ESR1 (estrogen receptor 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: ESR1 (estrogen receptor 1) Canis lupus familiaris
Analyze
Symbol: ESR1
Name: estrogen receptor 1
RGD ID: 12091856
Description: ENCODES a protein that exhibits DNA binding (ortholog); enzyme binding (ortholog); estrogen receptor activity (ortholog); INVOLVED IN androgen metabolic process (ortholog); antral ovarian follicle growth (ortholog); baculum development (ortholog); PARTICIPATES IN bisphenol A response pathway; estrogen signaling pathway; follicle-stimulating hormone signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Alzheimer's disease (ortholog); Animal Disease Models (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); mitochondrion (ortholog); INTERACTS WITH 17beta-estradiol; progesterone
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ERALPHA; estrogen receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1142,081,952 - 42,368,544 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl142,081,969 - 42,368,544 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha142,923,315 - 43,207,109 (+)NCBI
ROS_Cfam_1.0142,267,417 - 42,551,842 (+)NCBI
UMICH_Zoey_3.1142,140,418 - 42,417,150 (+)NCBI
UNSW_CanFamBas_1.0141,990,600 - 42,280,338 (+)NCBI
UU_Cfam_GSD_1.0142,491,321 - 42,775,607 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
Animal Mammary Neoplasms  (ISO)
arteriosclerosis  (ISO)
arthrogryposis multiplex congenita-3  (ISO)
atherosclerosis  (ISO)
autosomal dominant Emery-Dreifuss muscular dystrophy 4  (ISO)
autosomal recessive spinocerebellar ataxia 8  (ISO)
bone disease  (ISO)
Bone Fractures  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
carcinoma  (ISO)
cataract 33  (ISO)
cerebellar ataxia  (ISO)
Chronic Periodontitis  (ISO)
coronary artery disease  (ISO)
cryptorchidism  (ISO)
Diabetic Nephropathies  (ISO)
Disease Progression  (ISO)
Emery-Dreifuss muscular dystrophy  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
Estrogen Resistance  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Female Infertility  (ISO)
Female Urogenital Diseases  (ISO)
Feminization  (ISO)
glomerulonephritis  (ISO)
Hand Osteoarthritis  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Hyperalgesia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
in situ carcinoma  (ISO)
infertility  (ISO)
Knee Osteoarthritis  (ISO)
leiomyoma  (ISO)
leukemia  (ISO)
Leydig cell tumor  (ISO)
Liver Neoplasms  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lymphangioleiomyomatosis  (ISO)
macular degeneration  (ISO)
male infertility  (ISO)
malignant astrocytoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (ISO)
Mesothelioma  (ISO)
Metabolic Bone Diseases  (ISO)
migraine  (ISO)
mitochondrial metabolism disease  (ISO)
Musculoskeletal Pain  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm Recurrence, Local  (ISO)
Neoplastic Cell Transformation  (ISO)
neuroblastoma  (ISO)
obesity  (ISO)
oligospermia  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Hip  (ISO)
osteoporosis  (ISO)
Osteoporotic Fractures  (ISO)
ovarian cancer  (ISO)
Parkinsonism  (ISO)
peritonitis  (ISO)
pleurisy  (ISO)
Postmenopausal Osteoporosis  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
Spinal Cord Injuries  (ISO)
Spinal Fractures  (ISO)
sporadic breast cancer  (ISO)
Subarachnoid Hemorrhage  (ISO)
substance-induced psychosis  (ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Urination Disorders  (ISO)
Varicose Ulcer  (ISO)
vitiligo  (ISO)
Vulvar Lichen Sclerosus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
androgen metabolic process  (IEA,ISO)
antral ovarian follicle growth  (IEA,ISO)
baculum development  (ISO)
cellular response to estradiol stimulus  (IEA)
cellular response to estrogen stimulus  (IEA,ISO)
decidualization  (ISO)
epithelial cell development  (IEA,ISO)
epithelial cell proliferation involved in mammary gland duct elongation  (IEA,ISO)
intracellular estrogen receptor signaling pathway  (IEA)
intracellular steroid hormone receptor signaling pathway  (IBA,ISO)
male gonad development  (IEA,ISO)
mammary gland alveolus development  (IEA,ISO)
mammary gland branching involved in pregnancy  (IEA,ISO)
negative regulation of DNA-binding transcription factor activity  (IEA)
negative regulation of gene expression  (ISO)
negative regulation of glucose import  (ISO)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (IEA)
negative regulation of neuron death  (ISO)
negative regulation of production of miRNAs involved in gene silencing by miRNA  (IEA)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of triglyceride metabolic process  (ISO)
osteoblast development  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of DNA-binding transcription factor activity  (IEA)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of phospholipase C activity  (ISO)
positive regulation of RNA polymerase II transcription preinitiation complex assembly  (IEA)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  (IEA,ISO)
prostate epithelial cord elongation  (IEA,ISO)
protein localization to chromatin  (IEA)
regulation of apoptotic process  (IEA,ISO)
regulation of branching involved in prostate gland morphogenesis  (IEA,ISO)
regulation of inflammatory response  (IEA,ISO)
regulation of neuron apoptotic process  (ISO)
regulation of toll-like receptor signaling pathway  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription, DNA-templated  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
Sertoli cell development  (ISO)
Sertoli cell proliferation  (ISO)
stem cell differentiation  (IEA)
uterus development  (IEA,ISO)
