Aldh1a1 (aldehyde dehydrogenase family 1, subfamily A1) - Rat Genome Database

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Gene: Aldh1a1 (aldehyde dehydrogenase family 1, subfamily A1) Mus musculus
Analyze
Symbol: Aldh1a1
Name: aldehyde dehydrogenase family 1, subfamily A1
RGD ID: 1332089
MGI Page MGI
Description: Enables 3-chloroallyl aldehyde dehydrogenase activity and aminobutyraldehyde dehydrogenase (NAD+) activity. Involved in fructose catabolic process; gamma-aminobutyric acid biosynthetic process; and negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including optic cup morphogenesis involved in camera-type eye development; positive regulation of apoptotic process; and retinoid metabolic process. Located in axon and synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ALDH1A1 (aldehyde dehydrogenase 1 family member A1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-deoxyglucosone dehydrogenase; Ahd; Ahd-; Ahd-2; Ahd2; alcohol dehydrogenase family 1, subfamily A1; alcohol dehydrogenase family 1, subfamily A2; ALD; aldehyde dehydrogenase 1, liver cytosolic (class 1); aldehyde dehydrogenase 1A1; aldehyde dehydrogenase family 1 member A1; aldehyde dehydrogenase, cytosolic; ALDH-E1; Aldh1; Aldh1a2; ALHDII; E1; Ral; RALDH 1; Raldh1; retinal dehydrogenase 1
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391920,469,947 - 20,620,827 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1920,470,079 - 20,620,829 (+)EnsemblGRCm39 Ensembl
GRCm381920,492,583 - 20,643,463 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1920,492,715 - 20,643,465 (+)EnsemblGRCm38mm10GRCm38
MGSCv371920,676,472 - 20,717,952 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361920,669,079 - 20,710,559 (+)NCBIMGSCv36mm8
Celera1921,323,202 - 21,366,435 (+)NCBICelera
Cytogenetic Map19BNCBI
cM Map1913.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-nitropropane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-diaminotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one  (ISO)
2-acetamidofluorene  (ISO)
2-amino-4,6-dinitrotoluene  (ISO)
2-butoxyethanol  (EXP)
2-hexenal  (EXP)
2-nitro-p-phenylenediamine  (ISO)
2-nitroanisole  (ISO)
2-nitrofluorene  (ISO)
2-nitropropane  (ISO)
22-Hydroxycholesterol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4'-hydroxyacetophenone  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(diethylamino)benzaldehyde  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-acetylaminofluorene  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-Amino-2-nitrophenol  (ISO)
4-dimethylaminocinnamaldehyde  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-nitro-1,2-phenylenediamine  (ISO)
4-nitrophenol  (ISO)
4-nitrophenyl acetate  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-Hydroxythalidomide  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7H-xanthine  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinal  (ISO)
9H-xanthine  (ISO)
acetaldehyde  (EXP,ISO)
acetamide  (ISO)
acetic acid  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
actinomycin D  (ISO)
adenosine 5'-monophosphate  (ISO)
aflatoxin B1  (ISO)
Aldophosphamide  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (ISO)
alpha-hexachlorocyclohexane  (ISO)
alpha-Zearalanol  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
amphetamine  (EXP)
anthracen-2-amine  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
auramine O  (ISO)
azathioprine  (ISO)
bacitracin  (ISO)
benzaldehyde  (EXP,ISO)
benzbromarone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
benzophenone  (ISO)
benzyl isothiocyanate  (EXP)
beta-naphthoflavone  (ISO)
bifenthrin  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
bromobenzene  (ISO)
buta-1,3-diene  (EXP)
butylated hydroxyanisole  (EXP)
Butylbenzyl phthalate  (EXP)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (EXP,ISO)
captan  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP)
carboplatin  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chloroform  (ISO)
chlorohydrocarbon  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
ciglitazone  (ISO)
cimetidine  (ISO)
