Actr3 (ARP3 actin-related protein 3) - Rat Genome Database

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Gene: Actr3 (ARP3 actin-related protein 3) Mus musculus
Analyze
Symbol: Actr3
Name: ARP3 actin-related protein 3
RGD ID: 736323
MGI Page MGI
Description: Predicted to enable ATPase binding activity and actin binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to contribute to actin filament binding activity. Acts upstream of or within several processes, including cellular response to type II interferon; meiotic chromosome movement towards spindle pole; and meiotic cytokinesis. Located in brush border; cell-cell junction; and lamellipodium. Is expressed in several structures, including alimentary system; blastocyst; genitourinary system; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in opisthorchiasis. Orthologous to human ACTR3 (actin related protein 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1200003A09Rik; A; actin-like protein 3; actin-related protein 3; actin-related protein 3 homolog; Arp3; ARP3 actin-related protein 3 homolog; MGC118188
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Actr3-ps  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391125,320,642 - 125,363,464 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1125,320,642 - 125,363,464 (-)EnsemblGRCm39 Ensembl
GRCm381125,392,905 - 125,435,727 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1125,392,905 - 125,435,727 (-)EnsemblGRCm38mm10GRCm38
MGSCv371127,289,483 - 127,332,067 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361127,220,452 - 127,263,036 (-)NCBIMGSCv36mm8
Celera1128,040,526 - 128,085,756 (-)NCBICelera
Cytogenetic Map1E2.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
aniline  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP)
cisplatin  (ISO)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP)
gentamycin  (ISO)
heparin  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lovastatin  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
methidathion  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nefazodone  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (ISO)
propiconazole  (EXP)
resveratrol  (EXP)
SB 431542  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
theophylline  (ISO)
thioacetamide  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
warfarin  (EXP)
zearalenone  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (IEA)
Arp2/3 complex-mediated actin nucleation  (IBA,ISO)
astrocyte differentiation  (ISO)
asymmetric cell division  (IGI)
cell projection organization  (IEA)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to pyrimidine ribonucleotide  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to trichostatin A  (ISO)
cellular response to triterpenoid  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to type II interferon  (IGI)
cilium assembly  (ISO)
establishment or maintenance of cell polarity  (IGI)
meiotic cell cycle  (IGI)
meiotic chromosome movement towards spindle pole  (IGI)
meiotic cytokinesis  (IGI)
negative regulation of axon extension  (ISO)
negative regulation of bleb assembly  (ISO)
positive regulation of actin cytoskeleton reorganization  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of astrocyte differentiation  (ISO)
positive regulation of dendrite morphogenesis  (ISO)
positive regulation of dendritic spine morphogenesis  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of filopodium assembly  (ISO)
positive regulation of lamellipodium assembly  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein targeting to membrane  (ISO)
positive regulation of synapse assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
postsynapse organization  (ISO)
postsynaptic actin cytoskeleton organization  (ISO)
regulation of myosin II filament organization  (ISO)
response to estradiol  (ISO)
response to heparin  (ISO)
Sertoli cell barrier remodeling  (ISO)
spermatogenesis  (ISO)
spindle localization  (IGI)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Actin -related protein 3 (Arp3) is mutated in proteinuric BUF/Mna rats. Akiyama K, et al., Mamm Genome. 2008 Jan;19(1):41-50. Epub 2007 Dec 7.
2. Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells. Chiu TT, etal., Mol Biol Cell. 2010 Oct 15;21(20):3529-39. doi: 10.1091/mbc.E10-04-0316. Epub 2010 Aug 25.
3. A proteome analysis of the anterior cingulate cortex gray matter in schizophrenia. Clark D, etal., Mol Psychiatry. 2006 May;11(5):459-70, 423.
