Htr2c (5-hydroxytryptamine (serotonin) receptor 2C) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Htr2c (5-hydroxytryptamine (serotonin) receptor 2C) Mus musculus
Analyze
Symbol: Htr2c
Name: 5-hydroxytryptamine (serotonin) receptor 2C
RGD ID: 10748
MGI Page MGI
Description: Enables G protein-coupled serotonin receptor activity. Involved in several processes, including behavioral fear response; phospholipase C-activating serotonin receptor signaling pathway; and regulation of corticotropin-releasing hormone secretion. Acts upstream of or within positive regulation of calcium-mediated signaling and positive regulation of fat cell differentiation. Predicted to be located in external side of plasma membrane. Predicted to be part of G protein-coupled serotonin receptor complex. Predicted to be active in dendrite and plasma membrane. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; heart; and sensory organ. Used to study Prader-Willi syndrome and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in bipolar disorder; obesity; and schizophrenia. Orthologous to human HTR2C (5-hydroxytryptamine receptor 2C).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HT2C receptor; 5-HT2cR; 5-HTR2C; 5-hydroxytryptamine receptor 1C; 5-hydroxytryptamine receptor 2C; 5HT1c; Htr1; Htr1c; S; serotonin receptor 2C; SR1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X145,745,509 - 145,980,273 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX145,745,509 - 145,980,273 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X146,962,464 - 147,197,277 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX146,962,513 - 147,197,277 (+)Ensemblmm10GRCm38
MGSCv37X143,397,056 - 143,631,820 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X142,208,881 - 142,443,644 (+)NCBIMGSCv36mm8
CeleraX130,902,904 - 131,136,225 (+)NCBICelera
Cytogenetic MapXF2NCBI
cM MapX68.46NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (EXP)
1,2-dichloroethane  (EXP)
1-(3-chlorophenyl)piperazine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-bromopropane  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,4'-trichlorobiphenyl  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-chloro-6-(1-piperazinyl)pyrazine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
agomelatine  (ISO)
all-trans-retinoic acid  (ISO)
amitriptyline  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
aripiprazole  (ISO)
arsenite(3-)  (EXP,ISO)
atrazine  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (EXP)
calcitriol  (ISO)
carbamazepine  (ISO)
chlorpyrifos  (ISO)
citalopram  (ISO)
clomipramine  (ISO)
clozapine  (ISO)
cocaine  (EXP,ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dieldrin  (ISO)
dioxygen  (ISO)
dopamine  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
fenfluramine  (ISO)
fenvalerate  (ISO)
fluoxetine  (EXP,ISO)
fluphenazine  (ISO)
folic acid  (EXP)
genistein  (ISO)
haloperidol  (ISO)
imidacloprid  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
loxapine  (ISO)
maneb  (EXP)
mesulergine  (ISO)
methamphetamine  (EXP,ISO)
methimazole  (ISO)
methoxychlor  (ISO)
mianserin  (EXP,ISO)
mirtazapine  (ISO)
nefazodone  (ISO)
nitrates  (ISO)
Norfluoxetine  (ISO)
nortriptyline  (ISO)
okadaic acid  (ISO)
olanzapine  (EXP,ISO)
paraquat  (EXP,ISO)
paroxetine  (EXP)
PCB138  (EXP)
phenylmercury acetate  (ISO)
potassium dichromate  (EXP)
risperidone  (ISO)
sarpogrelate  (ISO)
SB 206553  (ISO)
SB 243213  (ISO)
SB 431542  (ISO)
scopolamine  (ISO)
serotonin  (EXP,ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
streptozocin  (EXP)
testosterone  (ISO)
thimerosal  (ISO)
titanium dioxide  (EXP)
trazodone  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
behavioral fear response  (IMP)
behavioral response to nicotine  (ISO)
cGMP-mediated signaling  (IEA,ISO)
chemical synaptic transmission  (IBA)
feeding behavior  (IEA,IMP,ISO)
G protein-coupled receptor signaling pathway  (IEA)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (IBA)
G protein-coupled serotonin receptor signaling pathway  (IEA,ISO)
intracellular calcium ion homeostasis  (IEA,ISO)
locomotory behavior  (IEA)
negative regulation of dopamine metabolic process  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IMP)
phospholipase C-activating serotonin receptor signaling pathway  (IBA,IEA,IMP,ISO)
phospholipase D-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of acetylcholine secretion, neurotransmission  (ISO)
