Stat5a (signal transducer and activator of transcription 5A) - Rat Genome Database

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Gene: Stat5a (signal transducer and activator of transcription 5A) Mus musculus
Symbol: Stat5a
Name: signal transducer and activator of transcription 5A
RGD ID: 11351
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and phosphate ion binding activity. Involved in growth hormone receptor signaling pathway via JAK-STAT and regulation of growth. Acts upstream of or within several processes, including positive regulation of leukocyte proliferation; regulation of hemopoiesis; and reproductive structure development. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and liver and biliary system. Orthologous to human STAT5A (signal transducer and activator of transcription 5A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AA959963; mammary gland factor STAT5A; STA; STAT5
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3911100,750,177 - 100,775,995 (+)NCBIGRCm39mm39
GRCm39 Ensembl11100,750,177 - 100,775,995 (+)Ensembl
GRCm3811100,859,351 - 100,885,169 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,859,351 - 100,885,169 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711100,720,665 - 100,746,483 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611100,675,494 - 100,701,259 (+)NCBImm8
MGSCv3611101,635,936 - 101,661,700 (+)NCBImm8
Cytogenetic Map11DNCBI
cM Map1163.77NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(S)-nicotine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4-hydroxynon-2-enal  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpinumisoflavone  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
benzoates  (EXP)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bromocriptine  (EXP)
calcitriol  (ISO)
chelerythrine  (ISO)
cholesterol  (EXP)
cisplatin  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
dichloromethane  (EXP)
diethylstilbestrol  (EXP,ISO)
Diisodecyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
estriol  (EXP)
fluorescein 5-isothiocyanate  (EXP)
Garcinol  (ISO)
genistein  (EXP)
gentamycin  (ISO)
Goe 6976  (EXP,ISO)
immunological adjuvant  (ISO)
isoprenaline  (EXP)
lipopolysaccharide  (EXP,ISO)
melatonin  (EXP)
metam  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methylphenidate  (EXP)
mycophenolic acid  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
nicotinic acid  (ISO)
nitric oxide  (EXP)
paracetamol  (EXP,ISO)
pevonedistat  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphane  (ISO)
piperine  (EXP)
pirinixic acid  (EXP)
ponatinib  (ISO)
progesterone  (EXP,ISO)
prostaglandin F2alpha  (ISO)
quizartinib  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
sorafenib  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
titanium dioxide  (EXP)
tofacitinib  (EXP,ISO)
toluene  (EXP)
toluene 2,4-diisocyanate  (EXP)
trichostatin A  (EXP)
troglitazone  (ISO)
tungsten  (EXP)
valproic acid  (EXP,ISO)
vitamin E  (ISO)
zearalenone  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activated T cell proliferation  (IDA,IGI)
B cell differentiation  (IGI)
cell population proliferation  (IDA,IGI)
cellular response to cytokine stimulus  (ISO)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (IDA)
cellular response to organic cyclic compound  (ISO)
cytokine-mediated signaling pathway  (IBA,IDA)
defense response  (IBA)
development of secondary female sexual characteristics  (IMP)
development of secondary male sexual characteristics  (IGI,IMP)
epithelial cell differentiation involved in prostate gland development  (IMP)
erythrocyte differentiation  (IGI)
female pregnancy  (IGI)
gamma-delta T cell differentiation  (IGI)
growth hormone receptor signaling pathway via JAK-STAT  (IBA,IDA)
lactation  (IMP,ISO)
lipid storage  (IGI)
luteinization  (IGI)
lymphocyte differentiation  (IGI)
mammary gland development  (IMP)
mammary gland epithelium development  (IGI,IMP)
mammary gland involution  (ISO)
mast cell apoptotic process  (IMP)
mast cell differentiation  (IMP)
mast cell proliferation  (IMP)
mitotic cell cycle  (IGI)
multicellular organismal reproductive process  (ISO)
myeloid cell apoptotic process  (IGI)
natural killer cell differentiation  (IGI,IMP)
natural killer cell mediated cytotoxicity  (IMP)
negative regulation of erythrocyte differentiation  (IGI)
negative regulation of mast cell apoptotic process  (IMP)
negative regulation of myeloid cell apoptotic process  (IGI)
peptidyl-tyrosine phosphorylation  (IDA)
Peyer's patch development  (IGI)
positive regulation of activated T cell proliferation  (IDA,IGI)
positive regulation of B cell differentiation  (IGI)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cell population proliferation  (IDA,IGI)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of gamma-delta T cell differentiation  (IGI)
positive regulation of inflammatory response  (IGI)
positive regulation of interleukin-2 production  (IGI)