ciprofibrate  (EXP,ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (EXP)
clofibrate  (EXP,ISO)
clofibric acid  (EXP,ISO)
clomipramine  (ISO)
clothianidin  (ISO)
clozapine  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corn oil  (ISO)
coumarin  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cyproconazole  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (ISO)
diamminedichloroplatinum  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenzofurans  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (EXP)
dichlorvos  (ISO)
dicrotophos  (ISO)
diethyl maleate  (EXP)
diethyl phthalate  (EXP)
diheptyl phthalate  (ISO)
diiodine  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diquat  (EXP)
disulfiram  (ISO)
diuron  (ISO)
doxorubicin  (EXP)
Echimidine  (ISO)
endosulfan  (ISO)
enilconazole  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (ISO)
ethanol  (EXP,ISO)
ethoxyquin  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
felbamate  (ISO)
fentin chloride  (ISO)
fipronil  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
fumonisin B1  (EXP)
furan  (ISO)
furosemide  (ISO)
gadodiamide hydrate  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glafenine  (ISO)
glutathione  (ISO)
graphene oxide  (EXP)
Heliotrine  (ISO)
hexanal  (ISO)
hydrogen peroxide  (ISO)
imipramine  (ISO)
indirubin-3'-monoxime  (EXP)
indole-3-methanol  (EXP,ISO)
inulin  (EXP)
irinotecan  (ISO)
ketoconazole  (ISO)
L-ethionine  (ISO)
lapatinib  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
Licochalcone B  (ISO)
limonin  (ISO)
lipopolysaccharide  (EXP)
magnesium atom  (ISO)
magnesium dichloride  (ISO)
malonaldehyde  (EXP,ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
miconazole  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
Monobutylphthalate  (EXP)
monosodium L-glutamate  (EXP)
monuron  (ISO)
Muraglitazar  (ISO)
N,N-bis(2-hydroxypropyl)nitrosamine  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
NAD zwitterion  (EXP,ISO)
NAD(+)  (EXP,ISO)
naphthalene  (EXP)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (EXP)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nimesulide  (ISO)
nitroglycerin  (ISO)
non-2-enal  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
okadaic acid  (EXP)
oleic acid  (ISO)
oltipraz  (EXP)
omeprazole  (ISO)
orphenadrine  (ISO)
ozone  (ISO)
p-toluidine  (ISO)
paclitaxel  (EXP,ISO)
para-Cresidine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phencyclidine  (EXP)
phenethyl isothiocyanate  (ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prochloraz  (ISO)
progesterone  (EXP)
propanal  (EXP,ISO)
propiconazole  (EXP,ISO)
pyrazinecarboxamide  (ISO)
pyrogallol  (EXP)
quartz  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
Salinomycin  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (ISO)
spironolactone  (EXP)
streptozocin  (ISO)
sulfasalazine  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
tanespimycin  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (ISO)
testosterone  (EXP)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thapsigargin  (ISO)
thiacloprid  (ISO)
thioacetamide  (ISO)
Thiotepa  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
trametinib  (ISO)
transplatin  (ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
trimethylarsine oxide  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
Tungsten carbide  (ISO)
ubiquinone-0  (ISO)
uracil  (ISO)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (ISO)
XAV939  (ISO)
Xmu-MP-1  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IDA)
cell projection  (IEA)
cytoplasm  (IEA)
cytosol  (ISO)
synapse  (IDA)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning of a cDNA encoding rat aldehyde dehydrogenase with high activity for retinal oxidation. Bhat PV, etal., Gene 1995 Dec 12;166(2):303-6.
2. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Identification of pancreatic cancer invasion-related proteins by proteomic analysis. Walsh N, etal., Proteome Sci. 2009 Feb 14;7:3.
12. Multiple retinol and retinal dehydrogenases catalyze all-trans-retinoic acid biosynthesis in astrocytes. Wang C, etal., J Biol Chem. 2011 Feb 25;286(8):6542-53. Epub 2010 Dec 7.
