Bcl2l1 (BCL2-like 1) - Rat Genome Database
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Gene: Bcl2l1 (BCL2-like 1) Mus musculus
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Symbol: Bcl2l1
Name: BCL2-like 1
RGD ID: 1552009
MGI Page MGI
Description: Predicted to have several functions, including BH3 domain binding activity; enzyme binding activity; and protein dimerization activity. Involved in several processes, including apoptotic signaling pathway; cellular response to organonitrogen compound; and gonad development. Localizes to cytosol; endoplasmic reticulum; and mitochondrial outer membrane. Predicted to colocalize with clathrin-coated pit and synaptic vesicle membrane. Is expressed in several structures, including alimentary system; central nervous system; immune system; reproductive system; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); leukemia (multiple); and pancreatic cancer. Orthologous to human BCL2L1 (BCL2 like 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: anti-apoptosis regulatory protein; apoptosis regulator Bcl-X; B-cell leukemia/lymphoma x; Bcl; Bcl(X; Bcl(X)L; bcl-; bcl-2-like protein 1; bcl-x; Bcl-XL; Bcl-Xs; bcl2-L-1; Bcl2l; BclX; MGC113803; MGC99998
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,600,652 - 152,675,723 (-)NCBIGRCm39mm39
GRCm382152,758,732 - 152,833,803 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,780,668 - 152,831,728 (-)EnsemblGRCm38mm10GRCm38
MGSCv372152,606,404 - 152,657,418 (-)NCBIGRCm37mm9NCBIm37
MGSCv362152,472,109 - 152,523,123 (-)NCBImm8
Celera2158,596,643 - 158,647,694 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenoma  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (IEP,ISO)
amyotrophic lateral sclerosis type 1  (ISO)
B-lymphoblastic leukemia/lymphoma  (IMP)
brain ischemia  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cerebral Hemorrhage  (ISO)
cervical cancer  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
colorectal adenocarcinoma  (ISO)
cryptorchidism  (ISO)
dilated cardiomyopathy  (ISO)
endometrial cancer  (ISO)
endometriosis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (IMP,ISO)
Experimental Pancreatitis, Acute  (ISO)
gastric ulcer  (ISO)
Head and Neck Neoplasms  (ISO)
Hearing Loss  (ISO)
hematopoietic system disease  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
impotence  (ISO)
leiomyoma  (ISO)
liver disease  (ISO)
Liver Reperfusion Injury  (ISO)
Lung Neoplasms  (ISO)
lymphoid leukemia  (ISO)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (ISO)
mental depression  (ISO)
multiple myeloma  (IMP,ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
nephroblastoma  (ISO)
ocular hypertension  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
plasma cell neoplasm  (IMP)
polycythemia vera  (ISO)
prostate carcinoma  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
Retina Reperfusion Injury  (ISO)
status epilepticus  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (IEP)
toxic encephalopathy  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
uterus interstitial leiomyoma  (ISO)
Viral Bronchiolitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (ISO)
(+)-dexrazoxane  (EXP)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20R)-protopanaxadiol  (ISO)
(R)-carnitine  (ISO)
(R)-lipoic acid  (ISO)
(R)-mevalonic acid  (ISO)
(R)-noradrenaline  (ISO)
(R)-Salsolinol  (ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,3-dinitrobenzene  (ISO)
1,3-Dinitropyrene  (EXP)
1-bromopropane  (ISO)
1-nitropyrene  (EXP)
10-Hydroxycamptothecin  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dichloroindophenol  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-deoxy-D-glucose  (EXP)
2-ethoxyethanol  (ISO)
2-methoxyethanol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-Methylenedioxyamphetamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methyladenine  (EXP,ISO)
3-nitropropanoic acid  (ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
4-nitro-m-cresol  (EXP)
4-nitrophenol  (EXP)
4-nonylphenol  (ISO)
4-vinylcyclohexene dioxide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-Hydroxycapric acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6-oxocampestanol  (ISO)
8-OH-DPAT  (EXP)
9,10-anthraquinone  (ISO)
