Esr1 (estrogen receptor 1 (alpha)) - Rat Genome Database

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Gene: Esr1 (estrogen receptor 1 (alpha)) Mus musculus
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Symbol: Esr1
Name: estrogen receptor 1 (alpha)
RGD ID: 10551
MGI Page MGI
Description: Enables chromatin binding activity; nuclear receptor activity; and sequence-specific DNA binding activity. Involved in cellular response to estradiol stimulus and stem cell differentiation. Acts upstream of or within several processes, including mammary gland development; regulation of defense response; and reproductive structure development. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study breast cancer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast cancer (multiple); type 2 diabetes mellitus; and vitiligo. Orthologous to human ESR1 (estrogen receptor 1).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AA420328; AU041214; C-terminally-truncated estrogen receptor alpha product-4; C-terminally-truncated estrogen receptor alpha product-5; C-terminally-truncated estrogen receptor alpha product-6; C-terminally-truncated estrogen receptor alpha product-7; E; ER; ER-; ER-alpha; ER[; ER[a]; ERa; ERalpha; Es; ESR; Estr; Estra; estradiol receptor; estrogen receptor; estrogen receptor alpha variant U1; estrogen receptor alpha variant U2; Nr; Nr3a1; nuclear receptor subfamily 3 group A member 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39104,561,989 - 4,955,633 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl104,561,593 - 4,955,614 (+)EnsemblGRCm39 Ensembl
GRCm38104,611,989 - 5,005,633 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl104,611,593 - 5,005,614 (+)EnsemblGRCm38mm10GRCm38
MGSCv37105,342,780 - 5,734,495 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36105,342,780 - 5,734,495 (-)NCBIMGSCv36mm8
Celera104,553,702 - 4,949,051 (+)NCBICelera
Cytogenetic Map10A1NCBI
cM Map102.03NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Esr1MouseAlzheimer's disease  ISOESR1 (Homo sapiens)1358612 RGD 
Esr1Mousearteriosclerosis  ISOESR1 (Homo sapiens)4892301 RGD 
Esr1Mouseatherosclerosis treatmentIMP 8553067 RGD 
Esr1MouseBone Fractures no_associationISOESR1 (Homo sapiens)10045827DNA:SNP and repeat:promoter:rs2234693 (human)RGD 
Esr1MouseBone Fractures  ISOESR1 (Homo sapiens)10045827DNA:SNP:intron:rs9340799 (human)RGD 
Esr1Mousebreast cancer treatmentISOESR1 (Homo sapiens)8552979 RGD 
Esr1Mousebreast cancer susceptibilityISOESR1 (Homo sapiens)8552982DNA:SNP:exon:2014G>A (human)RGD 
Esr1Mousebreast cancer no_associationISOESR1 (Homo sapiens)8552980DNA:SNPs: :rs2234693 and rs9340799 (human)RGD 
Esr1Mousebreast cancer no_associationISOESR1 (Homo sapiens)8553053DNA:SNP: :908A>G (p.K303R) (human)RGD 
Esr1Mousebreast cancer  ISOESR1 (Homo sapiens)8553052DNA:SNP: :908A>G (p.K303R) (human)RGD 
Esr1Mousebreast cancer disease_progressionISOESR1 (Homo sapiens)8552981DNA:amplificationRGD 
Esr1Mousebreast cancer susceptibilityISOESR1 (Homo sapiens)8552978DNA:SNPs more ...RGD 
Esr1Mousebreast carcinoma severityISOESR1 (Homo sapiens)2290017mRNA and protein:increased expression:breastRGD 
Esr1Mousebreast carcinoma disease_progressionISOESR1 (Homo sapiens)8552986protein:increased serine phosphorylationRGD 
Esr1MouseBreast Neoplasms  ISOESR1 (Homo sapiens)8553054DNA:SNP:3' utr:rs2747648 (human)RGD 
Esr1MouseBronchial Hyperreactivity  ISOESR1 (Homo sapiens)4892312 RGD 
Esr1Mousecataract 33  IMP 734947 RGD 
Esr1MouseChronic Periodontitis no_associationISOESR1 (Homo sapiens)10045837DNA:polymorphismRGD 
Esr1MouseChronic Periodontitis  ISOESR1 (Homo sapiens)10045837DNA:polymorphismRGD 
Esr1Mousecoronary artery disease  ISOESR1 (Homo sapiens)1580335 RGD 
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Esr1Mousearthrogryposis multiplex congenita-3  ISOESR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Arthrogryposis multiplex congenita 3 and myogenic typeClinVarPMID:25741868 and PMID:27782104
Esr1Mouseautosomal dominant Emery-Dreifuss muscular dystrophy 4  ISOESR1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
Esr1Mouseautosomal recessive spinocerebellar ataxia 8  ISOESR1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
Esr1MouseBreast Cancer, Familial  ISOESR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial cancer of breastClinVarPMID:10945602 more ...
Esr1MouseBreast Neoplasms  ISOESR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Breast neoplasmClinVarPMID:24185510 more ...
Esr1Mousecerebellar ataxia  ISOESR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Cerebellar ataxiaClinVar 
Esr1Mousechromosome 6q24-q25 deletion syndrome  ISOESR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 6q24-q25 deletion syndromeClinVarPMID:25741868 and PMID:38177409
Esr1MouseEmery-Dreifuss muscular dystrophy  ISOESR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Emery-Dreifuss muscular dystrophyClinVar 
Esr1MouseEstrogen Resistance  ISOESR1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15133719 more ...
Esr1Mousemigraine  ISOESR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Migraine with or without aura and susceptibility toClinVarPMID:15133719 and PMID:25741868
Esr1Mousemyocardial infarction  ISOESR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Myocardial infarction and susceptibility toClinVarPMID:11894143 more ...
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Esr1Mouseadenocarcinoma  ISOESR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15639718 and PMID:20458558
Esr1MouseAlzheimer's disease  ISOESR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17192785
Esr1MouseAnimal Disease Models  ISOESR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20962747
Esr1MouseAnimal Mammary Neoplasms  ISOESR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15637090 more ...
