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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:eriodictyol
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Accession:CHEBI:28412 term browser browse the term
Definition:A tetrahydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 7, 3' and 4' respectively.
Synonyms:related_synonym: (2S)-2-(3,4-DIHYDROXYPHENYL)-5,7-DIHYDROXY-2,3-DIHYDRO-4H-CHROMEN-4-ONE;   (S)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4-benzopyrone;   (S)-eriodictyol;   Eriodictiol;   Formula=C15H12O6;   InChI=1S/C15H12O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-5,13,16-19H,6H2/t13-/m0/s1;   InChIKey=SBHXYTNGIZCORC-ZDUSSCGKSA-N;   SMILES=Oc1cc(O)c2C(=O)C[C@H](Oc2c1)c1ccc(O)c(O)c1
 alt_id: CHEBI:23945;   CHEBI:4832;   CHEBI:49606
 xref: Beilstein:92358;   CAS:552-58-9;   KEGG:C05631;   KNApSAcK:C00000960;   LIPID_MAPS_instance:LMPK12140002;   LIPID_MAPS_instance:LMPK12140432
 xref_mesh: MESH:C007619


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eriodictyol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A multiple interactions ISO [ABCB1 protein results in decreased susceptibility to Doxorubicin] affects the reaction [eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]]; eriodictyol inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]] CTD PMID:20438634 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 decreases activity ISO eriodictyol results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Bcl2a1b B cell leukemia/lymphoma 2 related protein A1b multiple interactions ISO eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA] CTD PMID:20438634 NCBI chr 9:89,199,273...89,207,838
Ensembl chr 9:89,199,209...89,207,827
JBrowse link
G Cat catalase multiple interactions ISO eriodictyol inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein] CTD PMID:28978146 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions ISO eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA] CTD PMID:20438634 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA] CTD PMID:20438634 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Cxcl10 chemokine (C-X-C motif) ligand 10 multiple interactions EXP eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; eriodictyol inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA] CTD PMID:19426678 NCBI chr 5:92,346,638...92,348,889
Ensembl chr 5:92,346,638...92,348,889
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL8 mRNA] CTD PMID:20438634 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO eriodictyol inhibits the reaction [Arsenic Trioxide results in increased expression of GPT protein] CTD PMID:28978146 NCBI chr15:76,696,726...76,699,675
Ensembl chr15:76,695,716...76,699,686
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 decreases activity ISO eriodictyol results in decreased activity of GSTP1 protein CTD PMID:15041478 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO eriodictyol results in increased expression of HMOX1 protein
eriodictyol results in increased expression of HMOX1 mRNA; eriodictyol results in increased expression of HMOX1 protein
eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]
CTD PMID:16799064 PMID:28978146 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Ifng interferon gamma multiple interactions EXP eriodictyol inhibits the reaction [IFNG protein results in increased abundance of Nitrites] CTD PMID:23942037 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:21544733 PMID:31860763 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]
CTD PMID:20438634 PMID:21544733 PMID:31860763 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions EXP eriodictyol inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA] CTD PMID:19426678 NCBI chr 7:44,997,648...45,002,848
Ensembl chr 7:44,997,648...45,002,848
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP eriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein] CTD PMID:21544733 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP eriodictyol inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] CTD PMID:31860763 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression
multiple interactions
ISO eriodictyol results in increased expression of NFE2L2 protein
eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]
eriodictyol results in increased expression of NFE2L2 mRNA; eriodictyol results in increased expression of NFE2L2 protein
CTD PMID:16799064 PMID:28978146 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP
ISO
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]
CTD PMID:20438634 PMID:21544733 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein] CTD PMID:31860763 NCBI chr11:59,541,569...59,566,955
Ensembl chr11:59,541,568...59,566,956
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:31860763 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein] CTD PMID:20438634 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Tbk1 TANK-binding kinase 1 decreases activity ISO eriodictyol results in decreased activity of TBK1 protein CTD PMID:19426678 NCBI chr10:121,546,455...121,586,794
Ensembl chr10:121,546,455...121,586,787
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity
EXP eriodictyol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
eriodictyol results in decreased activity of TNF protein
CTD PMID:11123379 PMID:20438634 PMID:21544733 PMID:31860763 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 multiple interactions ISO eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA] CTD PMID:20438634 NCBI chr10:19,000,910...19,015,410
Ensembl chr10:19,000,910...19,015,657
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [ABCB1 protein results in decreased susceptibility to Doxorubicin] affects the reaction [eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]]; eriodictyol affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA] CTD PMID:20438634 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
homoeriodictyol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 multiple interactions ISO homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the localization of AIFM1 protein] CTD PMID:29902531 NCBI chr  X:48,474,944...48,513,563
Ensembl chr  X:48,474,944...48,513,563