[6]-Shogaol  (ISO)
acetochlor  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
adenosine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
AH23848  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allicin  (ISO)
alloxan  (ISO)
alpha-Zearalanol  (EXP)
aluminium atom  (ISO)
aluminium oxide  (ISO)
aluminium(0)  (ISO)
alvocidib  (ISO)
amino acid  (EXP)
ammonium chloride  (EXP,ISO)
amosite asbestos  (ISO)
amphibole asbestos  (ISO)
Anacardic acid  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
ANTIMYCIN  (EXP)
antirheumatic drug  (ISO)
AP20187  (ISO)
apigenin  (ISO)
apocynin  (EXP)
arachidonic acid  (ISO)
aripiprazole  (ISO)
arjunolic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
Atranorin  (EXP,ISO)
atrazine  (EXP,ISO)
azadirachtin A  (ISO)
azathioprine  (ISO)
azilsartan  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[b]fluoranthene  (ISO)
benzophenanthridine  (ISO)
benzothiazoles  (ISO)
Berbamine  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (EXP)
biochanin A  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
brassinin  (ISO)
brassinolide  (ISO)
buta-1,3-diene  (EXP)
butein  (EXP)
Butylparaben  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cafestol  (ISO)
caffeine  (EXP)
Calcimycin  (ISO)
calciol  (ISO)
calcitriol  (ISO)
calyculin a  (ISO)
camalexin  (ISO)
camptothecin  (ISO)
Candesartan cilexetil  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (EXP,ISO)
carmustine  (ISO)
carvedilol  (ISO)
casticin  (ISO)
cefaloridine  (ISO)
celecoxib  (ISO)
cetrorelix  (ISO)
chloroprene  (EXP)
chloroquine  (EXP)
chlorpromazine  (EXP)
chlorpyrifos  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
chrysazin  (ISO)
chrysin  (ISO)
chrysin 5,7-dimethyl ether  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP,ISO)
citric acid  (ISO)
Clivoline  (ISO)
clofarabine  (ISO)
clofibrate  (EXP)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
cordycepin  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (EXP,ISO)
CU-O LINKAGE  (ISO)
cucurbitacin E  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
dactolisib  (ISO)
daidzein  (ISO)
Deguelin  (ISO)
dehydroepiandrosterone  (ISO)
dehydroepiandrosterone sulfate  (ISO)
demethoxyfumitremorgin C  (ISO)
deoxynivalenol  (ISO)
depsipeptide  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
dextromethorphan  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
diazoxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
dipyridamole  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
doxycycline  (EXP)
elemental selenium  (ISO)
endosulfan  (EXP,ISO)
entinostat  (EXP)
erdosteine  (EXP)
Erionite  (EXP)
esculetin  (ISO)
etacrynic acid  (ISO)
ethanol  (ISO)
etoposide  (ISO)
eugenol  (EXP)
Evodiamine  (ISO)
fenofibrate  (ISO)
fenvalerate  (ISO)
finasteride  (ISO)
fisetin  (ISO)
flavonoids  (ISO)
flubendazole  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
fucoxanthin  (ISO)
fulvestrant  (ISO)
furan  (ISO)
Fusarenone X  (EXP)
galangin  (ISO)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-tocopherol  (ISO)
Gastrodin  (EXP)
geldanamycin  (ISO)
gemcitabine  (EXP,ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
geraniol  (ISO)
glucose  (ISO)
glutathione  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypol  (ISO)
GW 6471  (EXP)
Gyrophoric acid  (ISO)
haloperidol  (ISO)
homoeriodictyol  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
hydroxamic acid  (ISO)
hydroxyurea  (ISO)
ibrutinib  (ISO)
ibuprofen  (ISO)
idelalisib  (ISO)
Ilimaquinone  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron dextran  (EXP)
iron(0)  (ISO)
isoflavones  (ISO)
isoflurane  (ISO)
isoliquiritigenin  (EXP,ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
isotretinoin  (ISO)
kaempferol  (ISO)
kurarinol  (EXP,ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lactacystin  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leptomycin B  (ISO)
linalool  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
lithocholic acid  (EXP)
lonafarnib  (ISO)
lonidamine  (ISO)
lovastatin  (ISO)
lutein  (ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mangiferin  (ISO)
melamine  (ISO)
melatonin  (ISO)
mercaptopurine  (ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
methylparaben  (ISO)