positive regulation of lymphocyte differentiation  (IGI)
positive regulation of mast cell differentiation  (IMP)
positive regulation of mast cell proliferation  (IMP)
positive regulation of mitotic cell cycle  (IGI)
positive regulation of multicellular organism growth  (IGI)
positive regulation of natural killer cell differentiation  (IMP)
positive regulation of natural killer cell mediated cytotoxicity  (IMP)
positive regulation of T cell proliferation  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP)
prostate gland epithelium morphogenesis  (IMP)
receptor signaling pathway via JAK-STAT  (IBA,IDA,ISO)
reelin-mediated signaling pathway  (ISO)
regulation of cell adhesion  (IMP)
regulation of cell population proliferation  (IBA)
regulation of DNA-templated transcription  (IEA)
regulation of epithelial cell differentiation  (IMP)
regulation of multicellular organism growth  (IGI)
regulation of steroid metabolic process  (IGI)
regulation of transcription by RNA polymerase II  (IBA,IDA,IGI)
response to ethanol  (ISO)
response to nutrient levels  (ISO)
response to peptide hormone  (IBA,IDA)
signal transduction  (IEA)
T cell differentiation in thymus  (IGI)
T cell homeostasis  (IGI)
T cell proliferation  (IMP)
taurine metabolic process  (IGI)
transcription by RNA polymerase II  (IGI,IMP,ISO)

Cellular Component
cytoplasm  (IDA,ISO)
cytosol  (ISO,TAS)
nucleoplasm  (ISO,TAS)
nucleus  (IDA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal acute inflammation  (IAGP)
abnormal branching of the mammary ductal tree  (IAGP)
abnormal CD4-positive T cell differentiation  (IAGP)
abnormal fat pad morphology  (IAGP)
abnormal leukocyte morphology  (IAGP)
abnormal leukopoiesis  (IAGP)
abnormal liver physiology  (IAGP)
abnormal lymphopoiesis  (IAGP)
abnormal mammary gland alveolus morphology  (IAGP)
abnormal mammary gland development  (IAGP)
abnormal mammary gland epithelium physiology  (IAGP)
abnormal mammary gland growth during lactation  (IAGP)
abnormal mammary gland growth during pregnancy  (IAGP)
abnormal mammary gland physiology  (IAGP)
abnormal mast cell differentiation  (IAGP)
abnormal mast cell morphology  (IAGP)
abnormal mast cell physiology  (IAGP)
abnormal milk ejection  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal neutrophil differentiation  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal proerythroblast morphology  (IAGP)
abnormal prostate gland epithelium morphology  (IAGP)
abnormal prostate gland physiology  (IAGP)
abnormal regulatory T cell physiology  (IAGP)
abnormal T cell subpopulation ratio  (IAGP)
absent mast cells  (IAGP)
anemia  (IAGP)
anisocytosis  (IAGP)
decreased body length  (IAGP)
decreased body weight  (IAGP)
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased cell proliferation  (IAGP)
decreased circulating insulin-like growth factor I level  (IAGP)
decreased corpora lutea number  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased erythroid progenitor cell number  (IAGP)
decreased hematocrit  (IAGP)
decreased hemoglobin content  (IAGP)
decreased insulin secretion  (IAGP)
decreased lean body mass  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased mast cell number  (IAGP)
decreased mean corpuscular hemoglobin  (IAGP)
decreased monocyte cell number  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased NK cell number  (IAGP)
decreased oxygen consumption  (IAGP)
decreased pancreatic beta cell mass  (IAGP)
decreased pancreatic beta cell proliferation  (IAGP)
decreased serotonin level  (IAGP)
decreased splenocyte number  (IAGP)
decreased T cell number  (IAGP)
decreased T cell proliferation  (IAGP)
disorganized pancreatic islets  (IAGP)
enlarged spleen  (IAGP)
female infertility  (IAGP)
hypochromic microcytic anemia  (IAGP)
impaired adaptive thermogenesis  (IAGP)
impaired glucose tolerance  (IAGP)
impaired natural killer cell mediated cytotoxicity  (IAGP)
increased apoptosis  (IAGP)
increased circulating free fatty acids level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating interleukin-17 level  (IAGP)
increased circulating iron level  (IAGP)
increased circulating leptin level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased interleukin-17 secretion  (IAGP)
increased lean body mass  (IAGP)
increased liver iron level  (IAGP)
increased mammary gland apoptosis  (IAGP)
increased neutrophil cell number  (IAGP)
increased percent body fat/body weight  (IAGP)
increased red blood cell distribution width  (IAGP)
increased T cell apoptosis  (IAGP)
increased total body fat amount  (IAGP)
increased total fat pad weight  (IAGP)
insulin resistance  (IAGP)
lactation failure  (IAGP)
microcytosis  (IAGP)
no abnormal phenotype detected  (IAGP)
obese  (IAGP)
poikilocytosis  (IAGP)
polyphagia  (IAGP)
premature death  (IAGP)
prostate gland cyst  (IAGP)
reticulocytosis  (IAGP)

References - curated
# Reference Title Reference Citation
1. STAT 5a expression in various lesions of the breast. Bratthauer GL, etal., Virchows Arch. 2006 Feb;448(2):165-71. Epub 2005 Aug 19.
2. Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis. Farouk S, etal., PLoS One. 2018 Oct 22;13(10):e0206130. doi: 10.1371/journal.pone.0206130. eCollection 2018.
3. Activation of the Jak/Stat signal transduction pathway in GH-treated rat osteoblast-like cells in culture. Gerland K, etal., Mol Cell Endocrinol. 2000 Oct 25;168(1-2):1-9.
4. Identification of immune checkpoint inhibitors and biomarkers among STAT family in stomach adenocarcinoma. Guo L, etal., Am J Transl Res. 2020 Sep 15;12(9):4977-4997. eCollection 2020.
5. STAT5A/B gene locus undergoes amplification during human prostate cancer progression. Haddad BR, etal., Am J Pathol. 2013 Jun;182(6):2264-75. doi: 10.1016/j.ajpath.2013.02.044. Epub 2013 May 7.
6. Enhanced Hsa-miR-181d/p-STAT3 and Hsa-miR-181d/p-STAT5A Ratios Mediate the Anticancer Effect of Garcinol in STAT3/5A-Addicted Glioblastoma. Liu HW, etal., Cancers (Basel). 2019 Nov 27;11(12). pii: cancers11121888. doi: 10.3390/cancers11121888.
7. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
8. MGDs mouse GO annotations MGD data from the GO Consortium
10. Role of ERalpha in the differential response of Stat5a loss in susceptibility to mammary preneoplasia and DMBA-induced carcinogenesis. Miermont AM, etal., Carcinogenesis. 2010 Jun;31(6):1124-31. doi: 10.1093/carcin/bgq048. Epub 2010 Feb 24.
11. The JAK-STAT signaling pathway: input and output integration. Murray PJ J Immunol. 2007 Mar 1;178(5):2623-9.
12. De-regulated STAT5A/miR-202-5p/USP15/Caspase-6 regulatory axis suppresses CML cell apoptosis and contributes to Imatinib resistance. Nie ZY, etal., J Exp Clin Cancer Res. 2020 Jan 17;39(1):17. doi: 10.1186/s13046-019-1502-7.
13. Proliferation and apoptosis in PhIP-induced rat mammary gland carcinomas with elevated phosphotyrosine-STAT5a. Papaconstantinou AD and Snyderwine EG, FEBS Lett. 2007 Jan 9;581(1):29-33. Epub 2006 Dec 5.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. Loss of Stat5a delays mammary cancer progression in a mouse model. Ren S, etal., Oncogene. 2002 Jun 20;21(27):4335-9.
17. Mouse MP Annotation Import Pipeline RGD automated import pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Possible role of Stat5a in rat mammary gland carcinogenesis. Shan L, etal., Breast Cancer Res Treat. 2004 Dec;88(3):263-72.
20. cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenzanthracene. Shan L, etal., Carcinogenesis. 2002 Oct;23(10):1561-8.
21. Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. Shan L, etal., Toxicol Pathol. 2005;33(7):768-75.
22. Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice. Shi SY, etal., J Biol Chem. 2017 Mar 3;292(9):3789-3799. doi: 10.1074/jbc.M116.752519. Epub 2017 Jan 18.
23. Mammary gland factor activated by prolactin on mammary epithelial cells and acute-phase response factor activated by interleukin-6 in liver cells share DNA binding and transactivation potential. Standke GJ, etal., Mol Endocrinol. 1994 Apr;8(4):469-77. doi: 10.1210/mend.8.4.7519723.