Esr1Mouseatherosclerosis  ISOESR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11894143
Esr1Mousebone disease  ISOESR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28505433
Esr1MouseBreast Neoplasms  ISOESR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17417639 more ...
Esr1Mousecarcinoma  ISOESR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15637090 and PMID:17173897
Esr1Mousecoronary artery disease  ISOESR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9396482 and PMID:20559769
Esr1MouseDisease Progression  ISOESR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20104649
Esr1MouseEndometrial Neoplasms  ISOESR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24185510
Esr1MouseExperimental Liver Neoplasms  ISOESR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35044086
Esr1MouseExperimental Mammary Neoplasms  ISOESR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15637090
Esr1MouseFemale Infertility  ISOESR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23710174
Esr1MouseFemale Urogenital Diseases  ISOESR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16002989
Esr1MouseFeminization  ISOESR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22275727
Esr1MouseGenetic Predisposition to Disease  ISOESR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35764155
Esr1Mouseglomerulonephritis  ISOESR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20962747
Esr1Mousehepatocellular carcinoma  ISOESR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19363144 and PMID:28284560
Esr1Mouseidiopathic pulmonary fibrosis  ISOESR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30165855
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Esr1Mousemyocardial infarction  ISOESR1 (Homo sapiens)1331525 GAD 
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Esr1Mousebreast cancer  IAGP 13592920OMIM:114480MouseDO 
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Esr1Mousebreast cancer  ISOESR1 (Homo sapiens)7240710 OMIM 
Esr1MouseEstrogen Resistance  ISOESR1 (Homo sapiens)7240710 OMIM 
Esr1Mousemigraine  ISOESR1 (Homo sapiens)7240710 OMIM 
Esr1Mousemyocardial infarction  ISOESR1 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Esr1Mouse(-)-bursehernin affects bindingISOESR1 (Homo sapiens)6480464bursehernin binds to ESR1 proteinCTDPMID:35631411
Esr1Mouse(-)-epigallocatechin 3-gallate increases expressionEXP 6480464epigallocatechin gallate results in increased expression of ESR1 proteinCTDPMID:34600025 and PMID:35863485
Esr1Mouse(-)-matairesinol affects bindingISOESR1 (Homo sapiens)6480464matairesinol binds to ESR1 proteinCTDPMID:35631411
Esr1Mouse(1->4)-beta-D-glucan multiple interactionsEXP 6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of ESR1 mRNACTDPMID:36331819
Esr1Mouse(2,4,5-trichlorophenoxy)acetic acid multiple interactionsISOESR1 (Homo sapiens)64804642 more ...CTDPMID:16626760
Esr1Mouse(24S)-24-hydroxycholesterol multiple interactionsISOESR1 (Homo sapiens)648046424-hydroxycholesterol binds to and results in decreased activity of ESR1 protein and 24-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]CTDPMID:17873880
Esr1Mouse(25R)-cholest-5-ene-3beta,26-diol multiple interactionsEXP 6480464ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA] and ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA]CTDPMID:17873880
Esr1Mouse(25R)-cholest-5-ene-3beta,26-diol affects response to substanceEXP 6480464ESR1 protein affects the susceptibility to 27-hydroxycholesterolCTDPMID:17873880
Esr1Mouse(25R)-cholest-5-ene-3beta,26-diol increases degradationISOESR1 (Homo sapiens)648046427-hydroxycholesterol results in increased degradation of ESR1 proteinCTDPMID:17872378
Esr1Mouse(25R)-cholest-5-ene-3beta,26-diol multiple interactionsISOESR1 (Homo sapiens)648046427-hydroxycholesterol binds to and affects the folding of and results in increased activity of ESR1 protein more ...CTDPMID:17872378 and PMID:17873880
Esr1Mouse(3-phenoxyphenyl)methanol multiple interactionsISOESR1 (Homo sapiens)64804643-phenoxybenzylalcohol binds to and results in increased activity of ESR1 proteinCTDPMID:16395479 and PMID:33049310
Esr1Mouse(3-phenoxyphenyl)methanol decreases expressionISOESR1 (Homo sapiens)64804643-phenoxybenzylalcohol results in decreased expression of ESR1 mRNACTDPMID:20397420
Esr1Mouse(E)-thiamethoxam decreases expressionEXP 6480464Thiamethoxam results in decreased expression of ESR1 proteinCTDPMID:33533595
Esr1Mouse(E)-thiamethoxam affects bindingISOESR1 (Homo sapiens)6480464Thiamethoxam binds to ESR1 proteinCTDPMID:31550567
Esr1Mouse(R)-camphor multiple interactionsISOESR1 (Homo sapiens)6480464Camphor binds to and results in increased activity of ESR1 proteinCTDPMID:27633901
Esr1Mouse(R)-linalyl acetate increases activityISOESR1 (Homo sapiens)6480464linalyl acetate results in increased activity of ESR1 proteinCTDPMID:31393563
Esr1Mouse(R)-linalyl acetate multiple interactionsISOESR1 (Homo sapiens)6480464NCOA2 protein promotes the reaction [linalyl acetate results in increased activity of ESR1 protein]CTDPMID:31393563
Esr1Mouse(R)-salsolinol increases activityISOESR1 (Homo sapiens)6480464salsolinol results in increased activity of ESR1 proteinCTDPMID:24020587
