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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10717
Species: Mus musculus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:28230
Term: hesperetin
Definition: A trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position.
Chemical ID: MESH:C013015
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionEXP 6480464CTDhesperetin results in increased expression of HMOX1 proteinPMID:15316927
Hmox1multiple interactionsEXP 6480464CTDhesperetin promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]; hesperetin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]PMID:15316927 PMID:31153982
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDhesperetin results in increased expression of HMOX1 proteinPMID:31153982
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTD[Cisplatin co-treated with hesperetin] results in increased expression of HMOX1 proteinPMID:31153982
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