Gene: Htr2c (5-hydroxytryptamine (serotonin) receptor 2C) Mus musculus
Analyze
Symbol:
Htr2c
Name:
5-hydroxytryptamine (serotonin) receptor 2C
Description:
Exhibits G protein-coupled serotonin receptor activity. Involved in several processes, including behavioral fear response; phospholipase C-activating G protein-coupled receptor signaling pathway; and positive regulation of fat cell differentiation. Predicted to localize to the dendrite; external side of plasma membrane; and integral component of plasma membrane. Used to study Prader-Willi syndrome and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in bipolar disorder; obesity; and schizophrenia. Is expressed in several structures, including brain; exocrine gland; large intestine; testis; and thymus. Orthologous to human HTR2C (5-hydroxytryptamine receptor 2C).
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HT2C receptor; 5-HT2cR; 5-HTR2C; 5-hydroxytryptamine receptor 1C; 5-hydroxytryptamine receptor 2C; 5HT1c; Htr1c; serotonin receptor 2C; SR1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
HTR2C (5-hydroxytryptamine receptor 2C) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):
Htr2c (5-hydroxytryptamine receptor 2C) HGNC
EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Htr2c (5-hydroxytryptamine receptor 2C) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
HTR2C (5-hydroxytryptamine receptor 2C) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
HTR2C (5-hydroxytryptamine receptor 2C) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Htr2c (5-hydroxytryptamine receptor 2C) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
HTR2C (5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
HTR2C (5-hydroxytryptamine receptor 2C) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Htr2c (5-hydroxytryptamine receptor 2C) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Htr2c (5-hydroxytryptamine receptor 2C)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Homo sapiens (human):
HTR2C (5-hydroxytryptamine receptor 2C)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
htr2cl2 (5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 2)
Alliance
DIOPT (OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
htr2cl1 (5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, TreeFam)
Drosophila melanogaster (fruit fly):
5-HT2A
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
ser-1
Alliance
DIOPT (Ensembl Compara, InParanoid, OrthoFinder, PhylomeDB, Roundup)
Drosophila melanogaster (fruit fly):
5-HT2B
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, PhylomeDB)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 Ensembl X 146,962,513 - 147,197,277 (+) Ensembl GRCm38 X 146,962,464 - 147,197,277 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 X 143,397,056 - 143,631,820 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 X 142,208,881 - 142,443,644 (+) NCBI mm8 Celera X 130,902,904 - 131,136,225 (+) NCBI Celera Cytogenetic Map X F2 NCBI cM Map X 68.46 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
autistic disorder ISO RGD:736842 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:21681106 , PMID:30208311 osteoporosis ISO RGD:736842 8554872 ClinVar Annotator: match by term: Bone mineral density quantitative trait locus 18 ClinVar PMID:24088041 , PMID:26633545 prostate cancer ISO RGD:736842 8554872 ClinVar Annotator: match by term: Prostate cancer ClinVar PMID:23265383 schizophrenia ISO RGD:736842 8554872 ClinVar Annotator: match by term: Schizophrenia ClinVar PMID:21681106 , PMID:30208311 syndromic X-linked intellectual disability Lubs type ISO RGD:736842 8554872 ClinVar Annotator: match by term: MECP2 duplication syndrome ClinVar PMID:25741868
Imported Annotations - CTD
