Park7 (Parkinson disease (autosomal recessive, early onset) 7) - Rat Genome Database

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Gene: Park7 (Parkinson disease (autosomal recessive, early onset) 7) Mus musculus
Symbol: Park7
Name: Parkinson disease (autosomal recessive, early onset) 7
RGD ID: 1552781
Description: Enables oxygen sensor activity and peroxiredoxin activity. Involved in several processes, including detoxification of inorganic compound; negative regulation of intrinsic apoptotic signaling pathway; and negative regulation of protein metabolic process. Acts upstream of or within several processes, including dopamine uptake involved in synaptic transmission; membrane hyperpolarization; and positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway. Located in several cellular components, including cell body; endoplasmic reticulum; and mitochondrion. Is expressed in central nervous system and retina. Used to study Parkinson's disease 7. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; Parkinsonism; cerebral infarction; and middle cerebral artery infarction. Orthologous to human PARK7 (Parkinsonism associated deglycase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DJ-1; Dj1; maillard deglycase; parkinson disease protein 7 homolog; parkinsonism-associated deglycase; protein/nucleic acid deglycase DJ-1; RNA-binding protein regulatory subunit
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm19080  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm394150,981,590 - 150,994,378 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4150,981,590 - 150,998,894 (-)EnsemblGRCm39 Ensembl
GRCm384150,897,133 - 150,909,921 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,897,133 - 150,914,437 (-)EnsemblGRCm38mm10GRCm38
MGSCv374150,271,242 - 150,284,030 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364149,740,942 - 149,753,650 (-)NCBIMGSCv36mm8
Celera4153,174,297 - 153,187,100 (-)NCBICelera
Cytogenetic Map4E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (EXP)
1-bromopropane  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
4-phenylbutyric acid  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
amphetamine  (EXP)
arsenite(3-)  (ISO)
astemizole  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
butyric acid  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
chromium trinitrate  (EXP)
chromium(6+)  (EXP)
cisplatin  (EXP,ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
dexamethasone  (EXP)
diazinon  (ISO)
dibenziodolium  (EXP)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
fenazaquin  (EXP)
fenpyroximate  (EXP)
flavonoids  (ISO)
folic acid  (EXP)
glutathione  (ISO)
haloperidol  (EXP)
heparin  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
isoniazide  (EXP)
ivermectin  (ISO)
lactacystin  (ISO)
lipopolysaccharide  (EXP)
lutein  (EXP)
LY294002  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
meloxicam  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosomorpholine  (ISO)
nicotine  (EXP)
ouabain  (EXP)
oxidopamine  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorododecanoic acid  (ISO)
permethrin  (ISO)
phlorizin  (EXP)
potassium chromate  (EXP)
prostaglandin E2  (EXP)
pyridaben  (EXP)
Pyridostigmine bromide  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
rotenone  (EXP,ISO)
rutin  (ISO)
sarin  (ISO)
SB 203580  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
superoxide  (EXP)
T-2 toxin  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
toluene  (ISO)
trans-piceid  (ISO)
Tributyltin oxide  (EXP)
tungsten  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (IMP)
aging  (ISO)
autophagy  (IEA)
cellular detoxification of aldehyde  (ISO)
cellular detoxification of methylglyoxal  (ISO)
cellular response to DNA damage stimulus  (IEA)
cellular response to glyoxal  (IMP,ISO)
cellular response to hydrogen peroxide  (IMP,ISO)
cellular response to hypoxia  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to oxidative stress  (IMP,ISO)
cellular response to reactive oxygen species  (IMP)
detection of oxidative stress  (IMP)
detoxification of copper ion  (IMP,ISO)
detoxification of mercury ion  (IMP,ISO)
DNA repair  (ISO)
dopamine uptake involved in synaptic transmission  (IMP)
glucose homeostasis  (IMP)
glutathione deglycation  (ISO)
glycolate biosynthetic process  (IBA,IDA,ISO)
glyoxal metabolic process  (IBA,IDA,ISO)
guanine deglycation  (ISO)
guanine deglycation, glyoxal removal  (ISO)
guanine deglycation, methylglyoxal removal  (ISO)
histone modification  (ISO)
hydrogen peroxide metabolic process  (IMP,ISO)
inflammatory response  (IEA)
insulin secretion  (IMP)
lactate biosynthetic process  (ISO)
maternal process involved in female pregnancy  (ISO)
membrane depolarization  (IMP)
membrane hyperpolarization  (IMP)