metoprolol  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotaline  (EXP)
morin  (ISO)
morphine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-dimethylformamide  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
NAD zwitterion  (EXP)
NAD(+)  (EXP)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
Niclosamide  (ISO)
nicotine  (EXP)
nitric oxide  (ISO)
nitrobenzenes  (ISO)
nitrofen  (ISO)
nitroprusside  (ISO)
Nodularin  (ISO)
NSC 23766  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
oleanolic acid  (ISO)
oltipraz  (EXP)
ouabain  (ISO)
oxaliplatin  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
paricalcitol  (ISO)
parthenolide  (ISO)
PCB138  (EXP)
Pentoxifylline  (ISO)
pepstatin A  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (ISO)
pevonedistat  (ISO)
PHA-665752  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenol red  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
picrotoxin  (ISO)
pirinixic acid  (EXP)
PK-11195  (ISO)
platycodin D  (ISO)
potassium dichromate  (ISO)
Pranoprofen  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (ISO)
progesterone  (ISO)
promethazine  (ISO)
propiconazole  (EXP)
propofol  (ISO)
propylparaben  (ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
pterostilbene  (EXP,ISO)
purine-6-thiol  (ISO)
puromycin  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
ritonavir  (ISO)
Ro 31-8220  (ISO)
romidepsin  (ISO)
rotenone  (EXP)
rottlerin  (EXP,ISO)
rubimaillin  (ISO)
rutin  (ISO)
Salvianolic acid A  (EXP,ISO)
salvianolic acid B  (ISO)
sarin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
scutellarin  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (EXP)
simazine  (EXP)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sodium dichromate  (EXP,ISO)
sorafenib  (ISO)
spironolactone  (ISO)
stattic  (ISO)
staurosporine  (EXP,ISO)
stavudine  (ISO)
streptozocin  (EXP,ISO)
styrene  (ISO)
styrene oxide  (ISO)
succimer  (EXP)
succinic acid  (ISO)
sulforaphane  (EXP,ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
tanespimycin  (ISO)
taurine  (ISO)
tauroursodeoxycholic acid  (ISO)
Tautomycin  (ISO)
temozolomide  (ISO)
TEMPO  (EXP,ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (ISO)
thiostrepton  (ISO)
Thiotepa  (ISO)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
thymoquinone  (ISO)
tin(II) chloride (anhydrous)  (ISO)
titanium dioxide  (EXP,ISO)
tocopherol  (ISO)
Tomentosin  (ISO)
topotecan  (EXP)
tributylstannane  (EXP)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimethyltin  (EXP)
Triptolide  (EXP,ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
Tylophorine  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (EXP,ISO)
veliparib  (ISO)
vemurafenib  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (EXP,ISO)
wortmannin  (ISO)
zerumbone  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc protoporphyrin  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)
zolmitriptan  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
apoptotic process  (IEA)
apoptotic process in bone marrow cell  (IMP)
cell population proliferation  (IDA)
cellular response to alkaloid  (IDA)
cellular response to amino acid stimulus  (IMP)
cellular response to astaxanthin  (ISO)
cellular response to cAMP  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to drug  (ISO)
cellular response to erythropoietin  (ISO)
cellular response to gamma radiation  (IMP)
cellular response to hypoxia  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to prolactin  (ISO)
cellular response to thapsigargin  (ISO)
cellular response to tumor necrosis factor  (ISO)
cerebral cortex development  (ISO)
defense response to virus  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA,IMP)
fertilization  (IGI)
germ cell development  (IGI,IMP)
hepatocyte apoptotic process  (IMP)
in utero embryonic development  (IMP)
intrinsic apoptotic signaling pathway in response to DNA damage  (IBA,IMP)
male gonad development  (IMP)
mitochondrion morphogenesis  (IGI)
negative regulation of anoikis  (ISO)
negative regulation of apoptotic process  (IDA,IGI,IMP,ISO)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of execution phase of apoptosis  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (IBA,ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
