Hmox1 (heme oxygenase 1) - Rat Genome Database

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Gene: Hmox1 (heme oxygenase 1) Mus musculus
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Symbol: Hmox1
Name: heme oxygenase 1
RGD ID: 10717
MGI Page MGI
Description: Predicted to enable several functions, including arachidonic acid omega-hydroxylase activity; heme binding activity; and heme oxygenase (decyclizing) activity. Acts upstream of or within several processes, including cellular response to cadmium ion; cellular response to cisplatin; and regulation of macroautophagy. Located in nucleus. Is active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study hemochromatosis and malaria. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); factor VIII deficiency; lung disease (multiple); and sickle cell anemia. Orthologous to human HMOX1 (heme oxygenase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: D8Wsu38; D8Wsu38e; heme oxygenase (decycling) 1; Hemox; hemoxygenase; Hmo; Hmox; HO; HO-; HO-1; HO1; Hsp; Hsp32; P32 protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39875,820,246 - 75,827,221 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl875,820,249 - 75,827,217 (+)EnsemblGRCm39 Ensembl
GRCm38875,093,618 - 75,100,593 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl875,093,621 - 75,100,589 (+)EnsemblGRCm38mm10GRCm38
MGSCv37877,617,517 - 77,624,492 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36877,989,694 - 77,996,657 (+)NCBIMGSCv36mm8
Celera879,400,848 - 79,407,824 (+)NCBICelera
Cytogenetic Map8C1NCBI
cM Map835.59NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
acute chest syndrome  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adenylosuccinase lyase deficiency  (ISO)
adrenoleukodystrophy  (ISO)
adult respiratory distress syndrome  (ISO)
Altitude Sickness  (ISO)
Alzheimer's disease  (ISO)
arteriosclerosis  (IAGP)
asthma  (IDA,ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
Blast Crisis  (ISO)
blood coagulation disease  (ISO)
Brain Death  (ISO)
brain edema  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
bronchiolitis obliterans  (IMP)
Carbon Monoxide Poisoning  (ISO)
Carbon Tetrachloride Poisoning  (ISO)
Cardiomegaly  (ISO)
carotid artery disease  (ISO)
carotid artery thrombosis  (IMP)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (IMP)
Chemical and Drug Induced Liver Injury  (IEP,ISO)
chronic myeloid leukemia  (IEP)
chronic obstructive pulmonary disease  (ISO)
Chronic Tubulointerstitial Nephropathy  (IMP)
colitis  (ISO)
congestive heart failure  (ISO)
contact dermatitis  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
coronary restenosis  (ISO)
cystic fibrosis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
Dilatation, Pathologic  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
esophageal cancer  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
factor VIII deficiency  (ISO)
Fever  (ISO)
Fibrosis  (ISO)
gastroparesis  (ISO)
genetic disease  (ISO)
Graft Occlusion, Vascular  (IAGP)
Growth Disorders  (ISO)
Helicobacter Infections  (ISO)
Heme Oxygenase 1 Deficiency  (ISO)
hemochromatosis  (IAGP)
Hemolysis  (ISO)
hemolytic anemia  (ISO)
Hemorrhagic Shock  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatic encephalopathy  (ISO)
hepatic veno-occlusive disease  (ISO)
hepatitis  (ISO)
hepatopulmonary syndrome  (ISO)
hepatorenal syndrome  (ISO)
hyperinsulinism  (ISO)
Hyperoxic Lung Injury  (IEP)
Hyperplasia  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
hypertrophic cardiomyopathy  (ISO)
ileus  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
interstitial lung disease  (ISO)
Intestinal Reperfusion Injury  (ISO)
intracranial vasospasm  (ISO)
iron metabolism disease  (ISO)
ischemia  (ISO)
Kawasaki disease  (ISO)
Kidney Reperfusion Injury  (ISO)
learning disability  (ISO)
limb ischemia  (ISO)
liver disease  (ISO)
Liver Neoplasms  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (IMP,ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
Lung Reperfusion Injury  (ISO)
malaria  (IAGP)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neointima  (ISO)
Neonatal Hyperbilirubinemia  (ISO)
Neoplasm Invasiveness  (ISO)
neurodegenerative disease  (ISO)
newborn respiratory distress syndrome  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
pancreas disease  (ISO)
Paraparesis  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
Pathologic Constriction  (ISO)
peptic ulcer disease  (ISO)
Perennial Allergic Rhinitis  (ISO)
Pneumococcal Pneumonia  (IEP)
pneumonia  (ISO)
pneumothorax  (ISO)
portal hypertension  (ISO)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
primary biliary cholangitis  (ISO)
Prostatic Neoplasms  (ISO)
Pulmonary Edema of Mountaineers  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IMP,ISO)
pulmonary sarcoidosis  (ISO)
pulmonary venoocclusive disease  (ISO)
renal hypertension  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (ISO)
retinal disease  (ISO)
retinal ischemia  (ISO)
Rhabdomyolysis  (ISO)
Right Ventricular Hypertrophy  (IDA,ISO)
sciatic neuropathy  (ISO)
sickle cell anemia  (IEP,ISO)
silicosis  (IDA,ISO)
Sjogren's syndrome  (ISO)
Spinal Cord Injuries  (ISO)
spinocerebellar ataxia type 17  (ISO)
status epilepticus  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic mastocytosis  (ISO)
Testis Reperfusion Injury  (ISO)
thrombosis  (IDA,ISO)
toxic shock syndrome  (ISO)
type 2 diabetes mellitus  (ISO)
varicocele  (ISO)
Vascular System Injuries  (ISO)
Ventricular Fibrillation  (IAGP)
viral pneumonia  (IEP)
visceral leishmaniasis  (ISO)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-albicanol  (EXP)
(+)-alpha-viniferin  (EXP)
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (EXP,ISO)
(+)-schisandrin B  (ISO)
(+)-taxifolin  (EXP,ISO)
(+)-trans-(S)-allethrin  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-selegiline  (ISO)
(1->4)-beta-D-glucan  (EXP)
(1S)-bornane-2,3-dione  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(E)-cinnamyl alcohol  (EXP,ISO)
(R)-carnitine  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (ISO)
(R)-pantothenic acid  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-AMPA  (ISO)
(S)-colchicine  (ISO)
(S)-duloxetine hydrochloride  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
(S)-ropivacaine  (ISO)
(Z)-ligustilide  (EXP,ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1,1-trichloroethane  (EXP)
1,1-dichloroethene  (ISO)
1,10-phenanthroline  (ISO)
1,2,4-trichlorobenzene  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1,2-naphthoquinone  (ISO)
1,3-benzothiazole-2-thiol  (EXP,ISO)
1,3-dichloropropan-2-ol  (EXP,ISO)
1,3-dinitrobenzene  (ISO)
1,4-benzoquinone  (EXP,ISO)
1,4-dichlorobenzene  (EXP)
1,4-dithiothreitol  (EXP,ISO)
1,4-phenylenediamine  (EXP,ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP)
1-bromopropane  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
1-phenyl-1,2-propanedione  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
15-oxo-ETE  (ISO)
17-hydroxyjolkinolide B  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
1H-pyrazole  (EXP)
2''-galloylhyperin  (EXP,ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (EXP)
2'-hydroxychalcone  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2'-bipyridine  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dichloroindophenol  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-aminophenol  (ISO)
2-bromo-2-(bromomethyl)pentanedinitrile  (EXP,ISO)
2-butoxyethanol  (EXP)
2-chloroethanol  (ISO)
2-deoxy-D-glucose  (ISO)
2-hexenal  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (EXP)
2-nitrofluorene  (ISO)
2-palmitoylglycerol  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
20-hydroxyecdysone  (ISO)
22-Hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-dihydroxybenzoate  (EXP)
3,4-dihydroxybenzoic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-chloropropane-1,2-diol  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP,ISO)
3-Nitrofluoranthene  (ISO)
3-nitropropanoic acid  (ISO)
3-O-Caffeoyl-1-O-methylquinic acid  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,6-dioxoheptanoic acid  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-aminophenol  (ISO)
4-hydroxy-TEMPO  (EXP,ISO)
4-Hydroxybenzyl isothiocyanate  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methoxyacetophenone  (ISO)
4-nitrobenzyl bromide  (EXP,ISO)
4-nitrophenol  (EXP)
4-nitroquinoline N-oxide  (ISO)
4-phenylbutylamine  (ISO)
5,5-diethylbarbituric acid  (EXP)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aminolevulinic acid  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-bromo-2'-deoxyuridine  (EXP)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-aminonicotinamide  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (ISO)
7,8-dihydroxycoumarin  (ISO)
7beta-aminocephalosporanic acid  (ISO)
7H-xanthine  (ISO)
8-Br-cAMP  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
9,10-phenanthroquinone  (ISO)
9-cis-retinoic acid  (ISO)
9H-xanthine  (ISO)
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol  (ISO)
[6]-Shogaol  (EXP,ISO)
abamectin  (ISO)
acetamide  (ISO)
acetic acid  (ISO)
acetylcholine  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
actinomycin D  (EXP,ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin G1  (EXP)
AL 8810  (ISO)
alachlor  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
aldrin  (EXP)
alexidine  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (ISO)
allicin  (ISO)
allopurinol  (ISO)
alloxan  (ISO)
alloxanthine  (ISO)
allyl isothiocyanate  (EXP,ISO)
alpha,alpha-trehalose  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-linolenic acid  (ISO)
alpha-Solamarine  (EXP)
AM-251  (ISO)
aminoguanidine  (EXP,ISO)
amiodarone  (ISO)
amitrole  (ISO)
amlexanox  (EXP)
ammonia  (ISO)
ammonium acetate  (ISO)
ammonium chloride  (EXP,ISO)
ammonium hexachloroplatinate  (ISO)
ammonium hydroxide  (ISO)
ammonium sulfate  (ISO)
Ammothamnine  (EXP,ISO)
amphetamine  (ISO)
amphibole asbestos  (ISO)
amphotericin B  (ISO)
ampicillin  (ISO)
andrographolide  (EXP,ISO)
anethole  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimonite  (ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
arachidonic acid  (ISO)
aristolochic acid A  (EXP,ISO)
aristolochic acids  (ISO)
Aroclor 1254  (EXP)
arotinoid acid  (ISO)
arsane  (EXP,ISO)
arsenic acid  (ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
asperuloside  (EXP)
astaxanthin  (EXP,ISO)
astemizole  (ISO)
astragaloside IV  (EXP)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
atrazine  (EXP,ISO)
aucubin  (EXP)
auranofin  (EXP,ISO)
aureusidin  (ISO)
Aurin  (ISO)
azoxystrobin  (ISO)
bacitracin  (ISO)
bafilomycin A1  (ISO)
baicalein  (EXP,ISO)
baicalin  (EXP,ISO)
Bandrowski's base  (ISO)
BAPTA  (ISO)
Bardoxolone methyl  (EXP,ISO)
bathocuproine disulfonic acid  (ISO)
benfotiamine  (EXP)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[a]pyrene-7,8-dione  (ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP,ISO)
benzoic acid  (ISO)
benzoquinones  (EXP)
benzyl bromide  (ISO)
benzyl isothiocyanate  (EXP,ISO)
benzylideneacetone  (EXP)
beraprost  (ISO)
berberine  (EXP,ISO)
bergaptol  (ISO)
Bergenin  (EXP,ISO)
beta-D-glucosamine  (ISO)
beta-hexachlorocyclohexane  (EXP)
beta-naphthoflavone  (EXP,ISO)
beta-tocopherol  (ISO)
betulin  (ISO)
bifenthrin  (EXP)
bilirubin IXalpha  (EXP,ISO)
biliverdin  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
Bisphenol A glycidylmethacrylate  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP,ISO)
boric acid  (EXP,ISO)
boron nitride  (ISO)
bortezomib  (ISO)
bosentan  (ISO)
bromoacetate  (ISO)
bromobenzene  (EXP,ISO)
