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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10717
Species: Mus musculus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:50182
Term: 3,3'-diindolylmethane
Definition: An indole that has formula C17H14N2.
Chemical ID: MESH:C016392
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTD3,3'-diindolylmethane promotes the reaction [sulforaphane results in increased expression of HMOX1 mRNA]; AHR mutant form inhibits the reaction [3,3'-diindolylmethane promotes the reaction [sulforaphane results in increased expression of HMOX1 mRNA]]; ESR1 mutant form promotes the reaction [3,3'-diindolylmethane promotes the reaction [sulforaphane results in increased expression of HMOX1 mRNA]]PMID:23583297
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