Hyperkinesis ISO RGD:736842 11554173 CTD Direct Evidence: therapeutic CTD PMID:19347958 Metabolic Syndrome ISO RGD:736842 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17632216 more ... Neuralgia ISO RGD:736842 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28011743 obesity ISO RGD:736842 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17702092 , PMID:19142110 Weight Gain ISO RGD:736842 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19434072 , PMID:19997080 withdrawal disorder ISO RGD:736842 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17105947 Imported Annotations - MGI
Prader-Willi syndrome IEA 13592920 OMIM:176270 MouseDO type 2 diabetes mellitus IEA 13592920 OMIM:125853 more ... MouseDO
(+)-pilocarpine multiple interactions ISO RGD:2848 6480464 Carbamazepine inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]] more ... CTD PMID:19439326 , PMID:19700373 (+)-pilocarpine increases expression ISO RGD:2848 6480464 Pilocarpine results in increased expression of HTR2C mRNA, Pilocarpine results in increased expression of HTR2C protein CTD PMID:19700373 (+)-pilocarpine decreases expression ISO RGD:2848 6480464 Pilocarpine results in decreased expression of HTR2C mRNA, Pilocarpine results in decreased expression of HTR2C protein CTD PMID:19439326 1-(3-chlorophenyl)piperazine multiple interactions EXP 6480464 [1-(3-chlorophenyl)piperazine binds to and results in increased activity of HTR2C protein] which results in increased susceptibility to Cocaine CTD PMID:10541732 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile affects binding ISO RGD:736842 6480464 Citalopram binds to HTR2C protein CTD PMID:18083778 1-bromopropane increases expression ISO RGD:2848 6480464 1-bromopropane results in increased expression of HTR2C mRNA CTD PMID:19576243 17beta-estradiol affects expression ISO RGD:2848 6480464 Estradiol affects the expression of HTR2C mRNA CTD PMID:12008023 17beta-estradiol increases expression ISO RGD:2848 6480464 Estradiol results in increased expression of HTR2C mRNA CTD PMID:20068009 17beta-estradiol multiple interactions ISO RGD:2848 6480464 [Estradiol co-treated with Sertraline] affects the expression of HTR2C mRNA, Estradiol promotes the reaction [Sertraline results in increased expression of HTR2C mRNA] CTD PMID:18650020 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:2848 6480464 Tetrachlorodibenzodioxin results in increased expression of HTR2C mRNA CTD PMID:23871856 2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine affects binding ISO RGD:736842 6480464 4-iodo-2, 5-dimethoxyphenylisopropylamine binds to HTR2C protein CTD PMID:9857084 2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine multiple interactions ISO RGD:736842 6480464 1-(8-bromobenzo(1 more ... CTD PMID:9857084 2-chloro-6-(1-piperazinyl)pyrazine multiple interactions ISO RGD:2848 6480464 6-chloro-2-(1-piperazinyl)pyrazine binds to and results in increased activity of HTR2C protein CTD PMID:16521035 2-chloro-6-(1-piperazinyl)pyrazine multiple interactions EXP 6480464 [6-chloro-2-(1-piperazinyl)pyrazine binds to and results in increased activity of HTR2C protein] which results in increased susceptibility to Cocaine CTD PMID:10541732 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:2848 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of HTR2C protein CTD PMID:26068050 3,4-methylenedioxymethamphetamine multiple interactions ISO RGD:736842 6480464 N-Methyl-3, 4-methylenedioxyamphetamine inhibits the reaction [mesulergine binds to HTR2C protein] CTD PMID:29458138 6-propyl-2-thiouracil increases expression ISO RGD:2848 6480464 Propylthiouracil results in increased expression of HTR2C mRNA CTD PMID:24780913 , PMID:25825206 aflatoxin B1 affects expression ISO RGD:736842 6480464 Aflatoxin B1 affects the expression of HTR2C protein CTD PMID:20106945 aflatoxin B1 increases methylation ISO RGD:736842 6480464 Aflatoxin B1 results in increased methylation of HTR2C intron CTD PMID:30157460 aflatoxin B1 decreases methylation ISO RGD:736842 6480464 Aflatoxin B1 results in decreased methylation of HTR2C gene CTD PMID:27153756 agomelatine affects binding ISO RGD:736842 6480464 S 20098 analog binds to HTR2C protein, S 20098 binds to HTR2C protein CTD PMID:22301214 