OTTMUST00000013343,   OTTMUST00000013344
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361168,902,056 - 68,903,347 (+)MPROMDB
RGD ID:8675144
Promoter ID:EPDNEW_M15603
Type:initiation region
Name:Vamp2_1
Description:Mus musculus vesicle-associated membrane protein 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381169,088,528 - 69,088,588EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1313277 AgrOrtholog
Ensembl Genes ENSMUSG00000020894 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000021273 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000112611 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000021273 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000117780 UniProtKB/TrEMBL
InterPro Synaptobrevin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Synaptobrevin/VAMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V_SNARE_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VAMP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22318 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1313277 ENTREZGENE
NCBI Gene 22318 ENTREZGENE
PANTHER PTHR45701 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45701:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Synaptobrevin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Vamp2 PhenoGen
PIRSF Synaptobrevin_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS SYNAPTOBREVN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SYNAPTOBREVIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V_SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B0QZN5_MOUSE UniProtKB/TrEMBL
  O35619_MOUSE UniProtKB/TrEMBL
  P63044 ENTREZGENE
  Q8CHR4 ENTREZGENE, UniProtKB/TrEMBL
  VAMP2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q64357 UniProtKB/Swiss-Prot