Additional References at PubMed
PMID:751648   PMID:896803   PMID:1425331   PMID:1935685   PMID:2044153   PMID:2055490   PMID:2222572   PMID:2571572   PMID:4343087   PMID:7274657   PMID:7606739   PMID:7774911  
PMID:7835908   PMID:7958964   PMID:7993664   PMID:8058062   PMID:8093609   PMID:8393814   PMID:8663049   PMID:9092472   PMID:9097025   PMID:9166904   PMID:9819390   PMID:10191271  
PMID:10385706   PMID:10464095   PMID:10490294   PMID:10570467   PMID:10753524   PMID:10837133   PMID:10906479   PMID:10922068   PMID:11013254   PMID:11025231   PMID:11044606   PMID:11744377  
PMID:11747070   PMID:11876656   PMID:11959834   PMID:12128098   PMID:12454286   PMID:12477932   PMID:12576512   PMID:12610736   PMID:12693930   PMID:12808103   PMID:12834868   PMID:12851412  
PMID:14595844   PMID:14681479   PMID:15161092   PMID:15366004   PMID:15489334   PMID:15531370   PMID:15584907   PMID:15760467   PMID:15765518   PMID:15766748   PMID:16026781   PMID:16047160  
PMID:16109395   PMID:16207763   PMID:16326081   PMID:16339193   PMID:16438966   PMID:16602821   PMID:16611695   PMID:16615129   PMID:16782087   PMID:17010133   PMID:17175089   PMID:17257171  
PMID:17270348   PMID:17332066   PMID:17529981   PMID:17567582   PMID:17592014   PMID:17687036   PMID:18076286   PMID:18307411   PMID:18331719   PMID:18391535   PMID:18393306   PMID:18399539  
PMID:18561907   PMID:18665267   PMID:18971422   PMID:18985738   PMID:19448158   PMID:19449303   PMID:19515692   PMID:19519663   PMID:19549509   PMID:19618468   PMID:19737349   PMID:19783990  
PMID:19795519   PMID:19842188   PMID:20054864   PMID:20122913   PMID:20503368   PMID:20532162   PMID:21057506   PMID:21059124   PMID:21148184   PMID:21167960   PMID:21183788   PMID:21220692  
PMID:21256123   PMID:21267068   PMID:21308776   PMID:21436255   PMID:21539829   PMID:21784415   PMID:21820362   PMID:21873635   PMID:21895658   PMID:21953779   PMID:22069189   PMID:22195027  
PMID:22198153   PMID:22278924   PMID:22384032   PMID:22432025   PMID:22537018   PMID:22555438   PMID:22561685   PMID:22748019   PMID:22794259   PMID:22869719   PMID:22930583   PMID:22933113  
PMID:22998872   PMID:23012458   PMID:23142317   PMID:23193184   PMID:23213462   PMID:23444097   PMID:23484127   PMID:23536097   PMID:23625387   PMID:23637192   PMID:23786406   PMID:23806210  
PMID:23829703   PMID:23850584   PMID:23863478   PMID:23951127   PMID:23963803   PMID:24005908   PMID:24066094   PMID:24080087   PMID:24156634   PMID:24324671   PMID:24466150   PMID:24577091  
PMID:24797530   PMID:24865427   PMID:24952961   PMID:24997521   PMID:25064526   PMID:25127144   PMID:25155611   PMID:25261715   PMID:25311225   PMID:25523391   PMID:25577283   PMID:25715397  
PMID:25919081   PMID:26124079   PMID:26164566   PMID:26242870   PMID:26427057   PMID:26430123   PMID:26446231   PMID:26751691   PMID:26885858   PMID:26892828   PMID:27144456   PMID:27214556  
PMID:27572106   PMID:27597886   PMID:27746183   PMID:28117896   PMID:28130357   PMID:28250050   PMID:28274610   PMID:28378742   PMID:28706191   PMID:28715412   PMID:28800615   PMID:29093497  
PMID:29095919   PMID:29163030   PMID:29414685   PMID:29609731   PMID:29688375   PMID:29689292   PMID:29986869   PMID:30104732   PMID:30166332   PMID:30247516   PMID:30250298   PMID:30487180  
PMID:30705619   PMID:30718509   PMID:30837649   PMID:30885956   PMID:30930745   PMID:31043608   PMID:31365862   PMID:31401066   PMID:31515492   PMID:31772170   PMID:31847788   PMID:31913463  
PMID:32001436   PMID:32325033   PMID:32385093   PMID:32494737   PMID:32561725   PMID:32562661   PMID:32571845   PMID:32853992   PMID:33195246   PMID:33201874   PMID:33964960   PMID:34003106  
PMID:34525371   PMID:34599305   PMID:34623260   PMID:34702328   PMID:34758317   PMID:34884468   PMID:35084365   PMID:35315776   PMID:35443174   PMID:35574006   PMID:35656893   PMID:36094016  
PMID:36293380   PMID:36674903   PMID:37216517   PMID:37537242   PMID:37610090   PMID:37839992   PMID:37904003   PMID:38078651  