negative regulation of neuron apoptotic process  (IDA,IGI,IMP)
negative regulation of protein localization to plasma membrane  (ISO)
neuron apoptotic process  (IGI,IMP)
ovarian follicle development  (IGI,IMP,ISO)
positive regulation of apoptotic process  (IDA,ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of cell population proliferation  (IDA)
positive regulation of synaptic vesicle clustering  (ISO)
positive regulation of synaptic vesicle endocytosis  (ISO)
positive regulation of synaptic vesicle exocytosis  (ISO)
regulation of apoptotic process  (ISO)
regulation of cytokinesis  (ISO)
regulation of growth  (IMP)
regulation of long-term synaptic depression  (ISO)
regulation of mitochondrial membrane permeability  (ISO)
regulation of mitochondrial membrane potential  (ISO)
release of cytochrome c from mitochondria  (IGI,ISO)
response to cycloheximide  (IDA)
response to cytokine  (ISO)
response to drug  (ISO)
response to electrical stimulus  (ISO)
response to erythropoietin  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to inorganic substance  (ISO)
response to ischemia  (ISO)
response to lead ion  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
response to organonitrogen compound  (ISO)
response to oxidative stress  (ISO)
response to peptide hormone  (ISO)
response to radiation  (IMP)
response to virus  (IDA)
spermatogenesis  (IGI)
suppression by virus of host apoptotic process  (ISO)
synaptic vesicle recycling via endosome  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal apoptosis  (IAGP)
abnormal locus ceruleus morphology  (IAGP)
abnormal memory T cell physiology  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal ovarian folliculogenesis  (IAGP)
abnormal platelet morphology  (IAGP)
abnormal platelet physiology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal telencephalon development  (IAGP)
absent CD4-positive, alpha beta T cells  (IAGP)
absent CD8-positive, alpha-beta T cells  (IAGP)
azoospermia  (IAGP)
decreased apoptosis  (IAGP)
decreased body weight  (IAGP)
decreased brain weight  (IAGP)
decreased dopamine level  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased IgG1 level  (IAGP)
decreased interleukin-2 secretion  (IAGP)
decreased keratinocyte adhesion  (IAGP)
decreased litter size  (IAGP)
decreased male germ cell number  (IAGP)
decreased memory T cell number  (IAGP)
decreased neuron apoptosis  (IAGP)
decreased primordial germ cell number  (IAGP)
decreased substantia nigra size  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased T cell proliferation  (IAGP)
decreased thymocyte number  (IAGP)
exencephaly  (IAGP)
extramedullary hematopoiesis  (IAGP)
increased apoptosis  (IAGP)
increased cellular sensitivity to ultraviolet irradiation  (IAGP)
increased keratinocyte apoptosis  (IAGP)
increased megakaryocyte cell number  (IAGP)
increased neuron apoptosis  (IAGP)
increased pancreas tumor incidence  (IAGP)
male infertility  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
reduced female fertility  (IAGP)
small testis  (IAGP)
thrombocytopenia  (IAGP)
thrombocytosis  (IAGP)
References

References - curated
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Additional References at PubMed
PMID:7500043   PMID:7561075   PMID:7607090   PMID:7650367   PMID:7650488   PMID:7669718   PMID:7670999   PMID:7753802   PMID:7761398   PMID:7834748   PMID:7878471   PMID:7963517  
PMID:8157699   PMID:8244400   PMID:8587122   PMID:8605937   PMID:8624819   PMID:8625820   PMID:8626425   PMID:8627151   PMID:8640839   PMID:8798158   PMID:8798452   PMID:8804306  
PMID:8836552   PMID:8918887   PMID:8933760   PMID:8952545   PMID:9010037   PMID:9096145   PMID:9144489   PMID:9176392   PMID:9184696   PMID:9185996   PMID:9237103   PMID:9271117  
PMID:9366408   PMID:9372935   PMID:9390687   PMID:9430630   PMID:9525739   PMID:9525867   PMID:9529324   PMID:9605754   PMID:9697834   PMID:9716401   PMID:9771644   PMID:9867803  
PMID:9894607   PMID:9916985   PMID:9988219   PMID:10200490   PMID:10349636   PMID:10359572   PMID:10377054   PMID:10393176   PMID:10430628   PMID:10444588   PMID:10446348   PMID:10490101  
PMID:10508184   PMID:10519417   PMID:10618441   PMID:10652277   PMID:10662719   PMID:10807576   PMID:10859328   PMID:10875923   PMID:10894153   PMID:10922068   PMID:10960682   PMID:11042159  
