RGD Reference Report - Induction of heat shock proteins in the adult rat cerebral cortex following pilocarpine-induced status epilepticus. - Rat Genome Database

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Induction of heat shock proteins in the adult rat cerebral cortex following pilocarpine-induced status epilepticus.

Authors: Lively, S  Brown, IR 
Citation: Lively S and Brown IR, Brain Res. 2010 Oct 21.
RGD ID: 4145131
Pubmed: PMID:20971094   (View Abstract at PubMed)
DOI: DOI:10.1016/j.brainres.2010.10.055   (Journal Full-text)

The expression pattern of a global set of Hsps in the adult rat cerebral cortex was examined during the first week following pilocarpine-induced status epilepticus (SE). Hsp70 and Hsp32 protein were induced at 1 day post-SE and decreased thereafter, whereas Hsp25 exhibited a prolonged induction with increased levels at 3 and 7 days post-SE. Hsp70 was induced in neurons, while Hsp25 and Hsp32 localized to GFAP-positive hypertrophied astrocytes. The induction of Hsp25, Hsp32 and Hsp70 at 1 day following SE, suggests the involvement of these Hsps in early events after SE. Interestingly, while Hsp32 and Hsp70 expression was transient, Hsp25 demonstrated a sustained induction pattern, which may reflect an additional role of Hsp25 in subsequent remodeling events in the days following SE.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
status epilepticus  ISOHmox1 (Rattus norvegicus)4145131; 4145131protein:increased expression:cerebral cortex (rat)RGD 
status epilepticus  IEP 4145131protein:increased expression:cerebral cortex (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hmox1  (heme oxygenase 1)

Genes (Mus musculus)
Hmox1  (heme oxygenase 1)

Genes (Homo sapiens)
HMOX1  (heme oxygenase 1)


Additional Information