Genomics

Comparative Map Data
Aldh1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391920,469,947 - 20,620,827 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1920,470,079 - 20,620,829 (+)EnsemblGRCm39 Ensembl
GRCm381920,492,583 - 20,643,463 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1920,492,715 - 20,643,465 (+)EnsemblGRCm38mm10GRCm38
MGSCv371920,676,472 - 20,717,952 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361920,669,079 - 20,710,559 (+)NCBIMGSCv36mm8
Celera1921,323,202 - 21,366,435 (+)NCBICelera
Cytogenetic Map19BNCBI
cM Map1913.91NCBI
ALDH1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38972,900,671 - 72,953,053 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl972,900,671 - 73,080,442 (-)EnsemblGRCh38hg38GRCh38
GRCh37975,515,587 - 75,567,969 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36974,705,407 - 74,757,789 (-)NCBINCBI36Build 36hg18NCBI36
Build 34972,745,141 - 72,797,523NCBI
Celera946,088,447 - 46,140,830 (-)NCBICelera
Cytogenetic Map9q21.13NCBI
HuRef945,338,144 - 45,390,773 (-)NCBIHuRef
CHM1_1975,662,616 - 75,715,255 (-)NCBICHM1_1
T2T-CHM13v2.0985,051,589 - 85,103,957 (-)NCBIT2T-CHM13v2.0
Aldh1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,426,939 - 227,579,497 (+)NCBIGRCr8
mRatBN7.21218,000,470 - 218,152,962 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1218,042,127 - 218,152,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1226,448,507 - 226,490,531 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,385,074 - 233,427,098 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01226,203,095 - 226,245,121 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01238,222,689 - 238,264,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1238,222,521 - 238,264,330 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01245,340,587 - 245,562,970 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,731,675 - 223,773,285 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11223,895,697 - 223,937,307 (+)NCBI
Celera1215,379,207 - 215,421,068 (+)NCBICelera
Cytogenetic Map1q51NCBI
ALDH1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21172,085,972 - 72,265,332 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1972,091,914 - 72,271,273 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0951,737,305 - 51,916,648 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1971,680,352 - 71,859,144 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl971,680,890 - 71,814,085 (-)Ensemblpanpan1.1panPan2
ALDH1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1184,940,411 - 84,994,789 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl184,940,411 - 84,994,789 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha185,406,217 - 85,460,597 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0185,390,369 - 85,444,756 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl185,390,360 - 85,444,756 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1185,159,477 - 85,213,817 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0184,862,384 - 84,917,606 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0185,621,439 - 85,676,732 (+)NCBIUU_Cfam_GSD_1.0
Aldh1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947132,159,211 - 132,303,931 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365038,868,961 - 8,918,532 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365038,869,073 - 8,953,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,161,299 - 226,217,308 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,163,347 - 226,217,342 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,778,605 - 252,808,516 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11283,949,529 - 84,092,452 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1283,949,399 - 84,009,003 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603872,378,038 - 72,569,020 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldh1a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624811505,101 - 563,855 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624811505,297 - 563,795 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aldh1a1