Esr1Mouse(R,R,R)-alpha-tocopherol multiple interactionsISOEsr1 (Rattus norvegicus)6480464[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 mRNA] and [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 protein]CTDPMID:22389237
Esr1Mouse(S)-colchicine multiple interactionsISOESR1 (Homo sapiens)6480464Colchicine binds to and results in decreased activity of ESR1 proteinCTDPMID:25752796

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Biological Process
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Original Reference(s)
Esr1Mouseandrogen metabolic process acts_upstream_of_or_withinIMPMGI:21508972290270 PMID:18755802MGIPMID:18755802
Esr1Mouseantral ovarian follicle growth acts_upstream_of_or_withinIMPMGI:23867602290270 PMID:10976058MGIPMID:10976058
Esr1Mousebaculum development  ISOEsr1 (Rattus norvegicus)9068941 RGDPMID:21471296 and REF_RGD_ID:8552989
Esr1Mousecellular response to estradiol stimulus involved_inISOEsr1 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Esr1Mousecellular response to estradiol stimulus involved_inISSUniProtKB:P062112290270 UniProtGO_REF:0000024
Esr1Mousecellular response to estradiol stimulus involved_inISOUniProtKB:P033722290270 GO_CentralGO_REF:0000119
Esr1Mousecellular response to estradiol stimulus involved_inIDA 2290270 PMID:9448000UniProtPMID:9448000
Esr1Mousecellular response to estrogen stimulus involved_inIBAPANTHER:PTN002786965 more ...2290270 GO_CentralGO_REF:0000033
Esr1Mousecellular response to estrogen stimulus acts_upstream_of_or_withinIMPMGI:21508972290270 PMID:17901126MGIPMID:17901126
Esr1Mousecellular response to estrogen stimulus  ISOEsr1 (Rattus norvegicus)9068941 RGDPMID:17272396 and REF_RGD_ID:152177689
Esr1Mousecellular response to wortmannin  ISOEsr1 (Rattus norvegicus)9068941 RGDPMID:17272396 and REF_RGD_ID:152177689
Esr1Mousedecidualization  ISOEsr1 (Rattus norvegicus)9068941 RGDPMID:21248290 and REF_RGD_ID:8553214
Esr1Mouseepithelial cell development acts_upstream_of_or_withinIMPMGI:21508972290270 PMID:18755802MGIPMID:18755802
Esr1Mouseepithelial cell proliferation involved in mammary gland duct elongation acts_upstream_of_or_withinIMPMGI:21508972290270 PMID:12021201MGIPMID:12021201
Esr1Mouseestrogen receptor signaling pathway involved_inISOUniProtKB:P033722290270 GO_CentralGO_REF:0000119
Esr1Mouseestrogen receptor signaling pathway involved_inIEAUniProtKB:P03372 and ensembl:ENSP000002062492290270 EnsemblGO_REF:0000107
Esr1Mouseestrogen receptor signaling pathway involved_inIBAPANTHER:PTN002786965 and UniProtKB:P033722290270 GO_CentralGO_REF:0000033
Esr1Mousefibroblast proliferation acts_upstream_ofIMPMGI:21508972290270 PMID:18755802MGIPMID:18755802
Esr1Mousemale gonad development  ISOEsr1 (Rattus norvegicus)9068941 RGDPMID:20951417 and REF_RGD_ID:8553220
Esr1Mousemale gonad development acts_upstream_of_or_withinIMPMGI:21508972290270 PMID:18755802MGIPMID:18755802
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Cellular Component
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Esr1Mousechromatin is_active_inIBAPANTHER:PTN002377694 more ...2290270 GO_CentralGO_REF:0000033
Esr1Mousechromatin located_inISOUniProtKB:P033722290270 GO_CentralGO_REF:0000119
Esr1Mousecytoplasm located_inISSUniProtKB:P033722290270 UniProtGO_REF:0000024
Esr1Mousecytoplasm located_inIDA 2290270 PMID:12845704 and PMID:14552897MGIPMID:12845704 and PMID:14552897
Esr1Mousecytoplasm located_inISOUniProtKB:P033722290270 GO_CentralGO_REF:0000119
Esr1Mouseeuchromatin located_inIEAUniProtKB:P03372 and ensembl:ENSP000002062492290270 EnsemblGO_REF:0000107
Esr1Mouseeuchromatin located_inISOUniProtKB:P033722290270 GO_CentralGO_REF:0000119
Esr1MouseGolgi apparatus located_inIEAUniProtKB-SubCell:SL-01322290270 UniProtGO_REF:0000044
Esr1Mousenucleus located_inISOUniProtKB:P033722290270 GO_CentralGO_REF:0000119
Esr1Mousenucleus located_inISOEsr1 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Esr1Mousenucleus located_inIDA 2290270 PMID:11897499 more ...MGIPMID:11897499 more ...
Esr1Mousenucleus is_active_inIBAPANTHER:PTN001182563 more ...2290270 GO_CentralGO_REF:0000033
Esr1Mouseperikaryon  ISOEsr1 (Rattus norvegicus)9068941 RGDPMID:16122717 and REF_RGD_ID:1582179
Esr1Mouseperikaryon located_inISOEsr1 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Esr1Mouseperinuclear region of cytoplasm located_inISOEsr1 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Esr1Mouseperinuclear region of cytoplasm  ISOEsr1 (Rattus norvegicus)9068941 RGDPMID:17928626 and REF_RGD_ID:5128669
Esr1Mouseplasma membrane is_active_inISOUniProtKB:P033722290270 GO_CentralGO_REF:0000119
Esr1Mouseplasma membrane located_inIEAUniProtKB-SubCell:SL-00392290270 UniProtGO_REF:0000044
Esr1Mouseplasma membrane located_inISOUniProtKB:P033722290270 GO_CentralGO_REF:0000119
Esr1Mouseprotein-containing complex  ISOEsr1 (Rattus norvegicus)9068941 RGDPMID:18434427 and REF_RGD_ID:2311258
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Molecular Function
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Esr1Mouse14-3-3 protein binding enablesISOUniProtKB:P033722290270 GO_CentralGO_REF:0000119
Esr1Mouse14-3-3 protein binding enablesIEAUniProtKB:P03372 and ensembl:ENSP000002062492290270 EnsemblGO_REF:0000107
