Esr1 (estrogen receptor 1) - Rat Genome Database

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Gene: Esr1 (estrogen receptor 1) Chinchilla lanigera
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Symbol: Esr1
Name: estrogen receptor 1
RGD ID: 9034222
Description: ENCODES a protein that exhibits ATPase binding (ortholog); beta-catenin binding (ortholog); chromatin binding (ortholog); INVOLVED IN androgen metabolic process (ortholog); antral ovarian follicle growth (ortholog); baculum development (ortholog); PARTICIPATES IN bisphenol A response pathway; estrogen signaling pathway; follicle-stimulating hormone signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Alzheimer's disease (ortholog); Animal Disease Models (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: estrogen receptor
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554399,588,201 - 9,963,353 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554399,588,631 - 9,953,606 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
Animal Mammary Neoplasms  (ISO)
arteriosclerosis  (ISO)
Arthrogryposis Multiplex Congenita 3, Myogenic Type  (ISO)
atherosclerosis  (ISO)
autosomal dominant Emery-Dreifuss muscular dystrophy 4  (ISO)
autosomal recessive spinocerebellar ataxia 8  (ISO)
bone disease  (ISO)
Bone Fractures  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
carcinoma  (ISO)
cataract 33  (ISO)
cerebellar ataxia  (ISO)
Chronic Periodontitis  (ISO)
coronary artery disease  (ISO)
cryptorchidism  (ISO)
Diabetic Nephropathies  (ISO)
Disease Progression  (ISO)
Emery-Dreifuss muscular dystrophy  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
Estrogen Resistance  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Female Infertility  (ISO)
Female Urogenital Diseases  (ISO)
Feminization  (ISO)
glomerulonephritis  (ISO)
Hand Osteoarthritis  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Hyperalgesia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
in situ carcinoma  (ISO)
infertility  (ISO)
Knee Osteoarthritis  (ISO)
leiomyoma  (ISO)
leukemia  (ISO)
Leydig cell tumor  (ISO)
Liver Neoplasms  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lymphangioleiomyomatosis  (ISO)
macular degeneration  (ISO)
male infertility  (ISO)
malignant astrocytoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (ISO)
Mesothelioma  (ISO)
Metabolic Bone Diseases  (ISO)
migraine  (ISO)
mitochondrial metabolism disease  (ISO)
Musculoskeletal Pain  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm Recurrence, Local  (ISO)
Neoplastic Cell Transformation  (ISO)
neuroblastoma  (ISO)
obesity  (ISO)
oligospermia  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Hip  (ISO)
osteoporosis  (ISO)
Osteoporotic Fractures  (ISO)
ovarian cancer  (ISO)
Parkinsonism  (ISO)
peritonitis  (ISO)
pleurisy  (ISO)
Postmenopausal Osteoporosis  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
Spinal Cord Injuries  (ISO)
Spinal Fractures  (ISO)
sporadic breast cancer  (ISO)
Subarachnoid Hemorrhage  (ISO)
substance-induced psychosis  (ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Urination Disorders  (ISO)
Varicose Ulcer  (ISO)
vitiligo  (ISO)
Vulvar Lichen Sclerosus  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
androgen metabolic process  (ISO)
antral ovarian follicle growth  (ISO)
baculum development  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to estrogen stimulus  (ISO)
decidualization  (ISO)
epithelial cell development  (ISO)
epithelial cell proliferation involved in mammary gland duct elongation  (ISO)
intracellular estrogen receptor signaling pathway  (ISO)
intracellular steroid hormone receptor signaling pathway  (ISO)
male gonad development  (ISO)
mammary gland alveolus development  (ISO)
mammary gland branching involved in pregnancy  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glucose import  (ISO)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of production of miRNAs involved in gene silencing by miRNA  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of triglyceride metabolic process  (ISO)
osteoblast development  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of phospholipase C activity  (ISO)
positive regulation of RNA polymerase II transcription preinitiation complex assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  (ISO)
prostate epithelial cord elongation  (ISO)
protein localization to chromatin  (ISO)
regulation of apoptotic process  (ISO)
regulation of branching involved in prostate gland morphogenesis  (ISO)
regulation of inflammatory response  (ISO)
regulation of neuron apoptotic process  (ISO)
regulation of toll-like receptor signaling pathway  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
Sertoli cell development  (ISO)
Sertoli cell proliferation  (ISO)
stem cell differentiation  (ISO)
uterus development  (ISO)
vagina development  (ISO)