5587 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:131
Count of miRNA genes:117
Interacting mature miRNAs:121
Transcripts:ENSMUST00000087638
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122371338Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120695286Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19332855120539663Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
12801464Rta2_mretinal aging 2 (mouse)141230287425302874Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1301197Tlyr1_mthymic lymphoma resistance 1 (mouse)Not determined192053952825313796Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse

Markers in Region
Aldh1a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381920,629,071 - 20,630,740UniSTSGRCm38
MGSCv371920,703,561 - 20,705,230UniSTSGRCm37
Celera1921,366,267 - 21,366,434UniSTS
Celera1921,365,898 - 21,366,257UniSTS
Celera1921,353,706 - 21,353,803UniSTS
Cytogenetic Map19BUniSTS
cM Map1920.0UniSTS
cM Map1912.0UniSTS
cM Map1912.0UniSTS
M74570  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381920,643,152 - 20,643,310UniSTSGRCm38
MGSCv371920,717,642 - 20,717,800UniSTSGRCm37
Celera1921,366,125 - 21,366,283UniSTS
Cytogenetic Map19BUniSTS
cM Map1912.0UniSTS
Whitehead/MRC_RH19197.39UniSTS
Whitehead/MRC_RH19214.16UniSTS
Whitehead_YAC19 UniSTS
Aldh1a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19BUniSTS
Aldh1a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19BUniSTS
Aldh1a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381920,643,294 - 20,643,461UniSTSGRCm38
MGSCv371920,717,784 - 20,717,951UniSTSGRCm37
Celera1921,366,267 - 21,366,434UniSTS
Cytogenetic Map19BUniSTS
Aldh1a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381920,630,702 - 20,630,799UniSTSGRCm38
MGSCv371920,705,192 - 20,705,289UniSTSGRCm37
Celera1921,353,706 - 21,353,803UniSTS
Cytogenetic Map19BUniSTS
Aldh1a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19BUniSTS
Aldh1a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381920,642,925 - 20,643,284UniSTSGRCm38
MGSCv371920,717,415 - 20,717,774UniSTSGRCm37
Celera1921,365,898 - 21,366,257UniSTS
Cytogenetic Map19BUniSTS
M74570  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381920,643,295 - 20,643,377UniSTSGRCm38
MGSCv371920,717,785 - 20,717,867UniSTSGRCm37
Celera1921,366,268 - 21,366,350UniSTS
Cytogenetic Map19BUniSTS
Whitehead/MRC_RH19197.39UniSTS
Whitehead/MRC_RH19214.16UniSTS
Aldh1a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19BUniSTS
cM Map1912.0UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000087638   ⟹   ENSMUSP00000084918
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1920,579,325 - 20,620,826 (+)Ensembl
GRCm38.p6 Ensembl1920,601,961 - 20,643,462 (+)Ensembl
Ensembl Acc Id: ENSMUST00000224358
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1920,470,096 - 20,544,217 (+)Ensembl
GRCm38.p6 Ensembl1920,492,732 - 20,566,853 (+)Ensembl
Ensembl Acc Id: ENSMUST00000224807
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1920,470,079 - 20,533,774 (+)Ensembl
GRCm38.p6 Ensembl1920,492,715 - 20,556,410 (+)Ensembl
Ensembl Acc Id: ENSMUST00000225249
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1920,470,124 - 20,518,741 (+)Ensembl
GRCm38.p6 Ensembl1920,492,760 - 20,541,377 (+)Ensembl
Ensembl Acc Id: ENSMUST00000225313   ⟹   ENSMUSP00000153011
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1920,470,123 - 20,597,435 (+)Ensembl
GRCm38.p6 Ensembl1920,492,759 - 20,620,071 (+)Ensembl
Ensembl Acc Id: ENSMUST00000225337   ⟹   ENSMUSP00000153410
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1920,470,079 - 20,620,829 (+)Ensembl
GRCm38.p6 Ensembl1920,492,715 - 20,643,465 (+)Ensembl
RefSeq Acc Id: NM_001361503   ⟹   NP_001348432