Bromochloroacetonitrile  (ISO)
bromocriptine  (ISO)
Brusatol  (ISO)
Bucillamine  (ISO)
buspirone  (ISO)
buta-1,3-diene  (EXP)
butan-1-ol  (ISO)
butane-2,3-dione  (ISO)
butein  (ISO)
butylated hydroxyanisole  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
cadmium sulfate  (EXP,ISO)
Calcimycin  (ISO)
calciol  (EXP)
calcitriol  (EXP,ISO)
calcium atom  (ISO)
calcium dichloride  (EXP,ISO)
calcium oxalate  (ISO)
calcium(0)  (ISO)
Calphostin C  (ISO)
cannabidiol  (EXP,ISO)
capsaicin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbendazim  (ISO)
carbon disulfide  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (EXP,ISO)
carmustine  (ISO)
carnosic acid  (EXP,ISO)
Carnosol  (EXP,ISO)
carrageenan  (ISO)
carvedilol  (ISO)
catalpol  (EXP,ISO)
cefaloridine  (ISO)
celastrol  (EXP,ISO)
celecoxib  (EXP,ISO)
ceric oxide  (ISO)
cerium trichloride  (ISO)
ceruletide  (EXP)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chitosan  (ISO)
chloral hydrate  (ISO)
chloramine T  (ISO)
chloroacetaldehyde  (ISO)
chloroacetic acid  (ISO)
Chloroacetonitrile  (ISO)
chlorobenzene  (ISO)
chloroethene  (EXP)
chloroform  (EXP)
chlorogenic acid  (EXP,ISO)
chloromethylisothiazolinone  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
choline  (EXP)
chromium atom  (EXP,ISO)
chromium trinitrate  (ISO)
chromium trioxide  (EXP)
chromium(6+)  (EXP,ISO)
chrysin  (ISO)
ciclopirox  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
cilostazol  (EXP,ISO)
cimetidine  (ISO)
cinnamyl alcohol  (EXP,ISO)
cisplatin  (EXP,ISO)
citraconic acid  (EXP,ISO)
citral  (ISO)
clodronic acid  (EXP,ISO)
clofibrate  (EXP)
Clofop  (ISO)
clozapine  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (ISO)
coenzyme Q10  (ISO)
colforsin daropate hydrochloride  (ISO)
colistin  (EXP)
coniferyl aldehyde  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (EXP,ISO)
corilagin  (EXP)
cortisol  (ISO)
corynoline  (EXP)
coumermycin A1  (EXP)
crocidolite asbestos  (EXP,ISO)
crocin-1  (ISO)
crotonaldehyde  (ISO)
CU-O LINKAGE  (EXP,ISO)
cucurbitacin I  (ISO)
cumene hydroperoxide  (EXP)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyanidin cation  (EXP)
cyanocob(III)alamin  (EXP,ISO)
cyanuric chloride  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cypermethrin  (EXP,ISO)
cysteamine  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (EXP)
D-penicillamine  (ISO)
daidzein 7-O-beta-D-glucoside  (EXP)
dantrolene  (EXP)
dapagliflozin  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP,ISO)
deguelin  (ISO)
dehydroascorbic acid  (ISO)
dehydrocostus lactone  (EXP)
delphinidin  (ISO)
delta-tocopherol  (ISO)
demethoxycurcumin  (EXP,ISO)
Dendrobine  (ISO)
deoxycholic acid  (ISO)
Deoxycorticosterone acetate  (ISO)
deoxynivalenol  (EXP,ISO)
desferrioxamine B  (EXP,ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
dextran sulfate  (EXP)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (EXP,ISO)
Diallyltetrasulfane  (ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (EXP)
diazinon  (EXP,ISO)
diazoxide  (ISO)
dibenziodolium  (EXP,ISO)
Dibromoacetonitrile  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
Dichloroacetonitrile  (ISO)
dichloroacetyl chloride  (EXP)
dichloromethane  (EXP,ISO)
dichlorvos  (EXP)
diclofenac  (EXP,ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (EXP,ISO)
diethyl maleate  (EXP,ISO)
diethyl phthalate  (EXP)
diethyl sulfate  (ISO)
diethyldithiocarbamic acid  (ISO)
diethylene glycol  (ISO)
diethylstilbestrol  (ISO)
Diglycolic acid  (ISO)
dihydroactinidiolide  (ISO)
dihydroartemisinin  (ISO)
dihydroxyacetone  (EXP,ISO)
Diisodecyl phthalate  (EXP)
dimercaprol  (EXP)
dimethyl fumarate  (EXP,ISO)
dimethyl sulfate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP,ISO)
dimethylarsinous acid  (ISO)
dimethyldithiocarbamate  (ISO)
dinoseb  (EXP)
dioscin  (EXP,ISO)
diosmetin  (ISO)
dioxygen  (EXP,ISO)
diphenylcyclopropenone  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diprotium oxide  (EXP,ISO)
dipyridamole  (ISO)
diquat  (EXP,ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dithianon  (ISO)
dithionite(2-)  (ISO)
dobutamine  (ISO)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
duroquinone  (ISO)
ebselen  (ISO)
echinacoside  (ISO)
edaravone  (EXP,ISO)
elemental selenium  (EXP,ISO)
elesclomol  (ISO)
ellagic acid  (EXP,ISO)
emodin  (EXP,ISO)
enalapril  (ISO)
endosulfan  (ISO)
enflurane  (EXP)
entinostat  (ISO)
epalrestat  (EXP)
epichlorohydrin  (ISO)
epoxiconazole  (EXP)
erastin  (EXP)
erdosteine  (EXP,ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (EXP,ISO)
eriodictyol  (ISO)
erythromycin A  (ISO)
esmolol  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethionamide  (ISO)
ethoxyquin  (EXP)
Ethyl maltol  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
ethylene glycol dimethacrylate  (ISO)
eugenol  (EXP,ISO)
farnesol  (ISO)
farrerol  (EXP)
fasudil  (EXP)
felbamate  (ISO)
fenamidone  (EXP)
fenofibrate  (EXP,ISO)
fenpyroximate  (ISO)
fenvalerate  (ISO)
ferric ammonium citrate  (ISO)
ferric oxide  (EXP)
ferricyanide  (ISO)
ferroheme b  (EXP,ISO)
ferrosoferric oxide  (ISO)
ferrostatin-1  (EXP,ISO)
fisetin  (EXP,ISO)
flavonol  (EXP)
fluoranthene  (EXP)
fluorescein 5-isothiocyanate  (EXP)
fluoxetine  (EXP)
fluprostenol  (ISO)
flutamide  (EXP,ISO)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP,ISO)
formononetin  (ISO)
fructose  (EXP,ISO)
fucoxanthin  (ISO)
fulvestrant  (ISO)
fumonisin B1  (EXP)
furan  (EXP)
furazolidone  (ISO)
furosemide  (EXP,ISO)
gabapentin  (ISO)
galactose  (EXP,ISO)
galangin  (ISO)
gallic acid  (ISO)
gallocatechin  (EXP,ISO)
gamma-linolenic acid  (ISO)
gamma-tocopherol  (EXP,ISO)
Ganoderiol F  (EXP)
Garcinol  (ISO)
Gastrodin  (EXP,ISO)
gedunin  (ISO)
gefitinib  (EXP,ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
Genipin  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
geranial  (ISO)
Geraniin  (EXP)
geraniol  (ISO)
Gingerenone A  (EXP,ISO)
ginkgolide B  (EXP,ISO)
Ginkgolide C  (ISO)
ginsenoside Rb1  (EXP,ISO)
ginsenoside Rg1  (EXP)
Ginsenoside Rh4  (EXP,ISO)
gliclazide  (EXP,ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
Glutathione ethyl ester  (ISO)
glyburide  (ISO)
glycerol  (ISO)
glycerol 2-phosphate  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (EXP)
glyoxal  (EXP,ISO)
glyoxylic acid  (EXP)
glyphosate  (ISO)
Goe 6976  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypin  (ISO)
gossypol  (ISO)
griseofulvin  (EXP)
GW 6471  (EXP)
halothane  (EXP)
harman  (ISO)
heme b  (EXP,ISO)
hemin  (EXP,ISO)
heparin  (ISO)
herbimycin  (EXP,ISO)
hesperetin  (EXP,ISO)
hesperidin  (ISO)
Hexachloro-1,3-butadiene  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (EXP,ISO)
hexaflumuron  (ISO)
hexamethylene diisocyanate  (ISO)
hexanal  (ISO)
hexane  (ISO)
hydralazine  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP,ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
hydroxycitronellal  (ISO)
hydroxysafflor yellow A  (EXP)
hypochlorous acid  (EXP,ISO)
iberin  (ISO)
idarubicin  (ISO)
imidacloprid  (ISO)
imidazoles  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (EXP,ISO)
indolin-2-one  (EXP,ISO)
indoline  (ISO)
indometacin  (EXP,ISO)
iodixanol  (ISO)
iohexol  (ISO)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron dextran  (EXP,ISO)
iron dichloride  (ISO)
iron trichloride  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) citrate  (ISO)
iron(III) nitrilotriacetate  (EXP,ISO)
isobutyl nitrite  (EXP)
isoeugenol  (EXP,ISO)
isoflurane  (EXP,ISO)
isoimperatorin  (ISO)
isoliquiritigenin  (EXP)
isoniazide  (EXP,ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP,ISO)
ivermectin  (ISO)
kaempferol  (EXP,ISO)
kahweol  (ISO)
kainic acid  (ISO)
ketamine  (ISO)
ketoconazole  (ISO)
KN-93  (ISO)
KT 5720  (EXP,ISO)
L-1,4-dithiothreitol  (EXP,ISO)
L-arginine  (EXP)
L-ascorbic acid  (EXP,ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-cysteine  (EXP)
L-dehydroascorbic acid  (ISO)
L-glutamic acid  (EXP,ISO)
L-methionine  (EXP)
lactacystin  (EXP,ISO)
lactulose  (ISO)
lansoprazole  (EXP,ISO)
lapatinib  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (EXP,ISO)
Leonurine  (ISO)
letrozole  (ISO)
leukotriene B4  (EXP)
leukotriene C4  (EXP)
levetiracetam  (ISO)
Licochalcone B  (ISO)
lidocaine  (ISO)
lignan  (EXP)
limonene  (EXP,ISO)
limonin  (EXP)
linagliptin  (ISO)
linalool  (ISO)
linoleic acid  (EXP,ISO)
linsidomine  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP,ISO)
lipoxin A4  (ISO)
liquiritigenin  (ISO)
liquiritin  (EXP,ISO)
liraglutide  (ISO)
lithium atom  (EXP,ISO)
lithium chloride  (ISO)
lithium hydride  (EXP,ISO)
lithocholic acid  (EXP,ISO)
loganin  (EXP)
loliolide  (ISO)
lopinavir  (ISO)
losartan  (ISO)
lovastatin  (EXP,ISO)
lucidenic acid N  (EXP)
Lucidenic acid P  (EXP)
Lucidone  (ISO)
lutein  (EXP)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
lycopene  (EXP,ISO)
lysophosphatidylcholine  (ISO)
Macrosphelide B  (EXP)
magnesium dichloride  (ISO)
Magnolol  (EXP)
malaoxon  (ISO)
malathion  (ISO)
maleic acid  (ISO)
malonaldehyde  (ISO)
maneb  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
manidipine  (ISO)
masoprocol  (EXP,ISO)
mechlorethamine  (EXP,ISO)
mefloquine  (ISO)
meglumine amidotrizoate  (ISO)
MeIQx  (ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
mercaptoethanol  (EXP)
mercury atom  (EXP,ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
mesalamine  (ISO)
mesoporphyrin IX  (EXP)
metformin  (ISO)
methamphetamine  (EXP,ISO)
Methanandamide  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methyl 3,4,5-trihydroxybenzoate  (EXP)
methyl beta-cyclodextrin  (EXP)
methyl methacrylate  (EXP)
methyl methanesulfonate  (ISO)
methyl non-2-ynoate  (ISO)
methyl salicylate  (ISO)
methylarsonic acid  (EXP,ISO)
methylene blue  (EXP,ISO)
methylglyoxal  (EXP,ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
Methysticin  (EXP)
metoprolol  (ISO)
metronidazole  (EXP)
metyrapone  (ISO)
mevinphos  (ISO)
microcystin-LR  (EXP,ISO)
midostaurin  (ISO)
mifepristone  (ISO)
miquelianin  (ISO)
monascin  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotaline  (EXP,ISO)
monosodium L-glutamate  (EXP)
monothioglycerol  (ISO)
montelukast  (ISO)
morin  (ISO)
morphine  (EXP)
Morroniside  (EXP)
motexafin gadolinium  (ISO)
myricetin  (ISO)
N(4)-hydroxycytidine  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N,N-dimethylformamide  (ISO)
N-(6-acetamidohexyl)acetamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-[3-(aminomethyl)benzyl]acetamidine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethyl-N-nitrosourea  (EXP)
N-isopropyl-N'-phenyl-p-phenylenediamine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
N-methylformamide  (EXP)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
n-propyl gallate  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
nafenopin  (EXP)
naphthalene  (EXP,ISO)
naphthalene-1,2-diol  (ISO)
naringin  (EXP,ISO)
nefazodone  (ISO)
Neferine  (ISO)
nelfinavir  (EXP)
neomycin  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nickel sulfate  (EXP,ISO)
nicorandil  (ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nifedipine  (ISO)
nilotinib  (ISO)
nimesulide  (ISO)
nitisinone  (EXP)
nitric oxide  (EXP,ISO)
nitrites  (EXP)
nitrofen  (ISO)
nitrofurantoin  (ISO)
nitrogen dioxide  (EXP,ISO)
nitroglycerin  (EXP,ISO)
nitroprusside  (EXP,ISO)
nobiletin  (ISO)
Nodosin  (ISO)
Nonidet P-40  (ISO)
Nonylphenol  (ISO)
notoginsenoside R1  (EXP,ISO)
NS-398  (EXP,ISO)
NSC 23766  (EXP)
O-acetyl-L-carnitine  (ISO)
o-xylene  (ISO)
ochratoxin A  (EXP,ISO)
Octachlorostyrene  (ISO)
octadecanoic acid  (ISO)
octreotide  (ISO)
olanzapine  (EXP)
oleanolic acid  (EXP,ISO)
oleic acid  (ISO)
Olmesartan medoxomil  (ISO)
