RGD Reference Report - Lesional accumulation of heme oxygenase-1+ microglia/macrophages in rat traumatic brain injury. - Rat Genome Database

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Lesional accumulation of heme oxygenase-1+ microglia/macrophages in rat traumatic brain injury.

Authors: Liu, Y  Zhang, Z  Luo, B  Schluesener, HJ  Zhang, Z 
Citation: Liu Y, etal., Neuroreport. 2013 Apr 17;24(6):281-6. doi: 10.1097/WNR.0b013e32835f2810.
RGD ID: 10755702
Pubmed: PMID:23470432   (View Abstract at PubMed)
DOI: DOI:10.1097/WNR.0b013e32835f2810   (Journal Full-text)

Heme oxygenase-1 (HO-1) is an inducible rate-limiting enzyme for heme degradation. Here, we studied the HO-1 expression in an open-skull weight-drop-induced traumatic brain injury, with a focus on the early phase, most amenable to therapy. In normal rat brains of our study, HO-1 cells were rarely observed. Significant parenchymal accumulation of HO-1 non-neuron cells was observed 18 h post-traumatic brain injury and increased continuously during the investigating time. We also observed that the accumulated HO-1 non-neuron cells were mainly distributed in the perilesional areas and showed activated microglia/macrophage phenotypes with ramified or amoeboid morphologic characteristics. Further double-labeling experiments showed that most HO-1 non-neuron cells coexpressed CD68 and CD163, but not glial fibrillary acid protein. Our data suggest that HO-1 expression defines a subtype of activated microglia/macrophages involved in the early processes following traumatic brain injury.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
HMOX1HumanBrain Injuries  ISOHmox1 (Rattus norvegicus) RGD 
Hmox1RatBrain Injuries  IEP  RGD 
Hmox1MouseBrain Injuries  ISOHmox1 (Rattus norvegicus) RGD 


Genes (Rattus norvegicus)
Hmox1  (heme oxygenase 1)

Genes (Mus musculus)
Hmox1  (heme oxygenase 1)

Genes (Homo sapiens)
HMOX1  (heme oxygenase 1)