positive regulation of calcium-mediated signaling  (IDA)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of fat cell differentiation  (IMP)
positive regulation of gamma-aminobutyric acid secretion  (ISO)
positive regulation of phosphatidylinositol biosynthetic process  (IEA,ISO)
positive regulation of vasoconstriction  (ISO)
regulation of appetite  (IMP)
regulation of corticotropin-releasing hormone secretion  (IMP)
regulation of nervous system process  (IMP)
release of sequestered calcium ion into cytosol  (IBA,IEA,ISO)
response to xenobiotic stimulus  (ISO)
sensitization  (ISO)
serotonin receptor signaling pathway  (IBA)
signal transduction  (IEA)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal body temperature  (IAGP)
abnormal metabolism  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal pilomotor reflex  (IAGP)
abnormal respiratory quotient  (IAGP)
abnormal response to new environment  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal spatial learning  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
decreased body fat mass  (IAGP)
decreased body length  (IAGP)
decreased body mass index  (IAGP)
decreased body weight  (IAGP)
decreased brown adipose tissue mass  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating insulin-like growth factor I level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased food intake  (IAGP)
decreased grip strength  (IAGP)
decreased lean body mass  (IAGP)
decreased locomotor activity  (IAGP)
decreased oxygen consumption  (IAGP)
decreased white adipose tissue amount  (IAGP)
dehydration  (IAGP)
enhanced behavioral response to xenobiotic  (IAGP)
hunched posture  (IAGP)
hyperactivity  (IAGP)
hyperglycemia  (IAGP)
hypotonia  (IAGP)
impaired behavioral response to xenobiotic  (IAGP)
impaired coordination  (IAGP)
impaired glucose tolerance  (IAGP)
impaired passive avoidance behavior  (IAGP)
increased basal metabolism  (IAGP)
increased body weight  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating ghrelin level  (IAGP)
increased circulating glucagon level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating growth hormone level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating leptin level  (IAGP)
increased coping response  (IAGP)
increased energy expenditure  (IAGP)
increased epididymal fat pad weight  (IAGP)
increased food intake  (IAGP)
increased grooming behavior  (IAGP)
increased oxygen consumption  (IAGP)
increased percent body fat/body weight  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased renal fat pad weight  (IAGP)
increased susceptibility to age related obesity  (IAGP)
increased susceptibility to diet-induced obesity  (IAGP)
increased susceptibility to pharmacologically induced seizures  (IAGP)
increased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
increased white adipose tissue amount  (IAGP)
insulin resistance  (IAGP)
lethality at weaning, incomplete penetrance  (IAGP)
mottled coat  (IAGP)
polyphagia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
reduced long-term potentiation  (IAGP)
seizures  (IAGP)
slow postnatal weight gain  (IAGP)
sporadic seizures  (IAGP)
tonic seizures  (IAGP)
tonic-clonic seizures  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Synergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction. Cunningham KA, etal., ACS Chem Neurosci. 2013 Jan 16;4(1):110-21. doi: 10.1021/cn300072u. Epub 2012 Aug 11.
2. Effects of the 5-HT2C receptor agonist Ro60-0175 and the 5-HT2A receptor antagonist M100907 on nicotine self-administration and reinstatement. Fletcher PJ, etal., Neuropharmacology. 2012 Jun;62(7):2288-98. doi: 10.1016/j.neuropharm.2012.01.023. Epub 2012 Feb 8.
3. Allelic association analysis of the 5-HT2C receptor gene in bipolar affective disorder. Gutierrez B, etal., Neurosci Lett 1996 Jul 5;212(1):65-7.
4. Anxiolytic activity of a novel potent serotonin 5-HT2C receptor antagonist FR260010: a comparison with diazepam and buspirone. Harada K, etal., Eur J Pharmacol. 2006 Dec 28;553(1-3):171-84. Epub 2006 Sep 28.
5. Altered RNA editing of serotonin 2C receptor in a rat model of depression. Iwamoto K, etal., Neurosci Res. 2005 Sep;53(1):69-76.
6. Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse. Ji SP, etal., Nat Med. 2006 Mar;12(3):324-9. Epub 2006 Feb 12.
7. The serotonin-2 receptor modulator, (-)-trans-PAT, decreases voluntary ethanol consumption in rats. Kasper J, etal., Eur J Pharmacol. 2013 Oct 15;718(1-3):98-104. doi: 10.1016/j.ejphar.2013.09.008. Epub 2013 Sep 13.
8. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. MGD IEA MGD IEA
11. The association between HTR2C polymorphisms and obesity in psychiatric patients using antipsychotics: a cross-sectional study. Mulder H, etal., Pharmacogenomics J. 2006 Oct 3;.
12. Possible involvement of spinal noradrenergic mechanisms in the antiallodynic effect of intrathecally administered 5-HT(2C) receptor agonists in the rats with peripheral nerve injury. Obata H, etal., Eur J Pharmacol. 2007 Mar 30;.
13. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
14. A 5-HT2C receptor promoter polymorphism (HTR2C - 759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes. Pooley EC, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126(1):124-7.
15. Increased 5-HT2C receptor binding in the brain stem and cerebral cortex during liver regeneration and hepatic neoplasia in rats. Pyroja S, etal., J Neurol Sci. 2007 Mar 15;254(1-2):3-8. Epub 2007 Jan 26.
16. Mouse MP Annotation Import Pipeline RGD automated import pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Association between clozapine response and allelic variation in the 5-HT2C receptor gene. Sodhi MS, etal., Neuroreport 1995 Dec 29;7(1):169-72.
20. Discovering the mechanisms underlying serotonin (5-HT)2A and 5-HT2C receptor regulation following nicotine withdrawal in rats. Zaniewska M, etal., J Neurochem. 2015 Aug;134(4):704-16. doi: 10.1111/jnc.13192. Epub 2015 Jun 26.
21. Blockade of nucleus accumbens 5-HT2A and 5-HT2C receptors prevents the expression of cocaine-induced behavioral and neurochemical sensitization in rats. Zayara AE, etal., Psychopharmacology (Berl). 2011 Feb;213(2-3):321-35. doi: 10.1007/s00213-010-1996-3. Epub 2010 Sep 3.
Additional References at PubMed
PMID:1302605   PMID:1373499   PMID:1381232   PMID:1426253   PMID:1661811   PMID:3473504   PMID:7582481   PMID:7700379   PMID:8626447   PMID:8626761   PMID:8833759   PMID:9153397  
PMID:9165122   PMID:9241279   PMID:9457670   PMID:9730605   PMID:9771748   PMID:9844009   PMID:9878187   PMID:10023077   PMID:10349636   PMID:10352232   PMID:10353435   PMID:10501973  
PMID:10514821   PMID:10627607   PMID:10751458   PMID:10767319   PMID:10799679   PMID:10978843   PMID:11042159   PMID:11076861   PMID:11089532   PMID:11106375   PMID:11217851   PMID:11387227  
PMID:11754082   PMID:12097814   PMID:12150939   PMID:12427861   PMID:12431861   PMID:12477932   PMID:12486144   PMID:12534984   PMID:12540602   PMID:12614326   PMID:12678665   PMID:12682077  
PMID:12782219   PMID:12834793   PMID:14988405   PMID:15659601   PMID:16141072   PMID:16141073   PMID:16256085   PMID:16602821   PMID:16904273   PMID:16914526   PMID:16973729   PMID:17064660  
PMID:17287521   PMID:17307311   PMID:17360519   PMID:17367945   PMID:17451451   PMID:17561825   PMID:17596444   PMID:17620091   PMID:17677002   PMID:18039773   PMID:18039786   PMID:18256173  
PMID:18262506   PMID:18477467   PMID:18495184   PMID:18719666   PMID:19005016   PMID:19008301   PMID:19036977   PMID:19038216   PMID:19304781   PMID:19322172   PMID:19420382   PMID:19473847  
PMID:19501602   PMID:19523439   PMID:19553455   PMID:19737523   PMID:20165943   PMID:20181818   PMID:20394819   PMID:20495077   PMID:20582266   PMID:20624407   PMID:20651031   PMID:20668550  
PMID:20719859   PMID:20952540   PMID:21037584   PMID:21048120   PMID:21118683   PMID:21267068   PMID:21281651   PMID:21340474   PMID:21473759   PMID:21756875   PMID:21835345   PMID:21873635  
PMID:22569571   PMID:22640814   PMID:22800924   PMID:23192316   PMID:23247076   PMID:23303047   PMID:23349838   PMID:23933143   PMID:24177424   PMID:24204954   PMID:24345557   PMID:24733892  
PMID:24952961   PMID:25229718   PMID:25257581   PMID:25727097   PMID:25732068   PMID:25784603   PMID:26053401   PMID:26066076   PMID:26248536   PMID:26308619   PMID:26527397   PMID:26630489  
PMID:26977396   PMID:26999672   PMID:27516377   PMID:27556938   PMID:27568567   PMID:27693255   PMID:27882999   PMID:27931246   PMID:27934886   PMID:28031476   PMID:28186389   PMID:28258217  
PMID:28664341   PMID:28805659   PMID:28851741   PMID:29031711   PMID:29541541   PMID:29548885   PMID:29572515   PMID:29914853   PMID:29969651   PMID:30056125   PMID:30097291   PMID:30104733  
PMID:30146485   PMID:30792491   PMID:31299228   PMID:31415146   PMID:31489921   PMID:31786274   PMID:31959933   PMID:32961128   PMID:33016258   PMID:33156577   PMID:33304758   PMID:34553421  