Esr1MouseATPase binding enablesISOUniProtKB:P033722290270 PMID:12058073MGIPMID:12058073
Esr1Mousebeta-catenin binding enablesISOUniProtKB:P033722290270 GO_CentralGO_REF:0000119
Esr1Mousebeta-catenin binding enablesIEAUniProtKB:P03372 and ensembl:ENSP000002062492290270 EnsemblGO_REF:0000107
Esr1Mousecalmodulin binding enablesISOUniProtKB:P033722290270 GO_CentralGO_REF:0000119
Esr1Mousechromatin binding enablesISOUniProtKB:P033722290270 GO_CentralGO_REF:0000119
Esr1Mousechromatin binding enablesIDA 2290270 PMID:18202148 and PMID:24332041MGIPMID:18202148 and PMID:24332041
Esr1MouseDNA binding  ISOEsr1 (Rattus norvegicus)9068941 RGDPMID:12372009 and REF_RGD_ID:1358611
Esr1MouseDNA binding enablesISOEsr1 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Esr1MouseDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:P03372 and ensembl:ENSP000002062492290270 EnsemblGO_REF:0000107
Esr1MouseDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOUniProtKB:P033722290270 GO_CentralGO_REF:0000119
Esr1Mouseenzyme binding  ISOParp1 (Rattus norvegicus)9068941 RGDPMID:23493398 and REF_RGD_ID:10413906
Esr1Mouseenzyme binding enablesISOUniProtKB:P033722290270 GO_CentralGO_REF:0000119
Esr1Mouseenzyme binding enablesISOEsr1 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Esr1Mouseenzyme binding  ISOHsd17b10 (Rattus norvegicus)9068941 RGDPMID:19422801 and REF_RGD_ID:4890964
Esr1Mouseestrogen binding  ISOEsr1 (Rattus norvegicus)9068941 RGDPMID:11713241 and REF_RGD_ID:727330
Esr1Mouseestrogen response element binding enablesIBAPANTHER:PTN001182563 more ...2290270 GO_CentralGO_REF:0000033
Esr1Mouseestrogen response element binding enablesIEAUniProtKB:P03372 and ensembl:ENSP000002062492290270 EnsemblGO_REF:0000107
Esr1Mouseestrogen response element binding enablesISOUniProtKB:P033722290270 GO_CentralGO_REF:0000119
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RGD Manual Annotations


  

Imported Annotations - PID (archival)

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Esr1Mouseforkhead class A signaling pathway  ISOESR1 (Homo sapiens)6484113 PIDPID:200226
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Esr1Mouseabnormal B cell differentiation  IAGP 5509061 MGIPMID:10875230
Esr1Mouseabnormal B cell number  IAGP 5509061 MGIPMID:12603601
Esr1Mouseabnormal bone marrow cell number  IAGP 5509061 MGIPMID:12603601
Esr1Mouseabnormal bone marrow cell number  IAGP 5509061 MGIPMID:9647203
Esr1Mouseabnormal bone marrow cell physiology  IAGP 5509061 MGIPMID:21444817
Esr1Mouseabnormal bone mineralization  IAGP 5509061 MGIPMID:16234973
Esr1Mouseabnormal bone structure  IAGP 5509061 MGIPMID:16234973
Esr1Mouseabnormal branching of the mammary ductal tree  IAGP 5509061 MGIPMID:12351685
Esr1Mouseabnormal branching of the mammary ductal tree  IAGP 5509061 MGIPMID:17785410
Esr1Mouseabnormal cell migration  IAGP 5509061 MGIPMID:24371309
Esr1Mouseabnormal chondrocyte physiology  IAGP 5509061 MGIPMID:14753739
Esr1Mouseabnormal circulating cholesterol level  IAGP 5509061 MGIPMID:11160157
Esr1Mouseabnormal class switch recombination  IAGP 5509061 MGIPMID:12603601
Esr1Mouseabnormal colon goblet cell morphology  IAGP 5509061 MGIPMID:17332369
Esr1Mouseabnormal copulation behavior  IAGP 5509061 MGIPMID:11114183
Esr1Mouseabnormal cremaster muscle morphology  IAGP 5509061 MGIPMID:8723431
Esr1Mouseabnormal definitive hematopoiesis  IAGP 5509061 MGIPMID:10875230
Esr1Mouseabnormal efferent ductules of testis morphology  IAGP 5509061 MGIPMID:10670526
Esr1Mouseabnormal endometrium morphology  IAGP 5509061 MGIPMID:11311804
Esr1Mouseabnormal endometrium morphology  IAGP 5509061 MGIPMID:17046690
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#
Reference Title
Reference Citation
1. Mutational and polymorphic analysis of the estradiol receptor-alpha gene in men with symptomatic vertebral fractures. Allcroft LC, etal., Calcif Tissue Int. 2002 Nov;71(5):400-5. Epub 2002 Aug 19.
2. The promoter C specific ERalpha isoform is associated with tamoxifen outcome in breast cancer. Amaral S, etal., Breast Cancer Res Treat. 2009 Nov;118(2):323-31. doi: 10.1007/s10549-008-0241-9. Epub 2008 Nov 15.
3. The dinucleotide (CA) repeat polymorphism of estrogen receptor beta but not the dinucleotide (TA) repeat polymorphism of estrogen receptor alpha is associated with venous ulceration. Ashworth JJ, etal., J Steroid Biochem Mol Biol. 2005 Nov;97(3):266-70. Epub 2005 Sep 8.
4. Opposing roles of ERalpha and ERbeta in the genesis and progression of adenocarcinoma in the rat ventral prostate. Attia DM and Ederveen AG, Prostate. 2012 Jun 15;72(9):1013-22. doi: 10.1002/pros.21507. Epub 2011 Oct 24.
5. Breast cancer, estrogen receptor and ligands. Bai Z and Gust R, Arch Pharm (Weinheim). 2009 Mar;342(3):133-49.
6. The possible role of estrogen and selective estrogen receptor modulators in a rat model of Parkinson's disease. Baraka AM, etal., Life Sci. 2011 May 9;88(19-20):879-85. doi: 10.1016/j.lfs.2011.03.010. Epub 2011 Mar 21.
7. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
8. Association of estrogen receptor alpha gene polymorphisms and lifestyle factors with calcaneal quantitative ultrasound and osteoporosis in postmenopausal Vietnamese women. Binh TQ, etal., J Hum Genet. 2006;51(11):1022-9. Epub 2006 Sep 14.