4. Effect of Heme Oxygenase-1 Deficiency on Glomerular Proteomics. Detsika MG, etal., Am J Nephrol. 2016;43(6):441-50. doi: 10.1159/000446859. Epub 2016 Jun 2.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. RasGRP3 regulates the migration of glioma cells via interaction with Arp3. Lee HK, etal., Oncotarget. 2015 Jan 30;6(3):1850-64.
7. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. Involvement of Arp2/3 complex in the process of colorectal carcinogenesis. Otsubo T, etal., Mod Pathol. 2004 Apr;17(4):461-7.
11. Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairment. Ottis P, etal., PLoS One. 2013 Sep 19;8(9):e75112. doi: 10.1371/journal.pone.0075112. eCollection 2013.
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Plasma IgG autoantibody against actin-related protein 3 in liver fluke Opisthorchis viverrini infection. Rucksaken R, etal., Parasite Immunol. 2015 Jul;37(7):340-8. doi: 10.1111/pim.12188.
17. A combined metabonomic and proteomic approach identifies frontal cortex changes in a chronic phencyclidine rat model in relation to human schizophrenia brain pathology. Wesseling H, etal., Neuropsychopharmacology. 2013 Nov;38(12):2532-44. doi: 10.1038/npp.2013.160. Epub 2013 Jul 3.
18. CFL1 and Arp3 are biomarkers for metastasis and poor prognosis of squamous cell/adenosquamous carcinomas and adenocarcinomas of gallbladder. Yang ZL, etal., Cancer Invest. 2013 Feb;31(2):132-9. doi: 10.3109/07357907.2012.756113. Epub 2013 Jan 15.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11018051   PMID:11042159   PMID:11076861   PMID:11172053   PMID:11231575   PMID:12477932   PMID:12520002   PMID:12589062   PMID:14610273   PMID:14657280  
PMID:15085951   PMID:15135218   PMID:15247266   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16196101   PMID:16452087   PMID:16597702   PMID:17114649   PMID:17500055  
PMID:17721515   PMID:18035060   PMID:18307411   PMID:18799693   PMID:19068115   PMID:19144319   PMID:19423573   PMID:19922875   PMID:21267068   PMID:21406566   PMID:21494665   PMID:21873635  
PMID:21874009   PMID:22083510   PMID:22114352   PMID:22349694   PMID:22385962   PMID:22951093   PMID:22989773   PMID:23439682   PMID:23495010   PMID:23554489   PMID:23793062   PMID:24043783  
PMID:24457600   PMID:24998208   PMID:25220164   PMID:25315346   PMID:25737280   PMID:25843690   PMID:26028144   PMID:26370502   PMID:26655834   PMID:26975831   PMID:27181356   PMID:27385014  
PMID:27927957   PMID:29518331   PMID:30333137   PMID:30409884   PMID:30457570   PMID:30562941   PMID:30833597   PMID:31157616   PMID:31162944   PMID:31577955   PMID:31815664   PMID:31961823  
PMID:32079655   PMID:32325033   PMID:32581705   PMID:35658973  


Genomics

Comparative Map Data
Actr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391125,320,642 - 125,363,464 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1125,320,642 - 125,363,464 (-)EnsemblGRCm39 Ensembl
GRCm381125,392,905 - 125,435,727 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1125,392,905 - 125,435,727 (-)EnsemblGRCm38mm10GRCm38
MGSCv371127,289,483 - 127,332,067 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361127,220,452 - 127,263,036 (-)NCBIMGSCv36mm8
Celera1128,040,526 - 128,085,756 (-)NCBICelera
Cytogenetic Map1E2.3NCBI
ACTR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382113,889,934 - 113,962,596 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2113,890,063 - 113,962,596 (+)EnsemblGRCh38hg38GRCh38
GRCh372114,647,511 - 114,720,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362114,364,007 - 114,432,637 (+)NCBINCBI36Build 36hg18NCBI36
Build 342114,363,766 - 114,432,397NCBI
Celera2107,963,979 - 108,036,693 (+)NCBICelera
Cytogenetic Map2q14.1NCBI
HuRef2106,964,108 - 107,039,652 (+)NCBIHuRef
CHM1_12114,651,066 - 114,722,668 (+)NCBICHM1_1