Olprinone hydrochloride  (ISO)
omeprazole  (ISO)
Ophiopogonin D  (ISO)
organoselenium compound  (ISO)
oridonin  (ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-cresol  (ISO)
Pachymic acid  (EXP,ISO)
paclitaxel  (ISO)
paeoniflorin  (ISO)
Paeonol  (ISO)
Palbinone  (ISO)
palmatine  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
pelargonidin  (EXP)
pentachlorophenol  (ISO)
pentaerythritol tetranitrate  (EXP,ISO)
pentetrazol  (EXP)
Pentoxifylline  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
peroxides  (EXP)
peroxynitrous acid  (ISO)
phalloidin  (EXP)
phenacetin  (ISO)
phencyclidine  (ISO)
phenethyl caffeate  (EXP,ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylarsine oxide  (EXP,ISO)
phenylarsonic acid  (ISO)
phenylhydrazine  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP,ISO)
PhIP  (ISO)
phlorizin  (EXP)
phlorizin chalcone  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (EXP,ISO)
phosgene  (EXP,ISO)
phosphane  (ISO)
physostigmine  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
pinostrobin  (ISO)
pioglitazone  (EXP,ISO)
piperine  (EXP,ISO)
piperonyl butoxide  (ISO)
pipoxolan  (EXP)
pirfenidone  (EXP)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
plumbagin  (ISO)
pluronic P-123  (ISO)
Poloxamer  (ISO)
Polpunonic acid  (EXP,ISO)
poly(I:C)  (ISO)
poly(vinylpyrrolidone)  (ISO)
polymyxin B2  (EXP,ISO)
polysorbate 40  (ISO)
potassium bromate  (ISO)
potassium chloride  (ISO)
potassium dichromate  (EXP,ISO)
potassium iodide  (ISO)
pravastatin  (EXP,ISO)
prazosin  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
probucol  (EXP,ISO)
procyanidin B1  (ISO)
procyanidin B2  (ISO)
procyanidin B3  (EXP)
prodigiosin  (ISO)
progesterone  (EXP,ISO)
propacetamol  (EXP)
propan-2-ol  (ISO)
propiconazole  (ISO)
propofol  (ISO)
propranolol  (ISO)
prostaglandin A1  (EXP)
prostaglandin E2  (EXP,ISO)
protein kinase inhibitor  (ISO)
protoporphyrin  (ISO)
pterostilbene  (EXP,ISO)
puerarin  (EXP,ISO)
Punicalagin  (ISO)
puromycin  (ISO)
pyrazinecarboxamide  (ISO)
pyrazoles  (ISO)
pyrethrins  (ISO)
pyridine  (ISO)
Pyridostigmine bromide  (ISO)
pyrimidifen  (ISO)
pyrithione  (EXP)
pyrrolidine dithiocarbamate  (EXP,ISO)
pyrrolidines  (ISO)
pyrroloquinoline quinone  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quercetin 4'-O-beta-D-glucopyranoside  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ranitidine  (ISO)
raspberry ketone  (EXP)
razoxane  (EXP)
reactive oxygen species  (EXP,ISO)
resolvin D1  (EXP)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
Rhynchophylline  (EXP,ISO)
rifampicin  (EXP,ISO)
rimonabant  (ISO)
ritonavir  (ISO)
Ro 31-8220  (ISO)
roflumilast  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
Rutecarpine  (ISO)
rutin  (EXP)
ryanodine  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-(1,2-Dichlorovinyl)glutathione  (ISO)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
S-nitrosoglutathione  (ISO)
salvianolic acid B  (EXP,ISO)
saxagliptin  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SCH 23390  (ISO)
SCH772984  (ISO)
scopolamine  (EXP)
selenium atom  (EXP,ISO)
serpentine asbestos  (EXP,ISO)
sesquiterpene  (EXP,ISO)
sevoflurane  (EXP,ISO)
sildenafil citrate  (ISO)
silibinin  (ISO)
silicon atom  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
silver(1+) nitrate  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
sodium cholate  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
solanesol  (ISO)
Soman  (ISO)
spironolactone  (ISO)
staurosporine  (EXP,ISO)
sterigmatocystin  (ISO)
streptozocin  (EXP,ISO)
styrene  (EXP)
styrene oxide  (ISO)
succimer  (EXP,ISO)
sulfadimethoxine  (ISO)
sulfaphenazole  (ISO)
sulfasalazine  (ISO)
sulforaphane  (EXP,ISO)
sulfur dioxide  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
superoxide  (EXP,ISO)
surfactin  (ISO)
surfactin C  (ISO)
T-2 toxin  (EXP)
tacrine  (ISO)
tacrolimus hydrate  (EXP,ISO)
tadalafil  (ISO)
tamoxifen  (EXP,ISO)
tangeretin  (EXP,ISO)
Tanshinone I  (ISO)
taurine  (EXP,ISO)
tebufenpyrad  (ISO)
tectorigenin  (EXP)
temozolomide  (ISO)
TEMPO  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloro-1,4-benzoquinone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetrahydropalmatine  (ISO)
tetramethylpyrazine  (ISO)
tetrathiomolybdate(2-)  (ISO)
thallium sulfate  (ISO)
thapsigargin  (ISO)
thiazoles  (ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
thiostrepton  (ISO)
thiram  (EXP,ISO)
thymidine  (ISO)
thymine  (ISO)
thymoquinone  (ISO)
ticlopidine  (ISO)
tideglusib  (ISO)
tienilic acid  (ISO)
tin(II) chloride (anhydrous)  (ISO)
Tiopronin  (ISO)
Tiron  (EXP,ISO)
titanium dioxide  (EXP,ISO)
tobramycin  (ISO)
toluene  (EXP,ISO)
topotecan  (ISO)
trans-anethole  (ISO)
trans-isoeugenol  (EXP,ISO)
trans-rhaponticin  (ISO)
tranylcypromine  (ISO)
triacetin  (ISO)
triacsin C  (ISO)
tributylstannane  (EXP,ISO)
Tributyltin oxide  (EXP,ISO)
tricalcium bis(phosphate)  (EXP)
tricetin  (ISO)
Tricetinidin  (ISO)
trichloroacetaldehyde  (ISO)
trichloroacetic acid  (ISO)
Trichloroacetonitrile  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (EXP,ISO)
trilobatin  (EXP,ISO)
trimethylarsine oxide  (EXP)
trimethyltin  (EXP,ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
Tris(1-aziridinyl)phosphine oxide  (EXP)
tris(2-butoxyethyl) phosphate  (EXP,ISO)
troglitazone  (EXP,ISO)
tropisetron  (ISO)
trovafloxacin  (EXP)
Tungsten carbide  (ISO)
tunicamycin  (EXP,ISO)
tyrphostin AG 1478  (ISO)
undecan-2-one  (EXP,ISO)
urea  (EXP,ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vancomycin  (EXP,ISO)
vanillin  (ISO)
verapamil  (ISO)
verteporfin  (EXP)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
vitexin  (EXP)
warfarin  (ISO)
water  (EXP,ISO)
withaferin A  (EXP)
wortmannin  (EXP,ISO)
Xamoterol  (ISO)
Xanthatin  (ISO)
xanthohumol  (ISO)
XAV939  (ISO)
yttrium chloride  (ISO)
zearalenone  (EXP)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP,ISO)
zinc molecular entity  (ISO)
zinc oxide  (EXP,ISO)
zinc protoporphyrin  (EXP,ISO)
zinc pyrithione  (EXP,ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)
ziprasidone  (ISO)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
apoptotic process  (IEA)
cellular response to arsenic-containing substance  (IDA)
cellular response to cadmium ion  (IDA)
cellular response to cisplatin  (IMP)
cellular response to heat  (ISO)
cellular response to hypoxia  (ISO)
cellular response to nutrient  (ISO)
epithelial cell apoptotic process  (IMP)
erythrocyte homeostasis  (ISO)
heme catabolic process  (IBA,IGI,ISO)
heme metabolic process  (IDA)
heme oxidation  (IBA,ISO)
intracellular iron ion homeostasis  (ISO)
intracellular signal transduction  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
liver regeneration  (ISO)
macroautophagy  (IMP)
multicellular organismal-level iron ion homeostasis  (ISO)
negative regulation by host of viral transcription  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA binding  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of epithelial cell apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
negative regulation of macroautophagy  (IMP)
negative regulation of mast cell cytokine production  (ISO)
negative regulation of mast cell degranulation  (ISO)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
negative regulation of viral life cycle  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO)
positive regulation of epithelial cell apoptotic process  (IMP)
positive regulation of macroautophagy  (IMP)
positive regulation of smooth muscle cell proliferation  (ISO)
regulation of blood pressure  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to 3-methylcholanthrene  (ISO)
response to arachidonic acid  (ISO)
response to estrogen  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to nicotine  (ISO)
response to oxidative stress  (IBA,ISO)
response to xenobiotic stimulus  (ISO)
small GTPase-mediated signal transduction  (ISO)
wound healing involved in inflammatory response  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal artery morphology  (IAGP)
abnormal cardiac muscle contractility  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal cellular respiration  (IAGP)
abnormal craniofacial morphology  (IEA)
abnormal facial morphology  (IEA)
abnormal head shape  (IEA)
abnormal iron homeostasis  (IAGP)
abnormal leukocyte cell number  (IAGP)
abnormal lymph node cell ratio  (IAGP)
abnormal metabolism  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal placenta morphology  (IEA)
abnormal placenta size  (IEA)
abnormal redox activity  (IAGP)
abnormal response to cardiac infarction  (IAGP)
abnormal splenic cell ratio  (IAGP)
abnormal thrombosis  (IAGP)
abnormal vascular smooth muscle physiology  (IAGP)
anemia  (IAGP)
anisocytosis  (IAGP)
cachexia  (IAGP)
cardiac fibrosis  (IAGP)
cerebral edema  (IAGP)
chronic inflammation  (IAGP)
decreased body size  (IAGP)
decreased circulating alanine transaminase level  (IAGP)
decreased circulating aspartate transaminase level  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating iron level  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased fat cell size  (IAGP)
decreased hematocrit  (IAGP)
decreased hemoglobin content  (IAGP)
decreased inflammatory response  (IAGP)
decreased interferon-beta secretion  (IAGP)
decreased interleukin-1 beta secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased locomotor activity  (IAGP)
decreased macrophage cell number  (IAGP)
decreased mean corpuscular volume  (IAGP)
decreased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
decreased susceptibility to diet-induced hepatic steatosis  (IAGP)
decreased susceptibility to Paramyxoviridae infection  (IAGP)
decreased susceptibility to weight gain  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
dilated heart right ventricle  (IAGP)
edema  (IEA)
embryonic growth retardation  (IEA)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
extramedullary hematopoiesis  (IAGP)
glomerular crescent  (IAGP)
glomerulonephritis  (IAGP)
glomerulosclerosis  (IAGP)
hemorrhage  (IEA)
impaired hematopoiesis  (IAGP)
improved glucose tolerance  (IAGP)
increased B cell number  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased cardiomyocyte apoptosis  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating ferritin level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased energy expenditure  (IAGP)
increased erythroid progenitor cell number  (IAGP)
increased granulocyte number  (IAGP)
increased heart right ventricle weight  (IAGP)
increased inflammatory response  (IAGP)
increased insulin sensitivity  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased macrophage cell number  (IAGP)
increased myocardial infarct size  (IAGP)
increased renal tubule apoptosis  (IAGP)
increased splenocyte proliferation  (IAGP)
increased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased susceptibility to parasitic infection induced morbidity/mortality  (IAGP)
increased vascular smooth muscle cell proliferation  (IAGP)
infertility  (IAGP)
kidney failure  (IAGP)
liver failure  (IAGP)
liver fibrosis  (IAGP)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
microcytic anemia  (IAGP)
microphthalmia  (IEA)
myocardium necrosis  (IAGP)
oxidative stress  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
poor grooming  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
preweaning lethality, incomplete penetrance  (IEA)
proximal convoluted tubule brush border loss  (IAGP)
renal cast  (IAGP)
renal tubular necrosis  (IAGP)
small testis  (IAGP)
spleen hyperplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Aboutabl ME, etal., Br J Pharmacol. 2009 Dec;158(7):1808-19. doi: 10.1111/j.1476-5381.2009.00461.x.