vagina development  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:19424616   PMID:19936027   PMID:20453437   PMID:21615831   PMID:23574728   PMID:26767421   PMID:31506083  


Genomics

Comparative Map Data
ESR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1142,081,952 - 42,368,544 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl142,081,969 - 42,368,544 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha142,923,315 - 43,207,109 (+)NCBI
ROS_Cfam_1.0142,267,417 - 42,551,842 (+)NCBI
UMICH_Zoey_3.1142,140,418 - 42,417,150 (+)NCBI
UNSW_CanFamBas_1.0141,990,600 - 42,280,338 (+)NCBI
UU_Cfam_GSD_1.0142,491,321 - 42,775,607 (+)NCBI
ESR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6151,656,691 - 152,129,619 (+)EnsemblGRCh38hg38GRCh38
GRCh386151,654,148 - 152,129,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376151,977,807 - 152,450,754 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366152,170,379 - 152,466,099 (+)NCBINCBI36hg18NCBI36
Build 346152,220,799 - 152,516,520NCBI
Celera6152,745,469 - 153,158,143 (+)NCBI
Cytogenetic Map6q25.1-q25.2NCBI
HuRef6149,573,851 - 149,986,188 (+)NCBIHuRef
CHM1_16152,275,698 - 152,688,511 (+)NCBICHM1_1
Esr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39104,561,989 - 4,955,633 (+)NCBIGRCm39mm39
GRCm39 Ensembl104,561,593 - 4,955,614 (+)Ensembl
GRCm38104,611,989 - 5,005,633 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl104,611,593 - 5,005,614 (+)EnsemblGRCm38mm10GRCm38
MGSCv37105,342,780 - 5,734,495 (-)NCBIGRCm37mm9NCBIm37
MGSCv36105,342,780 - 5,734,495 (-)NCBImm8
Celera104,553,702 - 4,949,051 (+)NCBICelera
Cytogenetic Map10A1NCBI
cM Map102.03NCBI
Esr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2141,106,335 - 41,499,104 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl141,192,824 - 41,594,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0141,192,029 - 41,594,799 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0142,534,049 - 42,935,434 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4135,523,680 - 35,759,891 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1135,526,624 - 35,762,826NCBI
Celera136,921,417 - 37,175,762 (+)NCBICelera
Cytogenetic Map1q11NCBI
Esr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554399,588,201 - 9,963,353 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554399,588,631 - 9,953,606 (-)NCBIChiLan1.0ChiLan1.0
ESR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16154,200,521 - 154,635,806 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6154,317,002 - 154,631,551 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06149,507,599 - 149,918,523 (+)NCBIMhudiblu_PPA_v0panPan3
Esr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946137,259,082 - 137,635,196 (+)NCBI
SpeTri2.0NW_0049364894,616,839 - 4,887,179 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ESR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl114,217,036 - 14,493,363 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1114,217,032 - 14,604,906 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2116,546,666 - 16,577,163 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ESR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11379,153,418 - 79,554,552 (+)NCBI
ChlSab1.1 Ensembl1379,270,265 - 79,554,549 (+)Ensembl
Vero_WHO_p1.0NW_02366604051,453,078 - 51,888,098 (+)NCBI
Esr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247856,164,507 - 6,601,302 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 11 6 6
Low 4 5 4 6 6 8 10
Below cutoff 1 5 6 6 2 6 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000000680   ⟹   ENSCAFP00000000624
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl142,081,969 - 42,368,544 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000060440   ⟹   ENSCAFP00000050536
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl142,084,181 - 42,368,544 (+)Ensembl
RefSeq Acc Id: NM_001286958   ⟹   NP_001273887
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1142,081,969 - 42,368,544 (+)NCBI
Dog10K_Boxer_Tasha142,923,315 - 43,207,109 (+)NCBI
ROS_Cfam_1.0142,267,417 - 42,551,842 (+)NCBI
UMICH_Zoey_3.1142,140,418 - 42,417,150 (+)NCBI
UNSW_CanFamBas_1.0141,990,600 - 42,280,338 (+)NCBI
UU_Cfam_GSD_1.0142,491,321 - 42,775,607 (+)NCBI
Sequence:
RefSeq Acc Id: XM_014113908   ⟹   XP_013969383
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1142,081,952 - 42,327,925 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038653375   ⟹   XP_038509303
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0142,269,572 - 42,551,842 (+)NCBI
RefSeq Acc Id: XM_038653376   ⟹   XP_038509304
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0142,269,570 - 42,513,922 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001273887 (Get FASTA)   NCBI Sequence Viewer  
  XP_038509303 (Get FASTA)   NCBI Sequence Viewer  
  XP_038509304 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAC42096 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013969383   ⟸   XM_014113908
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001273887   ⟸   NM_001286958
- UniProtKB: F6V0I8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000050536   ⟸   ENSCAFT00000060440
RefSeq Acc Id: ENSCAFP00000000624   ⟸   ENSCAFT00000000680
RefSeq Acc Id: XP_038509304   ⟸   XM_038653376
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038509303   ⟸   XM_038653375
- Peptide Label: isoform X1
Protein Domains
NR LBD   Nuclear receptor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000430 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000000624 ENTREZGENE
Ensembl Transcript ENSCAFT00000000680 ENTREZGENE
NCBI Gene ESR1 ENTREZGENE
UniProt F6V0I8 ENTREZGENE
VGNC ID VGNC:40476 ENTREZGENE