methylglyoxal catabolic process to lactate  (ISO)
methylglyoxal metabolic process  (ISO)
mitochondrion organization  (IMP)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of cell death  (IMP,ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (ISO)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IMP,ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of hydrogen peroxide-induced cell death  (ISO)
negative regulation of hydrogen peroxide-induced neuron death  (IMP,ISO)
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway  (IMP,ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron death  (IBA,ISO)
negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of NMDA glutamate receptor activity  (ISO)
negative regulation of oxidative stress-induced cell death  (ISO)
negative regulation of oxidative stress-induced neuron death  (IMP)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
negative regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
negative regulation of protein acetylation  (ISO)
negative regulation of protein binding  (ISO)
negative regulation of protein catabolic process  (IMP)
negative regulation of protein export from nucleus  (ISO)
negative regulation of protein K48-linked deubiquitination  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein sumoylation  (ISO)
negative regulation of protein ubiquitination  (IMP,ISO)
negative regulation of reactive oxygen species biosynthetic process  (IMP)
negative regulation of smooth muscle cell migration  (ISO)
negative regulation of TRAIL-activated apoptotic signaling pathway  (ISO)
negative regulation of ubiquitin-protein transferase activity  (IC,ISO)
negative regulation of ubiquitin-specific protease activity  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
peptidyl-arginine deglycation  (ISO)
peptidyl-cysteine deglycation  (ISO)
peptidyl-lysine deglycation  (ISO)
positive regulation of acute inflammatory response to antigenic stimulus  (IMP)
positive regulation of androgen receptor activity  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of dopamine biosynthetic process  (ISO)
positive regulation of fertilization  (ISO)
positive regulation of gene expression  (IMP)
positive regulation of interleukin-8 production  (ISO)
positive regulation of L-dopa biosynthetic process  (ISO)
positive regulation of L-dopa decarboxylase activity  (ISO)
positive regulation of mitochondrial electron transport, NADH to ubiquinone  (IMP,ISO)
positive regulation of NAD(P)H oxidase activity  (IMP)
positive regulation of oxidative phosphorylation uncoupler activity  (IMP)
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (IMP)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of pyrroline-5-carboxylate reductase activity  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (IDA)
positive regulation of superoxide dismutase activity  (ISO)
positive regulation of transcription by RNA polymerase II  (IMP,ISO)
positive regulation of transcription regulatory region DNA binding  (ISO)
positive regulation of tyrosine 3-monooxygenase activity  (ISO)
protein deglycation, glyoxal removal  (ISO)
protein deglycation, methylglyoxal removal  (ISO)
protein deglycosylation  (ISO)
protein stabilization  (IMP,ISO)
proteolysis  (IEA)
regulation of androgen receptor signaling pathway  (ISO)
regulation of histone acetylation  (ISO)
regulation of histone ubiquitination  (ISO)
regulation of inflammatory response  (IMP)
regulation of mitochondrial membrane potential  (ISO)
regulation of neuron apoptotic process  (ISO)
regulation of TRAIL production  (ISO)
response to hydrogen peroxide  (IDA,IMP)
response to oxidative stress  (IBA,ISO)
response to xenobiotic stimulus  (ISO)
single fertilization  (IEA)
spermatogenesis  (ISO)
synaptic transmission, dopaminergic  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage. Aleyasin H, etal., Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18748-53. doi: 10.1073/pnas.0709379104. Epub 2007 Nov 14.
2. Neuroprotective function of DJ-1 in Parkinson's disease. Ariga H, etal., Oxid Med Cell Longev. 2013;2013:683920. doi: 10.1155/2013/683920. Epub 2013 May 16.
3. Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease. Dave KD, etal., Neurobiol Dis. 2014 Oct;70:190-203. doi: 10.1016/j.nbd.2014.06.009. Epub 2014 Jun 24.
4. Up-regulation of caveolin-1 by DJ-1 attenuates rat pulmonary arterial hypertension by inhibiting TGFβ/Smad signaling pathway. Gao W, etal., Exp Cell Res. 2017 Dec 1;361(1):192-198. doi: 10.1016/j.yexcr.2017.10.019. Epub 2017 Oct 22.
5. Protection against dopaminergic neurodegeneration in Parkinson's disease-model animals by a modulator of the oxidized form of DJ-1, a wild-type of familial Parkinson's disease-linked PARK7. Inden M, etal., J Pharmacol Sci. 2011;117(3):189-203. Epub 2011 Oct 29.
6. PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model. Inden M, etal., Neurobiol Dis. 2006 Oct;24(1):144-58. Epub 2006 Jul 24.
7. MGDs mouse GO annotations MGD data from the GO Consortium
9. L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system. Miller DW, etal., J Biol Chem. 2003 Sep 19;278(38):36588-95. Epub 2003 Jul 8.
10. DJ-1-binding compounds prevent oxidative stress-induced cell death and movement defect in Parkinson's disease model rats. Miyazaki S, etal., J Neurochem. 2008 Jun 1;105(6):2418-34. doi: 10.1111/j.1471-4159.2008.05327.x.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Rotenone-induced parkinsonism elicits behavioral impairments and differential expression of parkin, heat shock proteins and caspases in the rat. Sonia Angeline M, etal., Neuroscience. 2012 Sep 18;220:291-301. doi: 10.1016/j.neuroscience.2012.06.021. Epub 2012 Jun 16.
17. Regulation of dopamine presynaptic markers and receptors in the striatum of DJ-1 and Pink1 knockout rats. Sun J, etal., Neurosci Lett. 2013 Dec 17;557 Pt B:123-8. doi: 10.1016/j.neulet.2013.10.034. Epub 2013 Oct 22.
18. DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats. Yanagisawa D, etal., J Cereb Blood Flow Metab. 2008 Mar;28(3):563-78. doi: 10.1038/sj.jcbfm.9600553. Epub 2007 Sep 19.
Additional References at PubMed
PMID:8889548   PMID:9070310   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11223268   PMID:11811539   PMID:12132656   PMID:12446870   PMID:12466851  
PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:14625045   PMID:14652021   PMID:14752510   PMID:15489334   PMID:15502868   PMID:15721235   PMID:15745951   PMID:15782199  
PMID:15784737   PMID:15799973   PMID:15804505   PMID:15944198   PMID:16115732   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16624565   PMID:17015834   PMID:17034344   PMID:17120294  
PMID:17331951   PMID:17535435   PMID:17560790   PMID:17599367   PMID:17766438   PMID:17823202   PMID:17846173   PMID:18187333   PMID:18246449   PMID:18614015   PMID:18626009   PMID:18712292  
PMID:18799693   PMID:18822273   PMID:18930142   PMID:18974921   PMID:19063952   PMID:19144925   PMID:19229105   PMID:19276172   PMID:19293155   PMID:19423573   PMID:19680261   PMID:19683835  
PMID:19766170   PMID:19822128   PMID:19885556   PMID:20039949   PMID:20089532   PMID:20133695   PMID:20186336   PMID:20202083   PMID:20304780   PMID:20377612   PMID:20385180   PMID:20386724  
PMID:20457924   PMID:20516060   PMID:20639397   PMID:20708070   PMID:20708612   PMID:20800516   PMID:20940149   PMID:20969476   PMID:21035105   PMID:21068725   PMID:21097510   PMID:21195752  
PMID:21300143   PMID:21368136   PMID:21645620   PMID:21664494   PMID:21725356   PMID:21819105   PMID:21839811   PMID:21873635   PMID:21907265   PMID:22215708   PMID:22354994   PMID:22403686  
PMID:22492997   PMID:22523093   PMID:22526393   PMID:22542940   PMID:22555455   PMID:22609282   PMID:22611253   PMID:22666465   PMID:22792356   PMID:22871147   PMID:22872702   PMID:22922362  
PMID:22932389   PMID:22941107   PMID:23019375   PMID:23065353   PMID:23149933   PMID:23182168   PMID:23230227   PMID:23241025   PMID:23326576   PMID:23418303   PMID:23447676   PMID:23528847  
PMID:23530187   PMID:23587484   PMID:23622116   PMID:23743200   PMID:23792957   PMID:23847046   PMID:23969237   PMID:24070869   PMID:24075852   PMID:24128678   PMID:24243970   PMID:24269020  
PMID:24323315   PMID:24348900   PMID:24386432   PMID:24577080   PMID:24637782   PMID:24646099   PMID:24733019   PMID:24816140   PMID:24899725   PMID:24912681   PMID:24918637   PMID:24925581  
PMID:24936441   PMID:24947010   PMID:24953490   PMID:25058424   PMID:25082883   PMID:25448609   PMID:25463323   PMID:25500798   PMID:25623535   PMID:25670069   PMID:25706411   PMID:25737280  
PMID:25822630   PMID:25833141   PMID:25978603   PMID:26021615   PMID:26022125   PMID:26024237   PMID:26077864   PMID:26215528   PMID:26222260   PMID:26408915   PMID:26419955   PMID:26422139  
PMID:26462467   PMID:26464968   PMID:26546471   PMID:26634899   PMID:26691871   PMID:26836693   PMID:26873851   PMID:27108530   PMID:27109140   PMID:27171370   PMID:27277679   PMID:27325702  