9. Estrogen receptor alpha gene polymorphisms associated with incident aging macula disorder. Boekhoorn SS, etal., Invest Ophthalmol Vis Sci. 2007 Mar;48(3):1012-7.
10. Preliminary evidence for impaired estrogen receptor-alpha protein expression in osteoblasts and osteocytes from men with idiopathic osteoporosis. Braidman I, etal., Bone. 2000 May;26(5):423-7.
11. Association of the estrogen receptor alpha gene polymorphisms with sporadic Alzheimer's disease. Brandi ML, etal., Biochem Biophys Res Commun 1999 Nov 19;265(2):335-8.
12. Detection of aromatase and estrogen receptors (ERalpha, ERbeta1, ERbeta2) in human Leydig cell tumor. Carpino A, etal., Eur J Endocrinol. 2007 Aug;157(2):239-44.
13. Effects of agonists for estrogen receptor alpha and beta on ovariectomy-induced lower urinary tract dysfunction in the rat. Cheng CL and de Groat WC, Am J Physiol Renal Physiol. 2014 Jan;306(2):F181-7. doi: 10.1152/ajprenal.00298.2013. Epub 2013 Nov 20.
14. Callus formation is related to the expression ratios of estrogen receptors-alpha and -beta in ovariectomy-induced osteoporotic fracture healing. Chow SK, etal., Arch Orthop Trauma Surg. 2014 Oct;134(10):1405-16. doi: 10.1007/s00402-014-2070-0. Epub 2014 Aug 2.
15. Interaction between vitamin D receptor genotype and estrogen receptor alpha genotype influences vertebral fracture risk. Colin EM, etal., J Clin Endocrinol Metab. 2003 Aug;88(8):3777-84.
16. Risk factors for breast cancer characterized by the estrogen receptor alpha A908G (K303R) mutation. Conway K, etal., Breast Cancer Res. 2007;9(3):R36.
17. Estrogen receptor antagonist fulvestrant (ICI 182,780) inhibits the anti-inflammatory effect of glucocorticoids. Cuzzocrea S, etal., Mol Pharmacol. 2007 Jan;71(1):132-44. Epub 2006 Oct 11.
18. Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose. Dahlman I, etal., Pharmacogenet Genomics. 2008 Nov;18(11):967-75.
19. Association of single nucleotide polymorphisms in estrogen receptor alpha gene with susceptibility to knee osteoarthritis: a case-control study in a Chinese Han population. Dai X, etal., Biomed Res Int. 2014;2014:151457. doi: 10.1155/2014/151457. Epub 2014 Mar 17.
20. An estrogen receptor repressor induces cataract formation in transgenic mice. Davis VL, etal., Proc Natl Acad Sci U S A 2002 Jul 9;99(14):9427-32. Epub 2002 Jun 24.
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PMID:1472372   PMID:1673105   PMID:1874174   PMID:1975791   PMID:2484714   PMID:3753802   PMID:7476981   PMID:7592654   PMID:7664341   PMID:7873877   PMID:8013372   PMID:8248223  
PMID:8415723   PMID:8584021   PMID:8637881   PMID:8643509   PMID:8654869   PMID:8701078   PMID:8723431   PMID:8742702   PMID:8809190   PMID:8873065   PMID:8875885   PMID:8892316  
PMID:8895349   PMID:8901615   PMID:8901633   PMID:8977441   PMID:8978696   PMID:8999954   PMID:9037078   PMID:9070871   PMID:9094097   PMID:9142124   PMID:9153286   PMID:9171231  
PMID:9192892   PMID:9213137   PMID:9236206   PMID:9256346   PMID:9278514   PMID:9323845   PMID:9348186   PMID:9380750   PMID:9391155   PMID:9393999   PMID:9407129   PMID:9448000  
PMID:9607809   PMID:9647203   PMID:9733105   PMID:9751518   PMID:9801392   PMID:9832445   PMID:9832446   PMID:9861029   PMID:9927291   PMID:10022198   PMID:10037815   PMID:10097091  
PMID:10207113   PMID:10213494   PMID:10330493   PMID:10342850   PMID:10342861   PMID:10342864   PMID:10349636   PMID:10368776   PMID:10393183   PMID:10406480   PMID:10411913   PMID:10426580  
PMID:10433208   PMID:10448199   PMID:10456188   PMID:10491617   PMID:10510352   PMID:10512982   PMID:10552042   PMID:10558910   PMID:10575223   PMID:10579351   PMID:10582092   PMID:10600740  
PMID:10624800   PMID:10629111   PMID:10642567   PMID:10670526   PMID:10681503   PMID:10684800   PMID:10684871   PMID:10698205   PMID:10709760   PMID:10718905   PMID:10725249   PMID:10731637  
PMID:10732323   PMID:10733896   PMID:10757814   PMID:10775144   PMID:10788465   PMID:10793642   PMID:10805804   PMID:10818161   PMID:10867819   PMID:10875230   PMID:10880989   PMID:10899303  
PMID:10919284   PMID:10919287   PMID:10922068   PMID:10935020   PMID:10949085   PMID:10976058   PMID:11014235   PMID:11042159   PMID:11054687   PMID:11070086   PMID:11074057   PMID:11076861  
1 to 10 of 109 rows



Esr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39104,561,989 - 4,955,633 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl104,561,593 - 4,955,614 (+)EnsemblGRCm39 Ensembl
GRCm38104,611,989 - 5,005,633 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl104,611,593 - 5,005,614 (+)EnsemblGRCm38mm10GRCm38
MGSCv37105,342,780 - 5,734,495 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36105,342,780 - 5,734,495 (-)NCBIMGSCv36mm8
Celera104,553,702 - 4,949,051 (+)NCBICelera
Cytogenetic Map10A1NCBI
cM Map102.03NCBI
ESR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386151,656,672 - 152,129,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6151,656,691 - 152,129,619 (+)EnsemblGRCh38hg38GRCh38
GRCh376151,977,807 - 152,450,754 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366152,170,379 - 152,466,099 (+)NCBINCBI36Build 36hg18NCBI36
Build 346152,220,799 - 152,516,520NCBI
Celera6152,745,469 - 153,158,143 (+)NCBICelera
Cytogenetic Map6q25.1-q25.2NCBI
HuRef6149,573,851 - 149,986,188 (+)NCBIHuRef
CHM1_16152,275,698 - 152,688,511 (+)NCBICHM1_1
T2T-CHM13v2.06152,857,871 - 153,330,911 (+)NCBIT2T-CHM13v2.0
Esr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8143,511,685 - 43,904,454 (+)NCBIGRCr8