T2T-CHM13v2.02114,314,590 - 114,387,240 (+)NCBIT2T-CHM13v2.0
Actr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21336,800,739 - 36,843,837 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1336,800,093 - 36,844,124 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1339,401,982 - 39,443,515 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01340,689,982 - 40,731,516 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01337,949,578 - 37,992,708 (-)NCBIRnor_WKY
Rnor_6.01341,695,520 - 41,738,622 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1341,695,183 - 41,738,658 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01346,808,187 - 46,850,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41337,861,558 - 37,904,589 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11337,876,286 - 37,879,398 (-)NCBI
Celera1336,607,886 - 36,650,420 (-)NCBICelera
Cytogenetic Map13q12NCBI
Actr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545915,216,914 - 15,284,013 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545915,216,914 - 15,284,013 (-)NCBIChiLan1.0ChiLan1.0
ACTR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B114,373,392 - 114,445,729 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B114,373,392 - 114,445,729 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B827,184 - 900,424 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ACTR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11935,097,968 - 35,133,330 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1935,098,639 - 35,169,724 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1935,329,635 - 35,387,572 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01936,533,033 - 36,590,987 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1936,533,040 - 36,591,315 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11935,181,031 - 35,238,936 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01935,342,002 - 35,399,933 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01936,561,512 - 36,619,469 (-)NCBIUU_Cfam_GSD_1.0
Actr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530385,918,173 - 85,977,081 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646955,639,068 - 55,699,640 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493646955,639,345 - 55,699,330 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1520,104,812 - 20,167,421 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11520,104,808 - 20,171,721 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21522,725,584 - 22,786,934 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACTR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11016,296,350 - 16,369,561 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1016,297,502 - 16,369,220 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660616,176,980 - 6,250,598 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473231,361,147 - 31,427,811 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473231,360,804 - 31,427,885 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:703
Count of miRNA genes:249
Interacting mature miRNAs:282
Transcripts:ENSMUST00000027579, ENSMUST00000178474
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167339159129727737Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174991977133290937Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)175976637128527737Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
13452395Leusq2_mleucocytosis susceptibility QTL 2 (mouse)180245593126386517Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182643189135615379Mouse
1357760Synch3_msynechia 3 (mouse)Not determined192901442126901550Mouse
27095913Scvln2_msacral vertebrae length 2, 5 week (mouse)194127725148775742Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195527725162027569Mouse