24. Modulation of signal transducers and activators of transcription (STAT) factor pathways during focal cerebral ischaemia: a gene expression array study in rat hippocampus after middle cerebral artery occlusion. Sun SL, etal., Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1097-101.
25. STAT5A Modulates Chemokine Receptor CCR6 Expression and Enhances Pre-B Cell Growth in a CCL20-Dependent Manner. Tsuruyama T, etal., J Cell Biochem. 2016 Nov;117(11):2630-42. doi: 10.1002/jcb.25558. Epub 2016 Apr 14.
26. STAT5 signaling is required for the efficient induction and maintenance of CML in mice. Ye D, etal., Blood. 2006 Jun 15;107(12):4917-25. doi: 10.1182/blood-2005-10-4110. Epub 2006 Mar 7.
Additional References at PubMed
PMID:7537213   PMID:7568026   PMID:7720707   PMID:8530075   PMID:8631883   PMID:8665851   PMID:8702683   PMID:8816482   PMID:8977232   PMID:9009201   PMID:9240457   PMID:9292509  
PMID:9390692   PMID:9528750   PMID:9630227   PMID:9751123   PMID:9841868   PMID:9841920   PMID:9852045   PMID:9874248   PMID:9887329   PMID:10066807   PMID:10072077   PMID:10200816  
PMID:10349636   PMID:10399365   PMID:10428030   PMID:10485656   PMID:10485657   PMID:10486277   PMID:10486314   PMID:10490100   PMID:10526573   PMID:10547072   PMID:10652277   PMID:10666213  
PMID:10675904   PMID:10713694   PMID:10743504   PMID:10781830   PMID:10835485   PMID:10844592   PMID:10851049   PMID:10851055   PMID:10851057   PMID:10908145   PMID:10979977   PMID:11013085  
PMID:11030348   PMID:11042159   PMID:11067862   PMID:11076861   PMID:11133161   PMID:11161808   PMID:11217851   PMID:11254359   PMID:11290598   PMID:11342429   PMID:11706048   PMID:11756158  
PMID:11981045   PMID:12040017   PMID:12048235   PMID:12147240   PMID:12198240   PMID:12217382   PMID:12220225   PMID:12388746   PMID:12393407   PMID:12393611   PMID:12421978   PMID:12456807  
PMID:12466851   PMID:12477932   PMID:12496367   PMID:12496402   PMID:12540601   PMID:12574125   PMID:12586844   PMID:12615921   PMID:12634107   PMID:12649593   PMID:12704203   PMID:12714518  
PMID:12753872   PMID:12835478   PMID:12860560   PMID:12901872   PMID:12952963   PMID:12954634   PMID:12954715   PMID:12970402   PMID:14500638   PMID:14522949   PMID:14605098   PMID:14607901  
PMID:14627821   PMID:14634095   PMID:14645506   PMID:14646587   PMID:14660670   PMID:14662325   PMID:14676278   PMID:14681479   PMID:14759523   PMID:15016718   PMID:15037546   PMID:15067053  
PMID:15069015   PMID:15070672   PMID:15102857   PMID:15294943   PMID:15304355   PMID:15322148   PMID:15340066   PMID:15353555   PMID:15354294   PMID:15358227   PMID:15471942   PMID:15498858  
PMID:15516974   PMID:15579639   PMID:15611091   PMID:15618518   PMID:15634877   PMID:15652752   PMID:15677453   PMID:15677477   PMID:15713743   PMID:15746188   PMID:15749913   PMID:15778369  
PMID:15782199   PMID:15863494   PMID:15870688   PMID:15899943   PMID:15947484   PMID:15967678   PMID:15980098   PMID:15983196   PMID:15998795   PMID:16025120   PMID:16141072   PMID:16141073  
PMID:16143305   PMID:16167341   PMID:16174761   PMID:16192273   PMID:16273100   PMID:16289036   PMID:16293218   PMID:16293640   PMID:16365403   PMID:16418296   PMID:16418573   PMID:16457814  
PMID:16493008   PMID:16532027   PMID:16569768   PMID:16596634   PMID:16602821   PMID:16650827   PMID:16757175   PMID:16775227   PMID:16887981   PMID:16920984   PMID:16973758   PMID:17003334  
PMID:17035345   PMID:17082570   PMID:17122075   PMID:17158201   PMID:17182563   PMID:17182565   PMID:17187062   PMID:17218386   PMID:17220171   PMID:17227828   PMID:17227909   PMID:17244351  
PMID:17244679   PMID:17317776   PMID:17356133   PMID:17360981   PMID:17363300   PMID:17372307   PMID:17382296   PMID:17447893   PMID:17462911   PMID:17485440   PMID:17504935   PMID:17510323  
PMID:17511959   PMID:17536022   PMID:17547694   PMID:17554063   PMID:17599554   PMID:17617599   PMID:17640063   PMID:17664008   PMID:17666591   PMID:17710127   PMID:17716968   PMID:17726024  
PMID:17728251   PMID:17884938   PMID:17911616   PMID:17938255   PMID:17951529   PMID:17976521   PMID:17981124   PMID:18024957   PMID:18209038   PMID:18239084   PMID:18246197   PMID:18259195  