PMID:34788630   PMID:35121849   PMID:35145065   PMID:35796804   PMID:36265442   PMID:36402746   PMID:36536256   PMID:36592795   PMID:37002196   PMID:37059187   PMID:37321213   PMID:38701344  
PMID:38917789   PMID:38941473  


Genomics

Comparative Map Data
Htr2c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X145,745,509 - 145,980,273 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX145,745,509 - 145,980,273 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X146,962,464 - 147,197,277 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX146,962,513 - 147,197,277 (+)Ensemblmm10GRCm38
MGSCv37X143,397,056 - 143,631,820 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X142,208,881 - 142,443,644 (+)NCBIMGSCv36mm8
CeleraX130,902,904 - 131,136,225 (+)NCBICelera
Cytogenetic MapXF2NCBI
cM MapX68.46NCBI
HTR2C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X114,584,086 - 114,910,061 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX114,584,078 - 114,910,061 (+)Ensemblhg38GRCh38
GRCh37X113,818,559 - 114,144,624 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X113,724,807 - 114,050,880 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X113,641,530 - 113,967,604NCBI
CeleraX114,253,715 - 114,579,778 (+)NCBICelera
Cytogenetic MapXq23NCBI
HuRefX103,403,272 - 103,731,741 (+)NCBIHuRef
CHM1_1X113,729,484 - 114,055,500 (+)NCBICHM1_1
T2T-CHM13v2.0X112,992,593 - 113,318,748 (+)NCBIT2T-CHM13v2.0
Htr2c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X115,453,190 - 115,682,325 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX115,452,842 - 115,682,324 (+)EnsemblGRCr8
mRatBN7.2X110,640,777 - 110,870,288 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX110,641,153 - 110,870,287 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX112,734,293 - 112,956,059 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X116,233,146 - 116,454,918 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X113,792,877 - 114,014,236 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X118,084,520 - 118,318,040 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX118,084,890 - 118,318,039 (+)Ensemblrn6Rnor6.0
Rnor_5.0X118,226,113 - 118,460,830 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X31,012,921 - 31,244,127 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX109,958,913 - 110,179,824 (+)NCBICelera
RGSC_v3.1X31,069,048 - 31,185,684 (-)NCBI
Cytogenetic MapXq34NCBI
Htr2c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955490910,415 - 1,126,373 (-)Ensembl
ChiLan1.0NW_004955490912,615 - 1,126,347 (-)NCBIChiLan1.0ChiLan1.0
HTR2C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X114,026,594 - 114,352,146 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X114,030,203 - 114,355,755 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X103,673,172 - 103,999,133 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X114,169,823 - 114,503,179 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX114,199,485 - 114,503,201 (+)EnsemblpanPan2panpan1.1
HTR2C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X87,342,800 - 87,641,224 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX87,342,792 - 87,638,579 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX73,595,073 - 73,759,737 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X89,055,367 - 89,357,473 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX89,055,355 - 89,357,011 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X86,633,342 - 86,797,977 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X88,307,583 - 88,472,268 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X88,140,047 - 88,305,373 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Htr2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X86,426,392 - 86,655,882 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364991,004,732 - 1,109,377 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364991,002,083 - 1,109,446 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTR2C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX94,053,456 - 94,313,355 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X94,053,415 - 94,313,352 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X108,811,549 - 108,871,722 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2X108,566,657 - 108,733,261 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HTR2C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X102,190,355 - 102,499,928 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX102,325,731 - 102,497,278 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606527,537,759 - 27,837,340 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Htr2c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249401,040,911 - 1,157,057 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249401,040,744 - 1,299,266 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Htr2c