1301123Cd8mts2_mCD8 memory T cell subset 2 (mouse)Not determined196618386130618557Mouse
1301753Tir3a_mtrypansomiasis infection response 3a (mouse)Not determined197053986131054190Mouse
13452398Leusq5_mleucocytosis susceptibility QTL 5 (mouse)198474785126386517Mouse
1301536Pbbcp1_mperipheral blood B cell percentage 1 (mouse)Not determined199507660133507845Mouse
1301193Lxw3_mlupus BXSB x NZW 3 (mouse)Not determined1102968534136968667Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
12790994Aaaq1_maortic arch angle QTL 1 (mouse)1109495943143495943Mouse
1301979Melm1_mmelanoma modifier 1 (mouse)Not determined1109638262143638479Mouse
1357600Obq17_mobesity QTL 17 (mouse)Not determined1110553179144553298Mouse
10401248Bglu12_mblood glucose level 12 (mouse)Not determined1110553179144553298Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112008822168186402Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
1301249Sbw1_msplenomegaly-NZB x NZW 1 (mouse)Not determined1112131005146131085Mouse
10045640Jckm4_mjuvenile cystic kidney modifier 4 (mouse)Not determined1116290836150290937Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
1302161Exq2_mexploratory and excitability QTL 2 (mouse)Not determined1118099720152099816Mouse
27226714Metcl1_mmetatarsal-calcaneal length 1, 5 week (mouse)1121727729139727738Mouse
27226740Metcl13_mmetatarsal-calcaneal length 13, 16 week (mouse)1121727729153775746Mouse
27226743Metcl7_mmetatarsal-calcaneal length 7, 10 week (mouse)1121727729153875746Mouse
27226767Tibl10_mtibia length 10, 10 week (mouse)1121727729164827569Mouse
27226799Feml5_mfemur length 5, 5 week (mouse)1122027729164827569Mouse
12880408V125Dq3_mvitamin D active form serum level QTL 3 (mouse)1122927738156927738Mouse


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001205385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001205386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_023735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC124528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC166158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF307855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK035443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV137086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC080806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000027579   ⟹   ENSMUSP00000027579
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1125,320,642 - 125,363,464 (-)Ensembl
GRCm38.p6 Ensembl1125,392,905 - 125,435,727 (-)Ensembl
RefSeq Acc Id: ENSMUST00000178474   ⟹   ENSMUSP00000137503
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1125,320,643 - 125,363,284 (-)Ensembl
GRCm38.p6 Ensembl1125,392,906 - 125,435,547 (-)Ensembl
RefSeq Acc Id: ENSMUST00000185280   ⟹   ENSMUSP00000140082
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1125,335,095 - 125,363,207 (-)Ensembl
GRCm38.p6 Ensembl1125,407,358 - 125,435,470 (-)Ensembl
RefSeq Acc Id: ENSMUST00000186008
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1125,321,221 - 125,325,349 (-)Ensembl
GRCm38.p6 Ensembl1125,393,484 - 125,397,612 (-)Ensembl
RefSeq Acc Id: ENSMUST00000187460   ⟹   ENSMUSP00000140000
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1125,335,086 - 125,363,444 (-)Ensembl
GRCm38.p6 Ensembl1125,407,349 - 125,435,707 (-)Ensembl
RefSeq Acc Id: ENSMUST00000188362
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1125,324,226 - 125,326,053 (-)Ensembl
GRCm38.p6 Ensembl1125,396,489 - 125,398,316 (-)Ensembl
RefSeq Acc Id: ENSMUST00000188497   ⟹   ENSMUSP00000140535
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1125,333,617 - 125,363,464 (-)Ensembl
GRCm38.p6 Ensembl1125,405,880 - 125,435,727 (-)Ensembl
RefSeq Acc Id: ENSMUST00000188827
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1125,343,801 - 125,363,165 (-)Ensembl