PMID:18276757   PMID:18286195   PMID:18287559   PMID:18292815   PMID:18342552   PMID:18424709   PMID:18424770   PMID:18456388   PMID:18460645   PMID:18464116   PMID:18492722   PMID:18499741  
PMID:18549798   PMID:18552213   PMID:18585098   PMID:18648510   PMID:18694996   PMID:18820682   PMID:18838617   PMID:18945591   PMID:18981157   PMID:19010462   PMID:19139262   PMID:19165346  
PMID:19234178   PMID:19258595   PMID:19269284   PMID:19332876   PMID:19345670   PMID:19414010   PMID:19417088   PMID:19494234   PMID:19500160   PMID:19571317   PMID:19605693   PMID:19647226  
PMID:19651644   PMID:19666510   PMID:19710468   PMID:19734904   PMID:19779039   PMID:19788420   PMID:19796718   PMID:19797429   PMID:19833766   PMID:19946273   PMID:19949423   PMID:20005840  
PMID:20008792   PMID:20028972   PMID:20059953   PMID:20075866   PMID:20118929   PMID:20133448   PMID:20161778   PMID:20162728   PMID:20188141   PMID:20201032   PMID:20231889   PMID:20235097  
PMID:20360400   PMID:20385773   PMID:20412781   PMID:20508164   PMID:20547543   PMID:20644163   PMID:20669261   PMID:20696842   PMID:20699217   PMID:20717961   PMID:20720003   PMID:20823455  
PMID:20849614   PMID:20881248   PMID:20966351   PMID:20974963   PMID:21036145   PMID:21041952   PMID:21084450   PMID:21127177   PMID:21169989   PMID:21178171   PMID:21217760   PMID:21262836  
PMID:21267068   PMID:21278738   PMID:21356387   PMID:21368206   PMID:21427222   PMID:21431790   PMID:21457934   PMID:21464042   PMID:21494231   PMID:21514445   PMID:21525287   PMID:21525380  
PMID:21541329   PMID:21542777   PMID:21593872   PMID:21606506   PMID:21677750   PMID:21688337   PMID:21725989   PMID:21731673   PMID:21772264   PMID:21785216   PMID:21873635   PMID:21911423  
PMID:21949021   PMID:22031092   PMID:22086418   PMID:22130676   PMID:22144185   PMID:22158971   PMID:22199350   PMID:22228679   PMID:22234689   PMID:22271576   PMID:22279106   PMID:22284677  
PMID:22318729   PMID:22319210   PMID:22389215   PMID:22402124   PMID:22446627   PMID:22455944   PMID:22496812   PMID:22520852   PMID:22581861   PMID:22588720   PMID:22678904   PMID:22711600  
PMID:22775396   PMID:22789541   PMID:22829284   PMID:22854263   PMID:22930452   PMID:22969412   PMID:22988430   PMID:22993203   PMID:23033267   PMID:23149921   PMID:23263556   PMID:23275557  
PMID:23313770   PMID:23340136   PMID:23435120   PMID:23438599   PMID:23440411   PMID:23453633   PMID:23565285   PMID:23610142   PMID:23631823   PMID:23696567   PMID:23727894   PMID:23797472  
PMID:23852341   PMID:23871207   PMID:24006458   PMID:24014651   PMID:24030252   PMID:24069548   PMID:24091328   PMID:24157859   PMID:24166977   PMID:24263804   PMID:24277936   PMID:24284627  
PMID:24309470   PMID:24367002   PMID:24367028   PMID:24376517   PMID:24463518   PMID:24469394   PMID:24497923   PMID:24586582   PMID:24678731   PMID:24749073   PMID:24821571   PMID:24821775  
PMID:24952961   PMID:24954415   PMID:25013898   PMID:25092144   PMID:25117410   PMID:25236432   PMID:25333229   PMID:25333863   PMID:25412660   PMID:25456130   PMID:25468562   PMID:25470773  
PMID:25550197   PMID:25579133   PMID:25596282   PMID:25642823   PMID:25691498   PMID:25769613   PMID:25801432   PMID:25821217   PMID:25826077   PMID:25885255   PMID:25896118   PMID:26159175  
PMID:26195811   PMID:26308771   PMID:26338970   PMID:26426795   PMID:26446995   PMID:26582580   PMID:26603207   PMID:26695351   PMID:26702099   PMID:26710253   PMID:26764350   PMID:26876184  
PMID:26976954   PMID:26999798   PMID:27046463   PMID:27074708   PMID:27077371   PMID:27131881   PMID:27260000   PMID:27276245   PMID:27417725   PMID:27436361   PMID:27485735   PMID:27494686  
PMID:27578791   PMID:27651463   PMID:27748374   PMID:27816761   PMID:27858140   PMID:27870635   PMID:27879203   PMID:28009300   PMID:28067668   PMID:28074064   PMID:28096407   PMID:28104302  
PMID:28278176   PMID:28344041   PMID:28390194   PMID:28500076   PMID:28606561   PMID:28798028   PMID:28806763   PMID:28916644   PMID:28930659   PMID:28982698   PMID:29042402   PMID:29078395  
PMID:29105654   PMID:29111497   PMID:29203513   PMID:29223399   PMID:29330306   PMID:29346554   PMID:29460051   PMID:29463562   PMID:29535264   PMID:29579399   PMID:29581031   PMID:29650953  