2. Heme oxygenase-1 is expressed in carotid atherosclerotic plaques infected by Helicobacter pylori and is more prevalent in asymptomatic subjects. Ameriso SF, etal., Stroke. 2005 Sep;36(9):1896-900. Epub 2005 Aug 11.
3. Role of heme oxygenase-1 in protection of the kidney after hemorrhagic shock. Arimori Y, etal., Int J Mol Med. 2010 Jul;26(1):27-32.
4. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with iron status in persons with type 2 diabetes mellitus. Arredondo M, etal., Am J Clin Nutr. 2007 Nov;86(5):1347-53.
5. Heme oxygenase-1-related carbon monoxide production and ventricular fibrillation in isolated ischemic/reperfused mouse myocardium. Bak I, etal., FASEB J. 2003 Nov;17(14):2133-5. Epub 2003 Sep 4.
6. The role of AT1-receptor blockade on reactive oxygen species and cardiac autonomic drive in experimental hyperthyroidism. Baraldi D, etal., Auton Neurosci. 2013 Oct;177(2):163-9. doi: 10.1016/j.autneu.2013.04.003. Epub 2013 Apr 26.
7. Heme oxygenase-1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with sickle cell disease. Bean CJ, etal., Blood. 2012 Nov 1;120(18):3822-8. doi: 10.1182/blood-2011-06-361642. Epub 2012 Sep 10.
8. Induction of Hsp27 and Hsp32 stress proteins and vimentin in glial cells of the rat hippocampus following hyperthermia. Bechtold DA and Brown IR, Neurochem Res 2003 Aug;28(8):1163-73.
9. Heme oxygenase-1 gene delivery by Sleeping Beauty inhibits vascular stasis in a murine model of sickle cell disease. Belcher JD, etal., J Mol Med (Berl). 2010 Jul;88(7):665-75. doi: 10.1007/s00109-010-0613-6. Epub 2010 Mar 23.
10. Pharmacological activation of heme oxygenase (HO)-1/carbon monoxide pathway prevents the development of peripheral neuropathic pain in Wistar rats. Bijjem KR, etal., Naunyn Schmiedebergs Arch Pharmacol. 2013 Jan;386(1):79-90. doi: 10.1007/s00210-012-0816-1. Epub 2012 Dec 9.
11. Hemin induction of HO-1 protects against LPS-induced septic ileus. Bortscher S, etal., J Surg Res. 2012 Dec;178(2):866-73. doi: 10.1016/j.jss.2012.07.064. Epub 2012 Aug 15.
12. Increase in heme oxygenase-1 levels ameliorates renovascular hypertension. Botros FT, etal., Kidney Int. 2005 Dec;68(6):2745-55.
13. Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism. Bruce CR, etal., Diabetes. 2003 Sep;52(9):2338-45.
14. Lentiviral-human heme oxygenase targeting endothelium improved vascular function in angiotensin II animal model of hypertension. Cao J, etal., Hum Gene Ther. 2011 Mar;22(3):271-82. doi: 10.1089/hum.2010.059. Epub 2011 Jan 27.
15. High-fat diet exacerbates renal dysfunction in SHR: reversal by induction of HO-1-adiponectin axis. Cao J, etal., Obesity (Silver Spring). 2012 May;20(5):945-53. doi: 10.1038/oby.2011.365. Epub 2011 Dec 22.
16. Regulation of heme oxygenase-1 by nitric oxide during hepatopulmonary syndrome. Carter EP, etal., Am J Physiol Lung Cell Mol Physiol 2002 Aug;283(2):L346-53.
17. Heme oxygenase-1 inhibition prevents intimal hyperplasia enhancing nitric oxide-dependent apoptosis of vascular smooth muscle cells. Cerrito MG, etal., Biol Pharm Bull. 2011;34(8):1204-14.
18. Baicalein protects against retinal ischemia by antioxidation, antiapoptosis, downregulation of HIF-1alpha, VEGF, and MMP-9 and upregulation of HO-1. Chao HM, etal., J Ocul Pharmacol Ther. 2013 Jul-Aug;29(6):539-49. doi: 10.1089/jop.2012.0179. Epub 2013 Mar 28.
19. Study on changes of heme oxygenase-1 expression in patients with coronary heart disease. Chen SM, etal., Clin Cardiol. 2005 Apr;28(4):197-201.
20. Elevated serum heme oxygenase-1 and insulin-like growth factor-1 levels in patients with Henoch-Schonlein purpura. Chen T, etal., Rheumatol Int. 2011 Mar;31(3):321-6. doi: 10.1007/s00296-009-1254-3. Epub 2009 Dec 16.
21. Increased vascular heme oxygenase-1 expression contributes to arterial vasodilation in experimental cirrhosis in rats. Chen YC, etal., Hepatology. 2004 Apr;39(4):1075-87.
22. Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients. Chen YH, etal., Hum Genet. 2002 Jul;111(1):1-8. Epub 2002 Jun 19.
23. Oxidant stress responses in influenza virus pneumonia: gene expression and transcription factor activation. Choi AM, etal., Am J Physiol. 1996 Sep;271(3 Pt 1):L383-91.
24. Beneficial effect of prolonged heme oxygenase 1 activation in a rat model of chronic heart failure. Collino M, etal., Dis Model Mech. 2013 Jul;6(4):1012-20. doi: 10.1242/dmm.011528. Epub 2013 Apr 16.
25. Heme oxygenase-1 plays a pro-life role in experimental brain stem death via nitric oxide synthase I/protein kinase G signaling at rostral ventrolateral medulla. Dai KY, etal., J Biomed Sci. 2010 Sep 7;17:72. doi: 10.1186/1423-0127-17-72.
26. Effectiveness of miltefosine treatment in targeting anti-leishmanial HO-1/Nrf-2-mediated oxidative responses in visceral leishmaniasis patients. Das S, etal., J Antimicrob Chemother. 2013 Sep;68(9):2059-65. doi: 10.1093/jac/dkt162. Epub 2013 May 31.
27. The protection by heme oxygenase-1 induction against thioacetamide-induced liver toxicity is associated with changes in arginine and asymmetric dimethylarginine. Develi-Is S, etal., Cell Biochem Funct. 2013 Mar;31(2):122-8. doi: 10.1002/cbf.2866. Epub 2012 Aug 13.
28. Hyperglycemia in streptozotocin-induced diabetic rat increases infarct size associated with low levels of myocardial HO-1 during ischemia/reperfusion. Di Filippo C, etal., Diabetes. 2005 Mar;54(3):803-10.
29. Therapeutic effect of placenta-derived mesenchymal stem cells on hypoxic-ischemic brain damage in rats. Ding HF, etal., World J Pediatr. 2015 Feb;11(1):74-82. doi: 10.1007/s12519-014-0531-8. Epub 2014 Dec 1.
30. Transient elevation of serum bilirubin (a heme oxygenase-1 metabolite) level in hemorrhagic stroke: bilirubin is a marker of oxidant stress. Dohi K, etal., Acta Neurochir Suppl. 2003;86:247-9.
31. Heme oxygenase (HO)-1 is upregulated in the nasal mucosa with allergic rhinitis. Elhini A, etal., Laryngoscope. 2006 Mar;116(3):446-50.
32. A microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with increased bilirubin and HDL levels but not with coronary artery disease. Endler G, etal., Thromb Haemost. 2004 Jan;91(1):155-61.
33. The protective effect of salvianolic acid B on blood-spinal cord barrier after compression spinal cord injury in rats. Fan ZK, etal., J Mol Neurosci. 2013 Nov;51(3):986-93. doi: 10.1007/s12031-013-0083-8. Epub 2013 Aug 14.
34. Increased heme oxygenase-1 expression in premature infants with respiratory distress syndrome. Farkas I, etal., Eur J Pediatr. 2008 Dec;167(12):1379-83. Epub 2008 Feb 27.
35. Absence of heme oxygenase-1 expression in the lung parenchyma exacerbates endotoxin-induced acute lung injury and decreases surfactant protein-B levels. Fredenburgh LE, etal., Cell Mol Biol (Noisy-le-grand). 2005 Oct 3;51(5):513-20.
36. Expression of heme oxygenase-1 protein and messenger RNA in permanent cerebral ischemia in rats. Fu R, etal., Neurol Res. 2006 Jan;28(1):38-45.
37. Heme oxygenase-1 polymorphism associated with severity of chronic obstructive pulmonary disease. Fu WP, etal., Chin Med J (Engl). 2007 Jan 5;120(1):12-6.
38. Relationship between COPD and polymorphisms of HOX-1 and mEPH in a Chinese population. Fu WP, etal., Oncol Rep. 2007 Feb;17(2):483-8.
39. Systemic perfluorohexane attenuates lung injury induced by lipopolysaccharide in rats: the role of heme oxygenase-1. Ge ZJ, etal., Pharmacol Rep. 2010 Jan-Feb;62(1):170-7.
40. Induction of heme oxygenase 1 attenuates placental ischemia-induced hypertension. George EM, etal., Hypertension. 2011 May;57(5):941-8. doi: 10.1161/HYPERTENSIONAHA.111.169755. Epub 2011 Mar 7.
41. Antioxidant role of heme oxygenase-1 in prehepatic portal hypertensive rats. Gonzales S, etal., World J Gastroenterol. 2006 Jul 14;12(26):4149-55.
42. The systemic administration of oleoylethanolamide exerts neuroprotection of the nigrostriatal system in experimental Parkinsonism. Gonzalez-Aparicio R, etal., Int J Neuropsychopharmacol. 2014 Mar;17(3):455-68. doi: 10.1017/S1461145713001259. Epub 2013 Oct 29.
43. Heme oxygenase-1 reduces murine monocrotaline-induced pulmonary inflammatory responses and resultant right ventricular overload. Goto J, etal., Antioxid Redox Signal. 2002 Aug;4(4):563-8.
44. Induction of heme oxygenase-1, biliverdin reductase and H-ferritin in lung macrophage in smokers with primary spontaneous pneumothorax: role of HIF-1alpha. Goven D, etal., PLoS One. 2010 May 28;5(5):e10886.
45. Dynamic Changes of Heme Oxygenase-1 in the Hippocampus of Rats After Acute Carbon Monoxide Poisoning. Guan L, etal., Arch Environ Contam Toxicol. 2010 Apr 27.
46. Induction of heme oxygenase-1 with hemin attenuates hippocampal injury in rats after acute carbon monoxide poisoning. Guan L, etal., Toxicology. 2009 Aug 3;262(2):146-52. Epub 2009 Jun 9.
