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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10717
Species: Mus musculus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:28412
Term: eriodictyol
Definition: A tetrahydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 7, 3' and 4' respectively.
Chemical ID: MESH:C007619
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1decreases expressionISOHMOX1 (Homo sapiens)6480464CTDeriodictyol results in decreased expression of HMOX1 proteinPMID:37020356
Hmox1increases expressionISOHmox1 (Rattus norvegicus)6480464CTDeriodictyol results in increased expression of HMOX1 mRNA; eriodictyol results in increased expression of HMOX1 proteinPMID:28978146
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDeriodictyol results in increased expression of HMOX1 proteinPMID:16799064
Hmox1multiple interactionsISOHmox1 (Rattus norvegicus)6480464CTDeriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]PMID:28978146
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTDbardoxolone methyl inhibits the reaction [eriodictyol results in decreased expression of HMOX1 protein]PMID:37020356
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