PMID:27346864   PMID:27507650   PMID:27509531   PMID:27581498   PMID:27611333   PMID:27766037   PMID:27825319   PMID:27975168   PMID:28036277   PMID:28088625   PMID:28336262   PMID:28360124  
PMID:28369333   PMID:28378742   PMID:28408307   PMID:28627418   PMID:28671696   PMID:28882997   PMID:28941803   PMID:29021755   PMID:29097687   PMID:29105838   PMID:29142196   PMID:29272304  
PMID:29315581   PMID:29386384   PMID:29476075   PMID:29511860   PMID:30048497   PMID:30104666   PMID:30107296   PMID:30142366   PMID:30171910   PMID:30189364   PMID:30443192   PMID:30562941  
PMID:30595499   PMID:30696938   PMID:30755590   PMID:30796974   PMID:30837411   PMID:30908580   PMID:30954702   PMID:30995881   PMID:31313616   PMID:31313618   PMID:31353306   PMID:31487745  
PMID:31536960   PMID:31767755   PMID:31875550   PMID:32075910   PMID:32144268   PMID:32152416   PMID:32176388   PMID:32249515   PMID:32291905   PMID:32325033   PMID:32457148   PMID:32484300  
PMID:32526245   PMID:32554809   PMID:32715759   PMID:32826201   PMID:32999308   PMID:33024240   PMID:33246293   PMID:33633277   PMID:33766785   PMID:33795807   PMID:34014921   PMID:34093596  
PMID:34274951   PMID:34445085   PMID:34593886   PMID:35012549   PMID:35037711   PMID:35046029   PMID:35618940   PMID:36042578   PMID:36149763   PMID:36417873   PMID:36449316  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm394150,981,590 - 150,994,378 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4150,981,590 - 150,998,894 (-)EnsemblGRCm39 Ensembl
GRCm384150,897,133 - 150,909,921 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,897,133 - 150,914,437 (-)EnsemblGRCm38mm10GRCm38
MGSCv374150,271,242 - 150,284,030 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364149,740,942 - 149,753,650 (-)NCBIMGSCv36mm8
Celera4153,174,297 - 153,187,100 (-)NCBICelera
Cytogenetic Map4E2NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3817,961,711 - 7,985,505 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl17,954,291 - 7,985,505 (+)EnsemblGRCh38hg38GRCh38
GRCh3718,021,771 - 8,045,565 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3617,944,380 - 7,967,926 (+)NCBINCBI36Build 36hg18NCBI36
Build 3417,956,058 - 7,979,602NCBI
Celera17,128,771 - 7,152,398 (+)NCBICelera
Cytogenetic Map1p36.23NCBI
HuRef17,169,316 - 7,193,163 (+)NCBIHuRef
CHM1_118,009,469 - 8,033,097 (+)NCBICHM1_1
T2T-CHM13v2.017,492,675 - 7,516,444 (+)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.25161,353,718 - 161,376,993 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5161,353,719 - 161,376,970 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5164,071,138 - 164,094,398 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05165,887,564 - 165,910,960 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05165,849,775 - 165,873,035 (-)NCBIRnor_WKY
Rnor_6.05167,982,438 - 168,004,724 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,982,439 - 168,004,724 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05171,559,202 - 171,582,476 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45168,050,149 - 168,061,616 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15168,060,336 - 168,071,804 (-)NCBI
Celera5159,607,648 - 159,630,713 (-)NCBICelera
Cytogenetic Map5q36NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554864,969,497 - 4,985,885 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554864,974,130 - 4,985,927 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.117,969,265 - 7,993,271 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl17,969,280 - 7,993,271 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v016,722,260 - 6,745,915 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1561,576,219 - 61,592,325 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl561,576,069 - 61,592,303 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha561,584,413 - 61,601,125 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0561,791,984 - 61,808,701 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl561,792,439 - 61,808,700 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1561,791,244 - 61,807,961 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0561,656,017 - 61,672,730 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0562,059,399 - 62,076,120 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440505831,937,508 - 31,951,577 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366232,422,833 - 2,436,817 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366232,422,780 - 2,436,817 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl668,629,214 - 68,645,516 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1668,629,327 - 68,645,147 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2663,023,779 - 63,033,855 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.120123,776,084 - 123,808,031 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20123,776,297 - 123,798,434 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605427,810,002 - 27,834,129 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248183,900,917 - 3,911,042 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248183,900,917 - 3,915,457 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1770
Count of miRNA genes:583
Interacting mature miRNAs:692
Transcripts:ENSMUST00000030805, ENSMUST00000105673, ENSMUST00000105674, ENSMUST00000105675, ENSMUST00000105676, ENSMUST00000128075, ENSMUST00000132265, ENSMUST00000134751, ENSMUST00000146184, ENSMUST00000148626
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129465811151654550Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4133010494156860686Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133676733156860686Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134654451156860686Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134654451156860686Mouse
1300553Athsq1_matherosclerosis susceptibility QTL 1 (mouse)Not determined4137617848151654550Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138943725156860686Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384150,897,137 - 150,897,334UniSTSGRCm38
MGSCv374150,271,246 - 150,271,443UniSTSGRCm37
Celera4153,174,301 - 153,174,498UniSTS
Cytogenetic Map4E1UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384150,898,894 - 150,899,113UniSTSGRCm38
MGSCv374150,273,003 - 150,273,222UniSTSGRCm37
Celera4153,176,064 - 153,176,283UniSTS
Cytogenetic Map4E1UniSTS



Reference Sequences
RefSeq Acc Id: ENSMUST00000030805   ⟹   ENSMUSP00000030805
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4150,981,590 - 150,994,383 (-)Ensembl
GRCm38.p6 Ensembl4150,897,133 - 150,909,926 (-)Ensembl
RefSeq Acc Id: ENSMUST00000105673   ⟹   ENSMUSP00000101298
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4150,981,696 - 150,994,108 (-)Ensembl
GRCm38.p6 Ensembl4150,897,239 - 150,909,651 (-)Ensembl
RefSeq Acc Id: ENSMUST00000105674   ⟹   ENSMUSP00000101299
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4150,981,602 - 150,994,083 (-)Ensembl
GRCm38.p6 Ensembl4150,897,145 - 150,909,626 (-)Ensembl
RefSeq Acc Id: ENSMUST00000105675   ⟹   ENSMUSP00000101300
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4150,981,590 - 150,998,894 (-)Ensembl
GRCm38.p6 Ensembl4150,897,133 - 150,914,437 (-)Ensembl
RefSeq Acc Id: ENSMUST00000105676   ⟹   ENSMUSP00000101301
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4150,981,693 - 150,992,870 (-)Ensembl
GRCm38.p6 Ensembl4150,897,236 - 150,908,413 (-)Ensembl
RefSeq Acc Id: ENSMUST00000128075   ⟹   ENSMUSP00000115875
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4150,985,467 - 150,993,940 (-)Ensembl
GRCm38.p6 Ensembl4150,901,010 - 150,909,483 (-)Ensembl
RefSeq Acc Id: ENSMUST00000132265
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4150,981,841 - 150,986,292 (-)Ensembl
GRCm38.p6 Ensembl4150,897,384 - 150,901,835 (-)Ensembl
RefSeq Acc Id: ENSMUST00000134751   ⟹   ENSMUSP00000122265
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4150,989,583 - 150,994,325 (-)Ensembl
GRCm38.p6 Ensembl4150,905,126 - 150,909,868 (-)Ensembl
RefSeq Acc Id: ENSMUST00000146184   ⟹   ENSMUSP00000120832
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4150,989,707 - 150,998,663 (-)Ensembl
