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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10717
Species: Mus musculus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionEXP 6480464CTDEthinyl Estradiol results in increased expression of HMOX1 mRNAPMID:17555576
Hmox1multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HMOX1 mRNA; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of HMOX1 mRNA]PMID:12072388 PMID:17942748
Hmox1increases expressionISOHmox1 (Rattus norvegicus)6480464CTDEthinyl Estradiol results in increased expression of HMOX1 mRNA; Ethinyl Estradiol results in increased expression of HMOX1 proteinPMID:16926038
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