mRatBN7.2141,106,335 - 41,499,104 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl141,210,475 - 41,495,002 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx141,764,020 - 42,022,224 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0147,751,203 - 48,009,419 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0141,839,517 - 42,097,729 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0141,192,029 - 41,594,799 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl141,192,824 - 41,594,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0142,534,049 - 42,935,434 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4135,523,680 - 35,759,891 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1135,526,624 - 35,762,826NCBI
Celera136,921,417 - 37,175,762 (+)NCBICelera
Cytogenetic Map1q11NCBI
Esr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554399,588,201 - 9,963,353 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554399,588,631 - 9,953,606 (-)NCBIChiLan1.0ChiLan1.0
ESR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25171,714,055 - 172,130,308 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16169,722,942 - 170,016,810 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06149,507,599 - 149,918,523 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16154,200,521 - 154,635,806 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6154,317,002 - 154,631,551 (+)Ensemblpanpan1.1panPan2
ESR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1142,081,952 - 42,368,544 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl142,081,969 - 42,368,544 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha142,923,315 - 43,207,109 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0142,267,417 - 42,551,842 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl142,267,396 - 42,570,184 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1142,140,418 - 42,417,150 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0141,990,600 - 42,280,338 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0142,491,321 - 42,775,607 (+)NCBIUU_Cfam_GSD_1.0
Esr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946137,259,082 - 137,635,196 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364894,614,754 - 4,887,171 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364894,616,839 - 4,887,179 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ESR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl114,217,036 - 14,493,363 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1114,217,032 - 14,604,906 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2116,546,666 - 16,577,163 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ESR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11379,153,418 - 79,554,552 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1379,270,265 - 79,554,549 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604051,453,078 - 51,888,098 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Esr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247856,164,379 - 6,601,326 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247856,164,507 - 6,601,302 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Esr1
12622 total Variants

Predicted Target Of
Summary Value
Count of predictions:3073
Count of miRNA genes:830
Interacting mature miRNAs:1147
Transcripts:ENSMUST00000067086, ENSMUST00000105588, ENSMUST00000105589, ENSMUST00000105590, ENSMUST00000127145, ENSMUST00000127934, ENSMUST00000133985, ENSMUST00000137012, ENSMUST00000138828, ENSMUST00000149195
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 17 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
11532718Sluc44f_msusceptibility to lung cancer 44f (mouse)10126289265Mouse
1357813Ath20_matherosclerosis 20 (mouse)Not determined10328318537283334Mouse
11532717Sluc44g_msusceptibility to lung cancer 44g (mouse)10126289265Mouse
1300881Sluc29_msusceptibility to lung cancer 29 (mouse)Not determined10126289265Mouse
12879494Facq1_mfear acquisition QTL 1 (mouse)10131279130Mouse
1300759Geot_mgeotaxia (mouse)Not determined10126289265Mouse
1300790Pgia6_mproteoglycan induced arthritis 6 (mouse)Not determined10381017137810295Mouse
15039341Nmrs28_mNAFLD-associated magnetic resonance shift 28 (mouse)1035100134351001Mouse
11533917Mts2_mmammary tumor susceptibility 2 (mouse)10126289265Mouse
1300997Eae15_msusceptibility to experimental allergic encephalomyelitis 15 (mouse)Not determined10440815438408276Mouse

1 to 10 of 17 rows
AU018232  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38105,003,555 - 5,003,655UniSTSGRCm38
MGSCv37105,342,886 - 5,342,986UniSTSGRCm37
Celera104,948,845 - 4,948,945UniSTS
Cytogenetic Map10A1UniSTS
cM Map1012.0UniSTS
Whitehead/MRC_RH10129.35UniSTS
RH124384  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38105,003,554 - 5,003,710UniSTSGRCm38
MGSCv37105,342,831 - 5,342,987UniSTSGRCm37
Celera104,948,844 - 4,949,000UniSTS
Cytogenetic Map10A1UniSTS
cM Map1012.0UniSTS
UniSTS:236299  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38104,857,066 - 4,857,302UniSTSGRCm38
MGSCv37105,489,239 - 5,489,475UniSTSGRCm37
Celera104,799,538 - 4,799,774UniSTS
Cytogenetic Map10A1UniSTS
cM Map1012.0UniSTS
PMC25853P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38104,712,362 - 4,712,722UniSTSGRCm38
MGSCv37105,633,819 - 5,634,179UniSTSGRCm37
Celera104,655,806 - 4,656,166UniSTS
Cytogenetic Map10A1UniSTS
cM Map1012.0UniSTS
Esr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10A1UniSTS
cM Map1012.0UniSTS
cM Map1012.0UniSTS
Esr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10A1UniSTS
Esr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10A1UniSTS
cM Map1012.0UniSTS
Esr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10A1UniSTS
Esr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10A1UniSTS
Esr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10A1UniSTS






1 to 30 of 63 rows