all-trans-retinoic acid decreases expression ISO RGD:736842 6480464 Tretinoin results in decreased expression of HTR2C mRNA CTD PMID:21934132 amitriptyline affects binding ISO RGD:736842 6480464 Amitriptyline binds to HTR2C protein CTD PMID:18083778 ammonium chloride affects expression ISO RGD:2848 6480464 Ammonium Chloride affects the expression of HTR2C mRNA CTD PMID:16483693 aripiprazole multiple interactions ISO RGD:736842 6480464 Aripiprazole binds to and affects the activity of HTR2C protein CTD PMID:21823597 arsenite(3-) increases methylation ISO RGD:736842 6480464 arsenite results in increased methylation of HTR2C promoter CTD PMID:23974009 atrazine affects methylation ISO RGD:2848 6480464 Atrazine affects the methylation of HTR2C gene CTD PMID:28931070 bis(2-chloroethyl) sulfide increases expression EXP 6480464 Mustard Gas results in increased expression of HTR2C mRNA CTD PMID:15674844 bisphenol A decreases expression ISO RGD:2848 6480464 bisphenol A results in decreased expression of HTR2C mRNA CTD PMID:25181051 more ... bisphenol A multiple interactions ISO RGD:2848 6480464 [bisphenol A co-treated with Genistein] results in increased methylation of HTR2C gene CTD PMID:28505145 bisphenol A increases methylation ISO RGD:2848 6480464 bisphenol A results in increased methylation of HTR2C gene CTD PMID:28505145 bisphenol F decreases expression ISO RGD:2848 6480464 4, 4'-bisphenol F results in decreased expression of HTR2C mRNA CTD PMID:26186136 calcitriol multiple interactions ISO RGD:736842 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of HTR2C mRNA CTD PMID:21592394 calcitriol increases expression ISO RGD:736842 6480464 Calcitriol results in increased expression of HTR2C mRNA CTD PMID:16002434 , PMID:21592394 carbamazepine multiple interactions ISO RGD:2848 6480464 Carbamazepine inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]] more ... CTD PMID:19439326 , PMID:19700373 chlorpyrifos decreases expression ISO RGD:2848 6480464 Chlorpyrifos results in decreased expression of HTR2C mRNA CTD PMID:18668222 citalopram affects binding ISO RGD:736842 6480464 Citalopram binds to HTR2C protein CTD PMID:18083778 clomipramine affects binding ISO RGD:736842 6480464 Clomipramine binds to HTR2C protein CTD PMID:18083778 clomipramine increases expression ISO RGD:2848 6480464 Clomipramine results in increased expression of HTR2C protein CTD PMID:20619828 clozapine affects binding ISO RGD:736842 6480464 Clozapine binds to HTR2C protein CTD PMID:16983399 clozapine decreases expression ISO RGD:2848 6480464 Clozapine results in decreased expression of HTR2C mRNA CTD PMID:17868938 clozapine affects binding ISO RGD:2848 6480464 Clozapine binds to HTR2C protein CTD PMID:9723970 clozapine affects response to substance ISO RGD:736842 6480464 HTR2C gene polymorphism affects the susceptibility to Clozapine more ... CTD PMID:12668355 more ... cocaine multiple interactions EXP 6480464 [1-(3-chlorophenyl)piperazine binds to and results in increased activity of HTR2C protein] which results in increased susceptibility to Cocaine more ... CTD PMID:10541732 , PMID:12427861 cocaine decreases expression ISO RGD:2848 6480464 Cocaine results in decreased expression of HTR2C mRNA CTD PMID:16076954 cocaine increases response to substance EXP 6480464 HTR2C mutant form results in increased susceptibility to Cocaine CTD PMID:12427861 cyclosporin A decreases expression ISO RGD:736842 6480464 Cyclosporine results in decreased expression of HTR2C mRNA CTD PMID:20106945 diazinon decreases expression ISO RGD:2848 6480464 Diazinon results in decreased expression of HTR2C mRNA CTD PMID:17452286 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of HTR2C mRNA CTD PMID:21266533 dibutyl phthalate increases expression ISO RGD:2848 6480464 Dibutyl Phthalate results in increased expression of HTR2C mRNA CTD PMID:15620428 dieldrin affects expression ISO RGD:2848 6480464 Dieldrin affects the expression of HTR2C mRNA CTD PMID:18835401 dioxygen increases expression ISO