GRCm38.p6 Ensembl4150,905,250 - 150,914,206 (-)Ensembl
RefSeq Acc Id: ENSMUST00000148626
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4150,988,016 - 150,994,285 (-)Ensembl
GRCm38.p6 Ensembl4150,903,559 - 150,909,828 (-)Ensembl
RefSeq Acc Id: NM_020569   ⟹   NP_065594
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm394150,981,590 - 150,994,378 (-)NCBI
GRCm384150,897,133 - 150,909,921 (-)NCBI
MGSCv374150,271,242 - 150,284,030 (-)RGD
Celera4153,174,297 - 153,187,100 (-)RGD
RefSeq Acc Id: XM_036164283   ⟹   XP_036020176
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm394150,981,590 - 150,986,619 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_065594   ⟸   NM_020569
- UniProtKB: Q3U509 (UniProtKB/Swiss-Prot),   Q99LX0 (UniProtKB/Swiss-Prot),   A0A8C6GVU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000101298   ⟸   ENSMUST00000105673
RefSeq Acc Id: ENSMUSP00000101299   ⟸   ENSMUST00000105674
RefSeq Acc Id: ENSMUSP00000101300   ⟸   ENSMUST00000105675
RefSeq Acc Id: ENSMUSP00000101301   ⟸   ENSMUST00000105676
RefSeq Acc Id: ENSMUSP00000120832   ⟸   ENSMUST00000146184
RefSeq Acc Id: ENSMUSP00000122265   ⟸   ENSMUST00000134751
RefSeq Acc Id: ENSMUSP00000115875   ⟸   ENSMUST00000128075
RefSeq Acc Id: ENSMUSP00000030805   ⟸   ENSMUST00000030805
RefSeq Acc Id: XP_036020176   ⟸   XM_036164283
- Peptide Label: isoform X1
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99LX0-F1-model_v2 AlphaFold Q99LX0 1-189 view protein structure

RGD ID:6848795
Promoter ID:MM_TRO:7223
SO ACC ID:SO:0000170
Tissues & Cell Lines:Brain,   Kidney,   Liver,   Lung
Mouse AssemblyChrPosition (strand)Source
MGSCv364150,271,316 - 150,271,816 (-)MPROMDB
RGD ID:6835819
Promoter ID:MM_KWN:40953
SO ACC ID:SO:0000170
Tissues & Cell Lines:Brain,   Kidney,   Liver,   Lung
Mouse AssemblyChrPosition (strand)Source
MGSCv364150,275,961 - 150,276,812 (-)MPROMDB
RGD ID:6835817
Promoter ID:MM_KWN:40955
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000105673,   ENSMUST00000105674,   ENSMUST00000105677,   OTTMUST00000023609,   OTTMUST00000023613,   OTTMUST00000023614,   OTTMUST00000023615
Mouse AssemblyChrPosition (strand)Source
MGSCv364150,283,366 - 150,284,317 (-)MPROMDB
RGD ID:6835822
Promoter ID:MM_KWN:40956
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000105675,   OTTMUST00000023793,   OTTMUST00000023805
Mouse AssemblyChrPosition (strand)Source
MGSCv364150,287,361 - 150,289,317 (-)MPROMDB
RGD ID:6885620
Promoter ID:EPDNEW_M6261
Type:initiation region
Description:Mus musculus Parkinson disease (autosomal recessive, early onset)7 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm384150,909,831 - 150,909,891EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2135637 AgrOrtholog
Ensembl Genes ENSMUSG00000028964 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000030805 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000101298 UniProtKB/Swiss-Prot
  ENSMUSP00000101299 UniProtKB/Swiss-Prot
  ENSMUSP00000101300 UniProtKB/Swiss-Prot
  ENSMUSP00000101301.2 UniProtKB/TrEMBL
  ENSMUSP00000115875.2 UniProtKB/TrEMBL
  ENSMUSP00000120832.2 UniProtKB/TrEMBL
  ENSMUSP00000122265.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000030805 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000105673 UniProtKB/Swiss-Prot
  ENSMUST00000105674 UniProtKB/Swiss-Prot
  ENSMUST00000105675 UniProtKB/Swiss-Prot
  ENSMUST00000105676.8 UniProtKB/TrEMBL
  ENSMUST00000128075.8 UniProtKB/TrEMBL
  ENSMUST00000134751.8 UniProtKB/TrEMBL
  ENSMUST00000146184.3 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Class_I_gatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DJ-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DJ-1/PfpI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:57320 UniProtKB/Swiss-Prot
Pfam DJ-1_PfpI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Park7 PhenoGen
Superfamily-SCOP SSF52317 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs not_thiJ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PARK7_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary O88306 UniProtKB/Swiss-Prot
  Q3THB9 UniProtKB/Swiss-Prot
  Q3U509 UniProtKB/Swiss-Prot