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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10717
Species: Mus musculus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:53063
Term: 2,4,6-trinitrobenzenesulfonic acid
Definition: The arenesulfonic acid that is benzenesulfonic acid with three nitro substituents in the 2-, 4- and 6-positions.
Chemical ID: MESH:D014302
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1decreases expressionISOHmox1 (Rattus norvegicus)6480464CTDTrinitrobenzenesulfonic Acid results in decreased expression of HMOX1 proteinPMID:33412153
Hmox1increases expressionISOHmox1 (Rattus norvegicus)6480464CTDTrinitrobenzenesulfonic Acid results in increased expression of HMOX1 mRNA; Trinitrobenzenesulfonic Acid results in increased expression of HMOX1 proteinPMID:25469038 PMID:30503585
Hmox1multiple interactionsISOHmox1 (Rattus norvegicus)6480464CTDdapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of HMOX1 protein]; Heme promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased activity of HMOX1 protein]; Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of HMOX1 protein]; Sulfur Dioxide inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of HMOX1 protein]; Trinitrobenzenesulfonic Acid results in increased expression of and results in increased activity of HMOX1 protein; zinc protoporphyrin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of HMOX1 protein]PMID:17292349 PMID:30503585 PMID:33412153
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