PMID:29728568   PMID:29794014   PMID:29921584   PMID:30081710   PMID:30377054   PMID:30571750   PMID:30662340   PMID:30664665   PMID:30671064   PMID:30679796   PMID:30779881   PMID:30930146  
PMID:30948494   PMID:31366244   PMID:31494175   PMID:31591503   PMID:31599926   PMID:31756168   PMID:31806625   PMID:32024640   PMID:32103006   PMID:32207362   PMID:32281944   PMID:32332067  
PMID:32350523   PMID:32446558   PMID:32473405   PMID:32748326   PMID:32985505   PMID:33000513   PMID:33199496   PMID:33326784   PMID:33334814   PMID:33490088   PMID:34453440   PMID:34526724  
PMID:34564702   PMID:34743736   PMID:34773997   PMID:34818373   PMID:34929316   PMID:34934004   PMID:35148200   PMID:35156727   PMID:35440032   PMID:35464049  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3911100,750,177 - 100,775,995 (+)NCBIGRCm39mm39
GRCm39 Ensembl11100,750,177 - 100,775,995 (+)Ensembl
GRCm3811100,859,351 - 100,885,169 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,859,351 - 100,885,169 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711100,720,665 - 100,746,483 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611100,675,494 - 100,701,259 (+)NCBImm8
MGSCv3611101,635,936 - 101,661,700 (+)NCBImm8
Cytogenetic Map11DNCBI
cM Map1163.77NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381742,287,547 - 42,311,943 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1742,287,547 - 42,311,943 (+)EnsemblGRCh38hg38GRCh38
GRCh371740,439,565 - 40,463,961 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,693,091 - 37,717,484 (+)NCBINCBI36hg18NCBI36
Build 341737,693,090 - 37,717,484NCBI
Celera1737,094,449 - 37,118,845 (+)NCBI
Cytogenetic Map17q21.2NCBI
HuRef1736,204,247 - 36,228,642 (+)NCBIHuRef
CHM1_11740,675,279 - 40,699,663 (+)NCBICHM1_1
T2T-CHM13v2.01743,144,034 - 43,168,430 (+)NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21085,785,537 - 85,809,869 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1085,785,537 - 85,809,866 (+)Ensembl
Rnor_6.01088,764,732 - 88,789,060 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,764,732 - 88,789,057 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,558,936 - 88,583,264 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,795,404 - 89,819,732 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11089,809,773 - 89,834,099 (+)NCBI
Celera1084,503,376 - 84,527,708 (+)NCBICelera
Cytogenetic Map10q31NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_00495545116,305,363 - 16,319,219 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11715,228,465 - 15,251,783 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,228,465 - 15,251,783 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01715,005,025 - 15,029,110 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1920,616,041 - 20,638,523 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,617,151 - 20,638,103 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,077,547 - 20,099,955 (-)NCBI
ROS_Cfam_1.0921,335,685 - 21,357,957 (-)NCBI
ROS_Cfam_1.0 Ensembl921,288,139 - 21,357,497 (-)Ensembl
UMICH_Zoey_3.1920,120,814 - 20,142,574 (-)NCBI
UNSW_CanFamBas_1.0920,387,762 - 20,409,305 (-)NCBI
UU_Cfam_GSD_1.0920,490,411 - 20,512,845 (-)NCBI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1220,474,227 - 20,499,138 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,474,221 - 20,498,785 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21224,563,982 - 24,581,115 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11663,959,265 - 63,986,627 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,960,515 - 63,985,026 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607734,770,565 - 34,795,956 (-)NCBIVero_WHO_p1.0

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811100,884,090 - 100,884,254UniSTSGRCm38
MGSCv3711100,745,404 - 100,745,568UniSTSGRCm37
Cytogenetic Map11DUniSTS
cM Map1160.5UniSTS
Whitehead_YAC11 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811100,884,976 - 100,885,073UniSTSGRCm38
MGSCv3711100,746,290 - 100,746,387UniSTSGRCm37
Cytogenetic Map11DUniSTS
