Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	10717
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Hmox1
Name:	heme oxygenase 1

Acc ID:	CHEBI:16990
Term:	bilirubin IXalpha
Definition:	A member of the class of biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin.
Chemical ID:	MESH:D001663

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Hmox1	multiple interactions	EXP		6480464	CTD	[Rotenone co-treated with Bilirubin] inhibits the reaction [Cannabidiol results in increased expression of HMOX1 mRNA]; Bilirubin inhibits the reaction [Cannabidiol results in increased expression of HMOX1 mRNA]; sodium arsenite promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]	PMID:22688006 PMID:32033040
Hmox1	affects activity	ISO	HMOX1 (Homo sapiens)	6480464	CTD	Bilirubin affects the activity of HMOX1 protein	PMID:12690112
Hmox1	increases abundance	ISO	HMOX1 (Homo sapiens)	6480464	CTD	HMOX1 protein results in increased abundance of Bilirubin	PMID:15226216
Hmox1	increases chemical synthesis	ISO	HMOX1 (Homo sapiens)	6480464	CTD	HMOX1 protein results in increased chemical synthesis of Bilirubin	PMID:26968795
Hmox1	increases expression	ISO	HMOX1 (Homo sapiens)	6480464	CTD	Bilirubin results in increased expression of HMOX1 mRNA	PMID:20196124
Hmox1	multiple interactions	ISO	Hmox1 (Rattus norvegicus)	6480464	CTD	[[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of HMOX1 mRNA] which results in increased chemical synthesis of Bilirubin; [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in increased abundance of Bilirubin	PMID:15226216 PMID:21401295
Hmox1	multiple interactions	ISO	HMOX1 (Homo sapiens)	6480464	CTD	[Ethanol results in increased expression of HMOX1 protein] which results in increased abundance of Bilirubin; Atazanavir Sulfate promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]; Bilirubin inhibits the reaction [[tin protoporphyrin IX results in decreased activity of HMOX1 protein] which results in increased chemical synthesis of Reactive Oxygen Species]; Bilirubin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Lopinavir promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]; Ritonavir promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]	PMID:12690112 PMID:15602829 PMID:26968795

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