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 protein] CTD PMID:29902531 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions ISO homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2L1 protein] CTD PMID:29902531 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Casp3 caspase 3 multiple interactions ISO homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein] CTD PMID:29902531 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp9 caspase 9 multiple interactions ISO homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein] CTD PMID:29902531 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase multiple interactions EXP homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein] CTD PMID:31850465 NCBI chr19:44,073,334...44,107,505
Ensembl chr19:44,073,335...44,107,480
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO homoeriodictyol results in decreased activity of CYP1A1 protein CTD PMID:10781868 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO homoeriodictyol results in decreased activity of CYP1B1 protein CTD PMID:10781868 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO homoeriodictyol results in increased expression of GCLM mRNA CTD PMID:29902531 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Ghrl ghrelin multiple interactions ISO [homoeriodictyol co-treated with Glucose] results in increased secretion of GHRL protein CTD PMID:28834253 NCBI chr 6:113,716,119...113,719,911
Ensembl chr 6:113,716,119...113,719,880
JBrowse link
G Ikbkb inhibitor of kappaB kinase beta multiple interactions EXP homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein] CTD PMID:31850465 NCBI chr 8:22,659,205...22,706,589
Ensembl chr 8:22,659,212...22,706,589
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:31850465 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions EXP homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:31850465 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO homoeriodictyol results in increased expression of and results in increased localization of NFE2L2 protein; homoeriodictyol results in increased stability of and results in increased expression of and results in increased activity of NFE2L2 protein; NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein] CTD PMID:29902531 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:31850465 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:31850465 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein]
homoeriodictyol results in increased expression of NQO1 mRNA
CTD PMID:29902531 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein] CTD PMID:29902531 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:31850465 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of RELA protein] CTD PMID:31850465 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:31850465 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
neoeriocitrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bglap bone gamma carboxyglutamate protein multiple interactions
increases expression
EXP neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of BGLAP mRNA]
neoeriocitrin results in increased expression of BGLAP mRNA
CTD PMID:21741227 NCBI chr 3:88,383,495...88,384,466
Ensembl chr 3:88,383,501...88,384,464
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions
increases expression
EXP neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of COL1A1 mRNA]
neoeriocitrin results in increased expression of COL1A1 mRNA
CTD PMID:21741227 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Runx2 runt related transcription factor 2 increases expression EXP neoeriocitrin results in increased expression of RUNX2 mRNA CTD PMID:21741227 NCBI chr17:44,495,987...44,814,797
Ensembl chr17:44,495,987...44,814,797
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21727
    chemical entity 21725
      molecular entity 21712
        polyatomic entity 21602
          heteroatomic molecular entity 21534
            hydroxides 20161
              organic hydroxy compound 19184
                hydroxyflavanone 308
                  tetrahydroxyflavanone 49
                    eriodictyol 43
                      (2S)-2-hydroxyeriodictyol 0
                      (2S)-eriodictoyl-7-O-beta-D-glucopyranosiduronic acid 0
                      (2S)-eriodictyol 7-O-(6''-O-galloyl)-beta-D-glucopyranoside 0
                      diinsininol 0
                      eriocitrin 0
                      eriodictoyl-7-O-sophoroside 0
                      homoeriodictyol + 21
                      neoeriocitrin 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 21727
    subatomic particle 21713
      composite particle 21713
        hadron 21713
          baryon 21713
            nucleon 21713
              atomic nucleus 21713
                atom 21713
                  main group element atom 21629
                    p-block element atom 21629
                      carbon group element atom 21434
                        carbon atom 21334
                          organic molecular entity 21334
                            organic molecule 21228
                              organic cyclic compound 20811
                                organic heterocyclic compound 19779
                                  oxacycle 18199
                                    benzopyran 10576
                                      1-benzopyran 10305
                                        flavonoid 6629
                                          flavans 3069
                                            flavanones 321
                                              hydroxyflavanone 308
                                                tetrahydroxyflavanone 49
                                                  eriodictyol 43
                                                    (2S)-2-hydroxyeriodictyol 0
                                                    (2S)-eriodictoyl-7-O-beta-D-glucopyranosiduronic acid 0
                                                    (2S)-eriodictyol 7-O-(6''-O-galloyl)-beta-D-glucopyranoside 0
                                                    diinsininol 0
                                                    eriocitrin 0
                                                    eriodictoyl-7-O-sophoroside 0
                                                    homoeriodictyol + 21
                                                    neoeriocitrin 3
paths to the root