47. Clinical restenosis after coronary stent implantation is associated with the heme oxygenase-1 gene promoter polymorphism and the heme oxygenase-1 +99G/C variant. Gulesserian T, etal., Clin Chem. 2005 Sep;51(9):1661-5. Epub 2005 Jul 14.
48. Effects of heme oxygenase-1 on pulmonary function and structure in rats with liver cirrhosis. Guo SB, etal., Chin Med J (Engl). 2011 Mar;124(6):918-22.
49. Transduction of PEP-1-heme oxygenase-1 fusion protein reduces myocardial ischemia/reperfusion injury in rats. He XH, etal., J Cardiovasc Pharmacol. 2013 Nov;62(5):436-42. doi: 10.1097/FJC.0b013e3182a0b638.
50. Microarray studies of genomic oxidative stress and cell cycle responses in obstructive sleep apnea. Hoffmann MS, etal., Antioxid Redox Signal. 2007 Jun;9(6):661-9.
51. Simvastatin ameliorates established pulmonary hypertension through a heme oxygenase-1 dependent pathway in rats. Hsu HH, etal., Respir Res. 2009 May 2;10:32.
52. 2-methoxycinnamaldehyde from Cinnamomum cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to HO-1 induction. Hwa JS, etal., J Ethnopharmacol. 2012 Jan 31;139(2):605-15. doi: 10.1016/j.jep.2011.12.001. Epub 2011 Dec 9.
53. Combinational therapy of ischemic brain stroke by delivery of heme oxygenase-1 gene and dexamethasone. Hyun H, etal., Biomaterials. 2011 Jan;32(1):306-15. doi: 10.1016/j.biomaterials.2010.08.116.
54. Hemin prevents in-stent stenosis in rat and rabbit models by inducing heme-oxygenase-1. Hyvelin JM, etal., J Vasc Surg. 2010 Feb;51(2):417-28.
55. Dietary alpha-linolenic acid-rich formula reduces adhesion molecules in rats with experimental colitis. Ibrahim A, etal., Nutrition. 2012 Jul;28(7-8):799-802. doi: 10.1016/j.nut.2011.10.008. Epub 2012 Jan 20.
56. Heme oxygenase-1 against vascular insufficiency: roles of atherosclerotic disorders. Ishikawa K Curr Pharm Des. 2003;9(30):2489-97.
57. Upregulation of cytoprotective defense mechanisms and hypoxia-responsive proteins imparts tolerance to acute hypobaric hypoxia. Jain K, etal., High Alt Med Biol. 2013 Mar;14(1):65-77. doi: 10.1089/ham.2012.1064.
58. Activation of hypoxia-inducible factor-1alpha via nuclear factor-kappa B in rats with chronic obstructive pulmonary disease. Jiang H, etal., Acta Biochim Biophys Sin (Shanghai). 2010 Jul;42(7):483-8. doi: 10.1093/abbs/gmq041. Epub 2010 Jun 10.
59. Postischemic cardiac recovery in heme oxygenase-1 transgenic ischemic/reperfused mouse myocardium. Juhasz B, etal., J Cell Mol Med. 2010 Aug 16.
60. Epigallocatechin-3-gallate protects kidneys from ischemia reperfusion injury by HO-1 upregulation and inhibition of macrophage infiltration. Kakuta Y, etal., Transpl Int. 2011 May;24(5):514-22. doi: 10.1111/j.1432-2277.2011.01224.x. Epub 2011 Feb 3.
61. Polymorphisms of heme oxygenase-1 and bilirubin UDP-glucuronosyltransferase genes are not associated with Kawasaki disease susceptibility. Kanai M, etal., Tohoku J Exp Med. 2003 Jul;200(3):155-9.
62. Heme oxygenase-1 gene promoter polymorphism is associated with coronary artery disease in Japanese patients with coronary risk factors. Kaneda H, etal., Arterioscler Thromb Vasc Biol. 2002 Oct 1;22(10):1680-5.
63. Heme oxygenase 1 modulates thrombomodulin and endothelial protein C receptor levels to attenuate septic kidney injury. Kang K, etal., Shock. 2013 Aug;40(2):136-43. doi: 10.1097/SHK.0b013e31829d23f5.
64. Vascular insult accompanied by overexpressed heme oxygenase-1 as a pathophysiological mechanism in experimental neurolathyrism with hind-leg paraparesis. Kawaguchi K, etal., Biochem Biophys Res Commun. 2012 Nov 9;428(1):160-6. doi: 10.1016/j.bbrc.2012.10.032. Epub 2012 Oct 12.
65. Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. Kawamura T, etal., Am J Physiol Lung Cell Mol Physiol. 2013 May 15;304(10):L646-56. doi: 10.1152/ajplung.00164.2012. Epub 2013 Mar 8.
66. Cytoprotective and antiapoptotic effects of IL-13 in hepatic cold ischemia/reperfusion injury are heme oxygenase-1 dependent. Ke B, etal., Am J Transplant. 2003 Sep;3(9):1076-82.
67. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
68. Association of susceptibility to the development of lung adenocarcinoma with the heme oxygenase-1 gene promoter polymorphism. Kikuchi A, etal., Hum Genet. 2005 Apr;116(5):354-60. Epub 2005 Feb 2.
69. Phenolic antioxidants tert-butyl-bisphenol and vitamin E decrease oxidative stress and enhance vascular function in an animal model of rhabdomyolysis yet do not improve acute renal dysfunction. Kim HB, etal., Free Radic Res. 2011 Sep;45(9):1000-12. doi: 10.3109/10715762.2011.590137. Epub 2011 Jul 5.
70. Caveolae compartmentalization of heme oxygenase-1 in endothelial cells. Kim HP, etal., FASEB J 2004 Jul;18(10):1080-9.
71. Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Behcet's disease. Kirino Y, etal., Arthritis Res Ther. 2008;10(1):R16. doi: 10.1186/ar2367. Epub 2008 Jan 31.
72. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, etal., Hum Mol Genet 1998 Nov;7(12):1967-78.
73. High extracellular induced sputum haem oxygenase-1 in sarcoidosis and chronic beryllium disease. Kokturk N, etal., Eur J Clin Invest. 2009 Jul;39(7):584-90. Epub 2009 Apr 27.
74. Sunitinib Inhibits Breast Cancer Cell Proliferation by Inducing Apoptosis, Cell-cycle Arrest and DNA Repair While Inhibiting NF-κB Signaling Pathways. Korashy HM, etal., Anticancer Res. 2017 Sep;37(9):4899-4909. doi: 10.21873/anticanres.11899.
75. Evaluation of the heme oxygenase-1 expression in esophagitis and esophageal cancer induced by different reflux experimental models and diethylnitrosamine. Kruel CR, etal., Acta Cir Bras. 2010 Jun;25(3):304-10.
76. Transient limb ischemia induces remote preconditioning in liver among rats: the protective role of heme oxygenase-1. Lai IR, etal., Transplantation. 2006 May 15;81(9):1311-7.
77. Expression and regulation of hemeoxygenase 1 in healthy human lung and interstitial lung disorders. Lakari E, etal., Hum Pathol. 2001 Nov;32(11):1257-63.
78. Expression of heme oxygenase-1 in response to myocardial infarction in rats. Lakkisto P, etal., J Mol Cell Cardiol. 2002 Oct;34(10):1357-65.
79. Heme oxygenase-1 mediated memorial and revivable protective effect of ischemic preconditioning on brain injury. Le LL, etal., CNS Neurosci Ther. 2013 Dec;19(12):963-8. doi: 10.1111/cns.12152. Epub 2013 Jul 22.
80. Anti-asthmatic effect of Sanguisorba officinalis L. and potential role of heme oxygenase-1 in an ovalbumin-induced murine asthma model. Lee NH, etal., Int J Mol Med. 2010 Aug;26(2):201-8.
81. Baicalein, an active component of Scutellaria baicalensis Georgi, improves cardiac contractile function in endotoxaemic rats via induction of heme oxygenase-1 and suppression of inflammatory responses. Lee YM, etal., J Ethnopharmacol. 2011 Apr 26;135(1):179-85. doi: 10.1016/j.jep.2011.03.009. Epub 2011 Mar 17.
82. Hypoxia inducible factor-1 alpha correlates the expression of heme oxygenase 1 gene in pulmonary arteries of rat with hypoxia-induced pulmonary hypertension. Li QF and Dai AG, Acta Biochim Biophys Sin (Shanghai). 2004 Feb;36(2):133-40.
83. Tin chloride enhances parvalbumin-positive interneuron survival by modulating heme metabolism in a model of cerebral ischemia. Li Volti G, etal., Neurosci Lett. 2011 Mar 29;492(1):33-8. doi: 10.1016/j.neulet.2011.01.048. Epub 2011 Jan 27.
84. Mesenchymal Stromal Cells Expressing Heme Oxygenase-1 Reverse Pulmonary Hypertension. Liang OD, etal., Stem Cells. 2010 Oct 18.
85. Lesional accumulation of heme oxygenase-1+ microglia/macrophages in rat traumatic brain injury. Liu Y, etal., Neuroreport. 2013 Apr 17;24(6):281-6. doi: 10.1097/WNR.0b013e32835f2810.
86. Induction of heat shock proteins in the adult rat cerebral cortex following pilocarpine-induced status epilepticus. Lively S and Brown IR, Brain Res. 2010 Oct 21.
87. Effect of hypertonic saline resuscitation on heme oxygenase-1 mRNA expression and apoptosis of the intestinal mucosa in a rat model of hemorrhagic shock. Lu YQ, etal., Chin Med J (Engl). 2010 Jun;123(11):1453-8.
88. Ischemic preconditioning of small bowel mitigates the late phase of reperfusion injury: heme oxygenase mediates cytoprotection. Mallick IH, etal., Am J Surg. 2010 Feb;199(2):223-31. doi: 10.1016/j.amjsurg.2009.01.011. Epub 2009 Apr 11.
89. Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease. Manaud G, etal., Am J Respir Cell Mol Biol. 2020 Jul;63(1):118-131. doi: 10.1165/rcmb.2019-0015OC.
90. Heme oxygenase-1 and the ischemia-reperfusion injury in the rat heart. Masini E, etal., Exp Biol Med (Maywood). 2003 May;228(5):546-9.
91. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
92. MGDs mouse GO annotations MGD data from the GO Consortium
93. MGD IEA MGD IEA
94. Expression of heme oxygenase-1 in the peripheral blood mononuclear cells from asthmatic patients. Mo B, etal., J Huazhong Univ Sci Technolog Med Sci. 2005;25(4):385-8.
95. A phosphodiesterase III inhibitor protects rat liver from sinusoidal obstruction syndrome through heme oxygenase-1 induction. Narita M, etal., Ann Surg. 2009 May;249(5):806-13.
96. Oxidative stress and induction of heme oxygenase-1 in the kidney in sickle cell disease. Nath KA, etal., Am J Pathol. 2001 Mar;158(3):893-903.
97. Heme protein-induced chronic renal inflammation: suppressive effect of induced heme oxygenase-1. Nath KA, etal., Kidney Int. 2001 Jan;59(1):106-17.
98. Hemin therapy suppresses inflammation and retroperitoneal adipocyte hypertrophy to improve glucose metabolism in obese rats co-morbid with insulin-resistant type-2 diabetes. Ndisang JF and Jadhav A, Diabetes Obes Metab. 2013 Nov;15(11):1029-39. doi: 10.1111/dom.12130. Epub 2013 Jun 30.
99. Selective regulation of blood pressure by heme oxygenase-1 in hypertension. Ndisang JF, etal., Hypertension. 2002 Sep;40(3):315-21.
100. Protein therapy using heme-oxygenase-1 fused to a polyarginine transduction domain attenuates cerebral vasospasm after experimental subarachnoid hemorrhage. Ogawa T, etal., J Cereb Blood Flow Metab. 2011 Nov;31(11):2231-42. doi: 10.1038/jcbfm.2011.87. Epub 2011 Jun 8.
101. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
102. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
103. A promoter variant of the heme oxygenase-1 gene may reduce the incidence of ischemic heart disease in Japanese. Ono K, etal., Atherosclerosis. 2004 Apr;173(2):315-9.
104. Association of a promoter variant of the haeme oxygenase-1 gene with hypertension in women. Ono K, etal., J Hypertens. 2003 Aug;21(8):1497-503.