6480 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:3546
Count of miRNA genes:779
Interacting mature miRNAs:1019
Transcripts:ENSMUST00000036303, ENSMUST00000096299, ENSMUST00000112831, ENSMUST00000131999, ENSMUST00000134368, ENSMUST00000149260, ENSMUST00000156697
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401118Pgia39_mproteoglycan induced arthritis 39 (mouse)Not determinedX144474380169476592Mouse
13208552Wght12_mweight 12 (mouse)X94043606149782996Mouse
1558900Bw3_mbody weight QTL 3 (mouse)Not determinedX133540040165298595Mouse
1302000Pgia25_mproteoglycan induced arthritis 2 (mouse)Not determinedX144474380169476592Mouse
13208556Lgth14_mbody length 14 (mouse)X94043606149782996Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
25314309Syncl5_msynaptonemal complex length 5 (mouse)X121909697152582996Mouse
13824981Svwq2_mseminal vesicle weight QTL 2 (mouse)X128900749153782996Mouse
1301209Cia19_mcollagen induced arthritis 19 (mouse)Not determinedX120993165160213038Mouse
1357823Spha3_msperm head anomaly 3 (mouse)Not determinedX102055848162758941Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
1301276Tswt_mtestis weight (mouse)Not determinedX138376411150789338Mouse
10412164Cmv2_mcytomegalovirus resistance 2 (mouse)Not determinedX125685149159685269Mouse

Markers in Region
X72230  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X147,195,134 - 147,195,248UniSTSGRCm38
MGSCv37X143,629,677 - 143,629,791UniSTSGRCm37
CeleraX131,134,082 - 131,134,196UniSTS
Cytogenetic MapXD-F4UniSTS
Whitehead/MRC_RHX1681.01UniSTS
G67051  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X147,072,526 - 147,073,033UniSTSGRCm38
MGSCv37X143,507,069 - 143,507,576UniSTSGRCm37
CeleraX131,012,822 - 131,013,329UniSTS
Cytogenetic MapXD-F4UniSTS
30.MMHAP67FLB6.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X147,183,798 - 147,183,950UniSTSGRCm38
MGSCv37X143,618,341 - 143,618,493UniSTSGRCm37
CeleraX131,122,691 - 131,122,843UniSTS
Cytogenetic MapXD-F4UniSTS
Whitehead_YACX UniSTS
PMC166422P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X147,193,938 - 147,194,237UniSTSGRCm38
MGSCv37X143,628,481 - 143,628,780UniSTSGRCm37
CeleraX131,132,887 - 131,133,186UniSTS
Cytogenetic MapXD-F4UniSTS
BB315810  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X147,197,107 - 147,197,194UniSTSGRCm38
MGSCv37X143,631,650 - 143,631,737UniSTSGRCm37
CeleraX131,136,055 - 131,136,142UniSTS
Cytogenetic MapXD-F4UniSTS
Whitehead/MRC_RH91128.43UniSTS
Htr2c  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXD-F4UniSTS
cM MapX66.15UniSTS
Htr2c  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X147,195,453 - 147,195,568UniSTSGRCm38
MGSCv37X143,629,996 - 143,630,111UniSTSGRCm37
CeleraX131,134,401 - 131,134,516UniSTS
Cytogenetic MapXD-F4UniSTS
cM MapX66.15UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001411391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030251228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH000483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK043320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK139392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL808014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC141085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX005219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M63685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X72230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000036303   ⟹   ENSMUSP00000043936
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX145,745,509 - 145,980,270 (+)Ensembl
GRCm38.p6 EnsemblX146,962,513 - 147,197,274 (+)Ensembl
Ensembl Acc Id: ENSMUST00000096299   ⟹   ENSMUSP00000094021
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX145,745,510 - 145,980,273 (+)Ensembl
GRCm38.p6 EnsemblX146,962,514 - 147,197,277 (+)Ensembl