RGD:736842 6480464 Oxygen deficiency results in increased expression of HTR2C mRNA CTD PMID:24236059 dopamine multiple interactions EXP 6480464 HTR2C protein affects the reaction [Cocaine results in increased abundance of Dopamine] CTD PMID:12427861 dorsomorphin multiple interactions ISO RGD:736842 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HTR2C mRNA CTD PMID:27188386 entinostat increases expression ISO RGD:736842 6480464 entinostat results in increased expression of HTR2C mRNA CTD PMID:26272509 ethanol affects splicing EXP 6480464 Ethanol affects the splicing of HTR2C mRNA CTD PMID:30319688 fenfluramine affects binding ISO RGD:736842 6480464 Fenfluramine binds to HTR2C protein CTD PMID:10617681 fluoxetine affects binding ISO RGD:736842 6480464 Fluoxetine binds to HTR2C protein CTD PMID:18083778 fluoxetine multiple interactions EXP 6480464 [[Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein more ... CTD PMID:19662385 fluoxetine multiple interactions ISO RGD:2848 6480464 [Fluoxetine results in increased abundance of Serotonin] which results in decreased expression of HTR2C mRNA more ... CTD PMID:21554931 , PMID:9050900 fluoxetine increases expression EXP 6480464 Fluoxetine results in increased expression of HTR2C mRNA, Fluoxetine results in increased expression of HTR2C mRNA alternative form CTD PMID:15659601 , PMID:21083617 fluphenazine affects binding ISO RGD:736842 6480464 Fluphenazine binds to HTR2C protein CTD PMID:17606915 folic acid increases expression EXP 6480464 Folic Acid results in increased expression of HTR2C mRNA CTD PMID:25006883 genistein multiple interactions ISO RGD:2848 6480464 [bisphenol A co-treated with Genistein] results in increased methylation of HTR2C gene CTD PMID:28505145 haloperidol decreases expression ISO RGD:2848 6480464 Haloperidol results in decreased expression of HTR2C mRNA CTD PMID:17868938 imidacloprid increases expression ISO RGD:2848 6480464 imidacloprid results in increased expression of HTR2C mRNA CTD PMID:27782041 lead diacetate affects expression ISO RGD:2848 6480464 lead acetate affects the expression of HTR2C mRNA CTD PMID:21864555 lead diacetate decreases expression ISO RGD:2848 6480464 lead acetate results in decreased expression of HTR2C mRNA CTD PMID:22641619 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of HTR2C mRNA CTD PMID:12057914 lipopolysaccharide affects response to substance ISO RGD:2848 6480464 HTR2C protein affects the susceptibility to Lipopolysaccharides CTD PMID:12479973 loxapine affects binding ISO RGD:2848 6480464 Loxapine analog binds to HTR2C protein, Loxapine binds to HTR2C protein CTD PMID:9723970 mesulergine affects binding ISO RGD:736842 6480464 mesulergine binds to HTR2C protein CTD PMID:18083778 , PMID:29458138 mesulergine multiple interactions ISO RGD:736842 6480464 N-Methyl-3, 4-methylenedioxyamphetamine inhibits the reaction [mesulergine binds to HTR2C protein] CTD PMID:29458138 mesulergine affects binding ISO RGD:2848 6480464 mesulergine binds to HTR2C protein CTD PMID:19439326 , PMID:19700373 mesulergine multiple interactions ISO RGD:2848 6480464 Carbamazepine inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]] more ... CTD PMID:19439326 , PMID:19700373 methamphetamine multiple interactions EXP 6480464 [Mianserin binds to and results in decreased activity of HTR2C protein] which results in decreased susceptibility to Methamphetamine CTD PMID:15213358 methamphetamine affects response to substance ISO RGD:2848 6480464 HTR2C protein affects the susceptibility to Methamphetamine CTD PMID:11751031 methoxychlor decreases expression ISO RGD:2848 6480464 Methoxychlor results in decreased expression of HTR2C mRNA CTD PMID:27103539 mianserin increases expression ISO RGD:736842 6480464 Mianserin results in increased expression of HTR2C protein CTD PMID:18083778 mianserin multiple interactions ISO RGD:736842 6480464 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline inhibits the reaction [Mianserin results in increased expression of