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391920,469,947 - 20,620,827 (+)NCBI
GRCm381920,492,583 - 20,643,463 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001361504   ⟹   NP_001348433
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391920,469,947 - 20,620,827 (+)NCBI
GRCm381920,492,583 - 20,643,463 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001361505   ⟹   NP_001348434
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391920,469,947 - 20,620,827 (+)NCBI
GRCm381920,492,583 - 20,643,463 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001361506   ⟹   NP_001348435
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391920,469,947 - 20,620,827 (+)NCBI
GRCm381920,492,583 - 20,643,463 (+)NCBI
Sequence:
RefSeq Acc Id: NM_013467   ⟹   NP_038495
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391920,579,332 - 20,620,827 (+)NCBI
GRCm381920,601,968 - 20,643,463 (+)NCBI
MGSCv371920,676,472 - 20,717,952 (+)RGD
Celera1921,323,202 - 21,366,435 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_038495   ⟸   NM_013467
- UniProtKB: Q7TQJ0 (UniProtKB/Swiss-Prot),   Q811J0 (UniProtKB/Swiss-Prot),   P24549 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001348432   ⟸   NM_001361503
- UniProtKB: Q7TQJ0 (UniProtKB/Swiss-Prot),   P24549 (UniProtKB/Swiss-Prot),   Q811J0 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001348433   ⟸   NM_001361504
- UniProtKB: Q7TQJ0 (UniProtKB/Swiss-Prot),   P24549 (UniProtKB/Swiss-Prot),   Q811J0 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001348434   ⟸   NM_001361505
- UniProtKB: Q7TQJ0 (UniProtKB/Swiss-Prot),   P24549 (UniProtKB/Swiss-Prot),   Q811J0 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001348435   ⟸   NM_001361506
- UniProtKB: Q7TQJ0 (UniProtKB/Swiss-Prot),   P24549 (UniProtKB/Swiss-Prot),   Q811J0 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000153011   ⟸   ENSMUST00000225313
Ensembl Acc Id: ENSMUSP00000153410   ⟸   ENSMUST00000225337
Ensembl Acc Id: ENSMUSP00000084918   ⟸   ENSMUST00000087638
Protein Domains
Aldehyde dehydrogenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24549-F1-model_v2 AlphaFold P24549 1-501 view protein structure

Promoters
RGD ID:13679084
Promoter ID:EPDNEW_M23691
Type:multiple initiation site
Name:Aldh1a1_1
Description:Mus musculus aldehyde dehydrogenase family 1, subfamily A1 ,transcript variant 5, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381920,601,968 - 20,602,028EPDNEW
RGD ID:6829825
Promoter ID:MM_KWN:26628
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver,   Lung
Transcripts:OTTMUST00000050305
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361920,676,214 - 20,676,714 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1353450 AgrOrtholog
Ensembl Genes ENSMUSG00000053279 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000087638 ENTREZGENE
  ENSMUST00000087638.4 UniProtKB/Swiss-Prot
  ENSMUST00000225313.2 UniProtKB/TrEMBL
  ENSMUST00000225337 ENTREZGENE
  ENSMUST00000225337.3 UniProtKB/Swiss-Prot
InterPro Ald_DH/histidinol_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_C UniProtKB/Swiss-Prot
  Ald_DH_CS_CYS UniProtKB/Swiss-Prot
  Ald_DH_CS_GLU UniProtKB/Swiss-Prot
  Ald_DH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde_DH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11668 UniProtKB/Swiss-Prot
MGD MGI:1353450 ENTREZGENE
NCBI Gene 11668 ENTREZGENE
PANTHER ALDEHYDE DEHYDROGENASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RETINAL DEHYDROGENASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldedh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ALDH1A1 RGD
PhenoGen Aldh1a1 PhenoGen
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/Swiss-Prot
  ALDEHYDE_DEHYDR_GLU UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A286YCZ0_MOUSE UniProtKB/TrEMBL
  AL1A1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q7TQJ0 ENTREZGENE
  Q811J0 ENTREZGENE
UniProt Secondary Q7TQJ0 UniProtKB/Swiss-Prot
  Q811J0 UniProtKB/Swiss-Prot