PMID:11044408   PMID:11060313   PMID:11076861   PMID:11086988   PMID:11092819   PMID:11114731   PMID:11146504   PMID:11150333   PMID:11152643   PMID:11217851   PMID:11259653   PMID:11290297  
PMID:11431698   PMID:11463391   PMID:11544199   PMID:11546872   PMID:11714801   PMID:11717309   PMID:11731240   PMID:11804960   PMID:11840165   PMID:11859372   PMID:11867266   PMID:11920608  
PMID:11980919   PMID:12011449   PMID:12023955   PMID:12093873   PMID:12115603   PMID:12118121   PMID:12121614   PMID:12140768   PMID:12160936   PMID:12213327   PMID:12232794   PMID:12359085  
PMID:12393593   PMID:12420213   PMID:12446462   PMID:12459462   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12540825   PMID:12576724   PMID:12621302   PMID:12665473   PMID:12707337  
PMID:12717433   PMID:12721309   PMID:12773577   PMID:12787408   PMID:12791942   PMID:12837294   PMID:12904583   PMID:12931191   PMID:12960174   PMID:12969969   PMID:14499110   PMID:14515276  
PMID:14517295   PMID:14550262   PMID:14559912   PMID:14610273   PMID:14623242   PMID:14625274   PMID:14651853   PMID:14679196   PMID:14694195   PMID:14699151   PMID:14749429   PMID:14962910  
PMID:14963330   PMID:15105372   PMID:15131699   PMID:15136728   PMID:15199411   PMID:15231831   PMID:15279625   PMID:15319285   PMID:15383573   PMID:15385505   PMID:15480996   PMID:15492043  
PMID:15529344   PMID:15611240   PMID:15698498   PMID:15728827   PMID:15749879   PMID:15761494   PMID:15769905   PMID:15769983   PMID:15782199   PMID:15836427   PMID:15861188   PMID:15870695  
PMID:15899920   PMID:15901672   PMID:15905539   PMID:15922711   PMID:15963785   PMID:16007126   PMID:16033881   PMID:16048439   PMID:16141072   PMID:16141073   PMID:16151013   PMID:16225850  
PMID:16227588   PMID:16339534   PMID:16492678   PMID:16581793   PMID:16603546   PMID:16705087   PMID:16723699   PMID:16815550   PMID:16904610   PMID:16938278   PMID:16945928   PMID:17046822  
PMID:17052454   PMID:17122152   PMID:17158961   PMID:17177603   PMID:17223694   PMID:17267035   PMID:17274640   PMID:17382885   PMID:17431131   PMID:17438128   PMID:17446862   PMID:17476283  
PMID:17541981   PMID:17597151   PMID:17626841   PMID:17699753   PMID:17728251   PMID:17850585   PMID:17982100   PMID:17998390   PMID:18006518   PMID:18037375   PMID:18048346   PMID:18191273  
PMID:18207304   PMID:18223655   PMID:18278458   PMID:18285708   PMID:18299329   PMID:18344980   PMID:18464116   PMID:18485751   PMID:18566418   PMID:18566606   PMID:18590823   PMID:18606610  
PMID:18632667   PMID:18694996   PMID:18758240   PMID:18779780   PMID:18799693   PMID:18818203   PMID:18843207   PMID:18957517   PMID:19017943   PMID:19017950   PMID:19049976   PMID:19082511  
PMID:19103748   PMID:19121340   PMID:19139267   PMID:19179380   PMID:19209227   PMID:19210546   PMID:19252138   PMID:19255249   PMID:19328553   PMID:19454669   PMID:19581414   PMID:19596183  
PMID:19644667   PMID:19654426   PMID:19667115   PMID:19676108   PMID:19759519   PMID:19816507   PMID:19865483   PMID:19880821   PMID:19946273   PMID:20086247   PMID:20139280   PMID:20206602  
PMID:20298742   PMID:20376577   PMID:20384988   PMID:20392943   PMID:20412781   PMID:20436477   PMID:20507983   PMID:20554038   PMID:20652952   PMID:20671748   PMID:20687901   PMID:20711497  
PMID:20711984   PMID:20799797   PMID:20885444   PMID:20929728   PMID:20974940   PMID:21052840   PMID:21084607   PMID:21095239   PMID:21146511   PMID:21173168   PMID:21264227   PMID:21339291  
PMID:21367852   PMID:21514445   PMID:21546903   PMID:21673344   PMID:21684326   PMID:21724914   PMID:21818117   PMID:21854985   PMID:21873635   PMID:21911424   PMID:21980434   PMID:21987637  
PMID:21997189   PMID:22037186   PMID:22043021   PMID:22086418   PMID:22101255   PMID:22197644   PMID:22209285   PMID:22240895   PMID:22279045   PMID:22374700   PMID:22380599   PMID:22382519  
PMID:22383704   PMID:22393362   PMID:22498308   PMID:22573883   PMID:22617452   PMID:22732506   PMID:22790873   PMID:22814966   PMID:22836101   PMID:22869734   PMID:22923619   PMID:22933114  
PMID:23040355   PMID:23091012   PMID:23203923   PMID:23332762   PMID:23377201   PMID:23530063   PMID:23666531   PMID:23670294   PMID:23677993   PMID:23720737   PMID:23767404   PMID:23823868  