105. Protective effect of heme oxygenase-1 on lung injury induced by erythrocyte instillation in rats. Pang QF, etal., Chin Med J (Engl). 2008 Sep 5;121(17):1688-92.
106. Evaluation of oxidative status and depression-like responses in Brown Norway rats with acute myeloid leukemia. Papiez MA, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2009 Jun 15;33(4):596-604. doi: 10.1016/j.pnpbp.2009.02.015. Epub 2009 Mar 3.
107. The microglial alpha7-acetylcholine nicotinic receptor is a key element in promoting neuroprotection by inducing heme oxygenase-1 via nuclear factor erythroid-2-related factor 2. Parada E, etal., Antioxid Redox Signal. 2013 Oct 10;19(11):1135-48. doi: 10.1089/ars.2012.4671. Epub 2013 Feb 25.
108. Ischemia/reperfusion Lung Injury Increases Serum Ferritin and Heme Oxygenase-1 in Rats. Park YY Korean J Physiol Pharmacol. 2009 Jun;13(3):181-7. Epub 2009 Jun 30.
109. Induction of heme oxygenase-1 expression inhibits platelet-dependent thrombosis. Peng L, etal., Antioxid Redox Signal. 2004 Aug;6(4):729-35.
110. Heme Oxygenase-1 Mediates the Protective Effects of Ischemic Preconditioning on Mitigating Lung Injury Induced by Lower Limb Ischemia-Reperfusion in Rats. Peng TC, etal., J Surg Res. 2010 Jun 30.
111. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
112. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
113. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
114. Development of inhibitory antibodies to therapeutic factor VIII in severe hemophilia A is associated with microsatellite polymorphisms in the HMOX1 promoter. Repesse Y, etal., Haematologica. 2013 Oct;98(10):1650-5. doi: 10.3324/haematol.2013.084665. Epub 2013 May 28.
115. Mouse MP Annotation Import Pipeline RGD automated import pipeline
116. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
117. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
118. Chronic tempol treatment attenuates the renal hemodynamic effects induced by a heme oxygenase inhibitor in streptozotocin diabetic rats. Rodriguez F, etal., Am J Physiol Regul Integr Comp Physiol. 2011 Nov;301(5):R1540-8. doi: 10.1152/ajpregu.00847.2010. Epub 2011 Aug 17.
119. Heme oxygenase-1, a potential biomarker of chronic silicosis, attenuates silica-induced lung injury. Sato T, etal., Am J Respir Crit Care Med. 2006 Oct 15;174(8):906-14. Epub 2006 Jul 20.
120. Heme oxygenase-1 gene promoter polymorphism is associated with abdominal aortic aneurysm. Schillinger M, etal., Thromb Res. 2002 Apr 15;106(2):131-6.
121. Expression of heme oxygenase-1 in the senescent and Alzheimer-diseased brain. Schipper HM, etal., Ann Neurol 1995 Jun;37(6):758-68.
122. Time course of Keap1-Nrf2 pathway expression after experimental intracerebral haemorrhage: correlation with brain oedema and neurological deficit. Shang H, etal., Free Radic Res. 2013 May;47(5):368-75. doi: 10.3109/10715762.2013.778403. Epub 2013 Mar 21.
123. Heme oxygenase-1 microsatellite polymorphism and haplotypes are associated with the development of acute respiratory distress syndrome. Sheu CC, etal., Intensive Care Med. 2009 Aug;35(8):1343-51. Epub 2009 Jun 13.
124. Synergistic induction of heme oxygenase-1 by nicaraven after subarachnoid hemorrhage to prevent delayed cerebral vasospasm. Shimada Y, etal., Eur J Pharmacol. 2009 Oct 12;620(1-3):16-20. Epub 2009 Aug 15.
125. Increased expression of Leydig cell haem oxygenase-1 preserves spermatogenesis in varicocele. Shiraishi K and Naito K, Hum Reprod. 2005 Sep;20(9):2608-13. Epub 2005 May 5.
126. Hypoxic preconditioning with cobalt ameliorates hypobaric hypoxia induced pulmonary edema in rat. Shukla D, etal., Eur J Pharmacol. 2011 Apr 10;656(1-3):101-9. doi: 10.1016/j.ejphar.2011.01.038. Epub 2011 Feb 4.
127. VEGF-induced heme oxygenase-1 confers cytoprotection from lethal hyperoxia in vivo. Siner JM, etal., FASEB J. 2007 May;21(7):1422-32. Epub 2007 Jan 30.
128. Inhibition of the NADPH oxidase regulates heme oxygenase 1 expression in chronic myeloid leukemia. Singh MM, etal., Cancer. 2012 Jul 1;118(13):3433-45. doi: 10.1002/cncr.26621. Epub 2011 Dec 2.
129. Induction of pro- and anti-inflammatory molecules in a mouse model of pneumococcal pneumonia after influenza. Smith MW, etal., Comp Med. 2007 Feb;57(1):82-9.
130. Zinc protoporphyrin aggravates cerebral ischemic injury following experimental subarachnoid hemorrhage. Sun BL, etal., Clin Hemorheol Microcirc. 2006;34(1-2):241-6.
131. Retinal protection from acute glaucoma-induced ischemia-reperfusion injury through pharmacologic induction of heme oxygenase-1. Sun MH, etal., Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4798-808. Epub 2010 Mar 31.
132. Intracranial heme metabolism and cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Suzuki H, etal., Stroke. 2003 Dec;34(12):2796-800. Epub 2003 Dec 1.
133. Facilitated angiogenesis induced by heme oxygenase-1 gene transfer in a rat model of hindlimb ischemia. Suzuki M, etal., Biochem Biophys Res Commun. 2003 Feb 28;302(1):138-43.
134. Right ventricle of patients undergoing congenital cardiac surgery differentially expresses haem oxygenase-1 and heat shock protein 70 genes. Takeuchi M, etal., J Int Med Res. 2003 Sep-Oct;31(5):413-7.
135. Induction of hepatic Bach1 mRNA expression by carbon tetrachloride-induced acute liver injury in rats. Tanioka N, etal., Biomed Rep. 2014 May;2(3):359-363. Epub 2014 Feb 7.
136. Antioxidant effects of diallyl trisulfide on high glucose-induced apoptosis are mediated by the PI3K/Akt-dependent activation of Nrf2 in cardiomyocytes. Tsai CY, etal., Int J Cardiol. 2013 Sep 30;168(2):1286-97. doi: 10.1016/j.ijcard.2012.12.004. Epub 2013 Feb 27.
137. Postconditioning with far-infrared irradiation increases heme oxygenase-1 expression and protects against ischemia/reperfusion injury in rat testis. Tu YP, etal., Life Sci. 2013 Jan 17;92(1):35-41. doi: 10.1016/j.lfs.2012.10.019. Epub 2012 Nov 7.
138. Role of melatonin and luzindole in rat mammary cancer. Umit UM, etal., J Invest Surg. 2012 Dec;25(6):345-53. doi: 10.3109/08941939.2012.665570.
139. Brain death induces renal expression of heme oxygenase-1 and heat shock protein 70. van Dullemen LF, etal., J Transl Med. 2013 Jan 29;11:22. doi: 10.1186/1479-5876-11-22.
140. Graft protective effects of heme oxygenase 1 in mouse tracheal transplant-related obliterative bronchiolitis. Visner GA, etal., Transplantation. 2003 Aug 27;76(4):650-6.
141. Influence of heme oxygenase-1 expression on immune liver fibrosis induced by cobalt protoporphyrin in rats. Wang F, etal., World J Gastroenterol. 2009 Jun 28;15(24):3009-14.
142. [Astragalus polysaccharides improved the cardiac function in Sjogren's syndrome model rats based on keap 1-Nrf2/ARE signaling pathway: a mechanism exploration]. Wang F, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014 May;34(5):566-74.
143. Paradoxical protection from atherosclerosis and thrombosis in a mouse model of sickle cell disease. Wang H, etal., Br J Haematol. 2013 Jul;162(1):120-9. doi: 10.1111/bjh.12342. Epub 2013 Apr 17.
144. Role of the heme oxygenase/carbon monoxide pathway in the pathogenesis and prevention of hepatic encephalopathy. Wang QM, etal., Mol Med Rep. 2013 Jul;8(1):67-74. doi: 10.3892/mmr.2013.1472. Epub 2013 May 13.
145. Targeted suppression of heme oxygenase-1 by small interference RNAs inhibits the production of bilirubin in neonatal rat with hyperbilirubinemia. Wu J, etal., BMC Mol Biol. 2009 Aug 1;10:77.
146. Ischemic postconditioning attenuates lung reperfusion injury and reduces systemic proinflammatory cytokine release via heme oxygenase 1. Xu B, etal., J Surg Res. 2011 Apr;166(2):e157-64. doi: 10.1016/j.jss.2010.11.902. Epub 2010 Dec 21.
147. Antioxidant N-acetylcysteine attenuates the reduction of Brg1 protein expression in the myocardium of type 1 diabetic rats. Xu J, etal., J Diabetes Res. 2013;2013:716219. doi: 10.1155/2013/716219. Epub 2013 Jun 18.
148. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Yamada N, etal., Am J Hum Genet. 2000 Jan;66(1):187-95.
149. Association of susceptibility to the development of pneumonia in the older Japanese population with haem oxygenase-1 gene promoter polymorphism. Yasuda H, etal., J Med Genet. 2006 Apr;43(4):e17.
150. Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling. Yet SF, etal., FASEB J. 2003 Sep;17(12):1759-61. Epub 2003 Jul 3.
151. Heme oxygenase-1 upregulation improves lipopolysaccharide-induced acute lung injury involving suppression of macrophage migration inhibitory factor. Yin H, etal., Mol Immunol. 2010 Sep;47(15):2443-9. Epub 2010 Jul 16.
152. Prevention by lansoprazole, a proton pump inhibitor, of indomethacin -induced small intestinal ulceration in rats through induction of heme oxygenase-1. Yoda Y, etal., J Physiol Pharmacol. 2010 Jun;61(3):287-94.
153. Protective effects of hemin pretreatment combined with ulinastatin on septic shock in rats. Yu JB and Yao SL, Chin Med J (Engl). 2008 Jan 5;121(1):49-55.
154. BTZO-15, an ARE-activator, ameliorates DSS- and TNBS-induced colitis in rats. Yukitake H, etal., PLoS One. 2011;6(8):e23256. doi: 10.1371/journal.pone.0023256. Epub 2011 Aug 10.
155. Protective role of heme oxygenase-1 against liver damage caused by hepatic ischemia and reperfusion in rats. Yun N, etal., Antioxid Redox Signal. 2010 Nov 15;13(10):1503-12. doi: 10.1089/ars.2009.2873.
156. Over-expression of HO-1 on mesenchymal stem cells promotes angiogenesis and improves myocardial function in infarcted myocardium. Zeng B, etal., J Biomed Sci. 2010 Oct 7;17:80.
157. Bicyclol upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. Zhang J, etal., Brain Res Bull. 2014 Jan;100:38-43. doi: 10.1016/j.brainresbull.2013.11.001. Epub 2013 Nov 16.
158. Amelioration of radiation-induced skin injury by adenovirus-mediated heme oxygenase-1 (HO-1) overexpression in rats. Zhang S, etal., Radiat Oncol. 2012 Jan 17;7:4. doi: 10.1186/1748-717X-7-4.
159. [A study of the role of heme oxygenase-1 expression in ventilator induced lung injury and its mechanism in rats.] Zhao WJ and Hu WW, Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2010 Jul;22(7):410-3.
160. Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo. Zheng L, etal., Biomed Pharmacother. 2018 Jan;97:481-488. doi: 10.1016/j.biopha.2017.10.153. Epub 2017 Nov 6.
161. Heme oxygenase-1 expression in human lungs with cystic fibrosis and cytoprotective effects against Pseudomonas aeruginosa in vitro. Zhou H, etal., Am J Respir Crit Care Med. 2004 Sep 15;170(6):633-40. Epub 2004 Jun 7.