cM Map1160.5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811100,885,415 - 100,885,657UniSTSGRCm38
MGSCv3711100,746,729 - 100,746,971UniSTSGRCm37
Cytogenetic Map11DUniSTS
cM Map1160.5UniSTS
cM Map1160.5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811100,884,090 - 100,884,195UniSTSGRCm38
MGSCv3711100,745,404 - 100,745,509UniSTSGRCm37
Cytogenetic Map11DUniSTS
cM Map1160.5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387129,395,110 - 129,395,808UniSTSGRCm38
GRCm3811100,877,780 - 100,878,942UniSTSGRCm38
MGSCv3711100,739,094 - 100,740,256UniSTSGRCm37
MGSCv377136,538,624 - 136,539,322UniSTSGRCm37
Celera7129,219,988 - 129,220,686UniSTS
Cytogenetic Map11DUniSTS
cM Map1160.5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11DUniSTS

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1941
Count of miRNA genes:641
Interacting mature miRNAs:809
Transcripts:ENSMUST00000004145, ENSMUST00000107356, ENSMUST00000107357, ENSMUST00000133036, ENSMUST00000135272, ENSMUST00000138083, ENSMUST00000154087
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Nucleotide Sequences
RefSeq Transcripts NM_001164062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001362680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017314402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA718536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF049104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF246978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ237938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY299491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY299492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC056647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY277646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY478099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ815793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU249543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U21103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U36502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z48538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000004145   ⟹   ENSMUSP00000004145
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11100,750,177 - 100,775,995 (+)Ensembl
GRCm38.p6 Ensembl11100,859,351 - 100,885,169 (+)Ensembl
RefSeq Acc Id: ENSMUST00000107356   ⟹   ENSMUSP00000102979
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11100,750,482 - 100,775,995 (+)Ensembl
GRCm38.p6 Ensembl11100,859,656 - 100,885,169 (+)Ensembl
RefSeq Acc Id: ENSMUST00000107357   ⟹   ENSMUSP00000102980
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11100,751,310 - 100,775,994 (+)Ensembl
GRCm38.p6 Ensembl11100,860,484 - 100,885,168 (+)Ensembl
RefSeq Acc Id: ENSMUST00000133036   ⟹   ENSMUSP00000117204
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11100,750,236 - 100,752,573 (+)Ensembl
GRCm38.p6 Ensembl11100,859,410 - 100,861,747 (+)Ensembl
RefSeq Acc Id: ENSMUST00000135272
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11100,769,845 - 100,770,933 (+)Ensembl
GRCm38.p6 Ensembl11100,879,019 - 100,880,107 (+)Ensembl
RefSeq Acc Id: ENSMUST00000138083   ⟹   ENSMUSP00000120039
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11100,751,171 - 100,754,046 (+)Ensembl
GRCm38.p6 Ensembl11100,860,345 - 100,863,220 (+)Ensembl
RefSeq Acc Id: ENSMUST00000154087
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11100,751,311 - 100,768,134 (+)Ensembl
GRCm38.p6 Ensembl11100,860,485 - 100,877,308 (+)Ensembl
RefSeq Acc Id: NM_001164062   ⟹   NP_001157534
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm3911100,751,310 - 100,775,995 (+)NCBI
GRCm3811100,860,484 - 100,885,169 (+)NCBI
MGSCv3711100,720,665 - 100,746,483 (+)RGD
RefSeq Acc Id: NM_001362680   ⟹   NP_001349609
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm3911100,750,482 - 100,775,995 (+)NCBI
GRCm3811100,859,656 - 100,885,169 (+)NCBI
RefSeq Acc Id: NM_011488   ⟹   NP_035618
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm3911100,750,177 - 100,775,995 (+)NCBI
GRCm3811100,859,351 - 100,885,169 (+)NCBI
MGSCv3711100,720,665 - 100,746,483 (+)RGD
RefSeq Acc Id: XM_006532721   ⟹   XP_006532784
