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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10717
Species: Mus musculus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:65408
Term: andrographolide
Definition: A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties.
Chemical ID: MESH:C030419
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionEXP 6480464CTDandrographolide results in increased expression of HMOX1 proteinPMID:29355602
Hmox1multiple interactionsEXP 6480464CTDandrographolide inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 mRNA]PMID:29355602
Hmox1decreases expressionISOHMOX1 (Homo sapiens)6480464CTDandrographolide results in decreased expression of HMOX1 mRNAPMID:35724838
Hmox1increases expressionISOHmox1 (Rattus norvegicus)6480464CTDandrographolide results in increased expression of HMOX1 mRNA; andrographolide results in increased expression of HMOX1 proteinPMID:25110055 PMID:29355602
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDandrographolide results in increased expression of HMOX1 proteinPMID:29165873 PMID:29355602 PMID:35724838
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTD[andrographolide co-treated with TNF protein] results in increased expression of HMOX1 mRNA; HMOX1 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; HMOX1 protein promotes the reaction [andrographolide results in increased expression of DUSP10 protein]PMID:27297870 PMID:29165873 PMID:35724838
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