Additional References at PubMed
PMID:1400499   PMID:3409220   PMID:7538129   PMID:7929191   PMID:8288554   PMID:8630002   PMID:8774698   PMID:8827514   PMID:8974842   PMID:9038135   PMID:9284910   PMID:9380735  
PMID:10037492   PMID:10207174   PMID:10231435   PMID:10329004   PMID:10349636   PMID:10559901   PMID:10725249   PMID:10729222   PMID:10793064   PMID:10807584   PMID:10811610   PMID:10922068  
PMID:11042159   PMID:11076861   PMID:11130978   PMID:11217851   PMID:11273999   PMID:11312611   PMID:11375280   PMID:11385506   PMID:11440978   PMID:11875494   PMID:11880364   PMID:11959104  
PMID:11983445   PMID:11986386   PMID:12006174   PMID:12078492   PMID:12078511   PMID:12112002   PMID:12177608   PMID:12220541   PMID:12225959   PMID:12230868   PMID:12356737   PMID:12456389  
PMID:12477932   PMID:12493591   PMID:12520002   PMID:12540779   PMID:12581208   PMID:12628482   PMID:12642589   PMID:12642904   PMID:12649278   PMID:12668974   PMID:12706494   PMID:12709578  
PMID:12716475   PMID:12753084   PMID:12777398   PMID:12853315   PMID:12918124   PMID:12926842   PMID:14504288   PMID:14610273   PMID:14649057   PMID:14657222   PMID:14681479   PMID:14753415  
PMID:15081633   PMID:15123630   PMID:15131800   PMID:15217802   PMID:15219417   PMID:15240108   PMID:15240748   PMID:15309569   PMID:15331427   PMID:15337692   PMID:15489334   PMID:15522193  
PMID:15589375   PMID:15590657   PMID:15596152   PMID:15640283   PMID:15699165   PMID:15734856   PMID:15831471   PMID:15833736   PMID:15919427   PMID:15919778   PMID:15993853   PMID:16014038  
PMID:16027238   PMID:16048902   PMID:16109301   PMID:16118392   PMID:16137650   PMID:16141072   PMID:16141073   PMID:16181103   PMID:16183037   PMID:16222706   PMID:16234431   PMID:16291820  
PMID:16309568   PMID:16365149   PMID:16371440   PMID:16439612   PMID:16456000   PMID:16473885   PMID:16476737   PMID:16487038   PMID:16602821   PMID:16625420   PMID:16651615   PMID:16704410  
PMID:16804400   PMID:16826603   PMID:16828716   PMID:16828975   PMID:16877550   PMID:16966352   PMID:16982915   PMID:16999934   PMID:17049489   PMID:17082514   PMID:17148680   PMID:17169158  
PMID:17175242   PMID:17242398   PMID:17256058   PMID:17303808   PMID:17339405   PMID:17351069   PMID:17362747   PMID:17384141   PMID:17401437   PMID:17416347   PMID:17430897   PMID:17442976  
PMID:17495224   PMID:17496899   PMID:17525251   PMID:17532486   PMID:17535857   PMID:17576813   PMID:17589347   PMID:17620093   PMID:17632083   PMID:17657593   PMID:17665394   PMID:17679649  
PMID:17728706   PMID:17873285   PMID:17883261   PMID:17885218   PMID:17901053   PMID:17919491   PMID:17933770   PMID:17991714   PMID:18022235   PMID:18025230   PMID:18037988   PMID:18060048  
PMID:18073186   PMID:18093990   PMID:18094356   PMID:18096165   PMID:18206660   PMID:18210237   PMID:18252008   PMID:18262556   PMID:18323531   PMID:18368029   PMID:18384522   PMID:18400743  
PMID:18404528   PMID:18426999   PMID:18474360   PMID:18495963   PMID:18509090   PMID:18511516   PMID:18523255   PMID:18534615   PMID:18535259   PMID:18555605   PMID:18556779   PMID:18560362  
PMID:18566435   PMID:18569078   PMID:18576916   PMID:18582925   PMID:18665050   PMID:18674596   PMID:18690550   PMID:18701634   PMID:18774956   PMID:18787101   PMID:18799693   PMID:18827744  
PMID:18845796   PMID:18845810   PMID:18948842   PMID:18988794   PMID:19036700   PMID:19036845   PMID:19056485   PMID:19060448   PMID:19097991   PMID:19122672   PMID:19176596   PMID:19183880  
PMID:19183882   PMID:19211986   PMID:19224872   PMID:19265153   PMID:19265160   PMID:19289500   PMID:19360320   PMID:19366789   PMID:19398754   PMID:19426286   PMID:19454702   PMID:19457866  
PMID:19458275   PMID:19465127   PMID:19474803   PMID:19487598   PMID:19495412   PMID:19498004   PMID:19536046   PMID:19542024   PMID:19543386   PMID:19578789   PMID:19608869   PMID:19657327  
PMID:19667931   PMID:19681826   PMID:19699520   PMID:19706490   PMID:19741462   PMID:19781175   PMID:19797175   PMID:19818781   PMID:19819905   PMID:19890094   PMID:20020468   PMID:20064636  
PMID:20178793   PMID:20185832   PMID:20303959   PMID:20348279   PMID:20378852   PMID:20395442   PMID:20398193   PMID:20404090   PMID:20417178   PMID:20450988   PMID:20486808   PMID:20501657  
PMID:20504881   PMID:20568122   PMID:20638948   PMID:20676377   PMID:20705711   PMID:20709802   PMID:20716120   PMID:20726230   PMID:20844238   PMID:20881280   PMID:20932343   PMID:20943080  
PMID:20969575   PMID:20979658   PMID:21041703   PMID:21048024   PMID:21069936   PMID:21071446   PMID:21111848   PMID:21118574   PMID:21131421   PMID:21144518   PMID:21216973   PMID:21248714  
PMID:21267068   PMID:21270129   PMID:21272610   PMID:21273783   PMID:21289052   PMID:21307647   PMID:21308776   PMID:21314960   PMID:21334424   PMID:21389693   PMID:21412771   PMID:21437904  
PMID:21437926   PMID:21444764   PMID:21444915   PMID:21454555   PMID:21458444   PMID:21511696   PMID:21518986   PMID:21529713   PMID:21554947   PMID:21613741   PMID:21631178   PMID:21655188  
PMID:21666111   PMID:21677132   PMID:21697243   PMID:21711123   PMID:21744344   PMID:21756853   PMID:21763292   PMID:21778140   PMID:21842368   PMID:21843620   PMID:21849621   PMID:21849978  
PMID:21855684   PMID:21865845   PMID:21867749   PMID:21873635   PMID:21873894   PMID:21945667   PMID:21953613   PMID:21963524   PMID:21971692   PMID:21987660   PMID:22034921   PMID:22045338  
PMID:22099756   PMID:22127667   PMID:22133191   PMID:22145771   PMID:22155388   PMID:22179318   PMID:22243794   PMID:22262768   PMID:22264017   PMID:22287607   PMID:22288898   PMID:22323595  
PMID:22349240   PMID:22426130   PMID:22429450   PMID:22461696   PMID:22479586   PMID:22490782   PMID:22495295   PMID:22518005   PMID:22522044   PMID:22593583   PMID:22594519   PMID:22728935  
PMID:22737862   PMID:22753217   PMID:22761690   PMID:22791292   PMID:22832873   PMID:22851545   PMID:22900010   PMID:22917518   PMID:22964851   PMID:22992020   PMID:23036869   PMID:23042187  
PMID:23065289   PMID:23087099   PMID:23112101   PMID:23187127   PMID:23188493   PMID:23209658   PMID:23267792   PMID:23285041   PMID:23295186   PMID:23390531   PMID:23395172   PMID:23435964  
PMID:23481491   PMID:23515704   PMID:23521418   PMID:23562577   PMID:23578787   PMID:23594402   PMID:23630967   PMID:23717538   PMID:23720344   PMID:23732814   PMID:23747519   PMID:23753410  
PMID:23771693   PMID:23771928   PMID:23861314   PMID:23906616   PMID:23936104   PMID:23994575   PMID:24017971   PMID:24024157   PMID:24038883   PMID:24086665   PMID:24088531   PMID:24095726  
PMID:24097973   PMID:24148794   PMID:24154866   PMID:24206054   PMID:24226420   PMID:24255720   PMID:24269680   PMID:24308158   PMID:24350834   PMID:24361890   PMID:24361900   PMID:24401606  
PMID:24423726   PMID:24440642   PMID:24478369   PMID:24486344   PMID:24494190   PMID:24511086   PMID:24532288   PMID:24578312   PMID:24599172   PMID:24604352   PMID:24623265   PMID:24630724  
PMID:24642709   PMID:24651442   PMID:24658657   PMID:24719331   PMID:24799032   PMID:24844779   PMID:24854244   PMID:24914543   PMID:24940620   PMID:24953853   PMID:24963040   PMID:24993528  
PMID:24995976   PMID:25004066   PMID:25014792   PMID:25050144   PMID:25086571   PMID:25091807   PMID:25107906   PMID:25108023   PMID:25112868   PMID:25114080   PMID:25141966   PMID:25162226  
PMID:25172914   PMID:25218961   PMID:25224969   PMID:25225402   PMID:25239913   PMID:25241054   PMID:25247420   PMID:25267616   PMID:25295542   PMID:25423075   PMID:25446127   PMID:25447985  
PMID:25475440   PMID:25475530   PMID:25478736   PMID:25482391   PMID:25493944   PMID:25580731   PMID:25582460   PMID:25619395   PMID:25640654   PMID:25641586   PMID:25665053   PMID:25677389  
PMID:25677507   PMID:25682599   PMID:25744452   PMID:25753484   PMID:25754743   PMID:25774501   PMID:25780042   PMID:25792017   PMID:25815437   PMID:25820397   PMID:25841764   PMID:25874599  
PMID:25883219   PMID:25895145   PMID:25943274   PMID:25951827   PMID:25975840   PMID:26011640   PMID:26047311   PMID:26071551   PMID:26083119   PMID:26114502   PMID:26142705   PMID:26184139  
PMID:26199344   PMID:26222436   PMID:26224716   PMID:26291391   PMID:26311113   PMID:26346162   PMID:26361083   PMID:26385576   PMID:26405158   PMID:26418896   PMID:26488552   PMID:26492067  
PMID:26505893   PMID:26595750   PMID:26630551   PMID:26644517   PMID:26647788   PMID:26725491   PMID:26730587   PMID:26745712   PMID:26765329   PMID:26830132   PMID:26852687   PMID:26879758  
PMID:26893174   PMID:26894432   PMID:26939788   PMID:26950613   PMID:26950856   PMID:26995887   PMID:27016074   PMID:27052497   PMID:27057920   PMID:27107768   PMID:27110594   PMID:27125672  
PMID:27168057   PMID:27198537   PMID:27224420   PMID:27300700   PMID:27313828   PMID:27316684   PMID:27317654   PMID:27318131   PMID:27338335   PMID:27343195   PMID:27383629   PMID:27383847  
PMID:27412411   PMID:27418542   PMID:27468759   PMID:27560112   PMID:27609199   PMID:27626316   PMID:27638854   PMID:27639646   PMID:27694475   PMID:27704316   PMID:27733322   PMID:27752990  
PMID:27798618   PMID:27810363   PMID:27817989   PMID:27860408   PMID:27867098   PMID:27884351   PMID:27907187   PMID:27974865   PMID:28033400   PMID:28052108   PMID:28068646   PMID:28088947  
PMID:28102348   PMID:28122344   PMID:28194437   PMID:28234792   PMID:28257879   PMID:28287466   PMID:28290522   PMID:28293084   PMID:28298633   PMID:28315822   PMID:28322133   PMID:28473878  
PMID:28487965   PMID:28515173   PMID:28534119   PMID:28566367   PMID:28569786   PMID:28576353   PMID:28576832   PMID:28595178   PMID:28619710   PMID:28683566   PMID:28684418   PMID:28697633  
PMID:28746897   PMID:28751936   PMID:28763300   PMID:28822969   PMID:28842295   PMID:28901476   PMID:28926834   PMID:28928455   PMID:28938188   PMID:29028772   PMID:29034470   PMID:29086419  
PMID:29111167   PMID:29115385   PMID:29121804   PMID:29164113   PMID:29169990   PMID:29180572   PMID:29216542   PMID:29247123   PMID:29277609   PMID:29305861   PMID:29316264   PMID:29359167  
PMID:29377252   PMID:29457983   PMID:29524517   PMID:29599896   PMID:29669713   PMID:29670287   PMID:29674665   PMID:29730008   PMID:29787756   PMID:29787809   PMID:29795214   PMID:29959995  
PMID:29996121   PMID:30018287   PMID:30040734   PMID:30041041   PMID:30054470   PMID:30068325   PMID:30101817   PMID:30153269   PMID:30200963   PMID:30282830   PMID:30316516   PMID:30327713  
PMID:30333233   PMID:30417353   PMID:30426485   PMID:30428359   PMID:30439604   PMID:30481230   PMID:30546363   PMID:30550785   PMID:30593539   PMID:30683864   PMID:30706191   PMID:30814596  
PMID:30818059   PMID:30833408   PMID:30904623   PMID:30950217   PMID:30987262   PMID:31043271   PMID:31049133   PMID:31056974   PMID:31057560   PMID:31071151   PMID:31121826   PMID:31220272  
PMID:31254959   PMID:31279900   PMID:31295319   PMID:31323030   PMID:31369826   PMID:31389006   PMID:31405954   PMID:31416050   PMID:31571584   PMID:31572363   PMID:31578032   PMID:31645120  
PMID:31664855   PMID:31679397   PMID:31705351   PMID:31733834   PMID:31746357   PMID:31746387   PMID:31781345   PMID:31791318   PMID:31796867   PMID:31825462   PMID:31861963   PMID:31885181  
PMID:31969881   PMID:32042051   PMID:32084514   PMID:32096914   PMID:32126118   PMID:32181358   PMID:32277848   PMID:32278282   PMID:32297710   PMID:32301543   PMID:32309436   PMID:32325033  
PMID:32335359   PMID:32342097   PMID:32369450   PMID:32461992   PMID:32476210   PMID:32534959   PMID:32554809   PMID:32568195   PMID:32587658   PMID:32599239   PMID:32601262   PMID:32602850  
PMID:32650596   PMID:32716106   PMID:32751152   PMID:32784053   PMID:32885420   PMID:32941941   PMID:32973183   PMID:32974338   PMID:32975326   PMID:32992485   PMID:33040827   PMID:33057437  
PMID:33092142   PMID:33112369   PMID:33113362   PMID:33137710   PMID:33207934   PMID:33212416   PMID:33355378   PMID:33383563   PMID:33396673   PMID:33399519   PMID:33467682   PMID:33495836  
PMID:33537027   PMID:33547170   PMID:33563837   PMID:33612466   PMID:33761761   PMID:33804125   PMID:33836179   PMID:33882313   PMID:33895485   PMID:34054870   PMID:34056710   PMID:34188052  
PMID:34198827   PMID:34236846   PMID:34368855   PMID:34388243   PMID:34398680   PMID:34508760   PMID:34617947   PMID:34663512   PMID:34885708   PMID:34918393   PMID:34943953   PMID:34946724  