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm3911100,751,029 - 100,775,995 (+)NCBI
GRCm3811100,860,201 - 100,885,169 (+)NCBI
RefSeq Acc Id: XM_017314402   ⟹   XP_017169891
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm3911100,751,437 - 100,775,995 (+)NCBI
GRCm3811100,860,609 - 100,885,169 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_035618   ⟸   NM_011488
- Peptide Label: isoform 1
- UniProtKB: P42230 (UniProtKB/Swiss-Prot),   Q3UZ79 (UniProtKB/TrEMBL),   Q9JIA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157534   ⟸   NM_001164062
- Peptide Label: isoform 2
- UniProtKB: B2C3G8 (UniProtKB/TrEMBL),   Q3UZ79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006532784   ⟸   XM_006532721
- Peptide Label: isoform X1
- UniProtKB: P42230 (UniProtKB/Swiss-Prot),   Q9JIA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017169891   ⟸   XM_017314402
- Peptide Label: isoform X1
- UniProtKB: P42230 (UniProtKB/Swiss-Prot),   Q9JIA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001349609   ⟸   NM_001362680
- Peptide Label: isoform 1
RefSeq Acc Id: ENSMUSP00000120039   ⟸   ENSMUST00000138083
RefSeq Acc Id: ENSMUSP00000117204   ⟸   ENSMUST00000133036
RefSeq Acc Id: ENSMUSP00000102979   ⟸   ENSMUST00000107356
RefSeq Acc Id: ENSMUSP00000102980   ⟸   ENSMUST00000107357
RefSeq Acc Id: ENSMUSP00000004145   ⟸   ENSMUST00000004145
Protein Domains
SH2   STAT_alpha   STAT_bind   STAT_int

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P42230-F1-model_v2 AlphaFold P42230 1-793 view protein structure

RGD ID:6822248
Promoter ID:MM_KWN:9824
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   Liver
Transcripts:ENSMUST00000107356,   OTTMUST00000004310,   OTTMUST00000004313
Mouse AssemblyChrPosition (strand)Source
MGSCv3611100,720,494 - 100,720,994 (+)MPROMDB
RGD ID:6822247
Promoter ID:MM_KWN:9825
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000107357,   NM_001164062,   OTTMUST00000004314,   UC007LMN.1
Mouse AssemblyChrPosition (strand)Source
MGSCv3611100,721,051 - 100,721,957 (+)MPROMDB
RGD ID:6822251
Promoter ID:MM_KWN:9827
SO ACC ID:SO:0000170
Tissues & Cell Lines:BoneMarrow_4Hour
Mouse AssemblyChrPosition (strand)Source
MGSCv3611100,740,431 - 100,740,931 (+)MPROMDB
RGD ID:6846914
Promoter ID:MM_ACW:8917
SO ACC ID:SO:0000170
Tissues & Cell Lines:BoneMarrow_4Hour
Mouse AssemblyChrPosition (strand)Source
MGSCv3611100,741,531 - 100,742,031 (+)MPROMDB
RGD ID:8676742
Promoter ID:EPDNEW_M16401
Type:initiation region
Description:Mus musculus signal transducer and activator of transcription5A , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm3811100,860,463 - 100,860,523EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103036 AgrOrtholog
Ensembl Genes ENSMUSG00000004043 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000004145 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000102979 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000102980.3 UniProtKB/TrEMBL
  ENSMUSP00000117204.2 UniProtKB/TrEMBL
  ENSMUSP00000120039.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000004145 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000107356 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000107357.4 UniProtKB/TrEMBL
  ENSMUST00000133036.8 UniProtKB/TrEMBL
  ENSMUST00000138083.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.532.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT5a/5b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_coiled-coil UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_DNA-bd_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_prot_interaction UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20850 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR11801 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11801:SF47 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_int UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Stat5a PhenoGen
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_int UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47655 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48092 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STA5A_MOUSE UniProtKB/Swiss-Prot