HTR2C protein], Mianserin binds to and affects the activity of HTR2C protein CTD PMID:18083778 mianserin multiple interactions EXP 6480464 [Mianserin binds to and results in decreased activity of HTR2C protein] which results in decreased susceptibility to Methamphetamine, Mianserin binds to and results in decreased activity of HTR2C protein CTD PMID:10978843 , PMID:15213358 mirtazapine increases expression ISO RGD:736842 6480464 mirtazapine results in increased expression of HTR2C protein CTD PMID:18083778 mirtazapine multiple interactions ISO RGD:736842 6480464 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline inhibits the reaction [mirtazapine results in increased expression of HTR2C protein], mirtazapine binds to and affects the activity of HTR2C protein CTD PMID:18083778 nefazodone affects binding ISO RGD:736842 6480464 nefazodone binds to HTR2C protein CTD PMID:18083778 nortriptyline decreases expression ISO RGD:736842 6480464 Nortriptyline results in decreased expression of HTR2C protein CTD PMID:8131152 olanzapine increases response to substance ISO RGD:736842 6480464 HTR2C gene polymorphism results in increased susceptibility to olanzapine CTD PMID:19434072 olanzapine affects binding EXP 6480464 olanzapine binds to HTR2C protein CTD PMID:24389121 olanzapine affects binding ISO RGD:736842 6480464 olanzapine binds to HTR2C protein CTD PMID:16983399 olanzapine affects response to substance ISO RGD:736842 6480464 HTR2C gene polymorphism affects the susceptibility to olanzapine more ... CTD PMID:15666332 more ... paroxetine multiple interactions EXP 6480464 [[Paroxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein more ... CTD PMID:19662385 phenylmercury acetate decreases expression ISO RGD:736842 6480464 Phenylmercuric Acetate results in decreased expression of HTR2C mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:736842 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HTR2C mRNA CTD PMID:27188386 potassium dichromate increases expression EXP 6480464 Potassium Dichromate results in increased expression of HTR2C mRNA CTD PMID:23608068 risperidone affects response to substance ISO RGD:736842 6480464 HTR2C gene polymorphism affects the susceptibility to Risperidone, HTR2C protein affects the susceptibility to Risperidone CTD PMID:19142101 risperidone multiple interactions ISO RGD:736842 6480464 HTR2C gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein] CTD PMID:19997080 risperidone increases response to substance ISO RGD:736842 6480464 HTR2C protein results in increased susceptibility to Risperidone CTD PMID:19997080 sarpogrelate affects binding ISO RGD:736842 6480464 sarpogrelate binds to HTR2C protein CTD PMID:16880620 SB 206553 increases expression ISO RGD:736842 6480464 SB 206553 results in increased expression of HTR2C protein CTD PMID:18083778 SB 206553 multiple interactions ISO RGD:2848 6480464 SB 206553 binds to and results in decreased activity of HTR2C protein CTD PMID:16521035 SB 243213 multiple interactions ISO RGD:736842 6480464 SB 243213 binds to and results in decreased activity of HTR2C protein CTD PMID:11489455 SB 431542 multiple interactions ISO RGD:736842 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HTR2C mRNA CTD PMID:27188386 scopolamine increases expression ISO RGD:2848 6480464 Scopolamine results in increased expression of HTR2C mRNA CTD PMID:17540011 serotonin affects expression EXP 6480464 Serotonin affects the expression of HTR2C mRNA CTD PMID:21083617 serotonin multiple interactions ISO RGD:2848 6480464 [Fluoxetine results in increased abundance of Serotonin] which results in decreased expression of HTR2C mRNA more ... CTD PMID:21554931 , PMID:9050900 sertraline multiple interactions ISO RGD:2848 6480464 [Estradiol co-treated with Sertraline] affects the expression of HTR2C mRNA, Estradiol promotes the reaction [Sertraline results in increased expression of HTR2C mRNA] CTD PMID:18650020 sertraline increases expression ISO RGD:2848 6480464 Sertraline results in