RefSeq Transcripts NM_001302531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_126357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006512433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006512434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006512435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011243066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011243068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB560752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB560753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB560754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB560755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB560756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB560757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB560758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB560759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB560760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB560841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB560843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB560846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB560848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB560853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB560854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC153573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC156393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC158617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 63 rows

Ensembl Acc Id: ENSMUST00000067086   ⟹   ENSMUSP00000070070
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl104,562,021 - 4,953,761 (+)Ensembl
GRCm38.p6 Ensembl104,612,021 - 5,003,761 (+)Ensembl
Ensembl Acc Id: ENSMUST00000105588   ⟹   ENSMUSP00000101213
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl104,660,155 - 4,917,336 (+)Ensembl
GRCm38.p6 Ensembl104,710,155 - 4,967,336 (+)Ensembl
Ensembl Acc Id: ENSMUST00000105589   ⟹   ENSMUSP00000101214
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl104,660,155 - 4,952,024 (+)Ensembl
GRCm38.p6 Ensembl104,710,155 - 5,002,024 (+)Ensembl
Ensembl Acc Id: ENSMUST00000105590   ⟹   ENSMUSP00000101215
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl104,561,989 - 4,955,614 (+)Ensembl
GRCm38.p6 Ensembl104,611,989 - 5,005,614 (+)Ensembl
Ensembl Acc Id: ENSMUST00000127145
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl104,662,651 - 4,734,824 (+)Ensembl
GRCm38.p6 Ensembl104,712,651 - 4,784,824 (+)Ensembl
Ensembl Acc Id: ENSMUST00000127934
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl104,872,970 - 4,947,930 (+)Ensembl
GRCm38.p6 Ensembl104,922,970 - 4,997,930 (+)Ensembl
Ensembl Acc Id: ENSMUST00000133985
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl104,561,996 - 4,621,884 (+)Ensembl
GRCm38.p6 Ensembl104,611,996 - 4,671,884 (+)Ensembl
Ensembl Acc Id: ENSMUST00000137012
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl104,886,526 - 4,951,656 (+)Ensembl
GRCm38.p6 Ensembl104,936,526 - 5,001,656 (+)Ensembl
Ensembl Acc Id: ENSMUST00000138828
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl104,562,013 - 4,807,509 (+)Ensembl
GRCm38.p6 Ensembl104,612,013 - 4,857,509 (+)Ensembl
Ensembl Acc Id: ENSMUST00000149195
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl104,561,593 - 4,843,083 (+)Ensembl
GRCm38.p6 Ensembl104,611,593 - 4,893,083 (+)Ensembl
RefSeq Acc Id: NM_001302531   ⟹   NP_001289460
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39104,660,158 - 4,955,633 (+)NCBI
GRCm38104,710,158 - 5,005,633 (+)NCBI
Celera104,553,645 - 4,950,922 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001302532   ⟹   NP_001289461
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39104,561,989 - 4,955,633 (+)NCBI
GRCm38104,611,989 - 5,005,633 (+)NCBI
Celera104,553,645 - 4,950,922 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001302533   ⟹   NP_001289462
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39104,660,158 - 4,917,336 (+)NCBI
GRCm38104,710,158 - 4,967,336 (+)NCBI
Celera104,553,645 - 4,950,922 (+)NCBI
Sequence:
RefSeq Acc Id: NM_007956   ⟹   NP_031982
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39104,561,989 - 4,955,633 (+)NCBI
GRCm38104,611,989 - 5,005,633 (+)NCBI
MGSCv37105,342,780 - 5,734,495 (-)RGD
Celera104,553,645 - 4,950,922 (+)NCBI
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_126357
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39104,561,989 - 4,843,083 (+)NCBI
GRCm38104,611,989 - 4,893,083 (+)NCBI
Celera104,553,645 - 4,950,922 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006512433   ⟹   XP_006512496
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39104,661,929 - 4,953,502 (+)NCBI
GRCm38104,711,966 - 5,001,656 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006512434   ⟹   XP_006512497
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39104,659,815 - 4,953,502 (+)NCBI
GRCm38104,709,834 - 5,001,656 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006512435   ⟹   XP_006512498
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39104,636,880 - 4,953,502 (+)NCBI
GRCm38104,686,894 - 5,001,656 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011243066   ⟹   XP_011241368
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39104,594,171 - 4,953,502 (+)NCBI
GRCm38104,644,286 - 5,001,995 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011243068   ⟹   XP_011241370
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39104,622,124 - 4,953,502 (+)NCBI
GRCm38104,672,179 - 5,001,656 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036155590   ⟹   XP_036011483
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39104,659,991 - 4,807,512 (+)NCBI
Sequence:
1 to 30 of 46 rows
Protein RefSeqs NP_001289460 (Get FASTA)   NCBI Sequence Viewer  
  NP_001289461 (Get FASTA)   NCBI Sequence Viewer  
  NP_001289462 (Get FASTA)   NCBI Sequence Viewer  
  NP_001415388 (Get FASTA)   NCBI Sequence Viewer  
  NP_031982 (Get FASTA)   NCBI Sequence Viewer  