PMID:34977500   PMID:35008897   PMID:35031770   PMID:35276215   PMID:35406657   PMID:35408953   PMID:35581352   PMID:35679889   PMID:35691510   PMID:35702793   PMID:35812724   PMID:35837403  
PMID:35923893   PMID:35955444   PMID:36008747   PMID:36058936   PMID:36086893   PMID:36092713   PMID:36100404   PMID:36113553   PMID:36149046   PMID:36203316   PMID:36211962   PMID:36238648  
PMID:36291740   PMID:36358522   PMID:36509314   PMID:36539019   PMID:36602456   PMID:36647427   PMID:36976101   PMID:36988555   PMID:37172425   PMID:37199892   PMID:37269088   PMID:37284503  
PMID:37302617   PMID:37422643   PMID:37442140   PMID:37480265   PMID:37490064   PMID:37598463   PMID:37677999   PMID:37838477   PMID:37890842   PMID:37948457   PMID:37972884   PMID:37979494  
PMID:38051262   PMID:38147696   PMID:38266827   PMID:38329323  


Genomics

Comparative Map Data
Hmox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39875,820,246 - 75,827,221 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl875,820,249 - 75,827,217 (+)EnsemblGRCm39 Ensembl
GRCm38875,093,618 - 75,100,593 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl875,093,621 - 75,100,589 (+)EnsemblGRCm38mm10GRCm38
MGSCv37877,617,517 - 77,624,492 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36877,989,694 - 77,996,657 (+)NCBIMGSCv36mm8
Celera879,400,848 - 79,407,824 (+)NCBICelera
Cytogenetic Map8C1NCBI
cM Map835.59NCBI
HMOX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382235,381,096 - 35,394,207 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2235,380,361 - 35,394,214 (+)EnsemblGRCh38hg38GRCh38
GRCh372235,777,089 - 35,790,200 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,107,087 - 34,120,194 (+)NCBINCBI36Build 36hg18NCBI36
Build 342234,101,640 - 34,114,748NCBI
Celera2219,579,740 - 19,592,881 (+)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2218,737,577 - 18,750,716 (+)NCBIHuRef
CHM1_12235,735,791 - 35,748,937 (+)NCBICHM1_1
T2T-CHM13v2.02235,839,114 - 35,852,226 (+)NCBIT2T-CHM13v2.0
Hmox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81913,452,365 - 13,479,823 (+)NCBIGRCr8
mRatBN7.21913,466,287 - 13,474,082 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1913,467,244 - 13,474,079 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1913,440,832 - 13,447,675 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01914,206,098 - 14,212,941 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01913,487,026 - 13,493,858 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01914,508,634 - 14,515,455 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1914,508,616 - 14,515,456 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01925,622,556 - 25,629,377 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41913,963,139 - 13,969,960 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11913,967,964 - 13,974,784 (+)NCBI
Celera1913,334,259 - 13,341,080 (+)NCBICelera
Cytogenetic Map19p11NCBI
Hmox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540543,124,510 - 43,130,979 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540543,124,447 - 43,128,873 (+)NCBIChiLan1.0ChiLan1.0
HMOX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22345,322,157 - 45,335,267 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12248,018,985 - 48,034,597 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02216,388,368 - 16,401,289 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12234,230,825 - 34,244,063 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2234,230,825 - 34,244,063 (+)Ensemblpanpan1.1panPan2
HMOX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11028,744,404 - 28,751,544 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1028,743,795 - 28,751,773 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1028,683,213 - 28,689,972 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01029,531,402 - 29,538,230 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1029,530,793 - 29,539,227 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11029,255,139 - 29,261,959 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01029,565,774 - 29,572,612 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01029,745,379 - 29,752,300 (-)NCBIUU_Cfam_GSD_1.0
Hmox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494512,031,937 - 12,038,780 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364925,042,330 - 5,049,311 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364925,042,353 - 5,049,216 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMOX1
(Sus scrofa - pig)
No map positions available.
HMOX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11918,144,466 - 18,157,944 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1918,144,545 - 18,157,971 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045107,791,541 - 107,805,610 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hmox1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624750342,146 - 345,887 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624750341,699 - 346,005 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hmox1
235 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:538
Count of miRNA genes:368
Interacting mature miRNAs:421
Transcripts:ENSMUST00000005548, ENSMUST00000159631, ENSMUST00000160341
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84474791478748059Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84809006482090180Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84809006482090180Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84819016882190288Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84924559183245673Mouse
14746987Manh64_mmandible shape 64 (mouse)85050595884505958Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85050595884505958Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85233484386334843Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85474046188740637Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85515925889159407Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85629887290298872Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85892810792928107Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85913640493136404Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86151347995513605Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6418673698186736Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86466617698666325Mouse
11039503Ccc4_mcolitis susceptibility in the Collaborative Cross 4 (mouse)86517423778002730Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86872247983326976Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined871032003105032123Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined871032003105032123Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7158942790929226Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871829531105829637Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined872122809106123021Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873929123107929226Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse

Markers in Region
PMC129038P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38875,092,944 - 75,093,094UniSTSGRCm38
MGSCv37877,616,843 - 77,616,993UniSTSGRCm37
Celera879,400,154 - 79,400,304UniSTS
Cytogenetic Map8C1UniSTS
cM Map835.0UniSTS
PMC164851P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38875,097,026 - 75,097,228UniSTSGRCm38
MGSCv37877,620,925 - 77,621,127UniSTSGRCm37
Celera879,404,253 - 79,404,455UniSTS
Cytogenetic Map8C1UniSTS
cM Map835.0UniSTS
PMC341742P5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38875,093,640 - 75,093,820UniSTSGRCm38
MGSCv37877,617,539 - 77,617,719UniSTSGRCm37
Celera879,400,870 - 79,401,050UniSTS
Cytogenetic Map8C1UniSTS
cM Map835.0UniSTS
PMC341742P6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38875,093,466 - 75,093,667UniSTSGRCm38
MGSCv37877,617,365 - 77,617,566UniSTSGRCm37
Celera879,400,696 - 79,400,897UniSTS
Cytogenetic Map8C1UniSTS
cM Map835.0UniSTS
PMC341742P7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38875,092,944 - 75,093,667UniSTSGRCm38
MGSCv37877,616,843 - 77,617,566UniSTSGRCm37
Celera879,400,154 - 79,400,897UniSTS
Cytogenetic Map8C1UniSTS
cM Map835.0UniSTS
Hmox1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38875,095,952 - 75,096,894UniSTSGRCm38
MGSCv37877,619,851 - 77,620,793UniSTSGRCm37
Celera879,403,179 - 79,404,121UniSTS
Cytogenetic Map8C1UniSTS
cM Map835.0UniSTS
d19arb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38875,094,253 - 75,094,438UniSTSGRCm38
MGSCv37877,618,152 - 77,618,337UniSTSGRCm37
Celera879,401,483 - 79,401,665UniSTS
Cytogenetic Map8C1UniSTS
cM Map835.0UniSTS
RH126510  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38875,100,322 - 75,100,527UniSTSGRCm38
MGSCv37877,624,221 - 77,624,426UniSTSGRCm37
Celera879,407,553 - 79,407,758UniSTS
Cytogenetic Map8C1UniSTS
cM Map835.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_010442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA186175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC005290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC084823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY319630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L37439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M33203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U70472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000005548   ⟹   ENSMUSP00000005548
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl875,820,249 - 75,827,217 (+)Ensembl
GRCm38.p6 Ensembl875,093,621 - 75,100,589 (+)Ensembl
RefSeq Acc Id: ENSMUST00000159631
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl875,823,472 - 75,825,669 (+)Ensembl
GRCm38.p6 Ensembl875,096,844 - 75,099,041 (+)Ensembl
RefSeq Acc Id: NM_010442   ⟹   NP_034572
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39875,820,246 - 75,827,221 (+)NCBI
GRCm38875,093,618 - 75,100,593 (+)ENTREZGENE
MGSCv37877,617,517 - 77,624,492 (+)RGD
Celera879,400,848 - 79,407,824 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034572   ⟸   NM_010442
- UniProtKB: P14901 (UniProtKB/Swiss-Prot),   Q3U5U6 (UniProtKB/TrEMBL),   Q3U5H8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000005548   ⟸   ENSMUST00000005548

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14901-F1-model_v2 AlphaFold P14901 1-289 view protein structure

Promoters
RGD ID:8667505
Promoter ID:EPDNEW_M11784
Type:initiation region
Name:Hmox1_1
Description:Mus musculus heme oxygenase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38875,093,622 - 75,093,682EPDNEW
RGD ID:6843293
Promoter ID:MM_KWN:54898
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000098626,   OTTMUST00000075866,   OTTMUST00000075909,   OTTMUST00000075910
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36877,616,811 - 77,617,837 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96163 AgrOrtholog
Ensembl Genes ENSMUSG00000005413 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000005548 ENTREZGENE
  ENSMUST00000005548.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.910.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Haem_Oase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_Oase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_Oase-like_multi-hlx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_oxygenase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15368 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96163 ENTREZGENE
NCBI Gene 15368 ENTREZGENE
PANTHER HEME OXYGENASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Heme_oxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hmox1 PhenoGen
PIRSF Haem_Oase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HAEMOXYGNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HEME_OXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48613 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt HMOX1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TVV4_MOUSE UniProtKB/TrEMBL
  Q3U5H8 ENTREZGENE, UniProtKB/TrEMBL
  Q3U5U6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-07 Hmox1  heme oxygenase 1    heme oxygenase (decycling) 1  Symbol and/or name change 5135510 APPROVED