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Gene: Apoa1 (apolipoprotein A-I) Mus musculus
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Symbol: Apoa1
Name: apolipoprotein A-I
RGD ID: 10173
Description: Exhibits several functions, including cholesterol transfer activity; high-density lipoprotein particle binding activity; and identical protein binding activity. Involved in several processes, including cholesterol biosynthetic process; cholesterol efflux; and regulation of intestinal cholesterol absorption. Localizes to extracellular space. Is expressed in embryo; intestine; liver; and stomach. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial hypercholesterolemia; familial visceral amyloidosis; non-alcoholic steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (apolipoprotein A1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Al; Alp-1; Ap; apo-AI; Apoa-1; apoA-I; apolipoprotein A1; Brp-; Brp-14; Ltw-; Ltw-1; Lvtw; Lvtw-1; MGC102525; Se; Sep; Sep-1; Sep-2; Sep2
Orthologs:
Homo sapiens (human) : APOA1 (apolipoprotein A1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Apoa1 (apolipoprotein A1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apoa1 (apolipoprotein A1)
Pan paniscus (bonobo/pygmy chimpanzee) : APOA1 (apolipoprotein A1)
Canis lupus familiaris (dog) : APOA1 (apolipoprotein A1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apoa1 (apolipoprotein A1)
Sus scrofa (pig) : APOA1 (apolipoprotein A1)
Chlorocebus sabaeus (African green monkey) : APOA1 (apolipoprotein A1)
Heterocephalus glaber (naked mole-rat) : Apoa1 (apolipoprotein A1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl946,228,580 - 46,230,466 (+)EnsemblGRCm38mm10GRCm38
GRCm38946,228,630 - 46,230,469 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37946,036,713 - 46,038,549 (+)NCBIGRCm37mm9NCBIm37
MGSCv36945,979,705 - 45,981,461 (+)NCBImm8
Celera943,517,584 - 43,519,420 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Apoa1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10173
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.