  XP_006512496 (Get FASTA)   NCBI Sequence Viewer  
  XP_006512497 (Get FASTA)   NCBI Sequence Viewer  
  XP_006512498 (Get FASTA)   NCBI Sequence Viewer  
  XP_011241368 (Get FASTA)   NCBI Sequence Viewer  
  XP_011241370 (Get FASTA)   NCBI Sequence Viewer  
  XP_036011483 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA37580 (Get FASTA)   NCBI Sequence Viewer  
  AAF22561 (Get FASTA)   NCBI Sequence Viewer  
  AAF22562 (Get FASTA)   NCBI Sequence Viewer  
  ACF17956 (Get FASTA)   NCBI Sequence Viewer  
  ACF17958 (Get FASTA)   NCBI Sequence Viewer  
  BAC29510 (Get FASTA)   NCBI Sequence Viewer  
  BAC30973 (Get FASTA)   NCBI Sequence Viewer  
  BAE22884 (Get FASTA)   NCBI Sequence Viewer  
  BAE24122 (Get FASTA)   NCBI Sequence Viewer  
  BAJ65337 (Get FASTA)   NCBI Sequence Viewer  
  BAJ65338 (Get FASTA)   NCBI Sequence Viewer  
  BAJ65339 (Get FASTA)   NCBI Sequence Viewer  
  BAJ65340 (Get FASTA)   NCBI Sequence Viewer  
  BAJ65341 (Get FASTA)   NCBI Sequence Viewer  
  BAJ65342 (Get FASTA)   NCBI Sequence Viewer  
  BAJ65343 (Get FASTA)   NCBI Sequence Viewer  
  BAJ65344 (Get FASTA)   NCBI Sequence Viewer  
  BAJ65345 (Get FASTA)   NCBI Sequence Viewer  
  BAX30174 (Get FASTA)   NCBI Sequence Viewer  
1 to 30 of 46 rows
1 to 5 of 14 rows
1 to 5 of 14 rows
RefSeq Acc Id: NP_031982   ⟸   NM_007956
- Peptide Label: isoform 1
- UniProtKB: Q9QY51 (UniProtKB/Swiss-Prot),   Q9JJT5 (UniProtKB/Swiss-Prot),   Q9QY52 (UniProtKB/Swiss-Prot),   P19785 (UniProtKB/Swiss-Prot),   E7FJU2 (UniProtKB/TrEMBL),   B3VQI7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006512498   ⟸   XM_006512435
- Peptide Label: isoform X1
- UniProtKB: Q9QY51 (UniProtKB/Swiss-Prot),   Q9JJT5 (UniProtKB/Swiss-Prot),   Q9QY52 (UniProtKB/Swiss-Prot),   P19785 (UniProtKB/Swiss-Prot),   E7FJU2 (UniProtKB/TrEMBL),   B3VQI7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006512497   ⟸   XM_006512434
- Peptide Label: isoform X1
- UniProtKB: Q9QY51 (UniProtKB/Swiss-Prot),   Q9JJT5 (UniProtKB/Swiss-Prot),   Q9QY52 (UniProtKB/Swiss-Prot),   P19785 (UniProtKB/Swiss-Prot),   E7FJU2 (UniProtKB/TrEMBL),   B3VQI7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006512496   ⟸   XM_006512433
- Peptide Label: isoform X1
- UniProtKB: Q9QY51 (UniProtKB/Swiss-Prot),   Q9JJT5 (UniProtKB/Swiss-Prot),   Q9QY52 (UniProtKB/Swiss-Prot),   P19785 (UniProtKB/Swiss-Prot),   E7FJU2 (UniProtKB/TrEMBL),   B3VQI7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001289461   ⟸   NM_001302532
- Peptide Label: isoform 1
- UniProtKB: Q9QY51 (UniProtKB/Swiss-Prot),   Q9JJT5 (UniProtKB/Swiss-Prot),   Q9QY52 (UniProtKB/Swiss-Prot),   P19785 (UniProtKB/Swiss-Prot),   E7FJU2 (UniProtKB/TrEMBL),   B3VQI7 (UniProtKB/TrEMBL)
- Sequence:
NR LBD   Nuclear receptor

Name Modeler Protein Id AA Range Protein Structure
AF-P19785-F1-model_v2 AlphaFold P19785 1-599 view protein structure

RGD ID:8671412
Promoter ID:EPDNEW_M13737
Type:initiation region
Name:Esr1_1
Description:Mus musculus estrogen receptor 1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13738  EPDNEW_M13739  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38104,612,008 - 4,612,068EPDNEW
RGD ID:8671414
Promoter ID:EPDNEW_M13738
Type:single initiation site
Name:Esr1_3
Description:Mus musculus estrogen receptor 1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13737  EPDNEW_M13739  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38104,709,009 - 4,709,069EPDNEW
RGD ID:8671416
Promoter ID:EPDNEW_M13739
Type:initiation region
Name:Esr1_2
Description:Mus musculus estrogen receptor 1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13737  EPDNEW_M13738  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38104,710,179 - 4,710,239EPDNEW
RGD ID:6819271
Promoter ID:MM_KWN:3439
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000105588,   UC007EGU.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36105,636,471 - 5,636,971 (-)MPROMDB
RGD ID:6819270
Promoter ID:MM_KWN:3440
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour,   Kidney,   Liver
Transcripts:ENSMUST00000105587,   ENSMUST00000105590,   OTTMUST00000049381,   OTTMUST00000049382,   OTTMUST00000049384,   OTTMUST00000049387
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36105,734,464 - 5,734,964 (-)MPROMDB


1 to 40 of 61 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000019768 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000067086 ENTREZGENE
  ENSMUST00000067086.14 UniProtKB/Swiss-Prot
  ENSMUST00000105588 ENTREZGENE
  ENSMUST00000105589 ENTREZGENE
  ENSMUST00000105589.2 UniProtKB/Swiss-Prot
  ENSMUST00000105590 ENTREZGENE
  ENSMUST00000105590.8 UniProtKB/Swiss-Prot
  ENSMUST00000149195 ENTREZGENE
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot
InterPro Estr_rcpt_N UniProtKB/Swiss-Prot
  NHR-like_dom_sf UniProtKB/Swiss-Prot
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot
  Nuclear_hormone_rcpt_NR3 UniProtKB/Swiss-Prot
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot
  Oest_rcpt/oest-rel_rcp UniProtKB/Swiss-Prot
  Oestr_rcpt UniProtKB/Swiss-Prot
  Oestrogen-typ_rcpt_final_C_dom UniProtKB/Swiss-Prot
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
KEGG Report mmu:13982 UniProtKB/Swiss-Prot
MGD MGI:1352467 ENTREZGENE
NCBI Gene 13982 ENTREZGENE
PANTHER KNIRPS-RELATED PROTEIN-RELATED UniProtKB/Swiss-Prot
Pfam ESR1_C UniProtKB/Swiss-Prot
  Hormone_recep UniProtKB/Swiss-Prot
  Oest_recep UniProtKB/Swiss-Prot
  zf-C4 UniProtKB/Swiss-Prot
PharmGKB ESR1 RGD
PhenoGen Esr1 PhenoGen
PIRSF ER-a UniProtKB/Swiss-Prot
  ER-like_NR UniProtKB/Swiss-Prot
PRINTS OESTROGENR UniProtKB/Swiss-Prot
  STRDHORMONER UniProtKB/Swiss-Prot
  STROIDFINGER UniProtKB/Swiss-Prot
PROSITE NR_LBD UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot
SMART HOLI UniProtKB/Swiss-Prot
1 to 40 of 61 rows