increased expression of HTR2C mRNA CTD PMID:18650020 testosterone decreases expression ISO RGD:736842 6480464 Testosterone results in decreased expression of HTR2C mRNA CTD PMID:21592394 testosterone multiple interactions ISO RGD:736842 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of HTR2C mRNA CTD PMID:21592394 thimerosal increases expression ISO RGD:736842 6480464 Thimerosal results in increased expression of HTR2C mRNA CTD PMID:27188386 titanium dioxide decreases expression EXP 6480464 titanium dioxide results in decreased expression of HTR2C mRNA CTD PMID:23557971 trazodone affects binding ISO RGD:736842 6480464 Trazodone binds to HTR2C protein CTD PMID:18083778 trichostatin A increases expression ISO RGD:736842 6480464 trichostatin A results in increased expression of HTR2C mRNA CTD PMID:24935251 valproic acid decreases expression ISO RGD:736842 6480464 Valproic Acid results in decreased expression of HTR2C mRNA CTD PMID:23179753 valproic acid increases expression ISO RGD:736842 6480464 Valproic Acid results in increased expression of HTR2C mRNA CTD PMID:24935251 , PMID:28001369 valproic acid affects expression ISO RGD:736842 6480464 Valproic Acid affects the expression of HTR2C mRNA CTD PMID:25979313 vorinostat decreases expression ISO RGD:736842 6480464 vorinostat results in decreased expression of HTR2C mRNA CTD PMID:27188386
Biological Process behavior IEA UniProtKB-KW:KW-0085 2290270 UniProt GO_REF:0000004, MGI:MGI:1354194 behavioral fear response IMP 2290270 (MGI:MGI:3798744, PMID:17451451) UniProtKB MGI:MGI:3798744 , PMID:17451451 behavioral response to nicotine ISO RGD:2848 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 cellular calcium ion homeostasis ISO UniProtKB:P28335 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 cGMP-mediated signaling ISO UniProtKB:P28335 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 chemical synaptic transmission IBA PANTHER:PTN000664111 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 feeding behavior ISO RGD:2848 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 feeding behavior IMP 2290270 (MGI:MGI:72086, PMID:7700379) UniProtKB MGI:MGI:72086 , PMID:7700379 G protein-coupled receptor signaling pathway IEA UniProtKB-KW:KW-0297 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 G protein-coupled receptor signaling pathway IEA InterPro:IPR000276 more ... 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA PANTHER:PTN000664111 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 inositol phosphate-mediated signaling ISO UniProtKB:P08909 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 locomotory behavior IEA InterPro:IPR000377 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 negative regulation of dopamine metabolic process ISO RGD:2848 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 negative regulation of locomotion ISO RGD:2848 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 phospholipase C-activating G protein-coupled receptor signaling pathway ISO UniProtKB:P28335 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 phospholipase C-activating G protein-coupled receptor signaling pathway IBA PANTHER:PTN000664115 , UniProtKB:P28335 2290270 (PMID:21873635) GO_Central PMID:21873635 phospholipase C-activating serotonin receptor signaling pathway ISO RGD:2848 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 phospholipase C-activating serotonin receptor signaling pathway IMP 2290270 (MGI:MGI:5140621, PMID:21835345) UniProtKB MGI:MGI:5140621 , PMID:21835345 phospholipase D-activating G protein-coupled receptor signaling pathway ISO RGD:2848 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of acetylcholine secretion, neurotransmission ISO RGD:2848 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IMP 2290270 (MGI:MGI:5140621, PMID:21835345) UniProtKB MGI:MGI:5140621 , PMID:21835345 positive regulation of ERK1 and ERK2 cascade ISO UniProtKB:P28335 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of fat cell differentiation