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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10717
Species: Mus musculus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:16480
Term: nitric oxide
Definition: A nitrogen oxide which is a free radical, each molecule of which consists of one nitrogen and one oxygen atom.
Chemical ID: MESH:D009569
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1affects activityEXP 6480464CTDNitric Oxide affects the activity of HMOX1 proteinPMID:17401437
Hmox1affects response to substanceEXP 6480464CTDHMOX1 protein affects the susceptibility to Nitric OxidePMID:19183270
Hmox1increases expressionEXP 6480464CTDNitric Oxide results in increased expression of HMOX1 mRNA; Nitric Oxide results in increased expression of HMOX1 proteinPMID:15220209 PMID:21690482
Hmox1decreases response to substanceISOHmox1 (Rattus norvegicus)6480464CTDHMOX1 protein results in decreased susceptibility to Nitric OxidePMID:17020887
Hmox1decreases response to substanceISOHMOX1 (Homo sapiens)6480464CTDHMOX1 protein results in decreased susceptibility to Nitric OxidePMID:18178725
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDNitric Oxide results in increased expression of HMOX1 proteinPMID:9699677
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTDHMOX1 protein promotes the reaction [[Raloxifene Hydrochloride results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide]; Nitric Oxide results in increased stability of and results in increased expression of HMOX1 mRNAPMID:20888885 PMID:9699677
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