PMID:23842495   PMID:23852275   PMID:23986435   PMID:24227720   PMID:24297914   PMID:24313893   PMID:24363325   PMID:24395247   PMID:24639356   PMID:24808369   PMID:24813943   PMID:24858047  
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PMID:28972012   PMID:29170477   PMID:29238043   PMID:29353044   PMID:29409032   PMID:29459767   PMID:29624724   PMID:29704100   PMID:30154103   PMID:30232009   PMID:30261081   PMID:30361616  
PMID:30485804   PMID:30683842   PMID:31296963   PMID:31581792   PMID:32325033   PMID:32535617   PMID:32721616   PMID:32968282  


Genomics

Comparative Map Data
Bcl2l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,600,652 - 152,675,723 (-)NCBIGRCm39mm39
GRCm382152,758,732 - 152,833,803 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,780,668 - 152,831,728 (-)EnsemblGRCm38mm10GRCm38
MGSCv372152,606,404 - 152,657,418 (-)NCBIGRCm37mm9NCBIm37
MGSCv362152,472,109 - 152,523,123 (-)NCBImm8
Celera2158,596,643 - 158,647,694 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.41NCBI
BCL2L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2031,664,452 - 31,723,989 (-)EnsemblGRCh38hg38GRCh38
GRCh382031,664,452 - 31,723,963 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372030,252,261 - 30,311,752 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362029,715,922 - 29,774,317 (-)NCBINCBI36hg18NCBI36
Build 342029,715,923 - 29,774,317NCBI
Celera2027,008,611 - 27,067,007 (-)NCBI
Cytogenetic Map20q11.21NCBI
HuRef2027,040,965 - 27,099,720 (-)NCBIHuRef
CHM1_12030,156,165 - 30,215,683 (-)NCBICHM1_1
Bcl2l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03148,259,594 - 148,314,191 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,259,596 - 148,313,810 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,662,586 - 154,716,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,129,087 - 143,180,199 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13143,082,602 - 143,084,431 (-)NCBI
Celera3140,002,906 - 140,053,959 (-)NCBICelera
Cytogenetic Map3q41NCBI
Bcl2l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542229,254,216 - 29,308,174 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542229,254,440 - 29,307,104 (+)NCBIChiLan1.0ChiLan1.0
BCL2L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12029,088,055 - 29,147,066 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2029,088,055 - 29,146,585 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02027,955,688 - 28,015,950 (-)NCBIMhudiblu_PPA_v0panPan3
BCL2L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2421,145,215 - 21,196,355 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12421,145,214 - 21,209,425 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Bcl2l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648518,654,046 - 18,707,324 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCL2L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1735,366,141 - 35,415,359 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11735,366,139 - 35,415,798 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21740,303,991 - 40,304,598 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BCL2L1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl236,058,919 - 36,116,470 (-)Ensembl
ChlSab1.1236,059,024 - 36,118,332 (-)NCBI
Bcl2l1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624741788,445 - 838,513 (+)NCBI

Position Markers
BB166591  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382152,823,333 - 152,823,438UniSTSGRCm38
MGSCv372152,649,069 - 152,649,174UniSTSGRCm37
Celera2158,639,345 - 158,639,450UniSTS
Cytogenetic Map2H1UniSTS
cM Map287.5UniSTS
Whitehead/MRC_RH21791.8UniSTS
PMC123054P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382152,829,668 - 152,830,086UniSTSGRCm38
MGSCv372152,655,404 - 152,655,822UniSTSGRCm37
Celera2158,645,680 - 158,646,098UniSTS
Cytogenetic Map2H1UniSTS
cM Map287.5UniSTS
PMC156147P6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382152,829,569 - 152,829,744UniSTSGRCm38
MGSCv372152,655,305 - 152,655,480UniSTSGRCm37
Celera2158,645,581 - 158,645,756UniSTS
Cytogenetic Map2H1UniSTS
cM Map287.5UniSTS
UniSTS:224427  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382152,781,824 - 152,781,975UniSTSGRCm38