IMP 2290270 (MGI:MGI:5316944, PMID:20719859) MGI MGI:MGI:5316944 , PMID:20719859 positive regulation of gamma-aminobutyric acid secretion ISO RGD:2848 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of phosphatidylinositol biosynthetic process ISO UniProtKB:P28335 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of vasoconstriction ISO RGD:2848 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 regulation of appetite IMP 2290270 (MGI:MGI:4849332, PMID:21048120) UniProtKB MGI:MGI:4849332 , PMID:21048120 regulation of corticotropin-releasing hormone secretion IMP 2290270 (MGI:MGI:3716046 more ... UniProtKB MGI:MGI:3716046 more ... regulation of nervous system process IMP 2290270 (MGI:MGI:3716046 more ... UniProtKB MGI:MGI:3716046 more ... regulation of sensory perception of pain ISO RGD:2848 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 release of sequestered calcium ion into cytosol ISO UniProtKB:P28335 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 release of sequestered calcium ion into cytosol IBA PANTHER:PTN000664115 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 response to drug ISO RGD:2848 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 response to drug IBA PANTHER:PTN000664115 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 response to drug ISO UniProtKB:P28335 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 serotonin receptor signaling pathway ISO UniProtKB:P28335 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 signal transduction IEA UniProtKB-KW:KW-0807 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 Cellular Component cell surface ISO RGD:2848 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 dendrite IBA PANTHER:PTN000664111 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 external side of plasma membrane ISO UniProtKB:P08909 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 integral component of membrane IEA InterPro:IPR000276 , InterPro:IPR017452 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 integral component of membrane IEA UniProtKB-KW:KW-0812 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 integral component of plasma membrane ISO UniProtKB:P28335 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 integral component of plasma membrane IBA FB:FBgn0000037 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 membrane IEA UniProtKB-KW:KW-0472 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 plasma membrane ISO UniProtKB:P28335 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 Molecular Function 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding ISO UniProtKB:P28335 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 drug binding ISO UniProtKB:P28335 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 G protein-coupled receptor activity IBA PANTHER:PTN000664111 , RGD:2518 2290270 (PMID:21873635) GO_Central PMID:21873635 G protein-coupled serotonin receptor activity ISO UniProtKB:P28335 2290270 (MGI:MGI:78583, PMID:7582481) MGI MGI:MGI:78583 , PMID:7582481 G protein-coupled serotonin receptor activity IBA FB:FBgn0004168 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 G protein-coupled serotonin receptor activity IMP 2290270 (MGI:MGI:5140621, PMID:21835345) UniProtKB MGI:MGI:5140621 , PMID:21835345 G protein-coupled serotonin receptor activity ISO UniProtKB:P08909 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 G protein-coupled serotonin receptor activity ISO RGD:2848 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 Gq/11-coupled serotonin receptor activity ISO UniProtKB:P28335 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 identical protein binding ISO UniProtKB:P28335 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 neurotransmitter receptor activity IBA PANTHER:PTN000664111 , RGD:71034 2290270 (PMID:21873635) GO_Central PMID:21873635 serotonin binding ISO UniProtKB:P28335 2290270 (MGI:MGI:78583, PMID:7582481) MGI GO_REF:0000096 more ...
Gene-Chemical Interaction Annotations