Ensembl Acc Id: ENSMUST00000112831   ⟹   ENSMUSP00000108450
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX145,746,019 - 145,966,148 (+)Ensembl
GRCm38.p6 EnsemblX146,963,023 - 147,183,152 (+)Ensembl
Ensembl Acc Id: ENSMUST00000131999
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX145,745,509 - 145,861,060 (+)Ensembl
GRCm38.p6 EnsemblX146,962,513 - 147,078,064 (+)Ensembl
Ensembl Acc Id: ENSMUST00000134368
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX145,745,626 - 145,855,525 (+)Ensembl
GRCm38.p6 EnsemblX146,962,630 - 147,072,529 (+)Ensembl
Ensembl Acc Id: ENSMUST00000149260
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX145,745,509 - 145,772,324 (+)Ensembl
GRCm38.p6 EnsemblX146,962,513 - 146,989,328 (+)Ensembl
Ensembl Acc Id: ENSMUST00000156697   ⟹   ENSMUSP00000138772
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX145,745,510 - 145,980,273 (+)Ensembl
GRCm38.p6 EnsemblX146,962,514 - 147,197,277 (+)Ensembl
RefSeq Acc Id: NM_001411391   ⟹   NP_001398320
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X145,745,509 - 145,980,273 (+)NCBI
RefSeq Acc Id: NM_008312   ⟹   NP_032338
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X145,745,509 - 145,980,273 (+)NCBI
GRCm38X146,962,513 - 147,197,277 (+)ENTREZGENE
MGSCv37X143,397,056 - 143,631,820 (+)RGD
CeleraX130,902,904 - 131,136,225 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030251228   ⟹   XP_030107088
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X145,745,509 - 145,980,273 (+)NCBI
GRCm38X146,962,464 - 147,197,277 (+)NCBI
Sequence:
RefSeq Acc Id: NP_032338   ⟸   NM_008312
- Peptide Label: isoform 1 precursor
- UniProtKB: B1ATN5 (UniProtKB/Swiss-Prot),   Q5WRU6 (UniProtKB/Swiss-Prot),   P34968 (UniProtKB/Swiss-Prot),   Q8BZI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030107088   ⟸   XM_030251228
- Peptide Label: isoform X1
Ensembl Acc Id: ENSMUSP00000108450   ⟸   ENSMUST00000112831
Ensembl Acc Id: ENSMUSP00000043936   ⟸   ENSMUST00000036303
Ensembl Acc Id: ENSMUSP00000138772   ⟸   ENSMUST00000156697
Ensembl Acc Id: ENSMUSP00000094021   ⟸   ENSMUST00000096299
RefSeq Acc Id: NP_001398320   ⟸   NM_001411391
- Peptide Label: isoform 2
- UniProtKB: S4R2T0 (UniProtKB/TrEMBL),   B1ATN4 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P34968-F1-model_v2 AlphaFold P34968 1-459 view protein structure

Promoters
RGD ID:6845840
Promoter ID:MM_KWN:62200
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_008312,   OTTMUST00000045549,   OTTMUST00000045550,   OTTMUST00000045551,   OTTMUST00000045552,   OTTMUST00000045553,   UC009UNE.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X143,396,861 - 143,397,361 (+)MPROMDB
RGD ID:13681582
Promoter ID:EPDNEW_M24940
Type:multiple initiation site
Name:Htr2c_1
Description:Mus musculus 5-hydroxytryptamine receptor 2C , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M24941  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X146,962,513 - 146,962,573EPDNEW
RGD ID:13681584
Promoter ID:EPDNEW_M24941
Type:multiple initiation site
Name:Htr2c_2
Description:Mus musculus 5-hydroxytryptamine receptor 2C , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M24940  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X147,019,954 - 147,020,014EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96281 AgrOrtholog
Ensembl Genes ENSMUSG00000041380 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000036303 ENTREZGENE
  ENSMUST00000036303.9 UniProtKB/Swiss-Prot
  ENSMUST00000096299.9 UniProtKB/Swiss-Prot
  ENSMUST00000156697 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro 5HT2C_rcpt UniProtKB/Swiss-Prot
  5HT_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report mmu:15560 UniProtKB/Swiss-Prot
MGD MGI:96281 ENTREZGENE
NCBI Gene 15560 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR UniProtKB/Swiss-Prot
  PTHR24247:SF32 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB HTR2C RGD
PhenoGen Htr2c PhenoGen
PRINTS 5HT2CRECEPTR UniProtKB/Swiss-Prot
  5HTRECEPTOR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt 5HT2C_MOUSE UniProtKB/Swiss-Prot
  B1ATN4 ENTREZGENE, UniProtKB/TrEMBL
  B1ATN5 ENTREZGENE
  B2RUD4_MOUSE UniProtKB/TrEMBL
  P34968 ENTREZGENE
  Q5WRU6 ENTREZGENE
  Q8BZI5 ENTREZGENE, UniProtKB/TrEMBL
  S4R2T0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B1ATN5 UniProtKB/Swiss-Prot
  Q5WRU6 UniProtKB/Swiss-Prot