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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10717
Species: Mus musculus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:31355
Term: carboplatin
Definition: A platinum coordination entity with cis square-planar geometry in which platinum(II) is coordinated to two ammonia ligands and a bidentate cyclobutane-1,1-dicarboxylate ligand.
Chemical ID: MESH:D016190
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1multiple interactionsEXP 6480464CTDHMOX1 protein inhibits the reaction [Carboplatin results in increased activity of NFATC4]

PMID:21198546
Hmox1decreases expressionISORGD:28066480464CTDCarboplatin results in decreased expression of HMOX1 mRNA

PMID:18172885
Hmox1decreases response to substanceISORGD:28066480464CTDHMOX1 protein results in decreased susceptibility to Carboplatin

PMID:20368269
Hmox1increases expressionISORGD:7309016480464CTDCarboplatin results in increased expression of HMOX1 mRNA

PMID:26260164
Hmox1multiple interactionsISORGD:28066480464CTDHMOX1 protein inhibits the reaction [Carboplatin results in increased activity of NFATC4]

PMID:21198546
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