Cellular Component

References


Genomics

Comparative Map Data
Esr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554399,588,201 - 9,963,353 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554399,588,631 - 9,953,606 (-)NCBIChiLan1.0ChiLan1.0
ESR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6151,656,691 - 152,129,619 (+)EnsemblGRCh38hg38GRCh38
GRCh386151,654,148 - 152,129,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376151,977,807 - 152,450,754 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366152,170,379 - 152,466,099 (+)NCBINCBI36hg18NCBI36
Build 346152,220,799 - 152,516,520NCBI
Celera6152,745,469 - 153,158,143 (+)NCBI
Cytogenetic Map6q25.1-q25.2NCBI
HuRef6149,573,851 - 149,986,188 (+)NCBIHuRef
CHM1_16152,275,698 - 152,688,511 (+)NCBICHM1_1
Esr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39104,561,989 - 4,955,633 (+)NCBIGRCm39mm39
GRCm39 Ensembl104,561,593 - 4,955,614 (+)Ensembl
GRCm38104,611,989 - 5,005,633 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl104,611,593 - 5,005,614 (+)EnsemblGRCm38mm10GRCm38
MGSCv37105,342,780 - 5,734,495 (-)NCBIGRCm37mm9NCBIm37
MGSCv36105,342,780 - 5,734,495 (-)NCBImm8
Celera104,553,702 - 4,949,051 (+)NCBICelera
Cytogenetic Map10A1NCBI
cM Map102.03NCBI
Esr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2141,106,335 - 41,499,104 (+)NCBI
Rnor_6.0 Ensembl141,192,824 - 41,594,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0141,192,029 - 41,594,799 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0142,534,049 - 42,935,434 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4135,523,680 - 35,759,891 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1135,526,624 - 35,762,826NCBI
Celera136,921,417 - 37,175,762 (+)NCBICelera
Cytogenetic Map1q11NCBI
ESR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16154,200,521 - 154,635,806 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6154,317,002 - 154,631,551 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06149,507,599 - 149,918,523 (+)NCBIMhudiblu_PPA_v0panPan3
ESR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1142,081,952 - 42,368,544 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl142,081,969 - 42,368,544 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha142,923,315 - 43,207,109 (+)NCBI
ROS_Cfam_1.0142,267,417 - 42,551,842 (+)NCBI
UMICH_Zoey_3.1142,140,418 - 42,417,150 (+)NCBI
UNSW_CanFamBas_1.0141,990,600 - 42,280,338 (+)NCBI
UU_Cfam_GSD_1.0142,491,321 - 42,775,607 (+)NCBI
Esr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946137,259,082 - 137,635,196 (+)NCBI
SpeTri2.0NW_0049364894,616,839 - 4,887,179 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ESR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl114,217,036 - 14,493,363 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1114,217,032 - 14,604,906 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2116,546,666 - 16,577,163 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ESR1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11379,153,418 - 79,554,552 (+)NCBI
ChlSab1.1 Ensembl1379,270,265 - 79,554,549 (+)Ensembl
Vero_WHO_p1.0NW_02366604051,453,078 - 51,888,098 (+)NCBI
Esr1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247856,164,507 - 6,601,302 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000004328   ⟹   ENSCLAP00000004246
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554399,588,201 - 9,963,353 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000004329   ⟹   ENSCLAP00000004247
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554399,588,201 - 9,888,918 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000004330   ⟹   ENSCLAP00000004248
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554399,588,201 - 9,857,460 (-)Ensembl
RefSeq Acc Id: XM_005390573   ⟹   XP_005390630
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554399,588,631 - 9,856,988 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005390574   ⟹   XP_005390631
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554399,588,631 - 9,888,528 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013517315   ⟹   XP_013372769
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554399,588,631 - 9,953,606 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005390630 (Get FASTA)   NCBI Sequence Viewer  
  XP_005390631 (Get FASTA)   NCBI Sequence Viewer  
  XP_013372769 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005390631   ⟸   XM_005390574
- Sequence:
RefSeq Acc Id: XP_005390630   ⟸   XM_005390573
- Sequence:
RefSeq Acc Id: XP_013372769   ⟸   XM_013517315
- Sequence:
RefSeq Acc Id: ENSCLAP00000004248   ⟸   ENSCLAT00000004330
RefSeq Acc Id: ENSCLAP00000004247   ⟸   ENSCLAT00000004329
RefSeq Acc Id: ENSCLAP00000004246   ⟸   ENSCLAT00000004328


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000003026 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000004246 ENTREZGENE
  ENSCLAP00000004247 ENTREZGENE
  ENSCLAP00000004248 ENTREZGENE
Ensembl Transcript ENSCLAT00000004328 ENTREZGENE
  ENSCLAT00000004329 ENTREZGENE
  ENSCLAT00000004330 ENTREZGENE
NCBI Gene Esr1 ENTREZGENE