MGSCv372152,607,560 - 152,607,711UniSTSGRCm37
Celera2158,597,799 - 158,597,950UniSTS
Cytogenetic Map2H1UniSTS
cM Map287.5UniSTS
Bcl2l  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2H1UniSTS
cM Map287.5UniSTS
Bcl2l1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv372152,655,329 - 152,655,847UniSTSGRCm37
Celera2158,645,605 - 158,646,123UniSTS
Cytogenetic Map2H1UniSTS
cM Map287.5UniSTS
PMC262691P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382152,781,582 - 152,781,730UniSTSGRCm38
MGSCv372152,607,318 - 152,607,466UniSTSGRCm37
Celera2158,597,557 - 158,597,705UniSTS
Cytogenetic Map2H1UniSTS
cM Map287.5UniSTS
PMC305873P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382152,829,941 - 152,830,423UniSTSGRCm38
MGSCv372152,655,677 - 152,656,159UniSTSGRCm37
Celera2158,645,953 - 158,646,435UniSTS
Cytogenetic Map2H1UniSTS
cM Map287.5UniSTS
PMC20354P5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382152,829,489 - 152,829,745UniSTSGRCm38
MGSCv372152,655,225 - 152,655,481UniSTSGRCm37
Celera2158,645,501 - 158,645,757UniSTS
Cytogenetic Map2H1UniSTS
cM Map287.5UniSTS
PMC262691P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382152,829,450 - 152,829,631UniSTSGRCm38
MGSCv372152,655,186 - 152,655,367UniSTSGRCm37
Celera2158,645,462 - 158,645,643UniSTS
Cytogenetic Map2H1UniSTS
cM Map287.5UniSTS
Bcl2l1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2H1UniSTS
BCL2L1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382152,829,593 - 152,830,111UniSTSGRCm38
MGSCv372152,655,329 - 152,655,847UniSTSGRCm37
Celera2158,645,605 - 158,646,123UniSTS
Cytogenetic Map2H1UniSTS
Bcl2l  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2H1UniSTS
cM Map287.5UniSTS
Bcl2l  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2H1UniSTS
cM Map287.5UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2124095391158095504Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145676855179677006Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2118112449174483070Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132182239166182410Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127822099161822198Mouse
1558842Tailq2_mtail length QTL 2 (mouse)Not determined2151799021162895154Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145355029179355165Mouse
4141033Wg2d_mweight gain in high growth mice 2d (mouse)Not determined143931525160461088Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142751556178800659Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145386799179386921Mouse
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135857301169857441Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2139124680173124809Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144673941181254801Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2150146982182113224Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151936377182113224Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127822099161822198Mouse
1357772Scfq1_msubcutaneous fat pad weight QTL 1 (mouse)Not determined2151799021162895154Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150370301182113224Mouse
1357862Epfq1_mepididymal fat pad weight QTL 1 (mouse)Not determined2151799021162895154Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2123041095157041211Mouse
1357484Bsbob_mBSB obesity (mouse)Not determined2143931525165823099Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149394987182113224Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143931525169276004Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148822973182113224Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135857301169857441Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285893925181254801Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265439402162677006Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135857301169857441Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135857301169857441Mouse
10412080Hylaq2_mHyperlocomotor activity related QTL 2 (mouse)Not determined2151799021164277226Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2111085773154512747Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150370301182113224Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)<