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Gene: Apoa1 (apolipoprotein A-I) Mus musculus
Symbol: Apoa1
Name: apolipoprotein A-I
RGD ID: 10173
Description: Exhibits several functions, including cholesterol transfer activity; high-density lipoprotein particle binding activity; and identical protein binding activity. Involved in several processes, including cholesterol biosynthetic process; cholesterol efflux; and regulation of intestinal cholesterol absorption. Localizes to extracellular space. Is expressed in embryo; intestine; liver; and stomach. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial hypercholesterolemia; familial visceral amyloidosis; non-alcoholic steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (apolipoprotein A1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Al; Alp-1; Ap; apo-AI; Apoa-1; apoA-I; apolipoprotein A1; Brp-; Brp-14; Ltw-; Ltw-1; Lvtw; Lvtw-1; MGC102525; Se; Sep; Sep-1; Sep-2; Sep2
Homo sapiens (human) : APOA1 (apolipoprotein A1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Apoa1 (apolipoprotein A1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apoa1 (apolipoprotein A1)
Pan paniscus (bonobo/pygmy chimpanzee) : APOA1 (apolipoprotein A1)
Canis lupus familiaris (dog) : APOA1 (apolipoprotein A1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apoa1 (apolipoprotein A1)
Sus scrofa (pig) : APOA1 (apolipoprotein A1)
Chlorocebus sabaeus (African green monkey) : APOA1 (apolipoprotein A1)
Heterocephalus glaber (naked mole-rat) : Apoa1 (apolipoprotein A1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl946,228,580 - 46,230,466 (+)EnsemblGRCm38mm10GRCm38
GRCm38946,228,630 - 46,230,469 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37946,036,713 - 46,038,549 (+)NCBIGRCm37mm9NCBIm37
MGSCv36945,979,705 - 45,981,461 (+)NCBImm8
Celera943,517,584 - 43,519,420 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Apoa1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10173
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.