GRCm38.p6 Ensembl1125,416,064 - 125,435,428 (-)Ensembl
RefSeq Acc Id: ENSMUST00000189192
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1125,333,598 - 125,336,678 (-)Ensembl
GRCm38.p6 Ensembl1125,405,861 - 125,408,941 (-)Ensembl
RefSeq Acc Id: ENSMUST00000191004   ⟹   ENSMUSP00000140953
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1125,335,029 - 125,363,191 (-)Ensembl
GRCm38.p6 Ensembl1125,407,292 - 125,435,454 (-)Ensembl
RefSeq Acc Id: ENSMUST00000191544   ⟹   ENSMUSP00000139674
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1125,333,647 - 125,362,383 (-)Ensembl
GRCm38.p6 Ensembl1125,405,910 - 125,434,646 (-)Ensembl
RefSeq Acc Id: ENSMUST00000191578   ⟹   ENSMUSP00000139886
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1125,321,627 - 125,363,218 (-)Ensembl
GRCm38.p6 Ensembl1125,393,890 - 125,435,481 (-)Ensembl
RefSeq Acc Id: NM_001205385   ⟹   NP_001192314
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391125,320,642 - 125,363,464 (-)NCBI
GRCm381125,392,905 - 125,435,727 (-)ENTREZGENE
Celera1128,040,525 - 128,085,993 (-)ENTREZGENE
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001205386   ⟹   NP_001192315
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391125,320,642 - 125,363,464 (-)NCBI
GRCm381125,392,905 - 125,435,727 (-)ENTREZGENE
Celera1128,040,525 - 128,085,993 (-)ENTREZGENE
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_023735   ⟹   NP_076224
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391125,320,642 - 125,363,464 (-)NCBI
GRCm381125,392,905 - 125,435,727 (-)ENTREZGENE
MGSCv371127,289,483 - 127,332,067 (-)RGD
Celera1128,040,525 - 128,085,993 (-)ENTREZGENE
cM Map1 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001192314 (Get FASTA)   NCBI Sequence Viewer  
  NP_001192315 (Get FASTA)   NCBI Sequence Viewer  
  NP_076224 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG27726 (Get FASTA)   NCBI Sequence Viewer  
  AAH05557 (Get FASTA)   NCBI Sequence Viewer  
  AAH80806 (Get FASTA)   NCBI Sequence Viewer  
  BAB23368 (Get FASTA)   NCBI Sequence Viewer  
  BAC38876 (Get FASTA)   NCBI Sequence Viewer  
  BAE26491 (Get FASTA)   NCBI Sequence Viewer  
  BAE28238 (Get FASTA)   NCBI Sequence Viewer  
  BAE29603 (Get FASTA)   NCBI Sequence Viewer  
  BAE29683 (Get FASTA)   NCBI Sequence Viewer  
  BAE31483 (Get FASTA)   NCBI Sequence Viewer  
  BAE31704 (Get FASTA)   NCBI Sequence Viewer  
  BAE31760 (Get FASTA)   NCBI Sequence Viewer  
  BAE31804 (Get FASTA)   NCBI Sequence Viewer  
  BAE34847 (Get FASTA)   NCBI Sequence Viewer  
  BAE35272 (Get FASTA)   NCBI Sequence Viewer  
  BAE35360 (Get FASTA)   NCBI Sequence Viewer  
  BAE35589 (Get FASTA)   NCBI Sequence Viewer  
  BAE38833 (Get FASTA)   NCBI Sequence Viewer  
  BAE38875 (Get FASTA)   NCBI Sequence Viewer  
  BAE39291 (Get FASTA)   NCBI Sequence Viewer  
  BAE39903 (Get FASTA)   NCBI Sequence Viewer  
  BAE40438 (Get FASTA)   NCBI Sequence Viewer  
  BAE40607 (Get FASTA)   NCBI Sequence Viewer  
  EDL39778 (Get FASTA)   NCBI Sequence Viewer  
  Q99JY9 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_076224   ⟸   NM_023735
- UniProtKB: Q9DC56 (UniProtKB/Swiss-Prot),   Q99JY9 (UniProtKB/Swiss-Prot),   Q3ULF7 (UniProtKB/TrEMBL),   A0A6P7QTE2 (UniProtKB/TrEMBL),   A0A8C6G6Q6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001192315   ⟸   NM_001205386
- UniProtKB: Q9DC56 (UniProtKB/Swiss-Prot),   Q99JY9 (UniProtKB/Swiss-Prot),   Q3ULF7 (UniProtKB/TrEMBL),   A0A6P7QTE2 (UniProtKB/TrEMBL),   A0A8C6G6Q6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001192314   ⟸   NM_001205385
- UniProtKB: Q9DC56 (UniProtKB/Swiss-Prot),   Q99JY9 (UniProtKB/Swiss-Prot),   Q3ULF7 (UniProtKB/TrEMBL),   A0A6P7QTE2 (UniProtKB/TrEMBL),   A0A8C6G6Q6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000027579   ⟸   ENSMUST00000027579
RefSeq Acc Id: ENSMUSP00000137503   ⟸   ENSMUST00000178474
RefSeq Acc Id: ENSMUSP00000140953   ⟸   ENSMUST00000191004
RefSeq Acc Id: ENSMUSP00000139674   ⟸   ENSMUST00000191544
RefSeq Acc Id: ENSMUSP00000139886   ⟸   ENSMUST00000191578
RefSeq Acc Id: ENSMUSP00000140082   ⟸   ENSMUST00000185280
RefSeq Acc Id: ENSMUSP00000140535   ⟸   ENSMUST00000188497
RefSeq Acc Id: ENSMUSP00000140000   ⟸   ENSMUST00000187460

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99JY9-F1-model_v2 AlphaFold Q99JY9 1-418 view protein structure

Promoters
RGD ID:6874758
Promoter ID:EPDNEW_M830
Type:initiation region
Name:Actr3_1
Description:Mus musculus ARP3 actin-related protein 3 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M831  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381125,435,484 - 125,435,544EPDNEW
RGD ID:6874760
Promoter ID:EPDNEW_M831
Type:initiation region
Name:Actr3_2
Description:Mus musculus ARP3 actin-related protein 3 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M830  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381125,435,673 - 125,435,733EPDNEW
RGD ID:6846577
Promoter ID:MM_ACW:2140
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ACTR3.ASEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361127,331,031 - 127,331,622 (-)MPROMDB
RGD ID:6817258
Promoter ID:MM_KWN:1930
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000027579,   UC007CKF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361127,331,796 - 127,332,647 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921367 AgrOrtholog
Ensembl Genes ENSMUSG00000026341 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000027579 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000137503 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000139674.2 UniProtKB/TrEMBL
  ENSMUSP00000139886.2 UniProtKB/TrEMBL
  ENSMUSP00000140000.2 UniProtKB/TrEMBL
  ENSMUSP00000140082.2 UniProtKB/TrEMBL
  ENSMUSP00000140535.2 UniProtKB/TrEMBL
  ENSMUSP00000140953.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000027579 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000178474 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000185280.2 UniProtKB/TrEMBL
  ENSMUST00000187460.7 UniProtKB/TrEMBL
  ENSMUST00000188497.7 UniProtKB/TrEMBL
  ENSMUST00000191004.7 UniProtKB/TrEMBL
  ENSMUST00000191544.7 UniProtKB/TrEMBL
  ENSMUST00000191578.7 UniProtKB/TrEMBL
InterPro Actin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Actin/actin-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arp3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:74117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1921367 ENTREZGENE
NCBI Gene 74117 ENTREZGENE
PANTHER PTHR11937 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11937:SF175 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Actin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Actr3 PhenoGen
PROSITE ACTINS_ACT_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ACTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WP86_MOUSE UniProtKB/TrEMBL
  A0A087WPR6_MOUSE UniProtKB/TrEMBL
  A0A087WQ14_MOUSE UniProtKB/TrEMBL
  A0A087WQ83_MOUSE UniProtKB/TrEMBL
  A0A087WRA1_MOUSE UniProtKB/TrEMBL
  A0A087WS98_MOUSE UniProtKB/TrEMBL
  A0A6P7QTE2 ENTREZGENE
  A0A8C6G6Q6 ENTREZGENE
  ARP3_MOUSE UniProtKB/Swiss-Prot
  Q3TGE1_MOUSE UniProtKB/TrEMBL
  Q3TGW0_MOUSE UniProtKB/TrEMBL
  Q3TWJ4_MOUSE UniProtKB/TrEMBL
  Q3UGH0_MOUSE UniProtKB/TrEMBL
  Q3ULF7 ENTREZGENE, UniProtKB/TrEMBL
  Q99JY9 ENTREZGENE
  Q9DC56 ENTREZGENE
  Q9ERF8_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q9DC56 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-10 Actr3  ARP3 actin-related protein 3  Actr3  ARP3 actin-related protein 3 homolog (yeast)  Symbol and/or name change 5135510 APPROVED